Effective targeting of PDGFRA-altered high-grade glioma with avapritinib

Authors: Mayr, Lisa ^{1, 2, 41}, Neyazi, Sina ^{1, 41}, Schwark, Kallen ^{3, 41}, Trissal, Maria ^{1, 41}, Beck, Alexander ⁴, Labelle, Jenna ¹, Eder, Sebastian K. ^{1, 5}, Weiler-Wichtl, Liesa ², Marques, Joana G. ¹, de Biagi-Junior, Carlos A.O. ¹, Lo Cascio, Costanza ¹, Chapman, Owen ⁶, Sridhar, Sunita ⁶, Kenkre, Rishaan ⁶, Dutta, Aditi ⁶, Wang, Shanqing ⁶, Wang, Jessica ⁶, Hack, Olivia ¹, Nascimento, Andrezza ¹, Nguyen, Cuong M. ¹, Castellani, Sophia ¹, Rozowsky, Jacob S. ¹, Groves, Andrew ¹, Panditharatna, Eshini ¹, Cruzeiro, Gustavo Alencastro Veiga ¹, Haase, Rebecca D. ¹, Tabatabai, Kuscha ¹, Madlener, Sibylle ², Wadden, Jack ³, Adam, Tiffany ³, Kong, Seongbae ³, Miclea, Madeline ³, Patel, Tirth ³, Bruckner, Katharina ^{2, 7}, Senfter, Daniel ², Lämmerer, Anna ^{2, 8, 9}, Supko, Jeffrey ¹⁰, Guntner, Armin S. ¹¹, Palova, Hana ¹², Neradil, Jakub ^{13, 14}, Stepien, Natalia ², Lötsch-Gojo, Daniela ⁷, Berger, Walter ^{8, 9}, Leiss, Ulrike ², Rosenmayr, Verena ², Dorfer, Christian ⁷, Dieckmann, Karin ¹⁵, Peyrl, Andreas ², Azizi, Amedeo A. ², Baumgartner, Alicia ^{1, 2}, Slaby, Ondrej ^{12, 16}, Pokorna, Petra ¹², Clark, Louise M. ¹⁷, Cameron, Amy ¹⁷, Nguyen, Quang-De ¹⁷, Wakimoto, Hiroaki ¹⁸, Dubois, Frank ¹, Greenwald, Noah F. ^{19, 20}, Bandopadhayay, Pratiti ¹, Beroukhim, Rameen ^{19, 21}, Ligon, Keith ¹, Kramm, Christof ²², Bronsema, Annika ²³, Bailey, Simon ^{24, 25}, Stucklin, Ana Guerreiro ²⁶, Mueller, Sabine ²⁷, Skrypek, Mary ²⁸, Martinez, Nina ²⁹, Bowers, Daniel C. ³⁰, Jones, David T.W. ^{31, 32}, Jones, Chris ³³, Jäger, Natalie ³⁴, Sterba, Jaroslav ³⁵, Müllauer, Leonhard ³⁶, Haberler, Christine ³⁷, Kumar-Sinha, Chandan ³⁸, Chinnaiyan, Arul ³⁸, Mody, Rajen ³, Chavez, Lukas ⁶, Furtner, Julia ^{39, 40}, Koschmann, Carl ^{3, 41, ∗}, Gojo, Johannes ^{2, 41, ∗∗}, Filbin, Mariella G. ^{1, 19, 41, 42, ∗∗∗}

Source: In Cancer Cell February 2025

GABAergic neuronal lineage development determines clinically actionable targets in diffuse hemispheric glioma, H3G34-mutant

