Targeting TRIP13 in favorable histology Wilms tumor with nuclear export inhibitors synergizes with doxorubicin.

Authors: Mittal, Karuna, Cooper, Garrett W., Lee, Benjamin P., Su, Yongdong, Skinner, Katie T., Shim, Jenny, Jonus, Hunter C., Kim, Won Jun, Doshi, Mihir, Almanza, Diego, Kynnap, Bryan D., Christie, Amanda L., Yang, Xiaoping, Cowley, Glenn S., Leeper, Brittaney A., Morton, Christopher L., Dwivedi, Bhakti, Lawrence, Taylor, Rupji, Manali, Keskula, Paula

Source: Communications Biology; 4/8/2024, Vol. 7 Issue 1, p1-13, 13p

Subject Terms: NEPHROBLASTOMA, HISTOLOGY, FUNCTIONAL genomics, DOXORUBICIN, CELL lines, OVERALL survival

Company/Entity: UNITED States. Food & Drug Administration

Sirtuin 6 is required for the integrated stress response and resistance to inhibition of transcriptional cyclin-dependent kinases.

Authors: Kartha, Nithya, Gianopulos, Jessica E., Schrank, Zachary, Cavender, Sarah M., Dobersch, Stephanie, Kynnap, Bryan D., Wallace-Povirk, Adrianne, Wladyka, Cynthia L., Santana, Juan F., Kim, Jaeseung C., Yu, Angela, Bridgwater, Caroline M., Fuchs, Kathrin, Dysinger, Sarah, Lampano, Aaron E., Notta, Faiyaz, Price, David H., Hsieh, Andrew C., Hingorani, Sunil R., Kugel, Sita

Source: Science Translational Medicine; 5/3/2023, Vol. 15 Issue 694, p1-16, 16p

Subject Terms: RESPONSE inhibition, SIRTUINS, PROTEIN stability, PANCREATIC duct, HISTONE deacetylase, TRANSCRIPTION factors, CYCLIN-dependent kinases

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