Haploidentical transplantation in primary refractory/relapsed secondary vs de novo AML: from the ALWP/EBMT

Authors: Nagler, Arnon, Labopin, Myriam, Tischer, Johanna, Raiola, Anna Maria, Kunadt, Desiree, Vydra, Jan, Blaise, Didier, Chiusolo, Patrizia, Fanin, Renato, Winkler, Julia, Forcade, Edouard, Van Gorkom, Gwendolyn, Ciceri, Fabio, Mohty, Mohamad

Source: In Blood Advances 13 August 2024 8(15):4223-4233

Remission induction versus immediate allogeneic haematopoietic stem cell transplantation for patients with relapsed or poor responsive acute myeloid leukaemia (ASAP): a randomised, open-label, phase 3, non-inferiority trial

Authors: Alakel, Nael, Albring, Jörn, Berdel, Wolfgang E., Bethge, Wolfgang, Bornhäuser, Martin, Bug, Gesine, Buhl, Christoph, Call, Simon, Crysandt, Martina, Egger-Heidrich, Katharina, Eßeling, Eva, Faul, Christoph, Franke, Georg-Nikolaus, Georgi, Julia-Annabell, Glück-Wolf, Julia, Groth, Christoph, Hauptrock, Beate, Heidenreich, Daniela, Janjetovic, Snjezana, Jost, Edgar, Kaufmann, Martin, Kindler, Thomas, Klein, Stefan A., Krause, Stefan W., Kreil, Sebastian, Kretschmann, Theresa, Kunadt, Desiree, Lang, Fabian, Lenz, Georg, Martin, Sonja, Marx, Julia, Middeke, Jan-Moritz, Mikesch, Jan-Henrik, Müller, Lutz P., Müller, Nadine, Niederland, Judith, Parmentier, Stefani, Petzold, Kathrin, Platzbecker, Uwe, Rank, Andreas, Reicherts, Christian, Röllig, Christoph, Rösler, Wolf, Schäfer-Eckart, Kerstin, Schaffrath, Judith, Schaich, Markus, Schetelig, Johannes, Schliemann, Christoph, Schmid, Christoph, Schneidawind, Dominik, Schubert, Jörg, Serve, Hubert, Sockel, Katja, Steffen, Björn, Stelljes, Matthias, Teipel, Raphael, von Bonin, Malte, Wagner-Drouet, Eva, Wass, Maxi, Wendelin, Knut, Middeke, Jan Moritz ^*, Wagner-Drouet, Eva-Maria, Müller, Lutz P, Krause, Stefan W, Klein, Stefan A, Baldauf, Henning, Stölzel, Friedrich, Petzold, Cathleen, Kriege, Oliver, Berdel, Wolfgang E, Ehninger, Gerhard, Schmidt, Alexander H

Source: In The Lancet Haematology May 2024 11(5):e324-e335

Influence of invasive aspergillosis during acute leukaemia treatment on survival after allogeneic stem cell transplantation: a prospective study of the EBMT Infectious Diseases Working Party

Authors: Penack, Olaf, Tridello, Gloria, Salmenniemi, Urpu, Martino, Rodrigo, Khanna, Nina, Perruccio, Katia, Fagioli, Franca, Richert-Przygonska, Monika, Labussière-Wallet, Hélène, Maertens, Johan, Jubert, Charlotte, Aljurf, Mahmoud, Pichler, Herbert, Kriván, Gergely, Kunadt, Desiree, Popova, Marina, Gabriel, Melissa, Calore, Elisabetta, Blau, Igor Wolfgang, Benedetti, Fabio, Itäla-Remes, Maija, de Kort, Elizabeth, Russo, Domenico, Faraci, Maura, Ménard, Anne-Lise, Borne, Peter von dem, Poiré, Xavier, Yesilipek, Akif, Gozdzik, Jolanta, Yeğin, Zeynep Arzu, Yañez, Lucrecia, Facchini, Luca, Van Gorkom, Gwendolyn, Thurner, Lorenz, Kocak, Ulker, Sampol, Antònia, Zuckerman, Tsila, Bierings, Marc, Mielke, Stephan, Ciceri, Fabio, Wendel, Lotus, Knelange, Nina, Mikulska, Malgorzata, Averbuch, Dina, Styczynski, Jan, Camara, Rafael de la, Cesaro, Simone

Source: In eClinicalMedicine January 2024 67

Germ line variant GFI1-36N affects DNA repair and sensitizes AML cells to DNA damage and repair therapy

