Lessons learned from 20 years of preclinical testing in pediatric cancers

Authors: Smith, Malcolm A., Houghton, Peter J., Lock, Richard B., Maris, John M., Gorlick, Richard, Kurmasheva, Raushan T., Li, Xiao-Nan, Teicher, Beverly A., Chuang, Jeffrey H., Dela Cruz, Filemon S., Dyer, Michael A., Kung, Andrew L., Lloyd, Michael W., Mossé, Yael P., Stearns, Timothy M., Stewart, Elizabeth A., Bult, Carol J., Erickson, Stephen W.

Source: In Pharmacology and Therapeutics December 2024 264

Impact of rabbit anti-thymocyte globulin (ATG) exposure on outcomes after ex vivo T-cell–depleted hematopoietic cell transplantation in pediatric and young adult patients

Authors: Lakkaraja, Madhavi, Mauguen, Audrey, Boulad, Farid, Cancio, Maria I., Curran, Kevin J., Harris, Andrew C., Kernan, Nancy A., Klein, Elizabeth, Kung, Andrew L., Oved, Joseph, Prockop, Susan, Scaradavou, Andromachi, Spitzer, Barbara, O'Reilly, Richard J., Boelens, Jaap Jan

Source: In Cytotherapy April 2024 26(4):351-359

Targeted Polymersome Delivery of a Stapled Peptide for Drugging the Tumor Protein p53:BCL-2-Family Axis in Diffuse Large B-Cell Lymphoma

Authors: Schnorenberg, Mathew R., Hawley, Katrina M., Thomas-Toth, Anika T., Watkins, Elyse A., Tian, Yu, Ting, Jeffrey M., Leak, Logan B., Kucera, Isadora M., Raczy, Michal M., Kung, Andrew L.

Source: ACS NANO. 17(23):23374-23390

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN632760613&indx=1&recIds=ETOCRN632760613

Association between busulfan exposure and survival in patients undergoing a CD34+ selected stem cell transplantation

Authors: Tamari, Roni, Scordo, Michael, Kunvarjee, Binni M., Proli, Anthony, Lin, Andrew, Flynn, Jessica, Cho, Christina, Devlin, Sean, Klein, Elizabeth, Boulad, Farid, Cancio, Maria I., Curran, Kevin J., Jakubowski, Ann A., Kernan, Nancy A., Kung, Andrew L., O’Reilly, Richard J., Papadopoulos, Esperanza B., Prockop, Susan, Scaradavou, Andromachi, Shaffer, Brian C., Shah, Gunjan, Spitzer, Barbara, Gyurkocza, Boglarka, Giralt, Sergio A., Perales, Miguel-Angel, Boelens, Jaap Jan

Source: In Blood Advances 26 September 2023 7(18):5225-5233

Validation of a non-oncogene encoded vulnerability to exportin 1 inhibition in pediatric renal tumors

Authors: Coutinho, Diego F., Mundi, Prabhjot S., Marks, Lianna J., Burke, Chelsey, Ortiz, Michael V., Diolaiti, Daniel, Bird, Lauren, Vallance, Kelly L., Ibáñez, Glorymar, You, Daoqi, Long, Matthew, Rosales, Nestor, Grunn, Adina, Ndengu, Andoyo, Siddiquee, Armaan, Gaviria, Ervin S., Rainey, Allison R., Fazlollahi, Ladan, Hosoi, Hajime, Califano, Andrea, Kung, Andrew L., Dela Cruz, Filemon S.

Source: In Med 11 November 2022 3(11):774-791

Antithymocyte globulin exposure in CD34+ T-cell–depleted allogeneic hematopoietic cell transplantation

Authors: Lakkaraja, Madhavi ^{*, †}, Scordo, Michael ^{*, †}, Mauguen, Audrey, Cho, Christina, Devlin, Sean, Ruiz, Josel D., Klein, Elizabeth, Avecilla, Scott T., Boulad, Farid, Cancio, Maria I., Curran, Kevin J., Jakubowski, Ann A., Kernan, Nancy A., Kung, Andrew L., O'Reilly, Richard J., Papadopoulos, Esperanza B., Prockop, Susan, van Roessel, Ichelle, Scaradavou, Andromachi, Shaffer, Brian C., Shah, Gunjan, Spitzer, Barbara, Tamari, Roni, Giralt, Sergio A., Perales, Miguel-Angel, Boelens, Jaap Jan ^*

