EPA Induces an Anti-Inflammatory Transcriptome in T Cells, Implicating a Triglyceride-Independent Pathway in Cardiovascular Risk Reduction

Authors: Reilly, Nathalie A. ^{a, b}, Dekkers, Koen F. ^a, Molenaar, Jeroen ^a, Arumugam, Sinthuja ^a, Kuipers, Thomas B. ^{a, c}, Ariyurek, Yavuz ^d, Hoeksema, Marten A. ^e, Jukema, J. Wouter ^{b, f}, Heijmans, Bastiaan T. ^{a, ∗}

Source: In JACC: Basic to Translational Science March 2025 10(3):383-395

Transcriptional and functional profiling identifies inflammation and endothelial-to-mesenchymal transition as potential drivers for phenotypic heterogeneity within a cohort of endothelial colony forming cells

Authors: Brands, Martijn, Koopman, Sjoerd, Bukkems, Laura, Cloesmeijer, Michael, Janssen, Alexander, Fijnvandraat, Karin, Gouw, Samantha, Mathôt, Ron, Haverman, Lotte, van den Akker, Emile, van den Biggelaar, Maartje, de Haas, Masja, Meijer, Sander, Voorberg, Jan, Del Castillo Alferez, Jessica, Zhang, Huan, Boender, Johan, Meijer, Stephan, Meijer, Karina, de Jong, Sean, Goedhart, Geertje, van der Bom, Anske, Bos, Mettine, Eikenboom, Jeroen, van der Meer, Felix, Laan, Sebastiaan, Schols, Saskia, Bierings, Ruben, Burdorf, Lex, Cnossen, Marjon, Hazelzet, Jan, Huisman, Elise, Kruip, Marieke, Leebeek, Frank, van Leeuwen, Nikki, Lingsma, Hester, de Maat, Moniek, van Moort, Iris, Polinder, Suzanne, Reitsma, Simone, Roest, Eliza, Arisz, Ryanne, Romano, Lorenzo, Al Arashi, Wala, van Hoorn, Shannon, Goedhart, Tine, Mussert, Caroline, Prameyllawati, Diaz, Uyl, Carin, Jansen, Nathalie, Fischer, Kathelijn, Ploos van Amstel, Hans Kristian, Urbanus, Rolf, Zivkovic, Minka, Bredenoord, Annelien, van der Graaf, Rieke, Baas, Lieke, Schutgens, Roger, Driessens, Mariëtte, Laan, Sebastiaan N.J., de Boer, Suzan, Dirven, Richard J., Kuipers, Thomas B., Mei, Hailiang

Source: In Journal of Thrombosis and Haemostasis July 2024 22(7):2027-2038

Causative mechanisms and clinical impact of immunoglobulin deficiencies in ataxia telangiectasia

Authors: Takada, Sanami, Weitering, Thomas J., van Os, Nienke J.H., Du, Likun, Pico-Knijnenburg, Ingrid, Kuipers, Thomas B., Mei, Hailiang, Salzer, Elisabeth, Willemsen, Michèl A.A.P., Weemaes, Corry M.R., Pan-Hammarstrom, Qiang, van der Burg, Mirjam

Source: In The Journal of Allergy and Clinical Immunology May 2024 153(5):1392-1405

Transcriptomic profiling of Polycystic Kidney Disease identifies paracrine factors in the early cyst microenvironment

Authors: Yasinoglu, Sevtap A. ^a, Kuipers, Thomas B. ^b, Suidgeest, Ernst ^c, van der Weerd, Louise ^c, Mei, Hailiang ^b, Baelde, Hans J. ^d, Peters, Dorien J.M. ^{a, ⁎}

Source: In BBA - Molecular Basis of Disease February 2024 1870(2)

RNA-sequencing to discover genes and signaling pathways associated with venous thromboembolism in glioblastoma patients: A case-control study

Authors: Kapteijn, Maaike Y., Lanting, Vincent R., Kaptein, Fleur H.J., Guman, Noori A.M., Laghmani, El Houari, Kuipers, Thomas B., Mei, Hailiang, Goeman, Jelle J., Mulder, Frits I., van Duinen, Sjoerd G., Taphoorn, Martin J.B., Dirven, Linda, Broekman, Marike L.D., van Es, Nick, Klok, Frederikus A., Koekkoek, Johan A.F., Versteeg, Henri H., Buijs, Jeroen T.

Source: In Thrombosis Research December 2023 232:27-34

Short salsalate administration affects cell proliferation, metabolism, and inflammation in polycystic kidney disease

Authors: Kanhai, Anish A., Sánchez-López, Elena, Kuipers, Thomas B., van Klinken, Jan B., Dijkstra, Kyra L., van der Veen, Inge, Baelde, Hans J., Song, Xuewen, Pei, York, Mei, Hailiang, Leonhard, Wouter N., Mayboroda, Oleg A., Peters, Dorien J.M.

