The discovery of Zika virus NS2B-NS3 inhibitors with antiviral activity via an integrated virtual screening approach

Authors: Mirza, Muhammad Usman, Alanko, Ida, Vanmeert, Michiel, Muzzarelli, Kendall M., Salo-Ahen, Outi M.H., Abdullah, Iskandar, Kovari, Iulia A., Claes, Sandra, De Jonghe, Steven, Schols, Dominique, Schinazi, Raymond F., Kovari, Ladislau C., Trant, John F., Ahmad, Sarfraz, Froeyen, Matheus

Source: In European Journal of Pharmaceutical Sciences 1 August 2022 175

Structural and Antiviral Studies of the Human Norovirus GII.4 Protease

Authors: Muzzarelli, Kendall M., Kuiper, Benjamin, Spellmon, Nicholas, Brunzelle, Joseph, Hackett, Justin, Amblard, Franck, Zhou, Shaoman, Liu, Peng, Kovari, Iulia A., Yang, Zhe

Source: Biochemistry. 58(7):900-907

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN619295594&indx=1&recIds=ETOCRN619295594

Expression, Purification and Characterization of a GII.4 Norovirus Protease from Minerva Virus

Authors: Kuiper, Benjamin D., Muzzarelli, Kendall M., Keusch, Bradley J., Holcomb, Joshua, Amblard, Franck, Liu, Peng, Zhou, Shaoman, Kovari, Iulia A., Yang, Zhe, Schinazi, Raymond F., Kovari, Ladislau C.

Source: Infectious disorders - drug targets. 18(3):224-232

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100078035927.0x000001&indx=1&recIds=ETOCvdc_100078035927.0x000001

The L33F darunavir resistance mutation acts as a molecular anchor reducing the flexibility of the HIV-1 protease 30s and 80s loops

Authors: Kuiper, Benjamin D., Keusch, Bradley J., Dewdney, Tamaria G., Chordia, Poorvi, Ross, Kyla, Brunzelle, Joseph S., Kovari, Iulia A., MacArthur, Rodger, Salimnia, Hossein, Kovari, Ladislau C.

Source: In Biochemistry and Biophysics Reports July 2015 2:160-165

Increased activity of unlinked Zika virus NS2B/NS3 protease compared to linked Zika virus protease

Authors: Kuiper, Benjamin D., Slater, Kristin, Spellmon, Nicholas, Holcomb, Joshua, Medapureddy, Prasanna, Muzzarelli, Kendall M., Yang, Zhe, Ovadia, Reuben, Amblard, Franck, Kovari, Iulia A., Schinazi, Raymond F., Kovari, Ladislau C.

Source: Biochemical and biophysical research communications. 492(4):668-673

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100061440802.0x000001&indx=1&recIds=ETOCvdc_100061440802.0x000001

A multi-drug resistant HIV-1 protease is resistant to the dimerization inhibitory activity of TLF-PafF

Authors: Yedidi, Ravikiran S., Proteasa, Gheorghe, Martin, Philip D., Liu, Zhigang, Vickrey, John F., Kovari, Iulia A., Kovari, Ladislau C.

Source: In Journal of Molecular Graphics and Modelling September 2014 53:105-111

P1 and P1′ para-fluoro phenyl groups show enhanced binding and favorable predicted pharmacological properties: Structure-based virtual screening of extended lopinavir analogs against multi-drug resistant HIV-1 protease

Authors: Yedidi, Ravikiran S., Liu, Zhigang, Kovari, Iulia A., Woster, Patrick M., Kovari, Ladislau C.

Source: In Journal of Molecular Graphics and Modelling February 2014 47:18-24

Ligand modifications to reduce the relative resistance of multi-drug resistant HIV-1 protease

Authors: Dewdney, Tamaria G., Wang, Yong, Liu, Zhigang, Sharma, Shiv K., Reiter, Samuel J., Brunzelle, Joseph S., Kovari, Iulia A., Woster, Patrick M., Kovari, Ladislau C.

Source: In Bioorganic & Medicinal Chemistry 1 December 2013 21(23):7430-7434

Reduced HIV-1 integrase flexibility as a mechanism for raltegravir resistance

Authors: Dewdney, Tamaria G., Wang, Yong, Kovari, Iulia A., Reiter, Samuel J., