Aficamten vs Metoprolol for Obstructive Hypertrophic Cardiomyopathy: MAPLE-HCM Rationale, Study Design, and Baseline Characteristics

Authors: Garcia-Pavia, Pablo ^{a, b, ∗}, Bilen, Ozlem ^c, Burroughs, Melissa ^d, Costabel, Juan Pablo ^e, de Barros Correia, Edileide ^f, Dybro, Anne M. ^g, Elliott, Perry ^h, Lakdawala, Neal K. ⁱ, Mann, Amy ^j, Nair, Ajith ^k, Nassif, Michael E. ^l, Poulsen, Steen H. ^g, Reant, Patricia ^m, Schulze, P. Christian ⁿ, Wang, Andrew ^o, Berhane, Indrias ^p, Heitner, Stephen B. ^p, Jacoby, Daniel L. ^p, Kupfer, Stuart ^p, Malik, Fady I. ^p, Meng, Lisa ^p, Sohn, Regina ^p, Wohltman, Amy ^p, Fifer, Michael A. ^q

Source: In JACC: Heart Failure February 2025 13(2):346-357

Impact of Aficamten on Disease and Symptom Burden in Obstructive Hypertrophic Cardiomyopathy: Results From SEQUOIA-HCM

Authors: Maron, Martin S. ^{a, ∗}, Masri, Ahmad ^b, Nassif, Michael E. ^c, Barriales-Villa, Roberto ^d, Abraham, Theodore P. ^e, Arad, Michael ^f, Cardim, Nuno ^g, Choudhury, Lubna ^h, Claggett, Brian ⁱ, Coats, Caroline J. ^j, Düngen, Hans-Dirk ^k, Garcia-Pavia, Pablo ^l, Hagège, Albert A. ^m, Januzzi, James L. ^{n, o}, Kulac, Ian ⁱ, Lee, Matthew M.Y. ^j, Lewis, Gregory D. ⁿ, Ma, Chang-Sheng ^p, Michels, Michelle ^q, Oreziak, Artur ^r, Owens, Anjali T. ^s, Spertus, John A. ^c, Solomon, Scott D. ⁱ, Tfelt-Hansen, Jacob ^t, van Sinttruije, Marion ^u, Veselka, Josef ^v, Watkins, Hugh C. ^w, Jacoby, Daniel L. ^x, Heitner, Stephen B. ^x, Kupfer, Stuart ^x, Malik, Fady I. ^x, Meng, Lisa ^x, Wohltman, Amy ^x, Olivotto, Iacopo ^y

Source: In Journal of the American College of Cardiology 5 November 2024 84(19):1821-1831

Standard-of-Care Medication Withdrawal in Patients With Obstructive Hypertrophic Cardiomyopathy Receiving Aficamten in FOREST-HCM

Authors: Masri, Ahmad ^{a, ∗}, Choudhury, Lubna ^b, Barriales-Villa, Roberto ^c, Elliott, Perry ^d, Maron, Martin S. ^e, Nassif, Michael E. ^f, Oreziak, Artur ^g, Owens, Anjali Tiku ^h, Saberi, Sara ⁱ, Tower-Rader, Albree ^j, Rader, Florian ^k, Garcia-Pavia, Pablo ^{l, m}, Olivotto, Iacopo ⁿ, Nagueh, Sherif F. ^o, Wang, Andrew ^p, Heitner, Stephen B. ^q, Jacoby, Daniel L. ^q, Kupfer, Stuart ^q, Malik, Fady I. ^q, Melloni, Chiara ^q, Meng, Lisa ^q, Wei, Jenny ^q, Sherrid, Mark V. ^r, Abraham, Theodore P. ^s

Source: In Journal of the American College of Cardiology 5 November 2024 84(19):1839-1849

Effect of Aficamten on Cardiac Structure and Function in Obstructive Hypertrophic Cardiomyopathy: SEQUOIA-HCM CMR Substudy

Authors: Masri, Ahmad ^{a, ∗}, Cardoso, Rhanderson N. ^b, Abraham, Theodore P. ^c, Claggett, Brian L. ^b, Coats, Caroline J. ^d, Hegde, Sheila M. ^e, Kulac, Ian J. ^b, Lee, Matthew M.Y. ^d, Maron, Martin S. ^f, Merkely, Bela ^g, Michels, Michelle ^h, Olivotto, Iacopo ⁱ, Oreziak, Artur ^j, Jacoby, Daniel L. ^k, Heitner, Stephen B. ^k, Kupfer, Stuart ^k, Malik, Fady I. ^k, Meng, Lisa ^k, Solomon, Scott D. ^e, Wohltman, Amy ^k, Kwong, Raymond Y. ^b, Kramer, Christopher M. ^l