Authors: Frank, Daria, Patnana, Pradeep Kumar, Vorwerk, Jan, Mao, Lianghao, Gopal, Lavanya Mokada, Jung, Noelle, Hennig, Thorben, Ruhnke, Leo, Frenz, Joris Maximillian, Kuppusamy, Maithreyan, Autry, Robert, Wei, Lanying, Sun, Kaiyan, Mohammed Ahmed, Helal Mohammed, Künstner, Axel, Busch, Hauke, Müller, Heiko, Hutter, Stephan, Hoermann, Gregor, Liu, Longlong, Xie, Xiaoqing, Al-Matary, Yahya, Nimmagadda, Subbaiah Chary, Cano, Fiorella Charles, Heuser, Michael, Thol, Felicitas, Göhring, Gudrun, Steinemann, Doris, Thomale, Jürgen, Leitner, Theo, Fischer, Anja, Rad, Roland, Röllig, Christoph, Altmann, Heidi, Kunadt, Desiree, Berdel, Wolfgang E., Hüve, Jana, Neumann, Felix, Klingauf, Jürgen, Calderon, Virginie, Opalka, Bertram, Dührsen, Ulrich, Rosenbauer, Frank, Dugas, Martin, Varghese, Julian, Reinhardt, Hans Christian, von Bubnoff, Nikolas, Möröy, Tarik, Lenz, Georg, Batcha, Aarif M. N., Giorgi, Marianna, Selvam, Murugan, Wang, Eunice, McWeeney, Shannon K., Tyner, Jeffrey W., Stölzel, Friedrich, Mann, Matthias, Jayavelu, Ashok Kumar, Khandanpour, Cyrus

Source: In Blood 21 December 2023 142(25):2175-2191

Paternal Split‐Liver Transplantation Followed by Haploidentical Hematopoietic Cell Transplantation in an Adult Patient With Protoporphyria‐Induced Liver Failure.

Authors: Stölzel, Ulrich, Jost, Lasse, Seehofer, Daniel, Egger‐Heidrich, Katharina, Scheuermann, Uwe, Hölig, Kristina, Stauch, Thomas, Kunadt, Desiree, Schuppan, Detlef, Schetelig, Johannes, Wohmann, Nils, Bornhäuser, Martin, Stölzel, Friedrich

Source: EJHaem; Feb2025, Vol. 6 Issue 1, p1-4, 4p

Differential impact of IDH1/2 mutational subclasses on outcome in adult AML: results from a large multicenter study

Authors: Middeke, Jan M. ^{*, **}, Metzeler, Klaus H. ^*, Röllig, Christoph, Krämer, Michael, Eckardt, Jan-Niklas, Stasik, Sebastian, Greif, Philipp A., Spiekermann, Karsten, Rothenberg-Thurley, Maja, Krug, Utz, Braess, Jan, Krämer, Alwin, Hochhaus, Andreas, Brümmendorf, Tim H., Naumann, Ralph, Steffen, Björn, Einsele, Hermann, Schaich, Markus, Burchert, Andreas, Neubauer, Andreas, Görlich, Dennis, Sauerland, Cristina, Schäfer-Eckart, Kerstin, Schliemann, Christoph, Krause, Stefan W., Hänel, Mathias, Frickhofen, Norbert, Noppeney, Richard, Kaiser, Ulrich, Kaufmann, Martin, Kunadt, Desiree, Wörmann, Bernhard, Sockel, Katja, von Bonin, Malte, Herold, Tobias, Müller-Tidow, Carsten, Platzbecker, Uwe, Berdel, Wolfgang E., Serve, Hubert, Baldus, Claudia D., Ehninger, Gerhard, Schetelig, Johannes, Hiddemann, Wolfgang, Bornhäuser, Martin, Stölzel, Friedrich ^*, Thiede, Christian ^*

Source: In Blood Advances 8 March 2022 6(5):1394-1405

Impact of busulfan versus treosulfan dose intensity in myelofibrosis undergoing hematopoietic cell transplantation.

Authors: Gagelmann, Nico, Schuh, Claudia, Flossdorf, Sarah, Kunadt, Desiree, Stelljes, Matthias, Blau, Igor W., Brecht, Arne, Bethge, Wolfgang, Schroeder, Thomas, Wulf, Gerald, Sala, Elisa, Bug, Gesine, Fleischhauer, Katharina, Kröger, Nicolaus

Source: American Journal of Hematology; Aug2024, Vol. 99 Issue 8, p1540-1549, 10p

Impact of IDH1 and IDH2 mutational subgroups in AML patients after allogeneic stem cell transplantation.

