Fasting in combination with the cocktail Sorafenib:Metformin blunts cellular plasticity and promotes liver cancer cell death via poly-metabolic exhaustion.

Authors: López-Cánovas, Juan L.¹ (AUTHOR), Naranjo-Martínez, Beatriz¹ (AUTHOR), Diaz-Ruiz, Alberto^1,2 (AUTHOR) alberto.diazruiz@imdea.org

Source: Cellular Oncology (2211-3428). Feb2025, Vol. 48 Issue 1, p161-182. 22p.

Subject Terms: *MEDICAL sciences, *METABOLIC reprogramming, *LIVER cancer, *CYTOLOGY, *LIFE sciences

Fecal microbiota transplantation, a tool to transfer healthy longevity

Authors: Novelle, Marta G., Naranjo-Martínez, Beatriz, López-Cánovas, Juan L., Díaz-Ruiz, Alberto

Source: In Ageing Research Reviews January 2025 103

Quantitative proteomic analysis unveils a critical role of VARS1 in hepatocellular carcinoma aggressiveness through the modulation of MAGI1 expression.

Authors: Hermán-Sánchez, Natalia, del Rio-Moreno, Mercedes, Ciria, Rubén, Sánchez-Frias, Marina E., Fernández-Barrena, Maite G., Uriarte, Iker, Chicano-Galvez, Eduardo, Ortea, Ignacio, Peralbo-Molina, Ángela, Briceño, Javier, Avila, Matías A., Rodríguez-Perálvarez, Manuel, Luque, Raúl M., López-Cánovas, Juan L., Gahete, Manuel D.

Source: Molecular Cancer; 1/14/2025, Vol. 24 Issue 1, p1-16, 16p

Subject Terms: AMINOACYL-tRNA synthetases, MEDICAL sciences, CYTOLOGY, LIFE sciences, HEPATOCELLULAR carcinoma

Dysregulation of the miRNome unveils a crosstalk between obesity and prostate cancer: miR-107 asa personalized diagnostic and therapeutic tool

Authors: Herrero-Aguayo, Vicente ^{1, 2, 3, 4}, Sáez-Martínez, Prudencio ^{1, 2, 3, 4}, Jiménez-Vacas, Juan M. ^{1, 2, 3, 4}, Moreno-Montilla, M. Trinidad ^{1, 2, 3, 4}, Montero-Hidalgo, Antonio J. ^{1, 2, 3, 4}, Pérez-Gómez, Jesús M. ^{1, 2, 3, 4}, López-Canovas, Juan L. ^{1, 2, 3, 4}, Porcel-Pastrana, Francisco ^{1, 2, 3, 4}, Carrasco-Valiente, Julia ^{1, 3, 5}, Anglada, Francisco J. ^{1, 3, 5}, Gómez-Gómez, Enrique ^{1, 3, 5}, Yubero-Serrano, Elena M. ^{1, 3, 4, 6}, Ibañez-Costa, Alejandro ^{1, 2, 3, 4}, Herrera-Martínez, Aura D. ^{1, 3, 7}, Sarmento-Cabral, André ^{1, 2, 3, 4}, Gahete, Manuel D. ^{1, 2, 3, 4, ∗∗}, Luque, Raúl M. ^{1, 2, 3, 4, ∗}

Source: In Molecular Therapy - Nucleic Acids 8 March 2022 27:1164-1178

Splicing factor SF3B1 is overexpressed and implicated in the aggressiveness and survival of hepatocellular carcinoma

Authors: López-Cánovas, Juan L., del Rio-Moreno, Mercedes, García-Fernandez, Helena, Jiménez-Vacas, Juan M., Moreno-Montilla, M.Trinidad, Sánchez-Frias, Marina E., Amado, Víctor, L-López, Fernando, Fondevila, Marcos F., Ciria, Rubén, Gómez-Luque, Irene, Briceño, Javier, Nogueiras, Rubén, de la Mata, Manuel, Castaño, Justo P., Rodriguez-Perálvarez, Manuel, Luque, Raúl M., Gahete, Manuel D.