Source: In Blood Advances 8 February 2022 6(3):1054-1063

STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma

Authors: Adane, Biniam, Alexe, Gabriela, Seong, Bo Kyung A., Lu, Diana, Hwang, Elizabeth E., Hnisz, Denes, Lareau, Caleb A., Ross, Linda, Lin, Shan, Dela Cruz, Filemon S., Richardson, Melissa, Weintraub, Abraham S., Wang, Sarah, Iniguez, Amanda Balboni, Dharia, Neekesh V., Conway, Amy Saur, Robichaud, Amanda L., Tanenbaum, Benjamin, Krill-Burger, John M., Vazquez, Francisca, Schenone, Monica, Berman, Jason N., Kung, Andrew L., Carr, Steven A., Aryee, Martin J., Young, Richard A., Crompton, Brian D., Stegmaier, Kimberly

Source: In Cancer Cell 14 June 2021 39(6):827-844

Supernumerary ring chromosome 1 syndrome leads to fusion-driven B-cell acute lymphoblastic leukemia in monozygotic twins

Authors: Gutiérrez-Abril, Jesús ¹, Gundem, Gunes ¹, Fiala, Elise ², Liosis, Konstantinos ¹, Farnoud, Noushin ¹, Leongamornlert, Dan ³, Amallraja, Anu ¹, Arango-Ossa, Juan E. ¹, Domenico, Dylan ¹, Levine, Max ¹, Medina-Martínez, Juan S. ¹, Stockfisch, Emily ², You, Daoqi ², Walsh, Mike ², Jasinski, Sylwia ⁴, Kung, Andrew L. ², Shukla, Neerav N. ^{2, ∗}, Carroll, William L. ^{5, ∗∗}, Papaemmanuil, Elli ^{1, ∗∗∗}

Source: In Blood Advances January 2025

Toxicity and response after CD19-specific CAR T-cell therapy in pediatric/young adult relapsed/refractory B-ALL

Authors: Curran, Kevin J. ^{1, 2, 3}, Margossian, Steven P. ^{4, 5}, Kernan, Nancy A. ^{1, 2, 3}, Silverman, Lewis B. ^{4, 5}, Williams, David A. ^{4, 5}, Shukla, Neerav ¹, Kobos, Rachel ¹, Forlenza, Christopher J. ¹, Steinherz, Peter ^{1, 2}, Prockop, Susan ^{1, 2}, Boulad, Farid ^{1, 2}, Spitzer, Barbara ^{1, 2}, Cancio, Maria I. ^{1, 2}, Boelens, Jaap Jan ¹, Kung, Andrew L. ¹, Khakoo, Yasmin ^{1, 2, 6}, Szenes, Victoria ¹, Park, Jae H. ^{3, 7}, Sauter, Craig S. ³, Heller, Glenn ⁸, Wang, Xiuyan ^{3, 9}, Senechal, Brigitte ^{3, 9}, O'Reilly, Richard J. ¹, Riviere, Isabelle ^{3, 7, 9}, Sadelain, Michel ^{3, 7}, Brentjens, Renier J. ^{3, 7}

Source: In Blood 26 December 2019 134(26):2361-2368

BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation

Authors: Li, Andrew G., Murphy, Elizabeth C., Culhane, Aedin C., Powell, Emily, Wang, Hua, Bronson, Roderick T., Von, Thanh, Giobbie-Hurder, Anita, Gelman, Rebecca S., Briggs, Kimberly J., Piwnica-Worms, Helen, Zhao, Jean J., Kung, Andrew L., Kaelin, William G., Livingston, David M.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2018 Oct 01. 115(41), E9600-E9609.

Access URL: https://www.jstor.org/stable/26532223

Recurrent EML4–NTRK3 fusions in infantile fibrosarcoma and congenital mesoblastic nephroma suggest a revised testing strategy

Authors: Church, Alanna J, Calicchio, Monica L, Nardi, Valentina, Skalova, Alena, Pinto, Andre, Dillon, Deborah A, Gomez-Fernandez, Carmen R, Manoj, Namitha, Haimes, Josh D, Stahl, Joshua A, Dela Cruz, Filemon S, Tannenbaum-Dvir, Sarah, Glade-Bender, Julia L, Kung, Andrew L, DuBois, Steven G, Kozakewich, Harry P, Janeway, Katherine A, Perez-Atayde, Antonio R, Harris, Marian H

Source: In Modern Pathology March 2018 31(3):463-473

Clinical Outcomes and Salvage Therapies of Pediatric Patients with Progressive B-ALL Following CD19 Chimeric Antigen Receptor (CAR) T Cell Therapy

Authors: Bidgoli, Alan, Yametti, Gloria Contreras, Shahid, Sanam, Harris, Andrew C., Cancio, Maria I., Spitzer, Barbara, Oved, Joseph H., O'Reilly, Richard J., Mauguen, Audrey, Scaradavou, Andromachi, Kung, Andrew L., Boelens, Jaap-Jan, Curran, Kevin J.

