Evorpacept alone and in combination with pembrolizumab or trastuzumab in patients with advanced solid tumours (ASPEN-01): a first-in-human, open-label, multicentre, phase 1 dose-escalation and dose-expansion study

Authors: Lakhani, Nehal J, Chow, Laura Q M, Gainor, Justin F, LoRusso, Patricia, Lee, Keun-Wook, Chung, Hyun Cheol, Lee, Jeeyun, Bang, Yung-Jue, Hodi, Frank Stephen, Kim, Won Seog, Santana-Davila, Rafael, Fanning, Philip, Squifflet, Pierre, Jin, Feng, Kuo, Tracy C, Wan, Hong I, Pons, Jaume, Randolph, Sophia S ^*, Messersmith, Wells A

Source: In The Lancet Oncology December 2021 22(12):1740-1751

Preclinical Evaluation of Allogeneic CAR T Cells Targeting BCMA for the Treatment of Multiple Myeloma

Authors: Sommer, Cesar, Boldajipour, Bijan, Kuo, Tracy C., Bentley, Trevor, Sutton, Janette, Chen, Amy, Geng, Tao, Dong, Holly, Galetto, Roman, Valton, Julien, Pertel, Thomas, Juillerat, Alexandre, Gariboldi, Annabelle, Pascua, Edward, Brown, Colleen, Chin, Sherman M., Sai, Tao, Ni, Yajin, Duchateau, Philippe, Smith, Julianne, Rajpal, Arvind, Van Blarcom, Thomas, Chaparro-Riggers, Javier, Sasu, Barbra J.

Source: In Molecular Therapy 5 June 2019 27(6):1126-1138

Discovery of high affinity, pan-allelic, and pan-mammalian reactive antibodies against the myeloid checkpoint receptor SIRPα

Authors: Sim, Janet, Sockolosky, Jonathan T., Sangalang, Emma, Izquierdo, Shelley, Pedersen, Darlene, Harriman, William, Wibowo, Ardian S., Carter, Josh, Madan, Anup, Doyle, Laura, Harrabi, Ons, Kauder, Steven E., Chen, Amy, Kuo, Tracy C., Wan, Hong, Pons, Jaume

Source: MAbs. 11(6):1036-1052

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100086072164.0x000001&indx=1&recIds=ETOCvdc_100086072164.0x000001

Targeting the myeloid checkpoint receptor SIRPα potentiates innate and adaptive immune responses to promote anti-tumor activity

Authors: Kuo, Tracy C., Chen, Amy, Harrabi, Ons, Sockolosky, Jonathan T., Zhang, Anli, Sangalang, Emma, Doyle, Laura V., Kauder, Steven E., Fontaine, Danielle, Bollini, Sangeetha, Han, Bora, Fu, Yang-Xin, Sim, Janet, Pons, Jaume, Wan, Hong I.

Source: Journal of hematology & oncology. 13(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190781005.0x000001&indx=1&recIds=ETOCvdc_100190781005.0x000001

Naive antibody gene-segment frequencies are heritable and unaltered by chronic lymphocyte ablation

Authors: Glanville, Jacob, Kuo, Tracy C., von Büdingen, H.-Christian, Guey, Lin, Berka, Jan, Sundar, Purnima D., Huerta, Gabriella, Mehta, Gautam R., Oksenberg, Jorge R., Hauser, Stephen L., Cox, David R., Rajpal, Arvind, Pons, Jaume

Source: Proceedings of the National Academy of Sciences of the United States of America, 2011 Dec . 108(50), 20066-20071.

Access URL: https://www.jstor.org/stable/23060076

Mechanisms controlling expression of the RAG locus during lymphocyte development

Authors: Kuo, Tracy C, Schlissel, Mark S

Source: In Current Opinion in Immunology 2009 21(2):173-178

ALX148 blocks CD47 and enhances innate and adaptive antitumor immunity with a favorable safety profile.

Authors: Kauder, Steven E.¹, Kuo, Tracy C.¹, Harrabi, Ons¹, Chen, Amy¹, Sangalang, Emma¹, Doyle, Laura¹, Rocha, Sony S.¹, Bollini, Sangeetha¹, Han, Bora¹, Sim, Janet¹, Pons, Jaume¹, Wan, Hong I.¹ hong@alxoncology.com

Source: PLoS ONE. 8/22/2018, Vol. 13 Issue 8, p1-33. 33p.