Source: In Cancer Letters 1 January 2021 496:72-83

Dysregulation of Components of the Inflammasome Machinery After Bariatric Surgery: Novel Targets for a Chronic Disease

Authors: Herrero-Aguayo, Vicente, Sáez-Martínez, Prudencio, López-Cánovas, Juan L, Prados-Carmona, Juan J, Alcántara-Laguna, María D, López, Fernando L, Molina-Puerta, María J, Calañas-Continente, Alfonso, Membrives, Antonio, Castilla, Juan, Ruiz-Ravelo, Juan, Alonso-Echague, Rosario, Yubero-Serrano, Elena M, Castaño, Justo P, Gahete, Manuel D, Gálvez-Moreno, María A, Luque, Raúl M, Herrera-Martínez, Aura D

Source: Journal of clinical endocrinology & metabolism. 106(12):e4917-e4934

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100139435224.0x000001&indx=1&recIds=ETOCvdc_100139435224.0x000001

Influence of Obesity in the miRNome: miR-4454, a Key Regulator of Insulin Response Via Splicing Modulation in Prostate

Authors: Herrero-Aguayo, Vicente, Jiménez-Vacas, Juan M, Sáez-Martínez, Prudencio, Gómez-Gómez, Enrique, López-Cánovas, Juan L, Garrido-Sánchez, Lourdes, Herrera-Martínez, Aura D, García-Bermejo, Laura, Macías-González, Manuel, López-Miranda, José, Castaño, Justo P, Gahete, Manuel D, Luque, Raúl M

Source: Journal of clinical endocrinology & metabolism. 106(2):e469-e484

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100142843447.0x000001&indx=1&recIds=ETOCvdc_100142843447.0x000001

Spliceosomal profiling identifies EIF4A3 as a novel oncogene in hepatocellular carcinoma acting through the modulation of FGFR4 splicing

Authors: López‐Cánovas, Juan L., Hermán‐Sánchez, Natalia, Moreno‐Montilla, Maria Trinidad, del Rio‐Moreno, Mercedes, Alors‐Perez, Emilia, Sánchez‐Frias, Marina E., Amado, Víctor, Ciria, Rubén, Briceño, Javier, Mata, Manuel, Castaño, Justo P., Rodriguez‐Perálvarez, Manuel, Luque, Raúl M., Gahete, Manuel D.

Source: Clinical and translational medicine. 12(11)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187362870.0x000001&indx=1&recIds=ETOCvdc_100187362870.0x000001

The Exon Junction Complex component EIF4A3 plays a splicing-linked oncogenic role in pancreatic ductal adenocarcinoma

Authors: Blázquez-Encinas, Ricardo, Alors-Pérez, Emilia, Moreno-Montilla, María Trinidad, García-Vioque, Víctor, Sánchez-Frías, Marina Esther, Mafficini, Andrea, López-Cánovas, Juan L., Bousquet, Corinne, Gahete, Manuel D., Lawlor, Rita T., Luque, Raúl M., Scarpa, Aldo, Arjona‐Sánchez, Álvaro, Pedraza-Arevalo, Sergio, Ibáñez-Costa, Alejandro, Castaño, Justo P.

Source: Cancer Gene Therapy; 20240101, Issue: Preprints p1-12, 12p

FRI-462-YI Aminoacyl-tRNA synthetases characterization and clinical potential in aggressive hepatocellular carcinoma

Authors: Hermán-Sánchez, Natalia, Zamora-Olaya, Javier M., Rodríguez-Perálvarez, Manuel, Luque, Raul M, López-Cánovas, Juan L., Gahete, Manuel D.

Source: In Journal of Hepatology June 2024 80 Supplement 1:S415-S415

PRPF8 increases the aggressiveness of hepatocellular carcinoma by regulating FAK/AKT pathway via fibronectin 1 splicing.

Authors: López-Cánovas, Juan L., Hermán-Sánchez, Natalia, del Rio-Moreno, Mercedes, Fuentes-Fayos, Antonio C., Lara-López, Araceli, Sánchez-Frias, Marina E., Amado, Víctor, Ciria, Rubén, Briceño, Javier, de la Mata, Manuel, Castaño, Justo P., Rodriguez-Perálvarez, Manuel, Luque, Raúl M., Gahete, Manuel D.

Source: Experimental & Molecular Medicine EMM; Jan2023, Vol. 55 Issue 1, p132-142, 11p

Influence of Obesity in the miRNome: miR-4454, a Key Regulator of Insulin Response Via Splicing Modulation in Prostate.

Authors: Herrero-Aguayo, Vicente, Jiménez-Vacas, Juan M., Sáez-Martínez, Prudencio, Gómez-Gómez, Enrique, López-Cánovas, Juan L., Garrido-Sánchez, Lourdes, Herrera-Martínez, Aura D., García-Bermejo, Laura, Macías-González, Manuel, López-Miranda, José, Castaño, Justo P., Gahete, Manuel D., Luque, Raúl M.

Source: Journal of Clinical Endocrinology & Metabolism; Feb2021, Vol. 106 Issue 2, pe469-e484, 16p

Subject Terms: RNA splicing, INSULIN receptors, INSULIN, OBESITY, LEPTIN, HYPERINSULINISM, SOMATOMEDIN, RNA metabolism