In vitro evolution driven by epistasis reveals alternative cholesterol-specific binding motifs of perfringolysin O

Authors: Šakanović, Aleksandra, Kranjc, Nace, Omersa, Neža, Aden, Saša, Kežar, Andreja, Kisovec, Matic, Zavec, Apolonija Bedina, Caserman, Simon, Gilbert, Robert J.C., Podobnik, Marjetka, Crnković, Ana, Anderluh, Gregor

Source: In Journal of Biological Chemistry September 2024 300(9)

Comprehensive characterization of a transgene insertion in a highly repetitive, centromeric region of Anopheles mosquitoes

Authors: Vitale, Matteo, Leo, Chiara, Courty, Thomas, Kranjc, Nace, Connolly, John B., Morselli, Giulia, Bamikole, Christopher, Haghighat-Khah, Roya Elaine, Bernardini, Federica, Fuchs, Silke

Source: Pathogens and global health. 117(3):273-283

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100179045754.0x000001&indx=1&recIds=ETOCvdc_100179045754.0x000001

Y chromosome shredding in Anopheles gambiae: Insight into the cellular dynamics of a novel synthetic sex ratio distorter.

Authors: Vitale, Matteo¹ (AUTHOR), Kranjc, Nace¹ (AUTHOR), Leigh, Jessica¹ (AUTHOR), Kyrou, Kyrous¹ (AUTHOR), Courty, Thomas¹ (AUTHOR), Marston, Louise¹ (AUTHOR), Grilli, Silvia¹ (AUTHOR), Crisanti, Andrea¹ (AUTHOR), Bernardini, Federica¹ (AUTHOR) f.bernardini11@imperial.ac.uk

Source: PLoS Genetics. 6/7/2024, Vol. 20 Issue 6, p1-29. 29p.

Subject Terms: *ANOPHELES gambiae, *Y chromosome, *DEVELOPMENTAL biology, *SEX ratio, *MALE reproductive organs, *SEX chromosomes, *ANIMAL offspring sex ratio, *SPERMATOZOA

Analysis of off-target effects in CRISPR-based gene drives in the human malaria mosquito

Authors: Garrood, William T., Kranjc, Nace, Petri, Karl, Kim, Daniel Y., Guo, Jimmy A., Hammond, Andrew M., Morianou, Ioanna, Pattanayak, Vikram, Joung, J. Keith, Crisanti, Andrea, Simoni, Alekos

Source: Proceedings of the National Academy of Sciences of the United States of America, 2021 Jun 01. 118(22), 1-8.

Access URL: https://www.jstor.org/stable/27040970

Genomic analyses revealed low genetic variation in the intron-exon boundary of the doublesex gene within the natural populations of An. gambiae s.l. in Burkina Faso.

Authors: Kientega, Mahamadi, Morianou, Ioanna, Traoré, Nouhoun, Kranjc, Nace, Kaboré, Honorine, Zongo, Odette N, Millogo, Abdoul-Azize, Epopa, Patric Stephane, Yao, Franck A., Belem, Adrien M G, Austin, Burt, Diabaté, Abdoulaye

Source: BMC Genomics; 12/18/2024, Vol. 25 Issue 1, p1-12, 12p

Subject Terms: SEX determination, GENETIC variation, GENOMICS, WHOLE genome sequencing, GENETIC polymorphisms, GENETIC sex determination

More than one way to bind to cholesterol: atypical variants of membrane-binding domain of perfringolysin O selected by ribosome displayElectronic supplementary information (ESI) available. See DOI: 10.1039/d0ra06976k

Authors: Šakanović, Aleksandra, Kranjc, Nace, Omersa, Neža, Podobnik, Marjetka, Anderluh, Gregor

Source: RSC advances. 10(63):38678-38682

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100110531040.0x000001&indx=1&recIds=ETOCvdc_100110531040.0x000001

Cellular mechanisms regulating synthetic sex ratio distortion in the Anopheles gambiae germline

Authors: Haghighat-Khah, Roya Elaine, Sharma, Atashi, Wunderlich, Mariana Reis, Morselli, Giulia, Marston, Louise Anna, Bamikole, Christopher, Hall, Ann, Kranjc, Nace, Taxiarchi, Chrysanthi, Sharakhov, Igor, Galizi, Roberto

