Modeling mechanisms of chemotherapy-induced peripheral neuropathy and chemotherapy transport using induced pluripotent stem cell-derived sensory neurons

Authors: Mortensen, Christina, Thomsen, Mikkel Thy, Chua, Katherina C., Hammer, Helen S., Nielsen, Flemming, Pötz, Oliver, Svenningsen, Asa Fex, Kroetz, Deanna L., Stage, Tore Bjerregaard

Source: In Neuropharmacology 1 November 2024 258

Host variation in type I interferon signaling genes (MX1), C–C chemokine receptor type 5 gene, and major histocompatibility complex class I alleles in treated HIV+ noncontrollers predict viral reservoir size

Authors: Siegel, David A., Thanh, Cassandra, Wan, Eunice, Hoh, Rebecca, Hobbs, Kristen, Pan, Tony, Gibson, Erica A., Kroetz, Deanna L., Martin, Jeffrey, Hecht, Frederick, Pilcher, Christopher, Martin, Maureen, Carrington, Mary, Pillai, Satish, Busch, Michael P., Stone, Mars, Levy, Claire N., Huang, Meei-Li, Roychoudhury, Pavitra, Hladik, Florian, Jerome, Keith R., Kiem, Hans-Peter, Henrich, Timothy J., Deeks, Steven G., Lee, Sulggi A.

Source: AIDS. 37(3):477-488

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Mechanistic insights into the pathogenesis of microtubule‐targeting agent‐induced peripheral neuropathy from pharmacogenetic and functional studies

Authors: Chua, Katherina C., El‐Haj, Nura, Priotti, Josefina, Kroetz, Deanna L.

Source: Basic & clinical pharmacology & toxicology. 130:60-74

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100138800243.0x000001&indx=1&recIds=ETOCvdc_100138800243.0x000001

New and Emerging Research on Solute Carrier and ATP Binding Cassette Transporters in Drug Discovery and Development: Outlook From the International Transporter Consortium

Authors: Giacomini, Kathleen M., Yee, Sook W., Koleske, Megan L., Zou, Ling, Matsson, Pär, Chen, Eugene C., Kroetz, Deanna L., Miller, Miles A., Gozalpour, Elnaz, Chu, Xiaoyan

Source: Clinical pharmacology & therapeutics. 112(3):540-561

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In-depth triacylglycerol profiling using MS3 Q-Trap mass spectrometry

Authors: Cabruja, Matias, Priotti, Josefina, Domizi, Pablo, Papsdorf, Katharina, Kroetz, Deanna L., Brunet, Anne, Contrepois, Kévin, Snyder, Michael P.

Source: In Analytica Chimica Acta 1 November 2021 1184

GSTP1 and ABCB1 Polymorphisms Predicting Toxicities and Clinical Management on Carboplatin and Paclitaxel‐Based Chemotherapy in Ovarian Cancer

Authors: Ferracini, Amanda Canato, Lopes-Aguiar, Leisa, Lourenço, Gustavo Jacob, Yoshida, Adriana, Lima, Carmen Silva Passos, Sarian, Luis Otávio, Derchain, Sophie, Kroetz, Deanna L., Mazzola, Priscila Gava

Source: Clinical and translational science. 14(2):720-728

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Human Induced Pluripotent Stem Cell Derived Sensory Neurons are Sensitive to the Neurotoxic Effects of Paclitaxel

Authors: Xiong, Chenling, Chua, Katherina C., Stage, Tore B., Priotti, Josefina, Kim, Jeffrey, Altman‐Merino, Anne, Chan, Daniel, Saraf, Krishna, Canato Ferracini, Amanda, Fattahi, Faranak, Kroetz, Deanna L.

Source: Clinical and translational science. 14(2):568-581

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100117512158.0x000001&indx=1&recIds=ETOCvdc_100117512158.0x000001

Role for Drug Transporters in Chemotherapy‐Induced Peripheral Neuropathy

Authors: Stage, Tore B., Hu, Shuiying, Sparreboom, Alex, Kroetz, Deanna L.

Source: Clinical and translational science. 14(2):460-467

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100117512187.0x000001&indx=1&recIds=ETOCvdc_100117512187.0x000001

Reversible inhibition of efflux transporters by hydrogel microdevices

Authors: Levy, Elizabeth S., Samy, Karen E., Lamson, Nicholas G., Whitehead, Kathryn A., Kroetz, Deanna L., Desai, Tejal A.

Source: In European Journal of Pharmaceutics and Biopharmaceutics December 2019 145:76-84

Apical Shear Stress Enhanced Organic Cation Transport in Human OCT2/MATE1-Transfected Madin-Darby Canine Kidney Cells Involves Ciliary Sensing

Authors: Jayagopal, Aishwarya, Brakeman, Paul R ^*, Soler, Peter, Ferrell, Nicholas, Fissell, William, Kroetz, Deanna L, Roy, Shuvo

Source: In The Journal of Pharmacology and Experimental Therapeutics June 2019 369(3):523-530

Genomewide Meta‐Analysis Validates a Role for S1PR1 in Microtubule Targeting Agent‐Induced Sensory Peripheral Neuropathy

Authors: Chua, Katherina C., Xiong, Chenling, Ho, Carol, Mushiroda, Taisei, Jiang, Chen, Mulkey, Flora, Lai, Dongbing, Schneider, Bryan P., Rashkin, Sara R., Witte, John S., Friedman, Paula N., Ratain, Mark J., McLeod, Howard L., Rugo, Hope S., Shulman, Lawrence N., Kubo, Michiaki, Owzar, Kouros, Kroetz, Deanna L.

