3D mesenchymal cell migration is driven by anterior cellular contraction that generates an extracellular matrix prestrain

Authors: Doyle, Andrew D., Sykora, Daniel J., Pacheco, Gustavo G., Kutys, Matthew L., Yamada, Kenneth M.

Source: In Developmental Cell 22 March 2021 56(6):826-841

Arp2/3 complex activity enables nuclear YAP for naïve pluripotency of human embryonic stem cells.

Authors: Meyer, Nathaniel Paul, Singh, Tania, Kutys, Matthew L., Nystul, Todd G., Barber, Diane L.

Source: eLife; 10/25/2024, p1-19, 19p

Proinflammatory immune cells disrupt angiogenesis and promote germinal matrix hemorrhage in prenatal human brain

Authors: Chen, Jiapei, Crouch, Elizabeth E., Zawadzki, Miriam E., Jacobs, Kyle A., Mayo, Lakyn N., Choi, Jennifer Ja-Yoon, Lin, Pin-Yeh, Shaikh, Saba, Tsui, Jessica, Gonzalez-Granero, Susana, Waller, Shamari, Kelekar, Avani, Kang, Gugene, Valenzuela, Edward J., Birrueta, Janeth Ochoa, Diafos, Loukas N., Wedderburn-Pugh, Kaylee, Di Marco, Barbara, Xia, Wenlong, Han, Claudia Z., Coufal, Nicole G., Glass, Christopher K., Fancy, Stephen P. J., Alfonso, Julieta, Kriegstein, Arnold R., Oldham, Michael C., Garcia-Verdugo, Jose Manuel, Kutys, Matthew L., Lehtinen, Maria K., Combes, Alexis J., Huang, Eric J.

Source: Nature Neuroscience; November 2024, Vol. 27 Issue: 11 p2115-2129, 15p

Doublecortin reinforces microtubules to promote growth cone advance in soft environments

Authors: Dema, Alessandro ^{1, 2, 3}, Charafeddine, Rabab A. ^{1, 2}, van Haren, Jeffrey ^{1, 4}, Rahgozar, Shima ¹, Viola, Giulia ^{1, 5}, Jacobs, Kyle A. ¹, Kutys, Matthew L. ¹, Wittmann, Torsten ^{1, 6, ∗}

Source: In Current Biology 16 December 2024 34(24):5822-5832

Forces and mechanotransduction in 3D vascular biology

Authors: Kutys, Matthew L, Chen, Christopher S

Source: In Current Opinion in Cell Biology October 2016 42:73-79

Notch1 cortical signaling regulates epithelial architecture and cell-cell adhesion.

Authors: White, Matthew J.¹, Jacobs, Kyle A.^1,2, Singh, Tania^1,3, Mayo, Lakyn N.^1,3, Lin, Annie^3,4,5, Chen, Christopher S.⁶, Young-wook Jun^3,4,5,7, Kutys, Matthew L.^1,2,3,7, matthew.kutys@ucsf.edu

Source: Journal of Cell Biology; 12/4/2023, Vol. 222 Issue 12, p1-18, 25p

A 3D biomimetic model of lymphatics reveals cell–cell junction tightening and lymphedema via a cytokine-induced ROCK2/JAM-A complex.

Authors: Lee, Esak, Siu-Lung Chan, Yang Lee, Polacheck, William J., Sukyoung Kwak, Aiyun Wen, Nguyen, Duc-Huy T., Kutys, Matthew L., Alimperti, Stella, Kolarzyk, Anna M., Tae Joon Kwak, Eyckmans, Jeroen, Bielenberg, Diane R., Hong Chen, Chen, Christopher S.

Source: Proceedings of the National Academy of Sciences of the United States of America; 10/10/2023, Vol. 120 Issue 41, p1-8, 14p

Subject Terms: RHO-associated kinases, LYMPHEDEMA, EXTRACELLULAR fluid, LYMPHATICS, FLUID pressure

‘Chip’-ing away at morphogenesis – application of organ-on-chip technologies to study tissue morphogenesis.

Authors: White, Matthew J., Singh, Tania, Wang, Eric, Smith, Quinton, Kutys, Matthew L.

Source: Journal of Cell Science; Oct2023, Vol. 136 Issue 19, p1-13, 13p

Subject Terms: BIOENGINEERING, GENE regulatory networks, DEVELOPMENTAL biology, CYTOLOGY, TISSUE engineering, TISSUES, MORPHOGENESIS

Dimensions in cell migration

Authors: Doyle, Andrew D, Petrie, Ryan J, Kutys, Matthew L, Yamada, Kenneth M

Source: In Current Opinion in Cell Biology October 2013 25(5):642-649

Regulation of cell adhesion and migration by cell-derived matrices

Authors: Kutys, Matthew L., Doyle, Andrew D., Yamada, Kenneth M.

Source: In Experimental Cell Research 1 October 2013 319(16):2434-2439

Uncovering mutation-specific morphogenic phenotypes and paracrine-mediated vessel dysfunction in a biomimetic vascularized mammary duct platform

Authors: Kutys, Matthew L., Polacheck, William J., Welch, Michaela K., Gagnon, Keith A., Koorman, Thijs, Kim, Sudong, Li, Linqing, McClatchey, Andrea I., Chen, Christopher S.

