Bioactive arabinoxylan oligomers via colonic fermentation and enzymatic catalysis: Evidence of interaction with toll-like receptors from in vitro, in silico and functional analysis

Authors: Guerreiro, Caroline de A. ^a, Andrade, Leandro A.D. ^b, Fernández-Lainez, Cynthia ^c, Fraga, Layanne N. ^b, López-Velázquez, Gabriel ^d, Marques, Tatiana M. ^e, Prado, Samira B.R. ^e, Brummer, Robert J. ^e, Nascimento, João Roberto O. ^{b, f}, Castro-Alves, Victor ^{a, ⁎}

Source: In Carbohydrate Polymers 15 March 2025 352

Immunostimulatory effects of isomalto/malto-polysaccharides via TLR2 and TLR4 in preventing doxycycline-induced cytokine loss

Authors: Silva-Lagos, Luis ^{a, ⁎}, Ijaz, Adil ^{b, c}, Buwalda, P. ^{d, e, 1}, Kassai, Sonia ^a, Klostermann, Cynthia E. ^{d, f}, Leemhuis, Hans ^e, Veldhuizen, Edwin J.A. ^b, Schols, Henk A. ^f, López-Velázquez, Gabriel ^g, de Vos, Paul ^a

Source: In Carbohydrate Polymers 15 February 2025 350

In silico design of ankyrin repeat proteins that bind to the insulin-like growth factor type 1 receptor

Authors: Mahecha-Ortíz, José Daniel ^a, Enríquez-Flores, Sergio ^b, De la Mora De la Mora, Ignacio ^b, Flores-López, Luis A. ^c, Gutierrez-Castrellón, Pedro ^{d, e}, López-Velázquez, Gabriel ^b, Sánchez-Mora, Ruth ^{a, ⁎}, García-Torres, Itzhel ^{b, ⁎⁎}

Source: In Journal of Molecular Graphics and Modelling September 2025 139

Crystal type, chain length and polydispersity impact the resistant starch type 3 immunomodulatory capacity via Toll-like receptors

Authors: Silva Lagos, Luis ^{a, ⁎}, Klostermann, Cynthia E. ^b, López-Velázquez, Gabriel ^c, Fernández-Lainez, Cynthia ^{a, d}, Leemhuis, Hans ^e, Oudhuis, A.A.C.M. Lizette ^e, Buwalda, Piet ^{b, e}, Schols, Henk A. ^f, de Vos, Paul ^a

Source: In Carbohydrate Polymers 15 January 2024 324

β(2 → 1)-β(2 → 6) and β(2 → 1) fructans protect from impairment of intestinal tight junction's gene expression and attenuate human dendritic cell responses in a fructan-dependent fashion

Authors: Fernández-Lainez, Cynthia ^{a, b, c, ⁎}, aan de Stegge, Myrthe ^a, Silva-Lagos, Luis Alfredo ^a, López-Velázquez, Gabriel ^d, de Vos, Paul ^a

Source: In Carbohydrate Polymers 15 November 2023 320

Is Your Kid Actin Out? A Series of Six Patients With Inherited Actin-Related Protein 2/3 Complex Subunit 1B Deficiency and Review of the Literature

Authors: Vásquez-Echeverri, Estefanía, Yamazaki-Nakashimada, Marco Antonio, Venegas Montoya, Edna, Scheffler Mendoza, Selma Cecilia, Castano-Jaramillo, Lina Maria, Medina-Torres, Edgar Alejandro, González-Serrano, Maria Edith, Espinosa-Navarro, Melissa, Bustamante Ogando, Juan Carlos, González-Villarreal, María Guadalupe, Ortega Cisneros, Margarita, Valencia Mayoral, Pedro Francisco, Consuelo Sanchez, Alejandra, Varela-Fascinetto, Gustavo, Ramírez-Uribe, Rosa María Nideshda, Salazar Gálvez, Yuridia, Bonifaz Alonzo, Laura Cecilia, Fuentes-Pananá, Ezequiel Moisés, Gómez Hernández, Noemí, Rojas Maruri, César Mauricio, Casanova, Jean-Laurent, Espinosa-Padilla, Sara Elva, Staines Boone, Aidé Tamara, López-Velázquez, Gabriel, Boisson, Bertrand, Lugo Reyes, Saul Oswaldo

Source: In The Journal of Allergy and Clinical Immunology: In Practice April 2023 11(4):1261-1280

TLR 2/1 interaction of pectin depends on its chemical structure and conformation

Authors: Jermendi, Éva, Fernández-Lainez, Cynthia, Beukema, Martin, López-Velázquez, Gabriel, van den Berg, Marco A., de Vos, Paul, Schols, Henk A.

