Permissible HLA mismatches in 9/10 unrelated donor pediatric stem cell transplants using HLA-EMMA: an EBMT Inborn Errors Working Party study

Authors: von Asmuth, Erik G. J., Hiensch, Fleur, Heidt, Sebastiaan, Mohseny, Alexander B., Roelen, Dave L., Kramer, Cynthia S. M., Claas, Frans H. J., Albert, Michael H., Neven, Bénédicte, Lankester, Arjan C., van Beek, Adriaan A.

Source: In Blood Advances 24 September 2024 8(18):4767-4777

HLA antibody affinity determination: From HLA‐specific monoclonal antibodies to donor HLA specific antibodies (DSA) in patient serum

Authors: Hug, Melanie N., Keller, Sabrina, Marty, Talea, Gygax, Daniel, Meinel, Dominik, Spies, Peter, Handschin, Joëlle, Kleiser, Marc, Vazquez, Noemi, Linnik, Janina, Buchli, Rico, Claas, Frans, Heidt, Sebastiaan, Kramer, Cynthia S. M., Bezstarosti, Suzanne, Lee, Jar‐How, Schaub, Stefan, Hönger, Gideon

Source: HLA. 102(3):278-300

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191318671.0x000001&indx=1&recIds=ETOCvdc_100191318671.0x000001

Using cloud infrastructure to facilitate data collection and conversion of HLA diagnostic data for the 18th International HLA and Immunogenetics Workshop

Authors: Matern, Benedict M., Niemann, Matthias, Nemparis, Ioannis, Schimanski, Andreas, Peereboom, Emma T. M., Kramer, Cynthia S. M., Heidt, Sebastiaan, Spierings, Eric

Source: HLA. 101(5):484-495

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100184878673.0x000001&indx=1&recIds=ETOCvdc_100184878673.0x000001

Site‐directed mutagenesis of HLA molecules reveals the functional epitope of a human HLA‐A1/A36‐specific monoclonal antibody

Authors: Meng, Tina, Bezstarosti, Suzanne, Singh, Ujjwala, Yap, Michelle, Scott, Laura, Petrosyan, Naiiry, Quiroz, Fred, Eps, Ned Van, Hui, Eric Ka‐Wai, Suh, David, Zhu, Quansheng, Pei, Rui, Kramer, Cynthia S. M., Claas, Frans H. J., Lowe, David, Heidt, Sebastiaan

Source: HLA. 101(2):138-142

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100171691312.0x000001&indx=1&recIds=ETOCvdc_100171691312.0x000001

Antibody verification of HLA class I and class II eplets by human monoclonal HLA antibodies.

Authors: Kramer, Cynthia S. M.¹ (AUTHOR) c.s.m.kramer@lumc.nl, Bezstarosti, Suzanne^1,2 (AUTHOR), Franke‐van Dijk, Marry E. I.¹ (AUTHOR), Vergunst, Manon¹ (AUTHOR), Roelen, Dave L.¹ (AUTHOR), Uyar‐Mercankaya, Merve¹ (AUTHOR), Voogt‐Bakker, Kim H.¹ (AUTHOR), Heidt, Sebastiaan¹ (AUTHOR)

Source: HLA: Immune Response Genetics. Jan2024, Vol. 103 Issue 1, p1-16. 16p.

Subject Terms: *MONOCLONAL antibodies, *RECOMBINANT molecules, *IMMUNOGLOBULINS, *ALLELES, *B cells, *BRAIN death, *TRANSPLANTATION of organs, tissues, etc., *HLA-DR antigens

Low incidence of IgA isotype of HLA antibodies in alloantigen exposed individuals

Authors: Car, Helena, Karahan, Gonca E., Dreyer, Geertje J., Brand‐Schaaf, Simone H., Vries, Aiko P. J., Kooten, Cees, Kramer, Cynthia S. M., Roelen, Dave L., Claas, Frans H. J., Heidt, Sebastiaan

Source: HLA. 97(2):101-111

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100114167615.0x000001&indx=1&recIds=ETOCvdc_100114167615.0x000001

Foetal Microchimerism Correlates With Foetal‐Maternal Histocompatibility Both During Pregnancy and Postpartum.

Authors: Staff, Anne Cathrine, Fjeldstad, Heidi E., Olsen, Maria B., Øgaard, Jonas, Viken, Marte K., Kramer, Cynthia S. M., Eikmans, Michael, Kroneis, Thomas, Sallinger, Katja, Kanaan, Sami B., Sugulle, Meryam, Jacobsen, Daniel P.

Source: HLA: Immune Response Genetics; Oct2024, Vol. 104 Issue 4, p1-11, 11p

Subject Terms: PREGNANT women, STEM cells, HISTOCOMPATIBILITY, MOTHERS, IMMUNE system

Generation and reactivity analysis of human recombinant monoclonal antibodies directed against epitopes on HLA‐DR

Authors: Kramer, Cynthia S. M., Franke‐van Dijk, Marry E. I., Bakker, Kim H., Uyar‐Mercankaya, Merve, Karahan, Gonca E., Roelen, Dave L., Claas, Frans H. J., Heidt, Sebastiaan

Source: American journal of transplantation. 20(12):3341-3353

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100110760443.0x000001&indx=1&recIds=ETOCvdc_100110760443.0x000001

HLA‐EMMA: A user‐friendly tool to analyse HLA class I and class II compatibility on the amino acid level

Authors: Kramer, Cynthia S. M., Koster, Johan, Haasnoot, Geert W., Roelen, Dave L., Claas, Frans H. J., Heidt, Sebastiaan

Source: HLA. 96(1):43-51

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100108412956.0x000001&indx=1&recIds=ETOCvdc_100108412956.0x000001

Introduction of the donor centre virtual crossmatch in Eurotransplant.