Source: In Journal of the American College of Cardiology 5 November 2024 84(19):1806-1817

Effect of Aficamten on Health Status Outcomes in Obstructive Hypertrophic Cardiomyopathy: Results From SEQUOIA-HCM

Authors: Sherrod, Charles F., IV ^{a, b, ∗}, Saberi, Sara ^c, Nassif, Michael E. ^{a, b}, Claggett, Brian L. ^d, Coats, Caroline J. ^e, Garcia-Pavia, Pablo ^f, Januzzi, James L. ^{g, h}, Lewis, Gregory D. ^g, Ma, Changsheng ⁱ, Maron, Martin S. ^j, Miao, Zi Michael ^d, Olivotto, Iacopo ^k, Veselka, Josef ^l, Butzner, Michael ^m, Jacoby, Daniel L. ^m, Heitner, Stephen B. ^m, Kupfer, Stuart ^m, Malik, Fady I. ^m, Meng, Lisa ^m, Wohltman, Amy ^m, Spertus, John A. ^{a, b}

Source: In Journal of the American College of Cardiology 5 November 2024 84(19):1773-1785

Impact of Aficamten on Echocardiographic Cardiac Structure and Function in Symptomatic Obstructive Hypertrophic Cardiomyopathy

Authors: Hegde, Sheila M. ^{a, ∗}, Claggett, Brian L. ^a, Wang, Xiaowen ^a, Jering, Karola ^a, Prasad, Narayana ^a, Roshanali, Farideh ^a, Masri, Ahmad ^b, Nassif, Michael E. ^c, Barriales-Villa, Roberto ^d, Abraham, Theodore P. ^e, Cardim, Nuno ^f, Coats, Caroline J. ^g, Kramer, Christopher M. ^h, Maron, Martin S. ⁱ, Michels, Michelle ^j, Olivotto, Iacopo ^k, Saberi, Sara ^l, Jacoby, Daniel L. ^m, Heitner, Stephen B. ^m, Kupfer, Stuart ^m, Meng, Lisa ^m, Wohltman, Amy ^m, Malik, Fady I. ^m, Solomon, Scott D. ^a

Source: In Journal of the American College of Cardiology 5 November 2024 84(19):1789-1802

Efficacy and Safety of Aficamten in Symptomatic Nonobstructive Hypertrophic Cardiomyopathy: Results From the REDWOOD-HCM Trial, Cohort 4

Authors: MASRI, AHMAD, SHERRID, MARK V., ABRAHAM, THEODORE P., CHOUDHURY, LUBNA, GARCIA-PAVIA, PABLO, KRAMER, CHRISTOPHER M., BARRIALES-VILLA, ROBERTO, OWENS, ANJALI T., RADER, FLORIAN, NAGUEH, SHERIF F., OLIVOTTO, IACOPO, SABERI, SARA, TOWER-RADER, ALBREE, WONG, TIMOTHY C., COATS, CAROLINE J., WATKINS, HUGH, FIFER, MICHAEL A., SOLOMON, SCOTT D., HEITNER, STEPHEN B., JACOBY, DANIEL L., KUPFER, STUART, MALIK, FADY I., MENG, LISA, SOHN, REGINA L., WOHLTMAN, AMY, MARON, MARTIN S.

Source: In Journal of Cardiac Failure November 2024 30(11):1439-1448

Cardiac Troponin and Treatment Effects of Omecamtiv Mecarbil: Results From the GALACTIC-HF Study

Authors: Felker, G. Michael ^{1, ⁎}, Solomon, Scott D. ², Metra, Marco ³, Mcmurray, John J.V. ⁴, Diaz, Rafael ⁵, Claggett, Brian ², Lanfear, David E. ⁶, Vandekerckhove, Hans ⁷, Biering-Sørensen, Tor ⁸, Lopes, Renato D. ¹, Arias-Mendoza, Alexandra ⁹, Momomura, Shin-Ichi ¹⁰, Corbalan, Ramon ¹¹, Ramires, Felix J.A. ¹², Zannad, Faiez ¹³, Heitner, Stephen B. ¹⁴, Divanji, Punag H. ¹⁴, Kupfer, Stuart ¹⁴, Malik, Fady I. ¹⁴, Teerlink, John R. ¹⁵

Source: In Journal of Cardiac Failure June 2024 30(6):755-763

The Effect of Omecamtiv Mecarbil in Hospitalized Patients as Compared With Outpatients With HFrEF: An Analysis of GALACTIC-HF

