Pharmacological and structural insights into nanvuranlat, a selective LAT1 (SLC7A5) inhibitor, and its N-acetyl metabolite with implications for cancer therapy

Authors: Chunhuan Jin, Xinyu Zhou, Minhui Xu, Hiroki Okanishi, Ryuichi Ohgaki, Yoshikatsu Kanai

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-14 (2025)

Subject Terms: Amino acid transporter, LAT1 inhibitor, Pharmacological selectivity, Drug metabolism & efficacy, Cancer therapy, Medicine, Science

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Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/c4d25c7097a94328abbb8a0746a81586

Amino acid transporter LAT1 is expressed on cancer cell-derived exosomes with potential as a diagnostic and prognostic biomarker

Authors: Yumiao Liu, Ryuichi Ohgaki, Hiroki Okanishi, Minhui Xu, Yoshikatsu Kanai

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)

Subject Terms: Exosome, Cancer, Biomarker, Amino acid transporter, LAT1, SLC7A5, Medicine, Science

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Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/74b37c0c844a40cbacb8a5bbe68dc6eb

The Regulation and Function of the Amino Acid Transporters LAT1, ASCT2, xCT in Urological Cancers

Authors: Xue Zhao, Shinichi Sakamoto, Shinpei Saito, Sangjon Pae, Yasutaka Yamada, Sanji Kanaoka, Jiaxing Wei, Yusuke Goto, Tomokazu Sazuka, Yusuke Imamura, Naohiko Anzai, Tomohiko Ichikawa

Source: Receptors, Vol 3, Iss 4, Pp 474-493 (2024)

Subject Terms: amino acid transporters, LAT1, ASCT2, xCT, urological cancer, inhibitor, Genetics, QH426-470, Physical and theoretical chemistry, QD450-801

File Description: electronic resource

Relation: https://www.mdpi.com/2813-2564/3/4/24; https://doaj.org/toc/2813-2564

Access URL: https://doaj.org/article/e4ec07e24ed14784856e5740b7801f30

Multi-omics analysis reveals phenylalanine enhance mitochondrial function and hypoxic endurance via LKB1/AMPK activation

Authors: Yi Wu, Yi Ma, Qiang Li, Jing Li, Di Zhang, Yuxin Zhang, Yue Li, Xiaorong Li, Pingxiang Xu, Lu Bai, Xuelin Zhou, Ming Xue

Source: Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-18 (2024)

Subject Terms: Hypoxia adaption, Multi-omics, Zebrafish model, Phenylalanine, LAT1, AMPK, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/a780e7316b864c5891ac55ce28544fb3

A novel paracetamol derivative alleviates lipopolysaccharide-induced neuroinflammation

Authors: Králová, Adéla ^⁎, Montaser, Ahmed B., Tampio, Janne, Adla, Santosh Kumar, Jalkanen, Aaro, Rysä, Jaana, Huttunen, Kristiina M.

Source: In European Journal of Pharmacology 15 May 2025 995

Expression rate of LAT1 in high-grade parotid gland carcinoma and potential of BNCT as a treatment option for recurrent parotid gland carcinoma

Authors: Kikuoka, Yusuke ^a, Aihara, Teruhito ^{a, b, ⁎}, Higashino, Masaaki ^b, Kurisu, Yoshitaka ^d, Haginomori, Shin-ichi ^{a, b}, Nihei, Keiji ^{a, c}, Ono, Koji ^{a, e}

Source: In Applied Radiation and Isotopes April 2025 218

Sciatic nerve analysis in thyroid hormone transporters Mct8 and Oatp1c1 knockout mice

Authors: Steffen Mayerl, Andrea Alcaide Martin, Reinhard Bauer, Heike Heuer

Source: European Thyroid Journal, Vol 14, Iss 1 (2025)

Subject Terms: sciatic nerve, lat1, lat2, mct10, slc16a2, slco1c1, t3, t4, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

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Relation: https://etj.bioscientifica.com/view/journals/etj/14/1/ETJ-24-0248.xml; https://doaj.org/toc/2235-0802

Access URL: https://doaj.org/article/20acced8fd5c4e30a724e5d147825b1e

l-Type amino acid transporter 1-targeting nanoparticles for antisense oligonucleotide delivery to the CNS

Authors: Yu Na Lim, In Soo Ryu, Yeon-Joo Jung, Gabriel Helmlinger, Insun Kim, Hye Won Park, Hansol Kang, Jina Lee, Hyo Jin Lee, Kang Seon Lee, Ha-Na Jang, Dae-In Ha, Junghyung Park, Jinyoung Won, Kyung Seob Lim, Chang-Yeop Jeon, Hyun-Jeong Cho, Hyun Su Min, Jin-Hyeob Ryu

