Subclonal TP53 and KRAS variants combined with poor treatment response identify ultrahigh-risk pediatric patients with T-ALL

Authors: Kempter, Tamara ^{1, 2}, Richter-Pechańska, Paulina ^{1, 2}, Michel, Katarzyna ¹, Rausch, Tobias ^{2, 3}, Erarslan-Uysal, Büşra ^{1, 2}, Eckert, Cornelia ⁴, Zimmermann, Martin ⁵, Stanulla, Martin ⁵, Schrappe, Martin ⁶, Cario, Gunnar ⁶, Köhrer, Stefan ^{7, 8}, Attarbaschi, Andishe ^{8, 9}, Korbel, Jan O. ^{2, 3, 10}, Kunz, Joachim B. ^{1, 2}, Kulozik, Andreas E. ^{1, 2, 11, ∗}

Source: In Blood Advances 25 March 2025 9(6):1267-1279

Betibeglogene autotemcel gene therapy in patients with transfusion-dependent, severe genotype β-thalassaemia (HGB-212): a non-randomised, multicentre, single-arm, open-label, single-dose, phase 3 trial

Authors: Kwiatkowski, Janet L ^*, Walters, Mark C, Hongeng, Suradej, Yannaki, Evangelia, Kulozik, Andreas E, Kunz, Joachim B, Sauer, Martin G, Thrasher, Adrian J, Thuret, Isabelle, Lal, Ashutosh, Tao, Ge, Ali, Shamshad, Thakar, Himal L, Elliot, Heidi, Lodaya, Ankit, Lee, Ji, Colvin, Richard A, Locatelli, Franco, Thompson, Alexis A

Source: In The Lancet 30 November-6 December 2024 404(10468):2175-2186

Treatment of pediatric patients and young adults with particle therapy at the Heidelberg Ion Therapy Center (HIT): establishment of workflow and initial clinical data

Authors: Combs Stephanie E, Kessel Kerstin A, Herfarth Klaus, Jensen Alexandra, Oertel Susanne, Blattmann Claudia, Ecker Swantje, Hoess Angelika, Martin Eike, Witt Olaf, Jäkel Oliver, Kulozik Andreas E, Debus Jürgen

Source: Radiation Oncology, Vol 7, Iss 1, p 170 (2012)

Subject Terms: Proton radiation, Carbon ion radiotherapy, Children, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.ro-journal.com/content/7/1/170; https://doaj.org/toc/1748-717X

Access URL: https://doaj.org/article/745d9b1b575a4c7db9283929bdaa67aa

In vivo efficacy of the histone deacetylase inhibitor suberoylanilide hydroxamic acid in combination with radiotherapy in a malignant rhabdoid tumor mouse model

Authors: Thiemann Markus, Oertel Susanne, Ehemann Volker, Weichert Wilko, Stenzinger Albrecht, Bischof Marc, Weber Klaus-J, Perez Ramon, Haberkorn Uwe, Kulozik Andreas E, Debus Jürgen, Huber Peter E, Battmann Claudia

Source: Radiation Oncology, Vol 7, Iss 1, p 52 (2012)

Subject Terms: Malignant rhabdoid tumor, In vivo, Radiotherapy, Histone deacetylase inhibition, Suberoylanilide hydroxamic acid, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.ro-journal.com/content/7/1/52; https://doaj.org/toc/1748-717X

Access URL: https://doaj.org/article/edd36ead10f9448197521502a6eb93f8

Combination of suberoylanilide hydroxamic acid with heavy ion therapy shows promising effects in infantile sarcoma cell lines

Authors: Kulozik Andreas E, Bischof Marc, Brons Stephan, Perez Ramon, Huber Peter E, Weber Klaus-J, Richter Karsten, Thiemann Markus, Oertel Susanne, Ehemann Volker, Debus Jürgen, Blattmann Claudia

Source: Radiation Oncology, Vol 6, Iss 1, p 119 (2011)

Subject Terms: Infantile sarcoma, histone deacetylase inhibition, heavy ion radiotherapy, suberoylanilide hydroxamic acid, SAHA, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.ro-journal.com/content/6/1/119; https://doaj.org/toc/1748-717X

Access URL: https://doaj.org/article/e4b69baa087a4c8a9786d9131e18fcb9

Outcome and prognostic factors of desmoplastic medulloblastoma treated within a multidisciplinary treatment concept

Authors: Rieken Stefan, Gaiser Timo, Mohr Angela, Welzel Thomas, Witt Olaf, Kulozik Andreas E, Wick Wolfgang, Debus Jürgen, Combs Stephanie E

Source: BMC Cancer, Vol 10, Iss 1, p 450 (2010)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.biomedcentral.com/1471-2407/10/450; https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/df33581bf3424155bae0626ed45c2c57

Non-randomized therapy trial to determine the safety and efficacy of heavy ion radiotherapy in patients with non-resectable osteosarcoma