Authors: DOCHERTY, KIERAN F., MCMURRAY, JOHN J.V., DIAZ, RAFAEL, FELKER, G. MICHAEL, METRA, MARCO, SOLOMON, SCOTT D., ADAMS, KIRKWOOD F., BÖHM, MICHAEL, BRINKLEY, DOUGLAS MARSHALL, ECHEVERRIA, LUIS E., GOUDEV, ASSEN R., HOWLETT, JONATHAN G., LUND, MAYANNA, PONIKOWSKI, PIOTR, YILMAZ, MEHMET B., ZANNAD, FAIEZ, CLAGGETT, BRIAN L., MIAO, ZI MICHAEL, ABBASI, SIDDIQUE A., DIVANJI, PUNAG, HEITNER, STEPHEN B., KUPFER, STUART, MALIK, FADY I., TEERLINK, JOHN R.

Source: In Journal of Cardiac Failure January 2024 30(1):26-35

Omecamtiv Mecarbil in Black Patients With Heart Failure and Reduced Ejection Fraction: Insights From GALACTIC-HF

Authors: Lanfear, David E., Njoroge, Joyce N., Adams, Kirkwood F., Anand, Inder, Fang, James C., Ramires, Felix, Sliwa-Hahnle, Karen, Badat, Aysha, Burgess, Lesley, Gorodeski, Eiran Z., Williams, Celeste, Diaz, Rafael, Felker, Gary M., McMurray, John J.V., Metra, Marco, Solomon, Scott, Miao, Zi Michael, Claggett, Brian L., Heitner, Stephen B., Kupfer, Stuart, Malik, Fady I., Teerlink, John R.

Source: In JACC: Heart Failure May 2023 11(5):569-579

Clinical Evaluation of the Effect of Aficamten on QT/QTc Interval in Healthy Participants.

Authors: Maharao, Neha, Xu, Donghong, Simkins, Tyrell J., Bowles, Owen, Liu, Genzhou, Benattia, Youcef, Griffith, Adrienne, Heitner, Stephen B., Kupfer, Stuart, German, Polina

Source: CTS: Clinical & Translational Science; Apr2025, Vol. 18 Issue 4, p1-9, 9p

Subject Terms: HYPERTROPHIC cardiomyopathy, ELECTROCARDIOGRAPHY, CARDIOVASCULAR agents, CLINICAL trials, MEDICAL research

Effect of Hepatic Impairment or Renal Impairment on the Pharmacokinetics of Aficamten: Aficamten in Hepatic or Renal Impairment: D. Xu et al.

Authors: Xu, Donghong, Lutz, Justin D., Divanji, Punag, Li, Jianlin, Benattia, Youcef, Griffith, Adrienne, Heitner, Stephen B., Kupfer, Stuart, German, Polina

Source: Clinical Pharmacokinetics; Mar2025, Vol. 64 Issue 3, p397-406, 10p

Subject Terms: PHARMACOKINETICS, HYPERTROPHIC cardiomyopathy, LIVER failure, DRUG dosage, KIDNEY diseases, MEDICAL research

Plasma neurofilament analysis in VITALITY-ALS.

Authors: Simkins, Tyrell J.¹ (AUTHOR) tsimkins@cytokinetics.com, Kupfer, Stuart¹ (AUTHOR), Malik, Fady I.¹ (AUTHOR), Meng, Lisa¹ (AUTHOR), Rudnicki, Stacy A.¹ (AUTHOR), Wei, Jenny¹ (AUTHOR), Shefner, Jeremy M.² (AUTHOR), Bowser, Robert³ (AUTHOR)

Source: Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. Feb2025, Vol. 26 Issue 1/2, p103-112. 10p.

Subject Terms: *AMYOTROPHIC lateral sclerosis, *PEARSON correlation (Statistics), *VITAL capacity (Respiration), *CYTOPLASMIC filaments, *DISEASE progression

Cardiac biomarkers and effects of aficamten in obstructive hypertrophic cardiomyopathy: the SEQUOIA-HCM trial.

Authors: Coats, Caroline J, Masri, Ahmad, Barriales-Villa, Roberto, Abraham, Theodore P, Brinkley, Douglas Marshall, Claggett, Brian L, Hagege, Albert, Hegde, Sheila M, Ho, Carolyn Y, Kulac, Ian J, Lee, Matthew M Y, Maron, Martin S, Olivotto, Iacopo, Owens, Anjali T, Solomon, Scott D, Tfelt-Hansen, Jacob, Watkins, Hugh, Jacoby, Daniel L, Heitner, Stephen B, Kupfer, Stuart

Source: European Heart Journal; 11/7/2024, Vol. 45 Issue 42, p4464-4478, 15p

Subject Terms: BRAIN natriuretic factor, TROPONIN I, HYPERTROPHIC cardiomyopathy, NATRIURETIC peptides, TREATMENT effectiveness

Aficamten and Cardiopulmonary Exercise Test Performance: A Substudy of the SEQUOIA-HCM Randomized Clinical Trial.