Subject Terms: *CD47 antigen, *CANCER treatment, *CANCER cells, *ANTINEOPLASTIC agents, *IMMUNOGLOBULINS

Blimp-1 Orchestrates Plasma Cell Differentiation by Extinguishing the Mature B Cell Gene Expression Program

Authors: Shaffer, A.L., Lin, Kuo-I, Kuo, Tracy C., Yu, Xin, Hurt, Elaine M., Rosenwald, Andreas, Giltnane, Jena M., Yang, Liming, Zhao, Hong, Calame, Kathryn ^*, Staudt, Louis M.

Source: In Immunity 2002 17(1):51-62

Mutation of csk, encoding the C-terminal Src kinase, reduces Pseudomonas aeruginosa internalization by mammalian cells and enhances bacterial cytotoxicity

Authors: Evans, David J., Kuo, Tracy C., Kwong, Mary, Van, Rajana, Fleiszig, Suzanne M.J.

Source: In Microbial Pathogenesis 2002 33(3):135-143

Anti-GD2 synergizes with CD47 blockade to mediate tumor eradication

Authors: Theruvath, Johanna, Menard, Marie, Smith, Benjamin A. H., Linde, Miles H., Coles, Garry L., Dalton, Guillermo Nicolas, Wu, Wei, Kiru, Louise, Delaidelli, Alberto, Sotillo, Elena, Silberstein, John L., Geraghty, Anna C., Banuelos, Allison, Radosevich, Molly Thomas, Dhingra, Shaurya, Heitzeneder, Sabine, Tousley, Aidan, Lattin, John, Xu, Peng, Huang, Jing, Nasholm, Nicole, He, Andy, Kuo, Tracy C., Sangalang, Emma R. B., Pons, Jaume, Barkal, Amira, Brewer, Rachel E., Marjon, Kristopher D., Vilches-Moure, Jose G., Marshall, Payton L., Fernandes, Ricardo, Monje, Michelle, Cochran, Jennifer R., Sorensen, Poul H., Daldrup-Link, Heike E., Weissman, Irving L., Sage, Julien, Majeti, Ravindra, Bertozzi, Carolyn R., Weiss, William A., Mackall, Crystal L., Majzner, Robbie G.

Source: Nature Medicine; February 2022, Vol. 28 Issue: 2 p333-344, 12p

ALX148 Enhances the Depth and Durability of Response to Multiple AML Therapies

Authors: Chen, Amy ^*, Harrabi, Ons ^*, Fong, Abraham P, Ruffner, Katherine L., Forgie, Alison J. ^*, Sim, Janet ^*, Randolph, Sophia S, Wan, Hong ^*, Pons, Jaume ^*, Kuo, Tracy C ^*

Source: In Blood 5 November 2020 136 Supplement 1:15-16

AID for Innate Immunity to Retroviral Transformation

Authors: Schlissel, Mark S., Kuo, Tracy C.

Source: In Immunity June 2006 24(6):671-672

ALX148 Is a High Affinity Sirpα Fusion Protein That Blocks CD47, Enhances the Activity of Anti-Cancer Antibodies and Checkpoint Inhibitors, and Has a Favorable Safety Profile in Preclinical Models

Authors: Kauder, Steven E ^*, Kuo, Tracy C ^*, Chen, Amy ^*, Harrabi, Ons ^*, Rocha, Sony S ^*, Doyle, Laura ^*, Bollini, Sangeetha ^*, Han, Bora ^*, Sangalang, Emma Ruth B ^*, Sim, Janet ^*, Randolph, Sophia, Pons, Jaume ^*, Wan, Hong I ^*

Source: In Blood 8 December 2017 130 Supplement 1:112-112

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Blimp-1-Dependent Repression of Pax-5Is Required for Differentiation of B Cells to Immunoglobulin M-Secreting Plasma Cells

Authors: Lin, Kuo-I, Angelin-Duclos, Cristina, Kuo, Tracy C., Calame, Kathryn

Source: Molecular and Cellular Biology; July 2002, Vol. 22 Issue: 13 p4771-4780, 10p