Authors: Bischof Marc, Nikoghosyan Anna, Combs Stephanie E, Karapanagiotou-Schenkel Irini, Unterberg Andreas, Ewerbeck Volker, Haufe Sabine, Rieken Stefan, Schulz-Ertner Daniela, Oertel Susanne, Blattmann Claudia, Jäkel Oliver, Huber Peter, Kulozik Andreas E, Debus Jürgen

Source: BMC Cancer, Vol 10, Iss 1, p 96 (2010)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.biomedcentral.com/1471-2407/10/96; https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/1ff25e828b7a49de89ec6e7e9724ad2d

Intensity Modulated Radiotherapy (IMRT) and Fractionated Stereotactic Radiotherapy (FSRT) for children with head-and-neck-rhabdomyosarcoma

Authors: Huber Peter E, Kulozik Andreas E, Behnisch Wolfgang, Combs Stephanie E, Debus Jürgen, Schulz-Ertner Daniela

Source: BMC Cancer, Vol 7, Iss 1, p 177 (2007)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.biomedcentral.com/1471-2407/7/177; https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/94482538ebb2473ba9ab00b996073d0b

Targeted long-read sequencing of the Ewing sarcoma 6p25.1 susceptibility locus identifies germline-somatic interactions with EWSR1-FLI1 binding

Authors: Lee, Olivia W., Rodrigues, Calvin, Lin, Shu-Hong, Luo, Wen, Jones, Kristine, Brown, Derek W., Zhou, Weiyin, Karlins, Eric, Khan, Sairah M., Baulande, Sylvain, Raynal, Virginie, Surdez, Didier, Reynaud, Stephanie, Rubio, Rebeca Alba, Zaidi, Sakina, Grossetête, Sandrine, Ballet, Stelly, Lapouble, Eve, Laurence, Valérie, Pierron, Gaelle, Gaspar, Nathalie, Corradini, Nadège, Marec-Bérard, Perrine, Rothman, Nathaniel, Dagnall, Casey L., Burdett, Laurie, Manning, Michelle, Wyatt, Kathleen, Yeager, Meredith, Chari, Raj, Leisenring, Wendy M., Kulozik, Andreas E., Kriebel, Jennifer, Meitinger, Thomas, Strauch, Konstantin, Kirchner, Thomas, Dirksen, Uta, Mirabello, Lisa, Tucker, Margaret A., Tirode, Franck, Armstrong, Gregory T., Bhatia, Smita, Robison, Leslie L., Yasui, Yutaka, Romero-Pérez, Laura, Hartmann, Wolfgang, Metzler, Markus, Diver, W. Ryan, Lori, Adriana, Freedman, Neal D., Hoover, Robert N., Morton, Lindsay M., Chanock, Stephen J., Grünewald, Thomas G.P., Delattre, Olivier, Machiela, Mitchell J.

Source: American journal of human genetics. 110(3):427-441

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100184723849.0x000001&indx=1&recIds=ETOCvdc_100184723849.0x000001

Combining daratumumab with CD47 blockade prolongs survival in preclinical models of pediatric T-ALL

Authors: Müller, Kristina ^*, Vogiatzi, Fotini ^*, Winterberg, Dorothee, Rösner, Thies, Lenk, Lennart, Bastian, Lorenz, Gehlert, Carina L., Autenrieb, Marie-Pauline, Brüggemann, Monika, Cario, Gunnar, Schrappe, Martin, Kulozik, Andreas E., Eckert, Cornelia, Bergmann, Anke K., Bornhauser, Beat, Bourquin, Jean-Pierre, Valerius, Thomas, Peipp, Matthias, Kellner, Christian, Schewe, Denis M. ^*

Source: In Blood 7 July 2022 140(1):45-57

Final results of the southwest German pilot study on cystic fibrosis newborn screening – Evaluation of an IRT/PAP protocol with IRT-dependent safety net

Authors: Sommerburg, Olaf, Stahl, Mirjam, Hämmerling, Susanne, Gramer, Gwendolyn, Muckenthaler, Martina U., Okun, Jürgen, Kohlmüller, Dirk, Happich, Margit, Kulozik, Andreas E., Mall, Marcus A., Hoffmann, Georg F.

Source: In Journal of Cystic Fibrosis May 2022 21(3):422-433

Constitutional PIGA mutations cause a novel subtype of hemochromatosis in patients with neurologic dysfunction

Authors: Muckenthaler, Lena, Marques, Oriana, Colucci, Silvia, Kunz, Joachim, Fabrowski, Piotr, Bast, Thomas, Altamura, Sandro, Höchsmann, Britta, Schrezenmeier, Hubert, Langlotz, Monika, Richter-Pechanska, Paulina, Rausch, Tobias, Hofmeister-Mielke, Nicole, Gunkel, Nikolas, Hentze, Matthias W., Kulozik, Andreas E., Muckenthaler, Martina U.

