MUC1-C Is a Common Driver of Acquired Osimertinib Resistance in NSCLC

Authors: Haratake, Naoki, Ozawa, Hiroki, Morimoto, Yoshihiro, Yamashita, Nami, Daimon, Tatsuaki, Bhattacharya, Atrayee, Wang, Keyi, Nakashoji, Ayako, Isozaki, Hideko, Shimokawa, Mototsugu, Kikutake, Chie, Suyama, Mikita, Hashinokuchi, Asato, Takada, Kazuki, Takenaka, Tomoyoshi, Yoshizumi, Tomoharu, Mitsudomi, Tetsuya, Hata, Aaron N., Kufe, Donald

Source: In Journal of Thoracic Oncology March 2024 19(3):434-450

Single‐cell analysis of localized prostate cancer patients links high Gleason score with an immunosuppressive profile

Authors: Adorno Febles, Victor R., Hao, Yuan, Ahsan, Aarif, Wu, Jiansheng, Qian, Yingzhi, Zhong, Hua, Loeb, Stacy, Makarov, Danil V., Lepor, Herbert, Wysock, James, Taneja, Samir S., Huang, William C., Becker, Daniel J., Balar, Arjun V., Melamed, Jonathan, Deng, Fang‐Ming, Ren, Qinghu, Kufe, Donald, Wong, Kwok‐Kin, Adeegbe, Dennis O., Deng, Jiehui, Wise, David R.

Source: Prostate. 83(9):840-849

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195918386.0x000001&indx=1&recIds=ETOCvdc_100195918386.0x000001

MUC1-C integrates aerobic glycolysis with suppression of oxidative phosphorylation in triple-negative breast cancer stem cells

Authors: Yamashita, Nami, Withers, Henry, Morimoto, Yoshihiro, Bhattacharya, Atrayee, Haratake, Naoki, Daimon, Tatsuaki, Fushimi, Atsushi, Nakashoji, Ayako, Thorner, Aaron R., Isenhart, Emily, Rosario, Spencer, Long, Mark D., Kufe, Donald

Source: In iScience 17 November 2023 26(11)

MUC1-C is necessary for SHP2 activation and BRAF inhibitor resistance in BRAF(V600E) mutant colorectal cancer

Authors: Morimoto, Yoshihiro, Yamashita, Nami, Hirose, Haruka, Fushimi, Atsushi, Haratake, Naoki, Daimon, Tatsuaki, Bhattacharya, Atrayee, Ahmad, Rehan, Suzuki, Yozo, Takahashi, Hidekazu, Kufe, Donald W.

Source: In Cancer Letters 10 April 2023 559

MUC1-C dictates neuroendocrine lineage specification in pancreatic ductal adenocarcinomas

Authors: Luan, Zhou, Morimoto, Yoshihiro, Fushimi, Atsushi, Yamashita, Nami, Suo, Wenhao, Bhattacharya, Atrayee, Hagiwara, Masayuki, Jin, Caining, Kufe, Donald

Source: Carcinogenesis. 43(1):67-76

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100141256087.0x000001&indx=1&recIds=ETOCvdc_100141256087.0x000001

Dependence on MUC1-C in Progression of Neuroendocrine Prostate Cancer.

Authors: Kufe, Donald¹ (AUTHOR) donald_kufe@dfci.harvard.edu

Source: International Journal of Molecular Sciences. Feb2023, Vol. 24 Issue 4, p3719. 13p.

Subject Terms: *CASTRATION-resistant prostate cancer, *PROSTATE cancer, *ANDROGEN receptors, *CANCER stem cells, *HOMEOSTASIS, *TRANSCRIPTION factors

Anti-MUC1-C Antibody–Conjugated Nanoparticles Potentiate the Efficacy of Fractionated Radiation Therapy

Authors: Detappe, Alexandre, Mathieu, Clélia, Jin, Caining, Agius, Michael P., Diringer, Marie-Charlotte, Tran, Vu-Long, Pivot, Xavier, Lux, Francois, Tillement, Olivier, Kufe, Donald, Ghoroghchian, Peter P.

Source: International journal of radiation oncology, biology, physics. 108(5):1380-1389

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100132369105.0x000001&indx=1&recIds=ETOCvdc_100132369105.0x000001

Role of the MUC1‐C oncoprotein in the acquisition of cisplatin resistance by urothelial carcinoma

Authors: Shigeta, Keisuke, Hasegawa, Masanori, Kikuchi, Eiji, Yasumizu, Yota, Kosaka, Takeo, Mizuno, Ryuichi, Mikami, Shuji, Miyajima, Akira, Kufe, Donald, Oya, Mototsugu

Source: Cancer science. 111(10):3639-3652

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100109046863.0x000001&indx=1&recIds=ETOCvdc_100109046863.0x000001

MUC1-C in chronic inflammation and carcinogenesis; emergence as a target for cancer treatment

Authors: Kufe, Donald W

Source: Carcinogenesis. 41(9):1173-1183

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100108982996.0x000001&indx=1&recIds=ETOCvdc_100108982996.0x000001

MUC1-C Dependence for the Progression of Pancreatic Neuroendocrine Tumors Identifies a Druggable Target for the Treatment of This Rare Cancer.

Authors: Ozawa, Hiroki, Haratake, Naoki, Nakashoji, Ayako, Daimon, Tatsuaki, Bhattacharya, Atrayee, Wang, Keyi, Shigeta, Keisuke, Fushimi, Atsushi, Fukuda, Kazumasa, Masugi, Yohei, Yamaguchi, Ryo, Kitago, Minoru, Kawakubo, Hirofumi, Kitagawa, Yuko, Kufe, Donald

Source: Biomedicines; Sep2024, Vol. 12 Issue 9, p1509, 19p

Subject Terms: ONCOGENIC proteins, NEUROENDOCRINE tumors, PROGRESSION-free survival, DISEASE progression, TUMOR classification

Emergence of MUC1 in Mammals for Adaptation of Barrier Epithelia.