Source: In iScience 17 November 2023 26(11)

Differential optineurin expression controls TGFβ signaling and is a key determinant for metastasis of triple negative breast cancer

Authors: Liu, Sijia, Dinther, Maarten, Hagenaars, Sophie C., Gu, Yuanzhuo, Kuipers, Thomas B., Mei, Hailiang, Gomez‐Puerto, Maria Catalina, Mesker, Wilma E., Dijke, Peter

Source: International journal of cancer. 152(12):2594-2606

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100182124401.0x000001&indx=1&recIds=ETOCvdc_100182124401.0x000001

Adults prenatally exposed to the Dutch Famine exhibit a metabolic signature associated with a broad spectrum of common diseases.

Authors: Taeubert, M. Jazmin¹ (AUTHOR), Kuipers, Thomas B.¹ (AUTHOR), Zhou, Jiayi² (AUTHOR), Li, Chihua^3,4,5 (AUTHOR), Wang, Shuang⁶ (AUTHOR), Wang, Tian⁶ (AUTHOR), Tobi, Elmar W.¹ (AUTHOR), Belsky, Daniel W.^2,3 (AUTHOR), Lumey, L. H.^1,3 (AUTHOR), Heijmans, Bastiaan T.¹ (AUTHOR) b.t.heijmans@lumc.nl

Source: BMC Medicine. 7/29/2024, Vol. 22 Issue 1, p1-10. 10p.

Subject Terms: *PRENATAL exposure, *TYPE 2 diabetes, *FAMINES, *NUCLEAR magnetic resonance, *BODY mass index, *METABOLIC disorders

Geographic Terms: UNITED Kingdom

The systemic inhibition of the terminal complement system reduces neuroinflammation but does not improve motor function in mouse models of CMT1A with overexpressed PMP22

Authors: Michailidou, Iliana, Vreijling, Jeroen, Rumpf, Matthijs, Loos, Maarten, Koopmans, Bastijn, Vlek, Nina, Straat, Nina, Agaser, Cedrick, Kuipers, Thomas B., Mei, Hailiang, Baas, Frank, Fluiter, Kees

Source: In Current Research in Neurobiology 2023 4

Improved Sézary cell detection and novel insights into immunophenotypic and molecular heterogeneity in Sézary syndrome

Authors: Najidh, Safa ^*, Tensen, Cornelis P., van der Sluijs-Gelling, Alita J., Teodosio, Cristina, Cats, Davy, Mei, Hailiang, Kuipers, Thomas B., Out-Luijting, Jacoba J., Zoutman, Willem H., van Hall, Thorbald, Orfao, Alberto, Almeida, Julia, van Dongen, Jacques J.M., Vermeer, Maarten H.

Source: In Blood 16 December 2021 138(24):2539-2554

LncRNA LITATS1 suppresses TGF‐β‐induced EMT and cancer cell plasticity by potentiating TβRI degradation

Authors: Fan, Chuannan, Wang, Qian, Kuipers, Thomas B, Cats, Davy, Iyengar, Prasanna Vasudevan, Hagenaars, Sophie C, Mesker, Wilma E, Devilee, Peter, Tollenaar, Rob A E M, Mei, Hailiang, Dijke, Peter

Source: EMBO journal. 42(10)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185739548.0x000001&indx=1&recIds=ETOCvdc_100185739548.0x000001

The role of DNA methylation in chondrogenesis of human iPSCs as a stable marker of cartilage quality.

Authors: Hajmousa, Ghazaleh, de Almeida, Rodrigo Coutinho, Bloks, Niek, Ruiz, Alejandro Rodríguez, Bouma, Marga, Slieker, Roderick, Kuipers, Thomas B., Nelissen, Rob G. H. H., Ito, Keita, Freund, Christian, Ramos, Yolande F. M., Meulenbelt, Ingrid

Source: Clinical Epigenetics; 10/15/2024, Vol. 16 Issue 1, p1-16, 16p

Subject Terms: CHONDROGENESIS, ARTICULAR cartilage, RNA methylation, DNA methylation, RNA sequencing, ENDOCHONDRAL ossification

PMP22 duplication dysregulates lipid homeostasis and plasma membrane organization in developing human Schwann cells.

Authors: Prior, Robert^1,2,3, rprior@uni-bonn.de, Silva, Alessio^1,2, Vangansewinkel, Tim^2,4, Idkowiak, Jakub^5,6, Tharkeshwar, Arun Kumar^1,2, Hellings, Tom P⁷, Michailidou, Iliana⁷, Vreijling, Jeroen⁷, Loos, Maarten⁸, Koopmans, Bastijn⁸, Vlek, Nina⁸, Agaser, Cedrick⁹, Kuipers, Thomas B⁹, Michiels, Christine^1,2, Rossaert, Elisabeth^1,2, Verschoren, Stijn^1,2, Vermeire, Wendy^1,2, Laat, Vincent de⁵, Dehairs, Jonas⁵, Eggermont, Kristel^1,2

Source: Brain: A Journal of Neurology; Sep2024, Vol. 147 Issue 9, p3113-3130, 18p

Twisting the theory on the origin of human umbilical cord coiling featuring monozygotic twins.