Source: Nature communications. 11(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100174576107.0x000001&indx=1&recIds=ETOCvdc_100174576107.0x000001

Rho GEFs and GAPs: Emerging integrators of extracellular matrix signaling

Authors: Kutys, Matthew L, Yamada, Kenneth M

Source: Small GTPases. 6(1):16-19

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100050607707.0x000001&indx=1&recIds=ETOCvdc_100050607707.0x000001

A convolutional neural network STIFMap reveals associations between stromal stiffness and EMT in breast cancer.

Authors: Stashko, Connor, Hayward, Mary-Kate, Northey, Jason J., Pearson, Neil, Ironside, Alastair J., Lakins, Johnathon N., Oria, Roger, Goyette, Marie-Anne, Mayo, Lakyn, Russnes, Hege G., Hwang, E. Shelley, Kutys, Matthew L., Polyak, Kornelia, Weaver, Valerie M.

Source: Nature Communications; 6/15/2023, Vol. 14 Issue 1, p1-16, 16p

Subject Terms: CONVOLUTIONAL neural networks, BREAST, BREAST cancer, ATOMIC force microscopy, EPITHELIAL-mesenchymal transition, TUMOR markers

Force Generation via β-Cardiac Myosin, Titin, and α-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions

Authors: Chopra, Anant, Kutys, Matthew L., Zhang, Kehan, Polacheck, William J., Sheng, Calvin C., Luu, Rebeccah J., Eyckmans, Jeroen, Hinson, J. Travis, Seidman, Jonathan G., Seidman, Christine E., Chen, Christopher S.

Source: Developmental cell. 44(1):87-96.e5

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100070134229.0x000001&indx=1&recIds=ETOCvdc_100070134229.0x000001

Modeling collective cell behavior in cancer: Perspectives from an interdisciplinary conversation

Authors: Adler, Frederick R., Anderson, Alexander R.A., Bhushan, Abhinav, Bogdan, Paul, Bravo-Cordero, Jose Javier, Brock, Amy, Chen, Yun, Cukierman, Edna, DelGiorno, Kathleen E., Denis, Gerald V., Ferrall-Fairbanks, Meghan C., Gartner, Zev Jordan, Germain, Ronald N., Gordon, Deborah M., Hunter, Ginger, Jolly, Mohit Kumar, Karacosta, Loukia Georgiou, Mythreye, Karthikeyan, Katira, Parag, Kulkarni, Rajan P., Kutys, Matthew L., Lander, Arthur D., Laughney, Ashley M., Levine, Herbert, Lou, Emil, Lowenstein, Pedro R., Masters, Kristyn S., Pe’er, Dana, Peyton, Shelly R., Platt, Manu O., Purvis, Jeremy E., Quon, Gerald, Richer, Jennifer K., Riddle, Nicole C., Rodriguez, Analiz, Snyder, Joshua C., Lee Szeto, Gregory, Tomlin, Claire J., Yanai, Itai, Zervantonakis, Ioannis K., Dueck, Hannah

Source: Cell Systems; April 2023, Vol. 14 Issue: 4 p252-257, 6p

Conversation before crossing: dissecting metastatic tumor-vascular interactions in microphysiological systems.

Authors: Mayo, Lakyn N.^1,2,3, Kutys, Matthew L.^1,2,4 matthew.kutys@ucsf.edu

Source: American Journal of Physiology: Cell Physiology. Nov2022, Vol. 323 Issue 5, pC1344-C1344. 12p.

Subject Terms: *METASTASIS, *CANCER invasiveness, *CELL morphology, *ENDOTHELIAL cells, *EXTRAVASATION, *CHATBOTS, *MICROPHYSIOLOGICAL systems

Adherens junctions organize size-selective proteolytic hotspots critical for Notch signalling

Authors: Kwak, Minsuk, Southard, Kaden M., Kim, Woon Ryoung, Lin, Annie, Kim, Nam Hyeong, Gopalappa, Ramu, Lee, Hyun Jung, An, Minji, Choi, Seo Hyun, Jung, Yunmin, Noh, Kunwoo, Farlow, Justin, Georgakopoulos, Anastasios, Robakis, Nikolaos K., Kang, Min K., Kutys, Matthew L., Seo, Daeha, Kim, Hyongbum Henry, Kim, Yong Ho, Cheon, Jinwoo, Gartner, Zev J., Jun, Young-wook

Source: Nature Cell Biology; December 2022, Vol. 24 Issue: 12 p1739-1753, 15p

An extracellular-matrix-specific GEF-GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration.

Authors: Kutys, Matthew L.¹, Yamada, Kenneth M.¹

Source: Nature Cell Biology. Sep2014, Vol. 16 Issue 9, p909-917. 9p.

Subject Terms: *RHO GTPases, *GUANOSINE triphosphatase, *EXTRACELLULAR matrix, *CELL migration, *GUANINE nucleotide exchange factors

Monte Carlo Analysis of Neck Linker Extension in Kinesin Molecular Motors.

Authors: Kutys, Matthew L.¹, Fricks, John² fricks@stat.psu.edu, Hancock, William O.¹ wohbio@engr.psu.edu

Source: PLoS Computational Biology. Nov2010, Vol. 6 Issue 11, p1-11. 11p. 2 Diagrams, 2 Charts, 3 Graphs.

Subject Terms: *PROTEIN conformation, *MONTE Carlo method, *KINESIN, *MOLECULAR biology, *MARKOV processes, *ADENOSINE triphosphatase

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