Authors: Kunadt, Desiree¹ (AUTHOR) desiree.kunadt@ukdd.de, Stasik, Sebastian¹ (AUTHOR), Metzeler, Klaus H.^2,3 (AUTHOR), Röllig, Christoph¹ (AUTHOR), Schliemann, Christoph⁴ (AUTHOR), Greif, Philipp A.² (AUTHOR), Spiekermann, Karsten² (AUTHOR), Rothenberg-Thurley, Maja² (AUTHOR), Krug, Utz⁵ (AUTHOR), Braess, Jan⁶ (AUTHOR), Krämer, Alwin⁷ (AUTHOR), Hochhaus, Andreas⁸ (AUTHOR), Scholl, Sebastian⁸ (AUTHOR), Hilgendorf, Inken⁸ (AUTHOR), Brümmendorf, Tim H.⁹ (AUTHOR), Jost, Edgar⁹ (AUTHOR), Steffen, Björn¹⁰ (AUTHOR), Bug, Gesine¹⁰ (AUTHOR), Einsele, Hermann¹¹ (AUTHOR), Görlich, Dennis¹² (AUTHOR)

Source: Journal of Hematology & Oncology. 9/5/2022, Vol. 15 Issue 1, p1-15. 15p.

Subject Terms: *STEM cell transplantation, *HEMATOPOIETIC stem cell transplantation, *ACUTE myeloid leukemia, *HIGH performance liquid chromatography, *PROGNOSIS

Remission induction versus immediate allogeneic haematopoietic stem cell transplantation for patients with relapsed or poor responsive acute myeloid leukaemia (ASAP): a randomised, open-label, phase 3, non-inferiority trial

Authors: Stelljes, Matthias, Middeke, Jan Moritz, Bug, Gesine, Wagner-Drouet, Eva-Maria, Müller, Lutz P, Schmid, Christoph, Krause, Stefan W, Bethge, Wolfgang, Jost, Edgar, Platzbecker, Uwe, Klein, Stefan A, Schubert, Jörg, Niederland, Judith, Kaufmann, Martin, Schäfer-Eckart, Kerstin, Schaich, Markus, Baldauf, Henning, Stölzel, Friedrich, Petzold, Cathleen, Röllig, Christoph, Alakel, Nael, Steffen, Björn, Hauptrock, Beate, Schliemann, Christoph, Sockel, Katja, Lang, Fabian, Kriege, Oliver, Schaffrath, Judith, Reicherts, Christian, Berdel, Wolfgang E, Serve, Hubert, Ehninger, Gerhard, Schmidt, Alexander H, Bornhäuser, Martin, Mikesch, Jan-Henrik, Schetelig, Johannes, Alakel, Nael, Albring, Jörn, Berdel, Wolfgang E., Bethge, Wolfgang, Bornhäuser, Martin, Bug, Gesine, Buhl, Christoph, Call, Simon, Crysandt, Martina, Egger-Heidrich, Katharina, Eßeling, Eva, Faul, Christoph, Franke, Georg-Nikolaus, Georgi, Julia-Annabell, Glück-Wolf, Julia, Groth, Christoph, Hauptrock, Beate, Heidenreich, Daniela, Janjetovic, Snjezana, Jost, Edgar, Kaufmann, Martin, Kindler, Thomas, Klein, Stefan A., Krause, Stefan W., Kreil, Sebastian, Kretschmann, Theresa, Kunadt, Desiree, Lang, Fabian, Lenz, Georg, Martin, Sonja, Marx, Julia, Middeke, Jan-Moritz, Mikesch, Jan-Henrik, Müller, Lutz P., Müller, Nadine, Niederland, Judith, Parmentier, Stefani, Petzold, Kathrin, Platzbecker, Uwe, Rank, Andreas, Reicherts, Christian, Röllig, Christoph, Rösler, Wolf, Schäfer-Eckart, Kerstin, Schaffrath, Judith, Schaich, Markus, Schetelig, Johannes, Schliemann, Christoph, Schmid, Christoph, Schneidawind, Dominik, Schubert, Jörg, Serve, Hubert, Sockel, Katja, Steffen, Björn, Stelljes, Matthias, Teipel, Raphael, von Bonin, Malte, Wagner-Drouet, Eva, Wass, Maxi, Wendelin, Knut

Source: The Lancet Haematology; May 2024, Vol. 11 Issue: 5 pe324-e335, 12p

Allogeneic hematopoietic cell transplantation for therapy-related myeloid neoplasms arising following treatment for multiple myeloma: a retrospective study on behalf of the Chronic Malignancies Working Party of the EBMT