Source: Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102340- (2024)

Subject Terms: MT: Oligonucleotides: Therapies and Applications, l-type amino acid transporter 1, LAT1, antisense oligonucleotide, ASO, LAT1-targeting nanoparticles, Therapeutics. Pharmacology, RM1-950

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Relation: http://www.sciencedirect.com/science/article/pii/S2162253124002270; https://doaj.org/toc/2162-2531

Access URL: https://doaj.org/article/75ccd5988ffe4c2d820c0368db49aea4

LAT1 expression in colorectal cancer cells is unresponsive to HIF-1/2α accumulation under experimental hypoxia

Authors: Ryuichi Ohgaki, Yuma Hirase, Minhui Xu, Hiroki Okanishi, Yoshikatsu Kanai

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)

Subject Terms: Hypoxia, Colorectal cancer, Amino acid transporter, LAT1, Hypoxia-inducible factor, Transcriptional regulation, Medicine, Science

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Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/c30514178ca64db0a559525dab83eee2

LAT1 transporter as a target for breast cancer diagnosis and therapy

Authors: Zhou, Zheyang ^{a, b}, Zhu, Tao ^{a, b}, Zheng, Wenlong ^{b, c}, Zou, Zhixiang ^{a, b}, Shan, Qingfei ^{a, b}, Chen, Qing ^{a, b, ⁎⁎}, Wang, Gang ^{a, b, ⁎⁎⁎}, Wang, Yang ^{a, b, ⁎}

Source: In European Journal of Medicinal Chemistry 5 February 2025 283

Prognostic significance of LAT1 expression in pleural mesothelioma

Authors: Ryo Taguchi, Kyoichi Kaira, Yu Miura, Tetsuya Umesaki, Atsuto Mouri, Hisao Imai, Hiroshi Kagamu, Masanori Yasuda, Yoshikatsu Kanai, Hiroyuki Nitanda, Hironori Ishida, Hirozo Sakaguchi

Source: Heliyon, Vol 10, Iss 17, Pp e37414- (2024)

Subject Terms: Malignant mesothelioma, LAT1, Prognosis, Immunohistochemistry, Predictive marker, Science (General), Q1-390, Social sciences (General), H1-99

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Relation: http://www.sciencedirect.com/science/article/pii/S2405844024134457; https://doaj.org/toc/2405-8440

Access URL: https://doaj.org/article/31c2c6cffc66424fb45f3b27bb180f1b

LAT1 supports mitotic progression through Golgi unlinking in an amino acid transport activity-independent manner

Authors: Yanagida, Sakura, Yuki, Ryuzaburo ^∗, Saito, Youhei, Nakayama, Yuji ^∗

Source: In Journal of Biological Chemistry October 2024 300(10)

Hypoxia-mimetic by CoCl2 increases SLC7A5 expression in breast cancer cells in vitro

Authors: Leonora Canhasi, Elisabet Tina, Anna Göthlin Eremo

Source: BMC Research Notes, Vol 16, Iss 1, Pp 1-7 (2023)

Subject Terms: Endocrine Breast cancer, Hypoxia, LAT1, SLC7A5, CoCl2, Medicine, Biology (General), QH301-705.5, Science (General), Q1-390

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Relation: https://doaj.org/toc/1756-0500

Access URL: https://doaj.org/article/035a57e4c7b3455f9f0cb057c26f7661

Development of L-phenylalanine-grafted poly (vinyl alcohol) scaffold for selective capturing of cancer cells

Authors: Ryoto Itani, Ryo Mitsuyasu, Kang Dong-hee, Kenta Homma, Michiya Matsusaki

Source: Talanta Open, Vol 9, Iss , Pp 100314- (2024)

Subject Terms: Phenylalanine, LAT1, Breast cancer cell, Poly (vinyl alcohol), Cancer cell adhesion, Analytical chemistry, QD71-142

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Relation: http://www.sciencedirect.com/science/article/pii/S2666831924000286; https://doaj.org/toc/2666-8319

Access URL: https://doaj.org/article/3cefdc717e974028b02b6dfafcb44909

Inhibition of amino acid transporter LAT1 in cancer cells suppresses G0/G1-S transition by downregulating cyclin D1 via p38 MAPK activation

Authors: Zhou, Xinyu ^a, Ohgaki, Ryuichi ^{a, b, ∗∗}, Jin, Chunhuan ^a, Xu, Minhui ^a, Okanishi, Hiroki ^a, Endou, Hitoshi ^c, Kanai, Yoshikatsu ^{a, b, ∗}

Source: In Journal of Pharmacological Sciences March 2024 154(3):182-191

Advanced Blood-Brain Barrier Drug Delivery

Contributors: Pardridge, William M.

