Long-term in vitro expansion of a human fetal pancreas stem cell that generates all three pancreatic cell lineages

Authors: Andersson-Rolf, Amanda ^{1, 2, ∗}, Groot, Kelvin ^{1, 2, 9}, Korving, Jeroen ^{1, 2}, Begthel, Harry ^{1, 2}, Hanegraaf, Maaike A.J. ³, VanInsberghe, Michael ^{1, 2}, Salmén, Fredrik ^{1, 2}, van den Brink, Stieneke ^{1, 2}, Lopez-Iglesias, Carmen ⁴, Peters, Peter J. ⁴, Krueger, Daniel ^{1, 2}, Beumer, Joep ⁶, Geurts, Maarten H. ^{1, 2, 5}, Alemany, Anna ⁷, Gehart, Helmuth ⁸, Carlotti, Françoise ³, de Koning, Eelco J.P. ³, Chuva de Sousa Lopes, Susana M. ⁷, van Oudenaarden, Alexander ^{1, 2}, van Es, Johan H. ^{1, 2}, Clevers, Hans ^{1, 2, 5, 6, 10, ∗∗}

Source: In Cell 26 December 2024 187(26):7394-7413

In vitro vascularization of 3D cell aggregates in microwells with integrated vascular beds

Authors: Fois, Maria G. ^a, Tahmasebi Birgani, Zeinab N. ^a, López-Iglesias, Carmen ^b, Knoops, Kèvin ^b, van Blitterswijk, Clemens ^a, Giselbrecht, Stefan ^{a, 1}, Habibović, Pamela ^{a, 1}, Truckenmüller, Roman K. ^{a, ⁎, 1}

Source: In Materials Today Bio December 2024 29

Human conjunctiva organoids to study ocular surface homeostasis and disease

Authors: Bannier-Hélaouët, Marie, Korving, Jeroen, Ma, Ziliang, Begthel, Harry, Giladi, Amir, Lamers, Mart M., van de Wetering, Willine J., Yawata, Nobuyo, Yawata, Makoto, LaPointe, Vanessa L.S., Dickman, Mor M., Kalmann, Rachel, Imhoff, Saskia M., van Es, Johan H., López-Iglesias, Carmen, Peters, Peter J., Haagmans, Bart L., Wu, Wei, Clevers, Hans

Source: In Cell Stem Cell 1 February 2024 31(2):227-243

Human fetal brain self-organizes into long-term expanding organoids

Authors: Hendriks, Delilah, Pagliaro, Anna, Andreatta, Francesco, Ma, Ziliang, van Giessen, Joey, Massalini, Simone, López-Iglesias, Carmen, van Son, Gijs J.F., DeMartino, Jeff, Damen, J. Mirjam A., Zoutendijk, Iris, Staliarova, Nadzeya, Bredenoord, Annelien L., Holstege, Frank C.P., Peters, Peter J., Margaritis, Thanasis, Chuva de Sousa Lopes, Susana, Wu, Wei, Clevers, Hans, Artegiani, Benedetta

Source: In Cell 1 February 2024 187(3):712-732

A Lamb1Dendra2 mouse model identifies basement-membrane-producing origins and dynamics in PyMT breast tumors

Authors: Morgner, Jessica, Bornes, Laura, Hahn, Kerstin, López-Iglesias, Carmen, Kroese, Lona, Pritchard, Colin E.J., Vennin, Claire, Peters, Peter J., Huijbers, Ivo, van Rheenen, Jacco

Source: In Developmental Cell 10 April 2023 58(7):535-549

Adult mouse and human organoids derived from thyroid follicular cells and modeling of Graves’ hyperthyroidism

Authors: van der Vaart, Jelte, Bosmans, Lynn, Sijbesma, Stijn F., Knoops, Kèvin, van de Wetering, Willine J., Otten, Henny G., Begthel, Harry, Rinkes, Inne H. M. Borel, Korving, Jeroen, Lentjes, Eef G. W. M., Lopez-Iglesias, Carmen, Peters, Peter J., van Santen, Hanneke M., Vriens, Menno R., Clevers, Hans

Source: Proceedings of the National Academy of Sciences of the United States of America, 2021 Dec . 118(51), 1-11.