Source: Pathogens and global health. 114(7):370-378

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100111510270.0x000001&indx=1&recIds=ETOCvdc_100111510270.0x000001

High-resolution transcriptional profiling of Anopheles gambiae spermatogenesis reveals mechanisms of sex chromosome regulation

Authors: Taxiarchi, Chrysanthi, Kranjc, Nace, Kriezis, Antonios, Kyrou, Kyros, Bernardini, Federica, Russell, Steven, Nolan, Tony, Crisanti, Andrea, Galizi, Roberto

Source: Scientific reports. 9(1):1-12

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190853812.0x000001&indx=1&recIds=ETOCvdc_100190853812.0x000001

Resistance to a CRISPR-based gene drive at an evolutionarily conserved site is revealed by mimicking genotype fixation.

Authors: Fuchs, Silke¹, Garrood, William T.¹, Beber, Anna², Hammond, Andrew^1,3, Galizi, Roberto⁴, Gribble, Matthew¹, Morselli, Giulia¹, Hui, Tin-Yu J.¹, Willis, Katie¹, Kranjc, Nace¹, Burt, Austin¹, Crisanti, Andrea^1,5, acrs@imperial.ac.uk, Nolan, Tony⁶, acrs@imperial.ac.uk

Source: PLoS Genetics; 10/5/2021, Vol. 17 Issue 10, p1-19, 19p

Regulating the expression of gene drives is key to increasing their invasive potential and the mitigation of resistance.

Authors: Hammond, Andrew^1,2, Karlsson, Xenia¹, Morianou, Ioanna¹, Kyrou, Kyros¹, Beaghton, Andrea¹, Gribble, Matthew¹, Kranjc, Nace¹, Galizi, Roberto¹, Burt, Austin¹, Crisanti, Andrea^1,3, acrs@imperial.ac.uk, Nolan, Tony⁴, acrs@imperial.ac.uk

Source: PLoS Genetics; 1/29/2021, Vol. 17 Issue 1, p1-21, 21p

Cross-Species Y Chromosome Function Between Malaria Vectors of the Anopheles gambiae Species Complex.

Authors: Bernardini, Federica¹, Galizi, Roberto¹, Wunderlich, Mariana¹, Taxiarchi, Chrysanthi¹, Kranjc, Nace¹, Kyrou, Kyros¹, Hammond, Andrew¹, Nolan, Tony¹, Lawniczak, Mara N. K.², Papathanos, Philippos Aris³, Crisanti, Andrea¹, a.drcrisanti@imperial.ac.uk, Windbichler, Nikolai¹, n.windbichler@imperial.ac.uk

Source: Genetics; Oct2017, Vol. 207 Issue 2, p729-740, 12p

The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito.

Authors: Hammond, Andrew M.¹, Kyrou, Kyros¹, Bruttini, Marco², North, Ace³, Galizi, Roberto¹, Karlsson, Xenia¹, Kranjc, Nace¹, Carpi, Francesco M.¹, D’Aurizio, Romina⁴, Crisanti, Andrea¹, acrs@imperial.ac.uk, Nolan, Tony¹, t.nolan@imperial.ac.uk

Source: PLoS Genetics; 10/04/2017, Vol. 13 Issue 10, p1-16, 16p

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Anopheles gambiae Genome Conservation as a Resource for Rational Gene Drive Target Site Selection.

Authors: Kranjc, Nace¹ (AUTHOR) n.kranjc@imperial.ac.uk, Crisanti, Andrea¹ (AUTHOR) a.drcrisanti@imperial.ac.uk, Nolan, Tony² (AUTHOR) tony.nolan@lstmed.ac.uk, Bernardini, Federica¹ (AUTHOR) tony.nolan@lstmed.ac.uk

Source: Insects (2075-4450). Feb2021, Vol. 12 Issue 2, p97-97. 1p.

Subject Terms: *ANOPHELES gambiae, *GERMPLASM conservation, *GENE targeting, *MALARIA, *GENOMES, *INSECT pests, *MOSQUITO vectors

Geographic Terms: SUB-Saharan Africa

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