Authors: Lee, Matthew M. Y., Masri, Ahmad, Nassif, Michael E., Barriales-Villa, Roberto, Abraham, Theodore P., Claggett, Brian L., Coats, Caroline J., Gimeno, Juan Ramón, Kulac, Ian J., Landsteiner, Isabela, Ma, Changsheng, Maron, Martin S., Olivotto, Iacopo, Owens, Anjali T., Solomon, Scott D., Veselka, Josef, Jacoby, Daniel L., Heitner, Stephen B., Kupfer, Stuart, Malik, Fady I.

Source: JAMA Cardiology; Nov2024, Vol. 9 Issue 11, p990-1000, 11p

Safety and efficacy of aficamten in patients with non‐obstructive hypertrophic cardiomyopathy: A 36‐week analysis from FOREST‐HCM.

Authors: Masri, Ahmad, Barriales‐Villa, Roberto, Elliott, Perry, Nassif, Michael E., Oreziak, Artur, Owens, Anjali T., Tower‐Rader, Albree, Heitner, Stephen B., Kupfer, Stuart, Malik, Fady I., Melloni, Chiara, Meng, Lisa, Wei, Jenny, Saberi, Sara

Source: European Journal of Heart Failure; Sep2024, Vol. 26 Issue 9, p1993-1998, 6p

Subject Terms: HYPERTROPHIC cardiomyopathy, VENTRICULAR ejection fraction, TROPONIN I, PULMONARY veins, ATRIAL fibrillation

Ischemic cardiac outcomes and hospitalizations according to prior macrovascular disease status in patients with type 2 diabetes and recent acute coronary syndrome from the Examination of Cardiovascular Outcomes with Alogliptin versus Standard of Care trial

Authors: Shimada, Yuichi J., Cannon, Christopher P., Liu, Yuyin, Wilson, Craig, Kupfer, Stuart, Menon, Venu, Cushman, William C., Mehta, Cyrus R., Bakris, George L., Zannad, Faeiz, White, William B.

Source: In American Heart Journal May 2016 175:18-27

Kiosk 6R-TC-04 - Effect of Aficamten on Structure and Function in Patients with Obstructive Hypertrophic Cardiomyopathy: The FOREST-HCM CMR Sub-study

Authors: Masri, Ahmad, Cardoso, Rhanderson, Abraham, Theodore, Choudhury, Lubna, Rader, Florian, Saberi, Sara, Tower-Rader, Albree, Wang, Andrew, Heitner, Stephen, Kupfer, Stuart, Malik, Fady, Melloni, Chiara, Wei, Jenny, Wohltman, Amy, Kwong, Raymond

Source: In Journal of Cardiovascular Magnetic Resonance Spring 2024 26 Supplement 1

Heart failure and mortality outcomes in patients with type 2 diabetes taking alogliptin versus placebo in EXAMINE: a multicentre, randomised, double-blind trial

Authors: Zannad, Faiez, Cannon, Christopher P, Cushman, William C, Bakris, George L, Menon, Venu, Perez, Alfonso T, Fleck, Penny R, Mehta, Cyrus R, Kupfer, Stuart, Wilson, Craig, Lam, Hung, White, William B

Source: In The Lancet 23-29 May 2015 385(9982):2067-2076

Improving cardiovascular clinical trials conduct in the United States: Recommendation from clinicians, researchers, sponsors, and regulators

Authors: Butler, Javed, Fonarow, Gregg C., O’Connor, Christopher, Adams, Kirkwood, Bonow, Robert O., Cody, Robert J., Collins, Sean P., Dunnmon, Preston, Dinh, Wilfried, Fiuzat, Mona, Georgiopoulou, Vasiliki V., Grant, Stephen, Kim, So-Young, Kupfer, Stuart, Lefkowitz, Martin, Mentz, Robert J., Misselwitz, Frank, Pitt, Bertram, Roessig, Lothar, Schelbert, Erik, Shah, Monica, Solomon, Scott, Stockbridge, Norman, Yancy, Clyde, Gheorghiade, Mihai

Source: In American Heart Journal March 2015 169(3):305-314