Applications of mRNA Delivery in Cancer Immunotherapy

Authors: Pan X, Zhang YWQ, Dai C, Zhang J, Zhang M, Chen X

Source: International Journal of Nanomedicine, Vol Volume 20, Pp 3339-3361 (2025)

Subject Terms: mrna immunotherapy, lnp-mrna, car, ici, tumor microenvironment modulation, personalized medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.dovepress.com/applications-of-mrna-delivery-in-cancer-immunotherapy-peer-reviewed-fulltext-article-IJN; https://doaj.org/toc/1178-2013

Access URL: https://doaj.org/article/d99d09be612c42f6865974c359dad33a

Protection efficacy of mRNA-based SARS-CoV-2 variant vaccine in non-human primates

Authors: Dongrong Yi, Yongxin Zhang, Jing Wang, Qian Liu, Ling Ma, Quanjie Li, Saisai Guo, Ruifang Zheng, Xiaoyu Li, Xingong Li, Yijie Dong, Shuaiyao Lu, Weiguo Zhang, Xiaozhong Peng, Shan Cen

Source: Acta Pharmaceutica Sinica B, Vol 15, Iss 2, Pp 934-946 (2025)

Subject Terms: SARS-CoV-2, mRNA-LNP, Vaccine, Spike glycoprotein, Non-human primate, Humoral immunity, Therapeutics. Pharmacology, RM1-950

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Relation: http://www.sciencedirect.com/science/article/pii/S221138352400460X; https://doaj.org/toc/2211-3835

Access URL: https://doaj.org/article/133793d546934d768fd6d06887cf510a

EIF4E-mediated biogenesis of circPHF14 promotes the growth and metastasis of pancreatic ductal adenocarcinoma via Wnt/β-catenin pathway

Authors: Zhou Fang, Zhuo Wu, Chao Yu, Qingyu Xie, Liangtang Zeng, Rufu Chen

Source: Molecular Cancer, Vol 24, Iss 1, Pp 1-20 (2025)

Subject Terms: Pancreatic ductal adenocarcinoma, circPHF14, WNT7A, PABPC1, EIF4E, LNP, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1476-4598

Access URL: https://doaj.org/article/09f72dedad7a4c878553bd604c8162bf

Methylprednisolone substituted lipid nanoparticles deliver C3 transferase mRNA for combined treatment of spinal cord injury

Authors: Haoru Dong, Zongxing He, Shiyi Cai, Haiqiang Ma, Lili Su, Jianfeng Li, Huiying Yang, Rong Xie

Source: Journal of Nanobiotechnology, Vol 23, Iss 1, Pp 1-17 (2025)

Subject Terms: Spinal cord injury, LNP, C3 transferase, Methylprednisolone, Anti-inflammation, Neuroprotection, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5

File Description: electronic resource

Relation: https://doaj.org/toc/1477-3155

Access URL: https://doaj.org/article/684885a7537f4236b7240fae1b7723c2

Authentication and Parking of the Vehicle Using License Plate Detection and Recognition in the Campus

Authors: Rao, Manjula Gururaj, G, Gagan, C, Nikhil T, Pradeep, A B

Source: 2022 International Conference on Artificial Intelligence and Data Engineering (AIDE) Artificial Intelligence and Data Engineering (AIDE), 2022 International Conference on. :74-79 Dec, 2022

Relation: 2022 International Conference on Artificial Intelligence and Data Engineering (AIDE)

Targeting FAP-positive chondrocytes in osteoarthritis: a novel lipid nanoparticle siRNA approach to mitigate cartilage degeneration

Authors: Xiang Zhao, Jieming Lin, Mingyang Liu, Dongxin Jiang, Yu Zhang, Xin Li, Bo Shi, Jun Jiang, Chunhui Ma, Hongda Shao, Qingrong Xu, Huang Ping, Jiajin Li, Yanzheng Gao

Source: Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-18 (2024)

Subject Terms: Osteoarthritis, FAP, LNP, Senescence, [68 Ga]Ga-FAPI-04 PET/CT, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5

File Description: electronic resource

Relation: https://doaj.org/toc/1477-3155

Access URL: https://doaj.org/article/97193c2a411b496bbb45e0b772781f27

An LNP-mRNA vaccine modulates innate cell trafficking and promotes polyfunctional Th1 CD4+ T cell responses to enhance BCG-induced protective immunity against Mycobacterium tuberculosisResearch in context