Source: In Carbohydrate Polymers 1 March 2023 303

Swine Gut Lactic Acid Bacteria and Their Exopolysaccharides Differentially Modulate Toll-like Receptor Signaling Depending on the Agave Fructans Used as a Carbon Source.

Authors: Sanhueza-Carrera, Enrique A., Fernández-Lainez, Cynthia, Castro-De la Mora, César, Ortega-Álvarez, Daniel, Mendoza-Camacho, Claudia, Cortéz-Sánchez, Jesús Manuel, Pérez-Guillé, Beatriz, de Vos, Paul, López-Velázquez, Gabriel

Source: Animals (2076-2615); Apr2025, Vol. 15 Issue 7, p1047, 19p

Subject Terms: LACTIC acid bacteria, SWINE diseases, AGRICULTURE, ANIMAL health, FRUCTANS

The Arg108Cys Variant of Methylmalonyl-CoA Mutase: Clinical Implications for the Mexican Population Based on Molecular Dynamics and Docking.

Authors: Vela-Amieva, Marcela, Delgado-Maldonado, Timoteo, Ortega-Valdez, Enrique, Rivera, Gildardo, López-Velázquez, Gabriel, Fernández-Lainez, Cynthia

Source: International Journal of Molecular Sciences; Apr2025, Vol. 26 Issue 7, p2887, 17p

Subject Terms: INBORN errors of metabolism, MEXICANS, CATALYTIC domains, MOLECULAR dynamics, TERTIARY structure

In Vitro Evaluation of Esters of Quinoxaline-1,4-di- N- oxide Derivatives as New Antitaeniasis Agents and Their Inhibitory Activity Against Triosephosphate Isomerase.

Authors: Palomares-Alonso, Francisca, González-González, Alonzo, Paz-González, Alma D., Ortiz-Pérez, Eyra, Martínez-Vázquez, Ana Verónica, García-Torres, Itzhel, López-Velázquez, Gabriel, Jung-Cook, Helgi, Rivera, Gildardo

Source: Pharmaceuticals (14248247); Mar2025, Vol. 18 Issue 3, p406, 14p

Subject Terms: TRIOSE-phosphate isomerase, TAENIA solium, ENZYME inactivation, CYSTICERCOSIS, NEUROCYSTICERCOSIS

Expanding the antiprotozoal activity and the mechanism of action of n-butyl and iso-butyl ester of quinoxaline-1,4-di-N-oxide derivatives against Giardia lamblia, Trichomonas vaginalis, and Entamoeba histolytica. An in vitro and in silico approach.

Authors: González-González, Alonzo, Sánchez-Sánchez, Oscar, Yépez-Mulia, Lilián, Delgado-Maldonado, Timoteo, Vázquez-Jiménez, Lenci K., López-Velázquez, Gabriel, de la Mora-de la Mora, José Ignacio, Pacheco-Gutierrez, Sebastian, Chino-Ríos, Laura, Arias, Diego, Moreno-Rodríguez, Adriana, Paz-González, Alma, Ortíz-Pérez, Eyra, Rivera, Gildardo

Source: Journal of Enzyme Inhibition & Medicinal Chemistry; Dec2024, Vol. 39 Issue 1, p1-15, 15p

Subject Terms: TRICHOMONAS vaginalis, ENTAMOEBA histolytica, TRIOSE-phosphate isomerase, GIARDIA lamblia, ENZYME inactivation

Characterization of proteolytic activities of Giardia lamblia with the ability to cleave His-tagged N-terminal sequences

Authors: de la Mora-de la Mora, José Ignacio, Enríquez-Flores, Sergio, Fernández-Lainez, Cynthia, Gutiérrez-Castrellón, Pedro, Olivos-García, Alfonso, González-Canto, Augusto, Hernández, Roberto, Luján, Hugo D., García-Torres, Itzhel, López-Velázquez, Gabriel

Source: In Molecular & Biochemical Parasitology March 2019 228:16-26

Methylglyoxal-Induced Modifications in Human Triosephosphate Isomerase: Structural and Functional Repercussions of Specific Mutations.

Authors: de la Mora-de la Mora, Ignacio, García-Torres, Itzhel, Flores-López, Luis Antonio, López-Velázquez, Gabriel, Hernández-Alcántara, Gloria, Gómez-Manzo, Saúl, Enríquez-Flores, Sergio

Source: Molecules; Nov2024, Vol. 29 Issue 21, p5047, 29p

Subject Terms: ENZYME inactivation, TRIOSE-phosphate isomerase, PROTEIN stability, POST-translational modification, MOLECULAR docking

Selective Inhibition of Deamidated Triosephosphate Isomerase by Disulfiram, Curcumin, and Sodium Dichloroacetate: Synergistic Therapeutic Strategies for T-Cell Acute Lymphoblastic Leukemia in Jurkat Cells.