Authors: Todtenhaupt, Pia, Kuipers, Thomas B., Dijkstra, Kyra L., Voortman, Lenard M., Franken, Laura A., Spekman, Jip A., Jonkman, Thomas H., Groene, Sophie G., Roest, Arno A. W., Haak, Monique C., Verweij, EJoanne T., van Pel, Melissa, Lopriore, Enrico, Heijmans, Bastiaan T., van der Meeren, Lotte E.

Source: Life Science Alliance; Aug2024, Vol. 7 Issue 8, p1-12, 12p

The lncRNA LETS1 promotes TGF-β–induced EMT and cancer cell migration by transcriptionally activating a TβR1-stabilizing mechanism.

Authors: Fan, Chuannan, González-Prieto, Román, Kuipers, Thomas B., Vertegaal, Alfred C. O., van Veelen, Peter A., Mei, Hailiang, ten Dijke, Peter

Source: Science Signaling; 6/20/2023, Vol. 16 Issue 790, p1-14, 14p

Subject Terms: CANCER cell migration, LINCRNA, T cell receptors, EPITHELIAL-mesenchymal transition, GENE expression, CANCER cells

Development, Characterization, and in vivo Validation of a Humanized C6 Monoclonal Antibody that Inhibits the Membrane Attack Complex.

Authors: Gytz Olesen, Heidi, Michailidou, Iliana, Zelek, Wioleta M., Vreijling, Jeroen, Ruizendaal, Patrick, de Klein, Ferry, Marquart, J. Arnoud, Kuipers, Thomas B., Mei, Hailiang, Zhang, Yuchun, Ahasan, Muhammad, Johnson, Krista K., Wang, Yi, Morgan, B. Paul, van Dijk, Marcus, Fluiter, Kees, Andersen, Gregers Rom, Baas, Frank

Source: Journal of Innate Immunity; 2023, Vol. 15 Issue 1, p16-36, 21p

Characterizing the secretome of licensed hiPSC-derived MSCs.

Authors: Ramos, Yolande F. M., Tertel, Tobias, Shaw, Georgina, Staubach, Simon, de Almeida, Rodrigo Coutinho, Suchiman, Eka, Kuipers, Thomas B., Mei, Hailiang, Barry, Frank, Murphy, Mary, Giebel, Bernd, Meulenbelt, Ingrid

Source: Stem Cell Research & Therapy; 9/2/2022, Vol. 13 Issue 1, p1-9, 9p

Subject Terms: STROMAL cells, EXTRACELLULAR vesicles, PEARSON correlation (Statistics), RNA sequencing, CELLULAR therapy, PLURIPOTENT stem cells, MESENCHYMAL stem cells

Bio-O2-02 - Improved Sézary cell detection and novel insights into immunophenotypic and molecular heterogeneity in Sézary syndrome

Authors: Najidh, Safa, Tensen, Cornelis P., van der Sluijs-Gelling, Alita J., Teodosio, Cristina, Cats, Davy, Mei, Hailiang, Kuipers, Thomas B., Out-Luijting, Jacoba J., Zoutman, Willem H., van Hall, Thorbald, Orfao, Alberto, Almeida, Julia, van Dongen, Jacques J.M., Vermeer, Maarten H.

Source: In European Journal of Cancer October 2021 156 Supplement 1:S6-S6

Development, Characterization, and in vivo Validation of a Humanized C6 Monoclonal Antibody that Inhibits the Membrane Attack Complex

Authors: Gytz Olesen, Heidi, Michailidou, Iliana, Zelek, Wioleta M., Vreijling, Jeroen, Ruizendaal, Patrick, de Klein, Ferry, Marquart, J. Arnoud, Kuipers, Thomas B., Mei, Hailiang, Zhang, Yuchun, Ahasan, Muhammad, Johnson, Krista K., Wang, Yi, Morgan, B. Paul, van Dijk, Marcus, Fluiter, Kees, Andersen, Gregers Rom, Baas, Frank

Source: Journal of Innate Immunity; 20220101, Issue: Preprints p1-21, 21p

Transcriptional and functional profiling identifies inflammation and endothelial-to-mesenchymal transition as potential drivers for phenotypic heterogeneity within a cohort of endothelial colony forming cells

Authors: Laan, Sebastiaan N.J., de Boer, Suzan, Dirven, Richard J., van Moort, Iris, Kuipers, Thomas B., Mei, Hailiang, Bierings, Ruben, Eikenboom, Jeroen

Source: Journal of Thrombosis and Haemostasis; 20240101, Issue: Preprints