Authors: Heidt, Sebastiaan¹ (AUTHOR) s.heidt@lumc.nl, Kramer, Cynthia S. M.¹ (AUTHOR), Haasnoot, Geert W.¹ (AUTHOR), Schmidt, Alexander H.² (AUTHOR), Zoet, Yvonne M.¹ (AUTHOR), Claas, Frans H. J.¹ (AUTHOR), Vogelaar, Serge³ (AUTHOR)

Source: HLA: Immune Response Genetics. Aug2024, Vol. 104 Issue 2, p1-7. 7p.

Subject Terms: *ALLOCATION of organs, tissues, etc., *CYTOTOXINS, *TRANSPLANTATION of organs, tissues, etc., *DATA transmission systems, *HISTOCOMPATIBILITY

Recombinant human monoclonal HLA antibodies of different IgG subclasses recognising the same epitope: Excellent tools to study differential effects of donor‐specific antibodies

Authors: Kramer, Cynthia S. M., Franke‐van Dijk, Marry E. I., Priddey, Ashley J., Pongrácz, Tamás, Gnudi, Elena, Car, Helena, Karahan, Gonca E., Beelen, Els, Zilvold‐van den Oever, Chalana C. C., Rademaker, Hendrik J., Haan, Noortje, Wuhrer, Manfred, Kosmoliaptsis, Vasilis, Parren, Paul W. H. I., Mulder, Arend, Roelen, Dave L., Claas, Frans H. J., Heidt, Sebastiaan

Source: Tissue antigens. 94(5):415-424

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100091429657.0x000001&indx=1&recIds=ETOCvdc_100091429657.0x000001

Qualitative, rather than quantitative, differences between HLA‐DQ alleles affect HLA‐DQ immunogenicity in organ transplantation.

Authors: Maguire, Chelsea, Crivello, Pietro, Fleischhauer, Katharina, Isaacson, Dylan, Casillas, Aurora, Kramer, Cynthia S. M., Copley, Hannah C., Heidt, Sebastiaan, Kosmoliaptsis, Vasilis, Meneghini, Maria, Gmeiner, Michael, Schold, Jesse, Louzoun, Yoram, Tambur, Anat R.

Source: HLA: Immune Response Genetics; Apr2024, Vol. 103 Issue 4, p1-20, 20p

Subject Terms: IMMUNE response, TRANSPLANTATION of organs, tissues, etc., BRAIN death, ALLELES, AUTOIMMUNITY, AMINO acids

Human anti-C1q autoantibodies bind specifically to solid-phase C1q and enhance phagocytosis but not complement activation.

Authors: Dijkstra, Douwe J., van de Bovenkamp, Fleur S., Abendstein, Leoni, Zuijderduijn, Rob, Pool, Jos, Kramer, Cynthia S. M., Slot, Linda M., Drijfhout, Jan W., de Vor, Lisanne, Gelderman, Kyra A., Rooijakkers, Suzan H. M., Zaldumbide, Arnaud, Vidarsson, Gestur, Sharp, Thomas H., Parren, Paul W. H. I., Trouw, Leendert A.

Source: Proceedings of the National Academy of Sciences of the United States of America; 12/12/2023, Vol. 120 Issue 50, p1-11, 18p

Subject Terms: PHAGOCYTOSIS, COMPLEMENT activation, AUTOANTIBODIES, IMMUNE response, IMMUNE complexes

A Comprehensive Evaluation of the Antibody-Verified Status of Eplets Listed in the HLA Epitope Registry.

Authors: Bezstarosti, Suzanne, Bakker, Kim H., Kramer, Cynthia S. M., de Fijter, Johan W., Reinders, Marlies E. J., Mulder, Arend, Claas, Frans H. J., Heidt, Sebastiaan

Source: Frontiers in Immunology; 1/28/2022, Vol. 13, p1-16, 16p

Subject Terms: ANTIBODY formation, HLA histocompatibility antigens, MONOCLONAL antibodies, IMMUNE response, BLOOD serum analysis

HLA-DQ-Specific Recombinant Human Monoclonal Antibodies Allow for In-Depth Analysis of HLA-DQ Epitopes.

Authors: Bezstarosti, Suzanne, Kramer, Cynthia S. M., Franke-van Dijk, Marry E. I., Vergunst, Manon, Bakker, Kim H., Uyar-Mercankaya, Merve, Buchli, Rico, Roelen, Dave L., de Fijter, Johan W., Claas, Frans H. J., Heidt, Sebastiaan

Source: Frontiers in Immunology; 1/7/2022, Vol. 12, p1-15, 15p

Subject Terms: MONOCLONAL antibodies, EPITOPES, IMMUNOLOGIC memory, AMINO acids, KIDNEY transplantation

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