Source: Transplantation and Cellular Therapy. 29(S):S216-S217

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100180673709.0x000001&indx=1&recIds=ETOCvdc_100180673709.0x000001

Bromodomain 4 inhibition leads to MYCN downregulation in Wilms tumor

Authors: Woods, Andrew D., Berlow, Noah E., Ortiz, Michael V., Dela Cruz, Filemon, Siddiquee, Armaan, Coutinho, Diego F., Purohit, Reshma, Freier, Katherine E. Tranbarger, Michalek, Joel E., Lathara, Melvin, Matlock, Kevin, Srivivasa, Ganapati, Royer‐Pokora, Brigitte, Veselska, Renata, Kung, Andrew L., Keller, Charles

Source: Pediatric blood & cancer. 69(2)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100137357141.0x000001&indx=1&recIds=ETOCvdc_100137357141.0x000001

BET bromodomain proteins regulate enhancer function during adipogenesis

Authors: Brown, Jonathan D., Feldman, Zachary B., Doherty, Sean P., Reyes, Jaime M., Rahl, Peter B., Lin, Charles Y., Sheng, Quanhu, Duan, Qiong, Federation, Alexander J., Kung, Andrew L., Haldar, Saptarsi M., Young, Richard A., Plutzky, Jorge, Bradner, James E.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2018 Feb . 115(9), 2144-2149.

Access URL: https://www.jstor.org/stable/26507955

Activation of Apoptosis in vivo by a Hydrocarbon-Stapled BH3 Helix

Authors: Walensky, Loren D., Kung, Andrew L., Escher, Iris, Malia, Thomas J., Barbuto, Scott, Wright, Renee D., Wagner, Gerhard, Verdine, Gregory L., Korsmeyer, Stanley J.

Source: Science, 2004 Sep 01. 305(5689), 1466-1470.

Access URL: https://www.jstor.org/stable/3837827

A Small-Molecule Antagonist of CXCR4 Inhibits Intracranial Growth of Primary Brain Tumors

Authors: Rubin, Joshua B., Kung, Andrew L., Klein, Robyn S., Chan, Jennifer A., Sun, YanPing, Schmidt, Karl, Kieran, Mark W., Luster, Andrew D., Segal, Rosalind A.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2003 Nov 01. 100(23), 13513-13518.

Access URL: https://www.jstor.org/stable/3148171

Distinct Roles for CREB-Binding Protein and p300 in Hematopoietic Stem Cell Self-Renewal

Authors: Rebel, Vivienne I., Kung, Andrew L., Tanner, Elizabeth A., Yang, Hong, Bronson, Roderick T., Livingston, David M.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2002 Nov 01. 99(23), 14789-14794.

Access URL: https://www.jstor.org/stable/3073670

Structural Basis for Recruitment of CBP/p300 by Hypoxia-Inducible Factor-1α

Authors: Freedman, Steven J., Sun, Zhen-Yu J., Poy, Florence, Kung, Andrew L., Livingston, David M., Wagner, Gerhard, Eck, Michael J.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2002 Apr . 99(8), 5367-5372.

Access URL: https://www.jstor.org/stable/3058498

Role of T-bet in Commitment of T H1 Cells before IL-12-Dependent Selection

Authors: Mullen, Alan C., High, Frances A., Hutchins, Anne S., Lee, Hubert W., Villarino, Alejandro V., Livingston, David M., Kung, Andrew L., Cereb, Nezih, Yao, Tso-Pang, Yang, Soo Y., Reiner, Steven L.

Source: Science, 2001 Jun 01. 292(5523), 1907-1910.

Access URL: https://www.jstor.org/stable/3083935

Two novel assays demonstrate persistent daratumumab exposure in a pediatric patient with delayed engraftment following allogeneic hematopoietic stem cell transplantation

Authors: Major-Monfried, Hannah, Hosszu, Kinga, McAvoy, Devin P., Vallone, Alexander, Shukla, Neerav, Gillio, Alfred, Spitzer, Barbara, Kung, Andrew L., Cancio, Maria, Curran, Kevin, Scaradavou, Andromachi, Oved, Joseph H., O'Reilly, Richard J., Boelens, Jaap Jan, Harris, Andrew C.

Source: In Cytotherapy May 2024 26(5):466-471