Authors: Flores-López, Luis A., De la Mora-De la Mora, Ignacio, Malagón-Reyes, Claudia M., García-Torres, Itzhel, Martínez-Pérez, Yoalli, López-Herrera, Gabriela, Hernández-Alcántara, Gloria, León-Avila, Gloria, López-Velázquez, Gabriel, Olaya-Vargas, Alberto, Gómez-Manzo, Saúl, Enríquez-Flores, Sergio

Source: Biomolecules (2218-273X); Oct2024, Vol. 14 Issue 10, p1295, 30p

Subject Terms: TRIOSE-phosphate isomerase, LYMPHOBLASTIC leukemia, CHILDHOOD cancer, ACUTE leukemia, DRUG repositioning, T cells

TATA-Binding Protein-Based Virtual Screening of FDA Drugs Identified New Anti-Giardiasis Agents.

Authors: Gaona-López, Carlos, Méndez-Álvarez, Domingo, Moreno-Rodríguez, Adriana, Bautista-Martínez, Juan Luis, De Fuentes-Vicente, José Antonio, Nogueda-Torres, Benjamín, García-Torres, Itzhel, López-Velázquez, Gabriel, Rivera, Gildardo

Source: International Journal of Molecular Sciences; Jun2024, Vol. 25 Issue 11, p6238, 20p

Subject Terms: PARASITIC diseases, GIARDIA lamblia, COMPUTER-assisted drug design, MOLECULAR dynamics, GIARDIASIS, MOLECULAR docking

Company/Entity: UNITED States. Food & Drug Administration, WORLD Health Organization

Improved yield, stability, and cleavage reaction of a novel tobacco etch virus protease mutant.

Authors: Enríquez-Flores, Sergio¹, De la Mora-De la Mora, José Ignacio¹, Flores-López, Luis Antonio^1,2, Cabrera, Nallely³, Fernández-Lainez, Cynthia⁴, Hernández-Alcántara, Gloria⁵, Guerrero-Beltrán, Carlos Enrique⁶, López-Velázquez, Gabriel¹, glv_1999@ciencias.unam.mx, García-Torres, Itzhel¹, garciaitzhel@gmail.com

Source: Applied Microbiology & Biotechnology; Feb2022, Vol. 106 Issue 4, p1475-1492, 18p

Proton pump inhibitors drastically modify triosephosphate isomerase from Giardia lamblia at functional and structural levels, providing molecular leads in the design of new antigiardiasic drugs

Authors: García-Torres, Itzhel, de la Mora-de la Mora, Ignacio, Marcial-Quino, Jaime, Gómez-Manzo, Saúl, Vanoye-Carlo, América, Navarrete-Vázquez, Gabriel, Colín-Lozano, Blanca, Gutiérrez-Castrellón, Pedro, Sierra-Palacios, Edgar, López-Velázquez, Gabriel, Enríquez-Flores, Sergio

Source: In BBA - General Subjects January 2016 1860(1) Part A:97-107

Limosilactobacillus reuteri DSM 17938 and ATCC PTA 6475 for the treatment of moderate to severe irritable bowel syndrome in adults: a randomized controlled trial.

Authors: Cruchet, Silvia, Hirsch, Sandra, Villa-López, Diana, Moreno-Portillo, Mucio, Palomo, Juan C., Abreu-Abreu, Ana T., Abdo-Francis, Juan M., Jiménez-Gutiérrez, Carlos, Rojano, Martin, López-Velázquez, Gabriel, Gutiérrez-Castrellón, Pedro

Source: Frontiers in Gastroenterology (Frontiers Media S.A.); 2024, p1-11, 11p

Subject Terms: IRRITABLE colon, RANDOMIZED controlled trials, ADULTS

Repurposing of rabeprazole as an anti-Trypanosoma cruzi drug that targets cellular triosephosphate isomerase.

Authors: García-Torres, Itzhel, De la Mora-De la Mora, Ignacio, López-Velázquez, Gabriel, Cabrera, Nallely, Flores-López, Luis Antonio, Becker, Ingeborg, Herrera-López, Juliana, Hernández, Roberto, Pérez-Montfort, Ruy, Enríquez-Flores, Sergio

Source: Journal of Enzyme Inhibition & Medicinal Chemistry; Dec2023, Vol. 38 Issue 1, p1-16, 16p

Subject Terms: TRIOSE-phosphate isomerase, ISOMERASES, ADVANCED glycation end-products, CHAGAS' disease, RECEPTOR for advanced glycation end products (RAGE), TRYPANOSOMA cruzi

Chapter 13 - Health benefits of Inulin and Agavin-type Fructans in Food: Impact on Microbiota, Immune and Gut Barrier Function

Authors: Fernández-Lainez, Cynthia, López-Velázquez, Gabriel, de Vos, Paul

Source: In The Book of Fructans 2023:211-234