Evolution of regulatory signatures in primate cortical neurons at cell-type resolution

Authors: Kozlenkov, Alexey, Vermunt, Marit W., Apontes, Pasha, Li, Junhao, Hao, Ke, Sherwood, Chet C., Hof, Patrick R., Ely, John J., Wegner, Michael, Mukamel, Eran A., Creyghton, Menno P., Koonin, Eugene V., Dracheva, Stella

Source: Proceedings of the National Academy of Sciences of the United States of America, 2020 Nov 01. 117(45), 28422-28432.

Access URL: https://www.jstor.org/stable/26970742

Multiomic single-cell profiling identifies critical regulators of postnatal brain

Authors: Clarence, Tereza, Bendl, Jaroslav, Cao, Xuan, Wang, Xinyi, Zheng, Shiwei, Hoffman, Gabriel E., Kozlenkov, Alexey, Hong, Aram, Iskhakova, Marina, Jaiswal, Manoj K., Murphy, Sarah, Yu, Alexander, Haroutunian, Vahram, Dracheva, Stella, Akbarian, Schahram, Fullard, John F., Yuan, Guo-Cheng, Lee, Donghoon, Roussos, Panos

Source: Nature Genetics; March 2025, Vol. 57 Issue: 3 p591-603, 13p

Cell Type-Specific Intralocus Interactions Reveal Oligodendrocyte Mechanisms in MS

Authors: Factor, Daniel C., Barbeau, Anna M., Allan, Kevin C., Hu, Lucille R., Madhavan, Mayur, Hoang, An T., Hazel, Kathryn E.A., Hall, Parker A., Nisraiyya, Sagar, Najm, Fadi J., Miller, Tyler E., Nevin, Zachary S., Karl, Robert T., Lima, Bruna R., Song, Yanwei, Sibert, Alexandra G., Dhillon, Gursimran K., Volsko, Christina, Bartels, Cynthia F., Adams, Drew J., Dutta, Ranjan, Gallagher, Michael D., Phu, William, Kozlenkov, Alexey, Dracheva, Stella, Scacheri, Peter C., Tesar, Paul J., Corradin, Olivia

Source: In Cell 16 April 2020 181(2):382-395

Molecular windows into the human brain for psychiatric disorders

Authors: Egervari, Gabor, Kozlenkov, Alexey, Dracheva, Stella, Hurd, Yasmin

Source: Molecular psychiatry. 24(5):653-673

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100133347902.0x000001&indx=1&recIds=ETOCvdc_100133347902.0x000001

Brain Cell Type Specific Gene Expression and Co-expression Network Architectures

Authors: McKenzie, Andrew, Wang, Minghui, Hauberg, Mads, Fullard, John, Kozlenkov, Alexey, Keenan, Alexandra, Hurd, Yasmin, Dracheva, Stella, Casaccia, Patrizia, Roussos, Panos, Zhang, Bin

Source: Scientific reports. 8(1):1-19

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100171410356.0x000001&indx=1&recIds=ETOCvdc_100171410356.0x000001

NeuN+ neuronal nuclei in non-human primate prefrontal cortex and subcortical white matter after clozapine exposure

Authors: Halene, Tobias B., Kozlenkov, Alexey, Jiang, Yan, Mitchell, Amanda C., Javidfar, Behnam, Dincer, Aslihan, Park, Royce, Wiseman, Jennifer, Croxson, Paula L., Giannaris, Eustathia Lela, Hof, Patrick R., Roussos, Panos, Dracheva, Stella, Hemby, Scott E., Akbarian, Schahram

Source: In Schizophrenia Research February 2016 170(2-3):235-244

Novel method of isolating nuclei of human oligodendrocyte precursor cells reveals substantial developmental changes in gene expression and H3K27ac histone modification.

Authors: Kozlenkov, Alexey, Vadukapuram, Ramu, Zhou, Ping, Fam, Peter, Wegner, Michael, Dracheva, Stella

Source: Glia; Jan2024, Vol. 72 Issue 1, p69-89, 21p

Repressive Epigenetic Changes at the mGlu2 Promoter in Frontal Cortex of 5-HT2A Knockout Mice

Authors: Kurita, Mitsumasa ¹, Moreno, José L., Holloway, Terrell, Kozlenkov, Alexey, Mocci, Giuseppe, García-Bea, Aintzane, Hanks, James B., Neve, Rachael, Nestler, Eric J., Russo, Scott J., González-Maeso, Javier ^*