Source: Clinical pharmacology & therapeutics. 108(3):625-634

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P‐Glycoprotein Inhibition Exacerbates Paclitaxel Neurotoxicity in Neurons and Patients With Cancer

Authors: Stage, Tore B., Mortensen, Christina, Khalaf, Sehbar, Steffensen, Vivien, Hammer, Helen S., Xiong, Chenling, Nielsen, Flemming, Poetz, Oliver, Svenningsen, Åsa Fex, Rodriguez‐Antona, Cristina, Kroetz, Deanna L.

Source: Clinical pharmacology & therapeutics. 108(3):671-680

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100108113399.0x000001&indx=1&recIds=ETOCvdc_100108113399.0x000001

Rare Variants in the ABCG2 Promoter Modulate In Vivo Activity

Authors: Eclov, Rachel J., Kim, Mee J., Smith, Robin, Ahituv, Nadav, Kroetz, Deanna L. ^*

Source: In Drug Metabolism and Disposition May 2018 46(5):636-642

Bevacizumab-induced hypertension: Clinical presentation and molecular understanding

Authors: Li, Megan, Kroetz, Deanna L.

Source: In Pharmacology and Therapeutics February 2018 182:152-160

Organic Anion Transporter Polypeptide 1B1 Polymorphism Modulates the Extent of Drug–Drug Interaction and Associated Biomarker Levels in Healthy Volunteers

Authors: Yee, Sook Wah, Giacomini, Marilyn M., Shen, Hong, Humphreys, W. Griffith, Horng, Howard, Brian, William, Lai, Yurong, Kroetz, Deanna L., Giacomini, Kathleen M.

Source: Clinical and translational science. 12(4):388-399

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Tumor Drug Penetration Measurements Could Be the Neglected Piece of the Personalized Cancer Treatment Puzzle

Authors: Bartelink, Imke H., Jones, Ella F., Shahidi‐Latham, Sheerin K., Lee, Pei Rong Evelyn, Zheng, Yanan, Vicini, Paolo, Veer, Laura, Wolf, Denise, Iagaru, Andrei, Kroetz, Deanna L., Prideaux, Brendan, Cilliers, Cornelius, Thurber, Greg M., Wimana, Zena, Gebhart, Geraldine

Source: Clinical pharmacology & therapeutics. 106(1):148-163

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100085028727.0x000001&indx=1&recIds=ETOCvdc_100085028727.0x000001

A practical first step using needs assessment and a survey approach to implementing a clinical pharmacogenomics consult service

Authors: Zakinova, Angela, Long‐Boyle, Janel R., French, Deborah, Croci, Rhiannon, Wilson, Leslie, Phillips, Kathryn A., Kroetz, Deanna L., Shin, Jaekyu, Tamraz, Bani

Source: Journal of the American College of Clinical Pharmacy. 2(3):214-221

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A Pharmacogenetic Prediction Model of Progression‐Free Survival in Breast Cancer using Genome‐Wide Genotyping Data from CALGB 40502 (Alliance)

Authors: Rashkin, Sara R., Chua, Katherina C., Ho, Carol, Mulkey, Flora, Jiang, Chen, Mushiroda, Tasei, Kubo, Michiaki, Friedman, Paula N., Rugo, Hope S., McLeod, Howard L., Ratain, Mark J., Castillos, Francisco, Naughton, Michael, Overmoyer, Beth, Toppmeyer, Deborah, Witte, John S., Owzar, Kouros, Kroetz, Deanna L.

Source: Clinical pharmacology & therapeutics. 105(3):738-745

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100117506226.0x000001&indx=1&recIds=ETOCvdc_100117506226.0x000001

Natural Variation in Human Membrane Transporter Genes Reveals Evolutionary and Functional Constraints

Authors: Leabman, Maya K., Huang, Conrad C., DeYoung, Joseph, Carlson, Elaine J., Taylor, Travis R., de la Cruz, Melanie, Johns, Susan J., Stryke, Doug, Kawamoto, Michiko, Urban, Thomas J., Kroetz, Deanna L., Ferrin, Thomas E., Clark, Andrew G., Risch, Neil, Herskowitz, Ira, Giacomini, Kathleen M.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2003 May . 100(10), 5896-5901.

Access URL: https://www.jstor.org/stable/3147514

Effect of Antioxidants in Medicinal Products on Intestinal Drug Transporters.

Authors: Kulkarni, Chetan P., Yang, Jia, Koleske, Megan L., Lara, Giovanni, Alam, Khondoker, Raw, Andre, Rege, Bhagwant, Zhao, Liang, Lu, Dongmei, Zhang, Lei, Yu, Lawrence X., Lionberger, Robert A., Giacomini, Kathleen M., Kroetz, Deanna L., Yee, Sook Wah

Source: Pharmaceutics; May2024, Vol. 16 Issue 5, p647, 13p

Subject Terms: INTESTINES, CARNOSIC acid, INTESTINAL absorption, BUTYLATED hydroxyanisole, DRUG absorption