Authors: Hannah Lukeman, Hareth Al-Wassiti, Stewart A. Fabb, Leonard Lim, Trixie Wang, Warwick J. Britton, Megan Steain, Colin W. Pouton, James A. Triccas, Claudio Counoupas

Source: EBioMedicine, Vol 113, Iss , Pp 105599- (2025)

Subject Terms: Mycobacterium tuberculosis, Vaccine, mRNA, LNP, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S235239642500043X; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/b98dcdbd74334933ae2a5a281a58a9d6

Targeted nasal delivery of LNP-mRNAs aerosolised by Rayleigh breakup technology

Authors: Li, Hao-Ying ^{a, ⁎}, Paramanandana, Abhimata ^a, Kim, Sally Yunsun ^a, Granger, Luke ^b, Raimi-Abraham, Bahijja Tolulope ^a, Shattock, Robin ^b, Makatsoris, Charalampos ^c, Forbes, Ben ^{a, ⁎}

Source: In International Journal of Pharmaceutics 15 March 2025 672

mRNA-LNP vaccine strategies: Effects of adjuvants on non-parenchymal liver cells and tolerance

Authors: Svensson, Malin ^{1, 4}, Limeres, María José ^{1, 4}, Zeyn, Yanira ², Gambaro, Rocio C. ¹, Islan, German A. ¹, Berti, Ignacio Rivero ¹, Fraude-El Ghazi, Silvia ¹, Pretsch, Leah ¹, Hilbert, Katja ¹, Schneider, Paul ², Kaps, Leonard ^{2, 3}, Bros, Matthias ², Gehring, Stephan ¹, Cacicedo, Maximiliano L. ^{1, ∗}

Source: In Molecular Therapy - Methods & Clinical Development 13 March 2025 33(1)

Characterization of a novel conditional knockout mouse model to assess efficacy of mRNA therapy in the context of severe OTC deficiency

Authors: Zhou, Jenny ¹, Liang, Shi ¹, Yin, Ling ¹, Frassetto, Andrea ¹, Graham, Anne-Renee ¹, White, Rebecca ¹, Principe, Maria ¹, Severson, Madelyn ¹, Palmer, Tiffany ¹, Naidu, Shan ¹, Jacquinet, Eric ¹, Zimmer, Mike ¹, Finn, Patrick F. ^{1, ∗}, Martini, Paolo G.V. ^{1, ∗∗}

Source: In Molecular Therapy 5 March 2025 33(3):1197-1212

Development of Etf-3-specific nanobodies to prevent Ehrlichia infection and LNP-mRNA delivery in cellular and murine models

Authors: Duan, Nan ^a, Lin, Mingqun ^a, Zhang, Wenqing ^a, Yan, Qi ^a, Chien, Rory C. ^a, Budachetri, Khemraj ^a, Denton, Stephen ^a, Kawahara, Jeffrey ^a, Lakritz, Jeffrey ^b, Zhong, Yichen ^c, Dong, Yizhou ^c, Rikihisa, Yasuko ^{a, ⁎}

Source: In Microbiological Research March 2025 292

Intracellular trafficking of lipid nanoparticles is hindered by cholesterol

Authors: Luo, Chengzhi ^{a, 1}, Li, Yunfei ^{a, 1}, Liu, Haidong ^{a, 1}, He, Jing ^a, Yang, Xiaojuan ^a, Zhao, E. ^a, Zi, Guanghui ^a, Liu, Li ^a, Hong, Yujia ^a, Wang, Hui ^a, Li, Ting ^a, Yang, Zhengyu ^a, Wang, Rui ^a, Xu, Yuhong ^{a, b, ⁎}, Peng, Baowei ^{a, b, c, ⁎}

Source: In International Journal of Pharmaceutics 25 February 2025 671

Personalized membrane protein vaccine based on a lipid nanoparticle delivery system prevents postoperative recurrence in colorectal cancer models

Authors: Shi, Guangzhao ^{a, 1}, Xu, Yuandong ^{b, 1}, Qiu, Haowei ^{b, 1}, Cao, Fei ^c, Xiao, Ze-Xiu ^d, Zhang, Changhua ^{a, ⁎}, Zha, Gao-Feng ^{a, b, ⁎}