Authors: Kufe, Donald W.¹ (AUTHOR) donald_kufe@dfci.harvard.edu

Source: Cancers. Oct2022, Vol. 14 Issue 19, p4805. 15p.

Subject Terms: *HOMEOSTASIS, *DISEASE progression, *INFLAMMATION, *CELL physiology, *GENE expression, *CELLULAR signal transduction, *IMMUNITY, *CELL proliferation, *MAMMALS, *EPITHELIAL cells

Concomitant Delivery of Paclitaxel and NuBCP-9 peptide for synergistic enhancement of cancer therapy

Authors: Gupta, Dikshi, Kumar, Manoj, Tyagi, Priyanka, Kapoor, Sumeet, Tyagi, Amit, Barman, Tarani Kanta, Kharbanda, Surender, Kufe, Donald, Singh, Harpal

Source: In Nanomedicine: Nanotechnology, Biology, and Medicine June 2018 14(4):1301-1313

Hypomethylating agent alters the immune microenvironment in acute myeloid leukaemia (AML) and enhances the immunogenicity of a dendritic cell/AML vaccine

Authors: Nahas, Myrna R., Stroopinsky, Dina, Rosenblatt, Jacalyn, Cole, Leandra, Pyzer, Athalia R., Anastasiadou, Eleni, Sergeeva, Anna, Ephraim, Adam, Washington, Abigail, Orr, Shira, McMasters, Malgorzata, Weinstock, Matthew, Jain, Salvia, Leaf, Rebecca K., Ghiasuddin, Haider, Rahimian, Maryam, Liegel, Jessica, Molldrem, Jeffrey J., Slack, Frank, Kufe, Donald, Avigan, David

Source: British journal of haematology. 185(4):679-690

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100083689968.0x000001&indx=1&recIds=ETOCvdc_100083689968.0x000001

MUC1-C represses the RASSF1A tumor suppressor in human carcinoma cells

Authors: Rajabi, Hasan, Hata, Tsuyoshi, Li, Wei, Long, Mark, Hu, Qiang, Liu, Song, Raina, Deepak, Kui, Ling, Yasumizu, Yota, Hong, Deli, Samur, Mehmet, Kufe, Donald

Source: Oncogene. 38(47):7266-7277

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191014976.0x000001&indx=1&recIds=ETOCvdc_100191014976.0x000001

MUC1-C integrates type II interferon and chromatin remodeling pathways in immunosuppression of prostate cancer

Authors: Hagiwara, Masayuki, Fushimi, Atsushi, Bhattacharya, Atrayee, Yamashita, Nami, Morimoto, Yoshihiro, Oya, Mototsugu, Withers, Henry G., Hu, Qiang, Liu, Tao, Liu, Song, Wong, Kwok K., Long, Mark D., Kufe, Donald

Source: Oncoimmunology. 11(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100168532612.0x000001&indx=1&recIds=ETOCvdc_100168532612.0x000001

MUC1-C Oncoprotein Integrates a Program of EMT, Epigenetic Reprogramming and Immune Evasion in Human Carcinomas

Authors: Rajabi, Hasan, Kufe, Donald

Source: In BBA - Reviews on Cancer August 2017 1868(1):117-122

Systemic delivery of the tumor necrosis factor gene to tumors by a novel dual DNA-nanocomplex in a nanoparticle system

Authors: Shukla, Vasundhara, Dalela, Manu, Vij, Manika, Weichselbaum, Ralph, Kharbanda, Surender, Ganguli, Munia, Kufe, Donald, Singh, Harpal

Source: In Nanomedicine: Nanotechnology, Biology, and Medicine July 2017 13(5):1833-1839

Manganese Superoxide Dismutase (SOD2) Inhibits Radiation-Induced Apoptosis by Stabilization of the Mitochondrial Membrane

Authors: Epperly, Michael W., Sikora, Christine A., DeFilippi, Stacy J., Gretton, Joan A., Zhan, Qimin, Kufe, Donald W., Greenberger, Joel S.

Source: Radiation Research, 2002 May 01. 157(5), 568-577.

Access URL: https://www.jstor.org/stable/3580682

XIST and MUC1-C form an auto-regulatory pathway in driving cancer progression.

Authors: Wang, Keyi, Bhattacharya, Atrayee, Haratake, Naoki, Daimon, Tatsuaki, Nakashoji, Ayako, Ozawa, Hiroki, Peng, Bo, Li, Wei, Kufe, Donald

Source: Cell Death & Disease; May2024, Vol. 15 Issue 5, p1-12, 12p

MUC1-mediated induction of myeloid-derived suppressor cells in patients with acute myeloid leukemia

Authors: Pyzer, Athalia Rachel, Stroopinsky, Dina, Rajabi, Hasan, Washington, Abigail, Tagde, Ashujit, Coll, Maxwell, Fung, Jacqueline, Bryant, Mary Paty, Cole, Leandra, Palmer, Kristen, Somaiya, Poorvi, Karp Leaf, Rebecca, Nahas, Myrna, Apel, Arie, Jain, Salvia, McMasters, Malgorzata, Mendez, Lourdes, Levine, James, Joyce, Robin, Arnason, Jon, Pandolfi, Pier Paolo, Kufe, Donald, Rosenblatt, Jacalyn, Avigan, David

Source: In Blood 30 March 2017 129(13):1791-1801