Hepatic cytochrome P450 deficiency in mouse models for intrahepatic cholestasis predispose to bile salt-induced cholestasis

Authors: Kunne, Cindy, de Graaff, Marijke, Duijst, Suzanne, de Waart, Dirk R, Oude Elferink, Ronald P J, Paulusma, Coen C

Source: In Laboratory Investigation October 2014 94(10):1103-1113

FXR-dependent reduction of hepatic steatosis in a bile salt deficient mouse model

Authors: Kunne, Cindy, Acco, Alexandra, Duijst, Suzanne, de Waart, Dirk R., Paulusma, Coen C., Gaemers, Ingrid, Oude Elferink, Ronald P.J.

Source: In BBA - Molecular Basis of Disease May 2014 1842(5):739-746

Actual Usage and Quality of Experimental Colitis Models in Preclinical Efficacy Testing: A Scoping Review

Authors: Zeeff, Sophia B., Kunne, Cindy, Bouma, Gerd, de Vries, Rob B., te Velde, Anje A.

Source: Inflammatory bowel diseases. 22(6):1296-1305

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100031854504.0x000001&indx=1&recIds=ETOCvdc_100031854504.0x000001

Oral Availability of Cefadroxil Depends on ABCC3 and ABCC4

Authors: de Waart, Dirk R. ^*, van de Wetering, Koen, Kunne, Cindy, Duijst, Suzanne, Paulusma, Coen C., Oude Elferink, Ronald P.J.

Source: In Drug Metabolism and Disposition March 2012 40(3):515-521

Complementary Functions of the Flippase ATP8B1 and the Floppase ABCB4 in Maintaining Canalicular Membrane Integrity

Authors: Groen, Annemiek, Romero, Marta Rodriguez, Kunne, Cindy, Hoosdally, Sarah J., Dixon, Peter H., Wooding, Carol, Williamson, Catherine, Seppen, Jurgen, van den Oever, Karin, Mok, Kam S., Paulusma, Coen C., Linton, Kenneth J., Oude Elferink, Ronald P.J.

Source: In Gastroenterology November 2011 141(5):1927-1937

Lipotoxicity and steatohepatitis in an overfed mouse model for non-alcoholic fatty liver disease

Authors: Gaemers, Ingrid C., Stallen, Jan M., Kunne, Cindy, Wallner, Christian, van Werven, Jochem, Nederveen, Aart, Lamers, Wouter H.

Source: In BBA - Molecular Basis of Disease April 2011 1812(4):447-458

Hepatic Transport Mechanisms of Cholyl-l-Lysyl-Fluorescein

Authors: de Waart, Dirk R. ^*, Häusler, Stephanie, Vlaming, Maria L.H., Kunne, Cindy, Hänggi, Emanuel, Gruss, Hans-Jurgen, Oude Elferink, Ronald P.J., Stieger, Bruno

Source: In The Journal of Pharmacology and Experimental Therapeutics July 2010 334(1):78-86

Glutamine Synthetase in Muscle Is Required for Glutamine Production during Fasting and Extrahepatic Ammonia Detoxification

Authors: He, Youji, Hakvoort, Theodorus B.M., Köhler, S. Eleonore, Vermeulen, Jacqueline L.M., de Waart, D. Rudi, de Theije, Chiel, ten Have, Gabrie A.M., van Eijk, Hans M.H., Kunne, Cindy, Labruyere, Wilhelmina T., Houten, Sander M., Sokolovic, Milka, Ruijter, Jan M., Deutz, Nicolaas E.P., Lamers, Wouter H.

Source: In Journal of Biological Chemistry 26 March 2010 285(13):9516-9524

The role of epoxidation and electrophile-responsive element-regulated gene transcription in the potentially beneficial and harmful effects of the coffee components cafestol and kahweol

Authors: van Cruchten, Saskia T.J., de Haan, Laura H.J., Mulder, Patrick P.J., Kunne, Cindy, Boekschoten, Mark V., Katan, Martijn B., Aarts, Jac M.M.J.G., Witkamp, Renger F.