Subject Terms: blood–brain barrier (BBB), brain drug delivery, prodrugs, solute carriers (SLCs), lysosomal storage disease, neuronopathic mucopolysaccharidosis, blood–brain barrier, neurodegeneration, enzyme replacement therapy, receptor-mediated transcytosis, transferrin receptor, insulin receptor, endothelium, receptor-mediated transport, carrier-mediated transport, genetic engineering, IgG fusion proteins, nanoparticles, liposomes, TrkB, agonist antibody, variable new antigen receptor (VNAR), neuroprotection, transferrin receptor 1 (TfR1), blood-brain barrier (BBB), 6-OHDA, Parkinson’s disease, bispecific antibody, alpha-synuclein (αSYN), Parkinson’s disease (PD), immunotherapy, monoclonal antibody, transferrin receptor (TfR), receptor-mediated transcytosis (RMT), single domains antibody, IGF1R, neurotensin, protein-based therapy, lysosomal storage disorders, fusion proteins, Alzheimer’s disease, neurotrophic factors, decoy receptors, ATP-binding cassette transporters, drug delivery, ischemic stroke, SLC transporters, lipid nanoparticle, ssPalm, mRNA transfection, hCMEC/D3 cells, cell toxicity, SWATH-MS, translation, chaperonin-containing TCP-1, proton-coupled organic cation antiporter, photo-affinity labeling, proteomics, SWATH-MS (sequential window acquisition of all theoretical-mass spectra), pharmacokinetics, compartmental models, physiologically based PK models, blood-brain barrier, antibody, cavernous sinus, BBB–peptide shuttle, brain delivery, solute carrier (SLC) transporters, amyotrophic lateral sclerosis (ALS), NSC-34 cell lines, taurine transporter (Taut), large amino acid transporter 1 (LAT1), monocarboxylate transporters (MCTs), organic cation transporters (OCTNs), choline transporter-like protein-1 (CTL1), TNF-α inhibitor, molecular Trojan horse, endosomal, liposome, nanoparticle, targeting, transferrin, Medicine and Nursing, Pharmacology

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Access URL: https://directory.doabooks.org/handle/20.500.12854/96729
https://mdpi.com/books/pdfview/book/6675

Amino acid derivative of probenecid potentiates apoptosis-inducing effects of vinblastine by increasing oxidative stress in a cancer cell-specific manner

Authors: Huttunen, Johanna ^a, Tampio, Janne ^a, Järvinen, Juulia ^a, Montaser, Ahmed B. ^a, Markowicz-Piasecka, Magdalena ^b, Huttunen, Kristiina M. ^{a, ∗}

Source: In Chemico-Biological Interactions 25 January 2024 388

A rapid and simple non-radioactive assay for measuring uptake by solute carrier transporters

Authors: Kunling Song, Longbin Zhang, Xian Fu, Linfeng Li, Gaolin Zhu, Mingjun Wu, Wei Zhang, Jia He, Sanyong Zhu, Yongjun Dang, Jun-Yan Liu, Chang Chen, Zufeng Guo

Source: Frontiers in Pharmacology, Vol 15 (2024)

Subject Terms: solute carrier transporter, uptake assay, LC-MS/MS, LAT1, NTCP, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2024.1355507/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/8e41ec9585a24c07afaabe531d922f46

Combination effects of amino acid transporter LAT1 inhibitor nanvuranlat and cytotoxic anticancer drug gemcitabine on pancreatic and biliary tract cancer cells

Authors: Kou Nishikubo, Ryuichi Ohgaki, Xingming Liu, Hiroki Okanishi, Minhui Xu, Hitoshi Endou, Yoshikatsu Kanai

Source: Cancer Cell International, Vol 23, Iss 1, Pp 1-13 (2023)

Subject Terms: Amino acid transporter, LAT1, SLC7A5, Large neutral amino acids, Essential amino acids, Molecularly targeted drugs, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2867

Access URL: https://doaj.org/article/e7e3be8231c3463188c9c0702abadfcd

Prognostic value of large amino acid transporter type 1 (LAT1) expression in pulmonary adenocarcinoma: A tissue microarray study

Authors: Azusa Terao, Hironori Ninomiya, Kengo Takeuchi

Source: Cancer Treatment and Research Communications, Vol 39, Iss , Pp 100814- (2024)

Subject Terms: LAT1, Immunohistochemistry, Pulmonary adenocarcinoma, Papillary subtype, Prognosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2468294224000261; https://doaj.org/toc/2468-2942

Access URL: https://doaj.org/article/fa7669b2a5f74bc3ab3e8b4c3b4757e4