Authors: Liu, Ilon, Alencastro Veiga Cruzeiro, Gustavo, Bjerke, Lynn, Rogers, Rebecca F., Grabovska, Yura, Beck, Alexander, Mackay, Alan, Barron, Tara, Hack, Olivia A., Quezada, Michael A., Molinari, Valeria, Shaw, McKenzie L., Perez-Somarriba, Marta, Temelso, Sara, Raynaud, Florence, Ruddle, Ruth, Panditharatna, Eshini, Englinger, Bernhard, Mire, Hafsa M., Jiang, Li, Nascimento, Andrezza, LaBelle, Jenna, Haase, Rebecca, Rozowsky, Jacob, Neyazi, Sina, Baumgartner, Alicia-Christina, Castellani, Sophia, Hoffman, Samantha E., Cameron, Amy, Morrow, Murry, Nguyen, Quang-De, Pericoli, Giulia, Madlener, Sibylle, Mayr, Lisa, Dorfer, Christian, Geyeregger, Rene, Rota, Christopher, Ricken, Gerda, Ligon, Keith L., Alexandrescu, Sanda, Cartaxo, Rodrigo T., Lau, Benison, Uphadhyaya, Santhosh, Koschmann, Carl, Braun, Emelie, Danan-Gotthold, Miri, Hu, Lijuan, Siletti, Kimberly, Sundström, Erik, Hodge, Rebecca, Lein, Ed, Agnihotri, Sameer, Eisenstat, David D., Stapleton, Simon, King, Andrew, Bleil, Cristina, Mastronuzzi, Angela, Cole, Kristina A., Waanders, Angela J., Montero Carcaboso, Angel, Schüller, Ulrich, Hargrave, Darren, Vinci, Maria, Carceller, Fernando, Haberler, Christine, Slavc, Irene, Linnarsson, Sten, Gojo, Johannes, Monje, Michelle, Jones, Chris, Filbin, Mariella G.

Source: In Cancer Cell 9 September 2024 42(9):1528-1548

TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory

Authors: Ausejo-Mauleon, Iker, Labiano, Sara, de la Nava, Daniel, Laspidea, Virginia, Zalacain, Marta, Marrodán, Lucía, García-Moure, Marc, González-Huarriz, Marisol, Hervás-Corpión, Irati, Dhandapani, Laasya, Vicent, Silvestre, Collantes, Maria, Peñuelas, Iván, Becher, Oren J., Filbin, Mariella G., Jiang, Li, Labelle, Jenna, de Biagi-Junior, Carlos A.O., Nazarian, Javad, Laternser, Sandra, Phoenix, Timothy N., van der Lugt, Jasper, Kranendonk, Mariette, Hoogendijk, Raoull, Mueller, Sabine, De Andrea, Carlos, Anderson, Ana C., Guruceaga, Elizabeth, Koschmann, Carl, Yadav, Viveka Nand, Gállego Pérez-Larraya, Jaime, Patiño-García, Ana, Pastor, Fernando, Alonso, Marta M.

Source: In Cancer Cell 13 November 2023 41(11):1911-1926

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Commercially Available Blocking Oligonucleotides Effectively Suppress Unwanted Hemolysis-Related miRNAs in a Large Whole-Blood RNA Cohort

Authors: LaBelle, Jenna, Bowser, Mark, Brown, Alison, Farnam, Leanna, Kho, Alvin, Li, Jiang, McGeachie, Michael, Chase, Robert, Piehl, Shannon, Allen, Kevin, Hobbs, Brian D., Weiss, Scott T., Hersh, Craig, Tantisira, Kelan, Amr, Sami S.

Source: In The Journal of Molecular Diagnostics June 2021 23(6):671-682

The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location

Authors: Liu, Ilon, Jiang, Li, Samuelsson, Erik R., Marco Salas, Sergio, Beck, Alexander, Hack, Olivia A., Jeong, Daeun, Shaw, McKenzie L., Englinger, Bernhard, LaBelle, Jenna, Mire, Hafsa M., Madlener, Sibylle, Mayr, Lisa, Quezada, Michael A., Trissal, Maria, Panditharatna, Eshini, Ernst, Kati J., Vogelzang, Jayne, Gatesman, Taylor A., Halbert, Matthew E., Palova, Hana, Pokorna, Petra, Sterba, Jaroslav, Slaby, Ondrej, Geyeregger, Rene, Diaz, Aaron, Findlay, Izac J., Dun, Matthew D., Resnick, Adam, Suvà, Mario L., Jones, David T. W., Agnihotri, Sameer, Svedlund, Jessica, Koschmann, Carl, Haberler, Christine, Czech, Thomas, Slavc, Irene, Cotter, Jennifer A., Ligon, Keith L., Alexandrescu, Sanda, Yung, W. K. Alfred, Arrillaga-Romany, Isabel, Gojo, Johannes, Monje, Michelle, Nilsson, Mats, Filbin, Mariella G.

Source: Nature Genetics; December 2022, Vol. 54 Issue: 12 p1881-1894, 14p