Access URL: https://www.jstor.org/stable/27117545

Tomographic analysis, CLEM: general discussion

Authors: Al-Otaibi, Natalie, Baatsen, Pieter, Bhella, David, Brescia, Rosaria, Bullough, Per, Daum, Bertram, de Bruin, Reinier, Frank, René, Kühlbrandt, Werner, López-Iglesias, Carmen, McLaren, Mathew, Menday, Rebbekah, Morrissey, Francis, Mullick, Debakshi, Paris, Giulia, Parker, Alexandra, Russo, Chris, Saibil, Helen, Scheres, Sjors H. W., Shah, Archna, Smith, Corinne, Thompson, Rebecca, Thorn, Andrea, Zanetti, Giulia, Zhao, Jingjing

Source: Faraday discussions. 240:142-151

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100164503723.0x000001&indx=1&recIds=ETOCvdc_100164503723.0x000001

Mycobacteria–host interactions in human bronchiolar airway organoids

Authors: Iakobachvili, Nino, Leon‐Icaza, Stephen Adonai, Knoops, Kèvin, Sachs, Norman, Mazères, Serge, Simeone, Roxane, Peixoto, Antonio, Bernard, Célia, Murris‐Espin, Marlène, Mazières, Julien, Cam, Kaymeuang, Chalut, Christian, Guilhot, Christophe, López‐Iglesias, Carmen, Ravelli, Raimond B. G., Neyrolles, Olivier, Meunier, Etienne, Lugo‐Villarino, Geanncarlo, Clevers, Hans, Cougoule, Céline, Peters, Peter J.

Source: Molecular microbiology. 117(3):682-692

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100144571182.0x000001&indx=1&recIds=ETOCvdc_100144571182.0x000001

Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation

Authors: He, Gui-Wei, Lin, Lin, DeMartino, Jeff, Zheng, Xuan, Staliarova, Nadzeya, Dayton, Talya, Begthel, Harry, van de Wetering, Willine J., Bodewes, Eduard, van Zon, Jeroen, Tans, Sander, Lopez-Iglesias, Carmen, Peters, Peter J., Wu, Wei, Kotlarz, Daniel, Klein, Christoph, Margaritis, Thanasis, Holstege, Frank, Clevers, Hans

Source: In Cell Stem Cell 1 September 2022 29(9):1333-1345

In situ and in vitro cryo-EM reveal structures of mycobacterial encapsulin assembly intermediates.

Authors: Berger, Casper, Lewis, Chris, Gao, Ye, Knoops, Kèvin, López-Iglesias, Carmen, Peters, Peter J., Ravelli, Raimond B. G.

Source: Communications Biology; 2/15/2025, Vol. 8 Issue 1, p1-11, 11p

Subject Terms: MYCOBACTERIUM leprae, MYCOBACTERIA, PHYSICAL sciences, STRUCTURAL shells, ION beams, MYCOBACTERIUM tuberculosis

The Curse of the Red Pearl: A Fibroblast-Specific Pearl-Necklace Mitochondrial Phenotype Caused by Phototoxicity.

Authors: Hemel, Irene M. G. M., Knoops, Kèvin, López-Iglesias, Carmen, Gerards, Mike

Source: Biomolecules (2218-273X); Feb2025, Vol. 15 Issue 2, p304, 15p

Subject Terms: MITOCHONDRIAL dynamics, CELL imaging, FLUORESCENT probes, CONFOCAL microscopy, ELECTRON microscopy

Structure of the Yersinia injectisome in intracellular host cell phagosomes revealed by cryo FIB electron tomography

Authors: Berger, Casper, Ravelli, Raimond B.G., López-Iglesias, Carmen, Kudryashev, Mikhail, Diepold, Andreas, Peters, Peter J.

Source: In Journal of Structural Biology March 2021 213(1)

Priming mycobacterial ESX-secreted protein B to form a channel-like structure

Authors: Gijsbers, Abril, Vinciauskaite, Vanesa, Siroy, Axel, Gao, Ye, Tria, Giancarlo, Mathew, Anjusha, Sánchez-Puig, Nuria, López-Iglesias, Carmen, Peters, Peter J., Ravelli, Raimond B.G.

Source: In Current Research in Structural Biology 2021 3:153-164

Human kidney organoids produce functional renin

Authors: Shankar, Anusha S., Du, Zhaoyu, Mora, Hector Tejeda, van den Bosch, Thierry P.P., Korevaar, Sander S., Van den Berg-Garrelds, Ingrid M., Bindels, Eric, Lopez-Iglesias, Carmen, Clahsen-van Groningen, Marian C., Gribnau, Joost, Baan, Carla C., Danser, A.H. Jan, Hoorn, Ewout J., Hoogduijn, Martin J.

