Daratumumab Use Prior to Kidney Transplant and T Cell–Mediated Rejection: A Case Report

Authors: Scalzo, Riley E., Sanoff, Scott L., Rege, Aparna S., Kwun, Jean, Knechtle, Stuart J., Barisoni, Laura, Byrns, Jennifer S.

Source: American journal of kidney diseases. 81(5):616-620

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Addition of interleukin-6 receptor blockade to carfilzomib-based desensitization in a highly sensitized nonhuman primate model

Authors: Anwar, Imran J., Ezekian, Brian, DeLaura, Isabel, Manook, Miriam, Schroder, Paul, Yoon, Janghoon, Curfman, Verna, Branum, Evelyn, Messina, Julia, Harnois, Melissa, Permar, Sallie R., Farris, Alton B., Kwun, Jean ^*, Knechtle, Stuart J. ^**

Source: In American Journal of Transplantation December 2022 22 Supplement 4:1-11

A novel method for in vitro culture and expansion of nonhuman primate B cells

Authors: DeLaura, Isabel, Schroder, Paul M., Yoon, Janghoon, Ladowski, Joseph, Anwar, Imran J., Ezekian, Brian, Schmitz, Robin, Fitch, Zachary W., Kwun, Jean, Knechtle, Stuart J.

Source: In Journal of Immunological Methods December 2022 511

Belatacept-Based Maintenance Immunosuppression Controls the Post-Transplant Humoral Immune Response in Highly Sensitized Nonhuman Primates

Authors: Schmitz, Robin, Fitch, Zachary W., Manook, Miriam, Schroder, Paul M., Choi, Ashley Y., Olaso, Danae, Yoon, Janghoon, Bae, Yeeun, Shaw, Brian I., Song, Mingqing, Kuchibhatla, Maragatha, Farris, Alton B., Kirk, Allan, Kwun, Jean, Knechtle, Stuart J.

Source: Kidney360. 3(12):2116-2130

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100188592314.0x000001&indx=1&recIds=ETOCvdc_100188592314.0x000001

Introducing thymus for promoting transplantation tolerance

Authors: Fitch, Zachary W., Kang, Lillian, Li, Jie, Knechtle, Stuart J., Turek, Joseph W., Kirk, Allan D., Markert, M. Louise, Kwun, Jean

Source: Journal of allergy and clinical immunology. 150(3):549-556

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100169280418.0x000001&indx=1&recIds=ETOCvdc_100169280418.0x000001

An IgM Cleaving Enzyme for Clearance of Anti‐Pig Xenoreactive Antibodies in a Nonhuman Primate Model.

Authors: Martinino, Alessandro, Smith, Timothy J., Elmore, Zachary C., Yoon, Janghoon, Ladowski, Joseph, Schiliro, Davide, Hull, Joshua A., Schwalb, Allie, Hu, Meghan, Spangler, Ryan, Lee, Kyo Won, Kim, Min Jung, Williams, Kyha, Jackson, Annette, Knechtle, Stuart J., Asokan, Aravind, Kwun, Jean

Source: Xenotransplantation; Jan/Feb2025, Vol. 32 Issue 1, p1-9, 9p

CD154 blockade effectively controls antibody-mediated rejection in highly sensitized nonhuman primate kidney transplant recipients.

Authors: Anwar, Imran J., DeLaura, Isabel, Ladowski, Joseph M., Schilirò, Davide, Gao, Qimeng, Manook, Miriam, Yoon, Janghoon, Belloni, Rafaela, Park, Angela, Schuster, Daniel J., Song, Mingqing, Lin, Lin, Farris, Alton B., Magnani, Diogo, Williams, Kyha, Kwun, Jean, Knechtle, Stuart J.

Source: Science Translational Medicine; 1/1/2025, Vol. 17 Issue 779, p1-14, 14p

Subject Terms: REGULATORY T cells, T helper cells, HLA histocompatibility antigens, B cells, GRAFT rejection, KIDNEY transplantation, IMMUNOSUPPRESSION

Preoperative carfilzomib and lulizumab based desensitization prolongs graft survival in a sensitized non-human primate model

Authors: Schroder, Paul M., Schmitz, Robin, Fitch, Zachary W., Ezekian, Brian, Yoon, Janghoon, Choi, Ashley Y., Manook, Miriam, Barbas, Andrew, Leopardi, Frank, Song, Mingqing, Farris, Alton B., Collins, Bradley, Kwun, Jean, Knechtle, Stuart J.

Source: In Kidney International January 2021 99(1):161-172

Immunoproteasome inhibition reduces donor specific antibody production and cardiac allograft vasculopathy in a mouse heart transplantation model.

Authors: Schwalb, Allison M., Anwar, Imran, DeLaura, Isabel, Ladowski, Joseph M., Yoon, Janghoon, Belloni, Rafaela, Song, Mingqing, Glass, Carolyn, Wang, Jun, Knechtle, Stuart, Kwun, Jean

Source: Frontiers in Transplantation; 2024, p1-8, 8p

Donor apoptotic cell–based therapy for effective inhibition of donor-specific memory T and B cells to promote long-term allograft survival in allosensitized recipients

Authors: Dangi, Anil, Yu, Shuangjin, Lee, Frances T., Burnette, Melanie, Knechtle, Stuart, Kwun, Jean, Luo, Xunrong ^*

Source: In American Journal of Transplantation October 2020 20(10):2728-2739

Experimental modeling of desensitization: What have we learned about preventing AMR?