Source: In Molecular Pharmacology June 2013 83(6):1166-1175

Common schizophrenia risk variants are enriched in open chromatin regions of human glutamatergic neurons

Authors: Hauberg, Mads E., Creus-Muncunill, Jordi, Bendl, Jaroslav, Kozlenkov, Alexey, Zeng, Biao, Corwin, Chuhyon, Chowdhury, Sarah, Kranz, Harald, Hurd, Yasmin L., Wegner, Michael, Børglum, Anders D., Dracheva, Stella, Ehrlich, Michelle E., Fullard, John F., Roussos, Panos

Source: Nature communications. 11(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100183556863.0x000001&indx=1&recIds=ETOCvdc_100183556863.0x000001

Divergent single cell transcriptome and epigenome alterations in ALS and FTD patients with C9orf72 mutation.

Authors: Li, Junhao, Jaiswal, Manoj K., Chien, Jo-Fan, Kozlenkov, Alexey, Jung, Jinyoung, Zhou, Ping, Gardashli, Mahammad, Pregent, Luc J., Engelberg-Cook, Erica, Dickson, Dennis W., Belzil, Veronique V., Mukamel, Eran A., Dracheva, Stella

Source: Nature Communications; 9/15/2023, Vol. 14 Issue 1, p1-22, 22p

Subject Terms: GENETIC regulation, AMYOTROPHIC lateral sclerosis, NEUROGLIA, CELL analysis, FRONTAL lobe, SOMATIC cell nuclear transfer, POSTMORTEM changes

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F93. CELL-TYPE SPECIFIC TRANSCRIPTOMIC PROFILING IN SCHIZOPHRENIA IDENTIFIES CHANGES IN GABAERGIC NEURONS AND OLIGODENDROCYTES AT TRANSCRIPT LEVEL

Authors: Mahoney, Rebecca, Bendl, Jaroslav, Kozlenkov, Alexey, Micallef, Courtney, Shao, Zhiping, Edelstien, Jonathan, Hoffman, Gabriel E., Seoighe, Cathal, Morris, Derek W., Haroutunian, Vahram, Dracheva, Stella, Fullard, John F., Roussos, Panos

Source: In European Neuropsychopharmacology October 2023 75 Supplement 1:S270-S270

TH72. THE ROLE OF DNA (HYDROXY) METHYLATION IN EPIGENETIC REGULATION OF EXCITATORY AND INHIBITORY NEURONS IN THE PREFRONTAL CORTEX OF PATIENTS WITH SCHIZOPHRENIA

Authors: Chien, Jo-fan, Li, Junhao, Kozlenkov, Alexey, Mukamel, Eran, Dracheva, Stella

Source: European neuropsychopharmacology. 51:e233-e233

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100141344364.0x000001&indx=1&recIds=ETOCvdc_100141344364.0x000001

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Function Assignment to Conserved Residues in Mammalian Alkaline Phosphatases

Authors: Kozlenkov, Alexey ^{‡, §}, Manes, Thomas ^{‡, §, ¶}, Hoylaerts, Marc F. ^‖, Millán, José Luis ^{‡, ¶, **}

Source: In Journal of Biological Chemistry 21 June 2002 277(25):22992-22999

Author Correction: Brain Cell Type Specific Gene Expression and Co-expression Network Architectures.

Authors: McKenzie, Andrew T., Wang, Minghui, Hauberg, Mads E., Fullard, John F., Kozlenkov, Alexey, Keenan, Alexandra, Hurd, Yasmin L., Dracheva, Stella, Casaccia, Patrizia, Roussos, Panos, Zhang, Bin

Source: Scientific Reports; 9/24/2021, Vol. 11 Issue 1, p1-4, 4p

Subject Terms: GENE expression, TECHNICAL reports

Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders.

Authors: Hu, Benxia, Won, Hyejung, Mah, Won, Park, Royce B., Kassim, Bibi, Spiess, Keeley, Kozlenkov, Alexey, Crowley, Cheynna A., Pochareddy, Sirisha, The PsychENCODE Consortium, Ashley-Koch, Allison E., Crawford, Gregory E., Garrett, Melanie E., Song, Lingyun, Safi, Alexias, Johnson, Graham D., Wray, Gregory A., Reddy, Timothy E., Goes, Fernando S., Zandi, Peter

Source: Nature Communications; 6/25/2021, Vol. 12 Issue 1, p1-13, 13p

Subject Terms: PLANT chromosomes, GENE regulatory networks, GENETIC variation, INTERNEURONS, CHROMATIN, REGULATOR genes, ETIOLOGY of diseases

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