Source: In The Journal of Nutritional Biochemistry 2010 21(8):757-763

Complex Pharmacokinetic Behavior of Ezetimibe Depends on Abcc2, Abcc3, and Abcg2

Authors: de Waart, Dirk R. ^*, Vlaming, Maria L.H., Kunne, Cindy, Schinkel, Alfred H., Elferink, Ronald P.J. Oude

Source: In Drug Metabolism and Disposition August 2009 37(8):1698-1702

Activity of the Bile Salt Export Pump (ABCB11) Is Critically Dependent on Canalicular Membrane Cholesterol Content

Authors: Paulusma, Coen C., de Waart, D.Rudi, Kunne, Cindy, Mok, Kam S., Elferink, Ronald P.J.Oude

Source: In Journal of Biological Chemistry 10 April 2009 284(15):9947-9954

Abcg5/8 Independent Biliary Cholesterol Excretion in Atp8b1-Deficient Mice

Authors: Groen, Annemiek, Kunne, Cindy, Jongsma, Geartsje, van den Oever, Karin, Mok, Kam S., Petruzzelli, Michele, Vrins, Carlos L.J., Bull, Laura, Paulusma, Coen C., Oude Elferink, Ronald P.J.

Source: In Gastroenterology June 2008 134(7):2091-2100

Direct Intestinal Cholesterol Secretion Contributes Significantly to Total Fecal Neutral Sterol Excretion in Mice

Authors: van der Velde, Astrid E., Vrins, Carlos L.J., van den Oever, Karin, Kunne, Cindy, Oude Elferink, Ronald P.J., Kuipers, Folkert, Groen, Albert K.

Source: In Gastroenterology September 2007 133(3):967-975

Intestinal bile salt absorption in Atp8b1 deficient mice

Authors: Groen, Annemiek, Kunne, Cindy, Paulusma, Coen C., Kramer, Werner, Agellon, Luis B., Bull, Laura N., Oude Elferink, Ronald P.J.

Source: In Journal of Hepatology 2007 47(1):114-122

The mechanism of ABCG5/ABCG8 in biliary cholesterol secretion in mice

Authors: Kosters, Astrid ^*, Kunne, Cindy ^*, Looije, Norbert ^*, Patel, Shailendra B., Oude Elferink, Ronald P.J. ^*, Groen, Albert K. ^*

Source: In Journal of Lipid Research September 2006 47(9):1959-1966

Adeno-associated Virus Vector Serotypes Mediate Sustained Correction of Bilirubin UDP Glucuronosyltransferase Deficiency in Rats

Authors: Seppen, Jurgen, Bakker, Conny, de Jong, Berry, Kunne, Cindy, van den Oever, Karin, Vandenberghe, Kristin, de Waart, Rudi, Twisk, Jaap, Bosma, Piter

Source: In Molecular Therapy June 2006 13(6):1085-1092

Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides

Authors: Zelcer, Noam, Wetering, Koen van de, Waart, Rudi de, Scheffer, George L., Marschall, Hanns-Ulrich, Wielinga, Peter R., Kuil, Annemieke, Kunne, Cindy, Smith, Alexander, Valk, Martin van der, Wijnholds, Jan, Elferink, Ronald Oude, Borst, Piet

Source: In Journal of Hepatology 2006 44(4):768-775

Inefficient Chronic Activation of Parietal Cells in Ae2a,b−/− Mice

Authors: Recalde, Sergio, Muruzábal, Francisco, Looije, Norbert, Kunne, Cindy, Burrell, María A., Sáez, Elena, Martínez-Ansó, Eduardo, Salas, January T., Mardones, Pablo, Prieto, Jesús, Medina, Juan F., Elferink, Ronald P.J. Oude

Source: In The American Journal of Pathology 2006 169(1):165-176

Kupffer Cells and Not Liver Sinusoidal Endothelial Cells Prevent Lentiviral Transduction of Hepatocytes

Authors: van Til, Niek P. ^*, Markusic, David M., van der Rijt, Roos, Kunne, Cindy, Hiralall, Johan K., Vreeling, Heleen, Frederiks, Wilma M., Oude-Elferink, Ronald P.J., Seppen, Jurgen

Source: In Molecular Therapy January 2005 11(1):26-34

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