Authors: Kwun, Jean ^*, Knechtle, Stuart

Source: In American Journal of Transplantation June 2020 20 Supplement 4:2-11

Transplant research in nonhuman primates to evaluate clinically relevant immune strategies in organ transplantation

Authors: Fitch, Zachary, Schmitz, Robin, Kwun, Jean, Hering, Bernhard, Madsen, Joren, Knechtle, Stuart J.

Source: In Transplantation Reviews July 2019 33(3):115-129

Th17 cell inhibition in a costimulation blockade‐based regimen for vascularized composite allotransplantation using a nonhuman primate model

Authors: Atia, Andrew, Moris, Dimitrios, McRae, MacKenzie, Song, Mingqing, Stempora, Linda, Leopardi, Francis, Williams, Kyha, Kwun, Jean, Parker, William, Cardones, Adela R., Kirk, Allan D., Cendales, Linda C.

Source: Transplant international. 33(10):1294-1301

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100133150731.0x000001&indx=1&recIds=ETOCvdc_100133150731.0x000001

B cells in transplant tolerance and rejection: friends or foes?

Authors: Schmitz, Robin, Fitch, Zachary W., Schroder, Paul M., Choi, Ashley Y., Jackson, Annette M., Knechtle, Stuart J., Kwun, Jean

Source: Transplant international. 33(1):30-40

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100095911605.0x000001&indx=1&recIds=ETOCvdc_100095911605.0x000001

Dual targeting: Combining costimulation blockade and bortezomib to permit kidney transplantation in sensitized recipients

Authors: Burghuber, Christopher K., Manook, Miriam, Ezekian, Brian, Gibby, Adriana C., Leopardi, Frank V., Song, Minqing, Jenks, Jennifer, Saccoccio, Frances, Permar, Sallie, Farris, Alton B., Iwakoshi, Neal N., Kwun, Jean ^*, Knechtle, Stuart J. ^**

Source: In American Journal of Transplantation March 2019 19(3):724-736

Is Allosensitization Detrimental to Pig Organ Xenotransplantation, and Is Xenosensitization Detrimental to Subsequent Organ Allotransplantation? A Debate Organized by the International Xenotransplantation Association (IXA).

Authors: Knechtle, Stuart, Jackson, Annette, Ladowski, Joseph, Kwun, Jean, Mangiola, Massimo, Tector, A. Joseph, Bühler, Léo H., Cozzi, Emanuele, Cooper, David K. C.

Source: Xenotransplantation; Sep2024, Vol. 31 Issue 5, p1-8, 8p

Subject Terms: HLA histocompatibility antigens, MAJOR histocompatibility complex, HISTOCOMPATIBILITY antigens, XENOTRANSPLANTATION, GRAFT survival

Allosensitisation in NHP results in cross‐reactive anti‐SLA antibodies not detected by a lymphocyte‐based flow cytometry crossmatch.

Authors: Ladowski, Joseph M., Chapman, Henry, DeLaura, Isabel, Anwar, Imran J., Yoon, Janghoon, Chen, Zheng, Clark, Adella, Chen, DongFeng, Knechtle, Stuart, Jackson, Annette, Rogers, Bruce, Kwun, Jean

Source: HLA: Immune Response Genetics; Jul2024, Vol. 104 Issue 1, p1-11, 11p

Subject Terms: SKIN grafting, HLA histocompatibility antigens, ERYTHROCYTES, KIDNEY transplantation, HISTOCOMPATIBILITY

Innate networking: Thrombotic microangiopathy, the activation of coagulation and complement in the sensitized kidney transplant recipient

Authors: Manook, Miriam, Kwun, Jean, Sacks, Steven, Dorling, Anthony, Mamode, Nizam, Knechtle, Stuart

Source: In Transplantation Reviews July 2018 32(3):119-126

Plastic-based acoustofluidic devices for high-throughput, biocompatible platelet separationElectronic supplementary information (ESI) available. See DOI: 10.1039/c8lc00527c

Authors: Gu, Yuyang, Chen, Chuyi, Wang, Zeyu, Huang, Po-Hsun, Fu, Hai, Wang, Lin, Wu, Mengxi, Chen, Yuchao, Gao, Tieyu, Gong, Jianying, Kwun, Jean, Arepally, Gowthami M., Huang, Tony Jun

Source: Lab on a chip. 19(3):394-402

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Damage‐Associated Molecular Patterns Induce Inflammatory Injury During Machine Preservation of the Liver: Potential Targets to Enhance a Promising Technology

Authors: Scheuermann, Uwe, Zhu, Minghua, Song, Mingqing, Yerxa, John, Gao, Qimeng, Davis, Robert P., Zhang, Min, Parker, William, Hartwig, Matthew G., Kwun, Jean, Brennan, Todd V., Lee, Jaewoo, Barbas, Andrew S.

Source: Liver transplantation. 25(4):610-626

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100082953852.0x000001&indx=1&recIds=ETOCvdc_100082953852.0x000001