Source: In Kidney International January 2021 99(1):134-147

Deletion of mTOR in liver epithelial cells enhances hepatic metastasis of colon cancer

Authors: Jiao, Long, Eickhoff, Roman, Egners, Antje, Jumpertz, Sandra, Roth, Johanna, Erdem, Merve, Kroh, Andreas, Duimel, Hans, López‐Iglesias, Carmen, Caro, Pilar, Heij, Lara R, Schmeding, Maximilian, Meierhofer, David, Neumann, Ulf P, Cramer, Thorsten

Source: Journal of pathology. 255(3):270-284

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131890974.0x000001&indx=1&recIds=ETOCvdc_100131890974.0x000001

Description and functional validation of human enteroendocrine cell sensors.

Authors: Beumer, Joep^1,2, joep.beumer@roche.com, Geurts, Maarten H.³, Geurts, Veerle³, Andersson-Rolf, Amanda³, Akkerman, Ninouk¹, Völlmy, Franziska⁴, Krueger, Daniel³, Busslinger, Georg A.³, Martínez-Silgado, Adriana³, Boot, Charelle³, Yousef Yengej, Fjodor A.^5,6, Puschhof, Jens³, Van de Wetering, Wiline J.⁷, Knoops, Kevin⁷, López-Iglesias, Carmen⁷, Peters, Peter J.⁷, Vivié, Judith A.⁸, Mooijman, Dylan⁹, van Es, Johan H.³, Clevers, Hans³, h.clevers@hubrecht.eu

Source: Science; 10/18/2024, Vol. 386 Issue 6719, p341-348, 8p, 5 Diagrams

High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells

Authors: Beumer, Joep, Puschhof, Jens, Bauzá-Martinez, Julia, Martínez-Silgado, Adriana, Elmentaite, Rasa, James, Kylie R., Ross, Alexander, Hendriks, Delilah, Artegiani, Benedetta, Busslinger, Georg A., Ponsioen, Bas, Andersson-Rolf, Amanda, Saftien, Aurelia, Boot, Charelle, Kretzschmar, Kai, Geurts, Maarten H., Bar-Ephraim, Yotam E., Pleguezuelos-Manzano, Cayetano, Post, Yorick, Begthel, Harry, van der Linden, Franka, Lopez-Iglesias, Carmen, van de Wetering, Willine J., van der Linden, Reinier, Peters, Peter J., Heck, Albert J.R., Goedhart, Joachim, Snippert, Hugo, Zilbauer, Matthias, Teichmann, Sarah A., Wu, Wei, Clevers, Hans

Source: In Cell 11 June 2020 181(6):1291-1306

Enteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletion

Authors: van Es, Johan H., Wiebrands, Kay, López-Iglesias, Carmen, van de Wetering, Marc, Zeinstra, Laura, van den Born, Maaike, Korving, Jeroen, Sasaki, Nobuo, Peters, Peter J., van Oudenaarden, Alexander, Clevers, Hans

Source: Proceedings of the National Academy of Sciences of the United States of America, 2019 Dec . 116(52), 26599-26605.

Access URL: https://www.jstor.org/stable/26897134

Long-term expansion and differentiation of adult murine epidermal stem cells in 3D organoid cultures

Authors: Boonekamp, Kim E., Kretzschmar, Kai, Wiener, Dominique J., Asra, Priyanca, Derakhshan, Sepideh, Puschhof, Jens, López-Iglesias, Carmen, Peters, Peter J., Basak, Onur, Clevers, Hans

Source: Proceedings of the National Academy of Sciences of the United States of America, 2019 Jul . 116(29), 14630-14638.

Access URL: https://www.jstor.org/stable/26760305

Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids

Authors: Artegiani, Benedetta, van Voorthuijsen, Lisa, Lindeboom, Rik G.H., Seinstra, Daniëlle, Heo, Inha, Tapia, Pablo, López-Iglesias, Carmen, Postrach, Daniel, Dayton, Talya, Oka, Rurika, Hu, Huili, van Boxtel, Ruben, van Es, Johan H., Offerhaus, Johan, Peters, Peter J., van Rheenen, Jacco, Vermeulen, Michiel, Clevers, Hans

Source: In Cell Stem Cell 6 June 2019 24(6):927-943