Source: In Acta Biomaterialia 15 January 2025 192:315-327

Lipid nanoparticle delivery of TALEN mRNA targeting LPA causes gene disruption and plasma lipoprotein(a) reduction in transgenic mice

Authors: Garcia, Daniel A. ^{1, ∗}, Pierre, Abigail F. ¹, Quirino, Linda ¹, Acharya, Grishma ¹, Vasudevan, Aishwarya ¹, Pei, Yihua ¹, Chung, Emily ¹, Chang, Jason Y.H. ¹, Lee, Samuel ¹, Endow, Michael ¹, Kuakini, Kristen ¹, Bresnahan, Michael ¹, Chumpitaz, Maria ¹, Rajappan, Kumar ¹, Parker, Suezanne ¹, Chivukula, Pad ¹, Boehme, Stefen A. ^{1, ∗∗}, Diaz-Trelles, Ramon ¹

Source: In Molecular Therapy 8 January 2025 33(1):90-103

CD47 peptide-cloaked lipid nanoparticles promote cell-specific mRNA delivery

Authors: Papp, Tyler Ellis ^{1, 7}, Zeng, Jianhao ^{1, 7}, Shahnawaz, Hamna ¹, Akyianu, Awurama ¹, Breda, Laura ², Yadegari, Amir ¹, Steward, Joseph ¹, Shi, Ruiqi ¹, Li, Qin ¹, Mui, Barbara L. ³, Tam, Ying K. ³, Weissman, Drew ^{1, 5}, Rivella, Stefano ^{2, 4, 5, 6}, Shuvaev, Vladimir ¹, Muzykantov, Vladimir R. ^{1, 5}, Parhiz, Hamideh ^{1, 5, ∗}

Source: In Molecular Therapy March 2025

Inhibition of IFNAR-JAK signaling enhances tolerability and transgene expression of systemic non-viral DNA delivery

Authors: Senapati, Sujata ¹, Bertolini, Thais B. ², Minnier, Michael A. ¹, Yazicioglu, Mustafa N. ¹, Markusic, David M. ², Zhang, Rui ¹, Wicks, Joan ³, Nahvi, Ali ¹, Herzog, Roland W. ², Walsh, Matthew C. ¹, Cejas, Pedro J. ^{1, ∗}, Armour, Sean M. ^{1, ∗∗}

Source: In Molecular Therapy - Nucleic Acids 10 June 2025 36(2)

Scalable production of uniform gene-loaded lipid nanoparticles via a fluidity-controlled membrane extrusion

Authors: Kim, Su-gyeom ^a, Park, Seong Hun ^b, Jeong, Seolyeong ^c, Song, Geonho ^b, Oh, Seung Soo ^{a, b, c}, Yi, Gi-Ra ^{a, b, ⁎}

Source: In Journal of Colloid And Interface Science June 2025 687:74-84

Characterization of lipid nanoparticles using macro mass photometry: Insights into size and mass

Authors: Wu, Jikang ^{a, ⁎, 1}, Zhang, Yu ^{b, 1}, Wu, Zhijie ^a, Townsend, Julia ^a, Crooks, Ivor ^c, Watt, Brenda ^d, Baik, Andrew ^b, Cygnar, Katherine ^b, Qiu, Haibo ^{a, ⁎⁎}, Li, Ning ^a

Source: In Analytica Chimica Acta 15 May 2025 1351

Interleukin-35 mRNA therapy for influenza virus-induced pneumonia in mice

Authors: Li, Yanyan ^{a, b, 1}, Liao, Yuqin ^{b, 1}, Miao, Yiqi ^{b, 1}, Yu, Changxiao ^b, Long, Jinrong ^b, Wu, Jiayu ^{b, c}, Zuo, Jun ^b, Zhang, Zhen ^b, Dou, Wei ^{b, c}, Wang, Xin ^b, Zhang, Bo ^c, Yu, Cuiyun ^{a, ⁎⁎}, Yang, Jing ^{b, ⁎}, Wang, Shengqi ^{b, ⁎⁎⁎}

Source: In European Journal of Pharmacology 15 April 2025 993

Progress in Gene Therapy for Hereditary Tyrosinemia Type 1

Authors: Helen Thomas, Robert C. Carlisle

Source: Pharmaceutics, Vol 17, Iss 3, p 387 (2025)

Subject Terms: tyrosinemia, gene therapy, lentivirus, LNP, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/17/3/387; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/48714d8c3d7548fdb7e2545ab04498d8