Authors: Raj, Kavita, Eikema, Diderik-Jan, Lawless, Sarah, Koster, Linda, Kunadt, Desiree, Kröger, Nicolaus, Platzbecker, Uwe, Stelljes, Matthias, Bethge, Wolfgang, Holderried, Tobias, Fanin, Renato, Zeiser, Robert, Kuball, Jürgen, Leblond, Véronique, Nicholson, Emma, Passweg, Jakob, Potter, Victoria, Bay, Jacques-Olivier, Bazarbachi, Ali, Corral, Lucía López, Gurnari, Carmelo, Scheid, Christof, Drozd-Sokolowska, Joanna, Morris, Treen Curly, Hayden, Patrick, Yakoub-Agha, Ibrahim, Robin, Marie, McLornan, Donal P.

Source: Bone Marrow Transplantation; 20240101, Issue: Preprints p1-7, 7p

Fascia training in patients undergoing allogeneic hematopoietic cell transplantation—a pilot study.

Authors: Weigmann-Faßbender, Sandra, Ulbricht, Hanna, de Schultz, Marianne, Pawandenat, Christine, Kunadt, Desiree, Wolff, Michaela, Giesemann, Nadine, Prate, Katja, Schetelig, Johannes, Bornhäuser, Martin, Stölzel, Friedrich, Knauthe, Nadja, Stölzel, Friederike

Source: Supportive Care in Cancer; Jan2023, Vol. 31 Issue 1, p1-12, 12p

Venetoclax Plus High-Dose Cytarabine and Mitoxantrone (HAM-Ven) As Salvage Treatment for Relapsed/Refractory AML: Updated Results of the Phase-I/II SAL Relax Trial

Authors: Ruhnke, Leo, Schliemann, Christoph, Mikesch, Jan-Henrik, Stelljes, Matthias, Fransecky, Lars, Steffen, Björn, Kaufmann, Martin, Burchert, Andreas, Rank, Andreas, Hanoun, Maher, Höllein, Alexander, Kraus, Sabrina, Hänel, Mathias, Schäfer-Eckart, Kerstin, Haake, Annett, Fiebig, Frank, Zukunft, Sven, Middeke, Jan Moritz, Kunadt, Désirée, Schetelig, Johannes, von Bonin, Malte, Röhnert, Maximilian Alexander, Oelschlägel, Uta, Stölzel, Friedrich, Baldus, Claudia D, Serve, Hubert, Wermke, Martin, Bornhäuser, Martin, Röllig, Christoph

Source: In Blood 28 November 2023 142 Supplement 1:160-160

Impact of KMT2A-PTD Mutational Subgroups on Outcome of AML Patients after Induction Therapy and Allogeneic Hematopoietic Cell Transplantation

Authors: Kunadt, Desiree, Zukunft, Sven, Metzeler, Klaus H, Röllig, Christoph, Schliemann, Christoph, Braess, Jan, Müller-Tidow, Carsten, Kraemer, Alwin, Scholl, Sebastian, Hilgendorf, Inken, Jost, Edgar, Steffen, Björn, Bug, Gesine, Einsele, Hermann, Schäfer-Eckart, Kerstin, Krause, Stefan W., Hänel, Mathias, Schroeder, Thomas, Kaufmann, Martin, Middeke, Jan Moritz, Sockel, Katja, Ruhnke, Leo, Platzbecker, Uwe, Serve, Hubert, Stelljes, Matthias, Baldus, Claudia D, Neubauer, Andreas, Schetelig, Johannes, Poitz, David, Thiede, Christian, Bornhäuser, Martin, Stölzel, Friedrich

Source: In Blood 2 November 2023 142 Supplement 1:2236-2236

Non-T-Depleted Haploidentical Transplantation with Post-Transplant Cyclophosphamide in Patients with Relapsed/Refractory Secondary Versus De Novo AML: A Study from the ALWP/EBMT

Authors: Nagler, Arnon, Labopin, Myriam, Tischer, Johanna, Raiola, Anna Maria, Kunadt, Desiree, Vydra, Jan, Blaise, Didier, Sica, Simona, Fanin, Renato, Winkler, Julia, Forcade, Edouard, Van Gorkom, Gwendolyn, Ciceri, Fabio, Mohty, Mohamad

Source: In Blood 2 November 2023 142 Supplement 1:1049-1049

Unrelated Donors below 35 Years of Age Should be Preferred over HLA-Matched Sibling Donors Older Than 50 Years for Patients with Myeloid Malignancies

