Auranofin repurposing for lung and pancreatic cancer: low CA12 expression as a marker of sensitivity in patient-derived organoids, with potentiated efficacy by AKT inhibition

Authors: Christophe Deben, Laurie Freire Boullosa, Felicia Rodrigues Fortes, Edgar Cardenas De La Hoz, Maxim Le Compte, Sofie Seghers, Marc Peeters, Steve Vanlanduit, Abraham Lin, Krijn K. Dijkstra, Paul Van Schil, Jeroen M. H. Hendriks, Hans Prenen, Geert Roeyen, Filip Lardon, Evelien Smits

Source: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-15 (2024)

Subject Terms: Auranofin Repurposing, NSCLC and PDAC Therapy, RNAseq Biomarkers, Drug Synergy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/8c03f6975c524c59adae79b1d8c7f709

Open questions in human lung organoid research

Authors: Tessa Hughes, Krijn K. Dijkstra, Emma L. Rawlins, Robert E. Hynds

Source: Frontiers in Pharmacology, Vol 13 (2023)

Subject Terms: lung stem cells, respiratory biology, 3D cell culture, in vitro models, epithelial cells, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2022.1083017/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/b651e0950c3b4330b130e47cf7e32e44

Patient-Derived Organoid Models of Human Neuroendocrine Carcinoma

Authors: Krijn K. Dijkstra, José G. van den Berg, Fleur Weeber, Joris van de Haar, Arno Velds, Sovann Kaing, Dennis D. G. C. Peters, Ferry A. L. M. Eskens, Derk-Jan A. de Groot, Margot E. T. Tesselaar, Emile E. Voest

Source: Frontiers in Endocrinology, Vol 12 (2021)

Subject Terms: gastroenteropancreatic neuroendocrine carcinoma (GEP-NEC), extrapulmonary neuroendocrine carcinoma, disease modeling, pre-clinical models, organoids, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2021.627819/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/737cc6a2352e4ea98121176d9873021f

Challenges in Establishing Pure Lung Cancer Organoids Limit Their Utility for Personalized Medicine

Authors: Krijn K. Dijkstra, Kim Monkhorst, Luuk J. Schipper, Koen J. Hartemink, Egbert F. Smit, Sovann Kaing, Rosa de Groot, Monika C. Wolkers, Hans Clevers, Edwin Cuppen, Emile E. Voest

Source: Cell Reports, Vol 31, Iss 5, Pp - (2020)

Subject Terms: organoids, personalized medicine, tumor purity, genomics, p63, non-small cell lung cancer, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124720305374; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/b469827b6c1c427c86f583c772baa165