Source: Blood. 139(9):1418-1422

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100183245067.0x000001&indx=1&recIds=ETOCvdc_100183245067.0x000001

Cui Bono? Identifying Patient Groups That May Benefit From Granulocyte Transfusions in Pediatric Hematology and Oncology

Authors: Johann, Pascal D., Wuchter, Patrick, Trojanova, Lenka, Sturm, Dominik, Lu, Kevin Hai-Ning, Kulozik, Andreas E., Kunz, Joachim B.

Source: Journal of pediatric hematology/oncology. 44(7):e968-e975

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100180179372.0x000001&indx=1&recIds=ETOCvdc_100180179372.0x000001

Differential Analysis of the Nuclear and the Cytoplasmic RNA Interactomes in Living Cells

Authors: Backlund, Michael, Kulozik, Andreas E.

Source: Methods in molecular biology. 2428:291-304

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN628708021&indx=1&recIds=ETOCRN628708021

NMD inhibition by 5-azacytidine augments presentation of immunogenic frameshift-derived neoepitopes

Authors: Becker, Jonas P., Helm, Dominic, Rettel, Mandy, Stein, Frank, Hernandez-Sanchez, Alejandro, Urban, Katharina, Gebert, Johannes, Kloor, Matthias, Neu-Yilik, Gabriele, von Knebel Doeberitz, Magnus, Hentze, Matthias W., Kulozik, Andreas E.

Source: In iScience 23 April 2021 24(4)

Prexasertib (LY2606368) reduces clonogenic survival by inducing apoptosis in primary patient‐derived osteosarcoma cells and synergizes with cisplatin and talazoparib

Authors: Heidler, Christopher L., Roth, Eva K., Thiemann, Markus, Blattmann, Claudia, Perez, Ramon L., Huber, Peter E., Kovac, Michal, Amthor, Beate, Neu‐Yilik, Gabriele, Kulozik, Andreas E.

Source: International journal of cancer. 147(4):1059-1070

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100107543096.0x000001&indx=1&recIds=ETOCvdc_100107543096.0x000001

The German sickle cell disease registry reveals a surprising risk of acute splenic sequestration and an increased transfusion requirement in patients with compound heterozygous sickle cell disease HbS/β‐thalassaemia and no or low HbA expression

Authors: Allard, Pierre, Tagliaferri, Laura, Weru, Vivienn, Cario, Holger, Lobitz, Stephan, Grosse, Regine, Bleeke, Matthias, Oevermann, Lena, Hakimeh, Dani, Jarisch, Andrea, Kopp‐Schneider, Annette, Kulozik, Andreas E., Kunz, Joachim B., Lassay, Lisa, Kontny, Udo, Frühwald, Michael, Westphal, Silke, Holzapfel, Johannes, Schulte, Johannes, Eckert, Maike

Source: European Journal of Haematology; Oct2024, Vol. 113 Issue 4, p501-509, 9p

Subject Terms: RED blood cell transfusion, SICKLE cell anemia, GENE expression, BLOOD transfusion, MEDICAL registries

Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia

Authors: Vanden Bempt, Marlies, Demeyer, Sofie, Broux, Michaël, De Bie, Jolien, Bornschein, Simon, Mentens, Nicole, Vandepoel, Roel, Geerdens, Ellen, Radaelli, Enrico, Bornhauser, Beat C., Kulozik, Andreas E., Meijerink, Jules P., Bourquin, Jean-Pierre, de Bock, Charles E., Cools, Jan

Source: In Cancer Cell 13 August 2018 34(2):271-285

Safety and Efficacy Outcomes in Pediatric Patients with Transfusion-Dependent β-Thalassemia (TDT) Receiving Betibeglogene Autotemcel (beti-cel; LentiGlobin for β-thalassemia) Gene Therapy in the Phase 3 Hgb-207 (Northstar-2) and Hgb-212 (Northstar-3) Studies

Authors: Walters, Mark C., Kwiatkowski, Janet L., Porter, John B., Hongeng, Suradej, Yannaki, Evangelia, Kulozik, Andreas E., Sauer, Martin G., Thrasher, Adrian J., Thuret, Isabelle, Lal, Ashutosh, Guo, Ruiting, Liu, Weijian, Colvin, Richard A., Locatelli, Franco, Thompson, Alexis A.

Source: Transplantation and Cellular Therapy. 27(S):S112-S114

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100134294355.0x000001&indx=1&recIds=ETOCvdc_100134294355.0x000001

Daratumumab eradicates minimal residual disease in a preclinical model of pediatric T-cell acute lymphoblastic leukemia

Authors: Vogiatzi, Fotini, Winterberg, Dorothee, Lenk, Lennart, Buchmann, Swantje, Cario, Gunnar, Schrappe, Martin, Peipp, Matthias, Richter-Pechanska, Paulina, Kulozik, Andreas E., Lentes, Jana

Source: Blood. 134(8):713-716

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN621216374&indx=1&recIds=ETOCRN621216374