Authors: Schetelig, Johannes, Baldauf, Henning, Rave, Carina, Bug, Gesine, Mueller, Lutz Peter Hermann, Wagner Drouet, Eva, Ayuk, Francis A., Bethge, Wolfgang Andreas, Stelljes, Matthias, Schröder, Thomas, Kunadt, Desiree, Sockel, Katja, Middeke, Jan Moritz, Fürst, Daniel, Schmidt, Alexander H., Fleischhauer, Katharina, Bornhäuser, Martin

Source: In Blood 2 November 2023 142 Supplement 1:1046-1046

Molecular profiling and clinical implications of patients with acute myeloid leukemia and extramedullary manifestations.

Authors: Eckardt, Jan-Niklas, Stölzel, Friedrich, Kunadt, Desiree, Röllig, Christoph, Stasik, Sebastian, Wagenführ, Lisa, Jöhrens, Korinna, Kuithan, Friederike, Krämer, Alwin, Scholl, Sebastian, Hochhaus, Andreas, Crysandt, Martina, Brümmendorf, Tim H., Naumann, Ralph, Steffen, Björn, Kunzmann, Volker, Einsele, Hermann, Schaich, Markus, Burchert, Andreas, Neubauer, Andreas

Source: Journal of Hematology & Oncology; 5/13/2022, Vol. 15 Issue 1, p1-13, 13p

Subject Terms: ACUTE myeloid leukemia, HEMATOPOIETIC stem cell transplantation, LEUKOCYTE count

Profound sympathetic neuropathy in the bone marrow of patients with acute myeloid leukemia

Authors: Kovtun, Iryna, von Bonin, Malte, Ibneeva, Liliia, Frimmel, Julia, Middeke, Jan Moritz, Kunadt, Desiree, Heberling, Lisa, Wobus, Manja, Bornhäuser, Martin, Grinenko, Tatyana

Source: Leukemia; 20230101, Issue: Preprints p1-5, 5p

Spatial heterogeneity and differential treatment response of acute myeloid leukemia and relapsed/refractory extramedullary disease after allogeneic hematopoietic cell transplantation.

Authors: Kunadt, Desiree, Herold, Sylvia, Poitz, David, Wagenführ, Lisa, Kretschmann, Theresa, Sockel, Katja, Ruhnke, Leo, Brückner, Stefan, Sommer, Ulrich, Meier, Frieder, Röllig, Christoph, von Bonin, Malte, Thiede, Christian, Schetelig, Johannes, Bornhäuser, Martin, Stölzel, Friedrich

Source: Therapeutic Advances in Hematology; Jan-Dec2022, Vol. 13, p1-8, 8p

Effective Immunosurveillance After Allogeneic Hematopoietic Stem Cell Transplantation in Acute Myeloid Leukemia.

Authors: Kunadt, Desiree, Stölzel, Friedrich

Source: Cancer Management & Research; Sep2021, Vol. 13, p7411-7427, 17p

Subject Terms: HEMATOPOIETIC stem cell transplantation, ACUTE myeloid leukemia, REGULATORY T cells, KILLER cells, BONE marrow cells

Multidrug-related protein 1 (MRP1) polymorphisms rs129081, rs212090, and rs212091 predict survival in normal karyotype acute myeloid leukemia.

Authors: Kunadt, Desiree¹ (AUTHOR) desiree.kunadt@uniklinikum-dresden.de, Dransfeld, Christian² (AUTHOR), Dill, Claudia¹ (AUTHOR), Schmiedgen, Maria¹ (AUTHOR), Kramer, Michael¹ (AUTHOR), Altmann, Heidi¹ (AUTHOR), Röllig, Christoph¹ (AUTHOR), Bornhäuser, Martin¹ (AUTHOR), Mahlknecht, Ulrich³ (AUTHOR), Schaich, Markus⁴ (AUTHOR), Stölzel, Friedrich¹ (AUTHOR)

Source: Annals of Hematology. Sep2020, Vol. 99 Issue 9, p2173-2180. 8p.

Subject Terms: *ACUTE myeloid leukemia, *ATP-binding cassette transporters, *BONE marrow, *DRUG resistance, *ACUTE myeloid leukemia diagnosis, *RESEARCH, *PREDICTIVE tests, *CLINICAL trials, *RESEARCH methodology, *GENETIC polymorphisms, *EVALUATION research, *MEDICAL cooperation, *COMPARATIVE studies, *CARRIER proteins, *LONGITUDINAL method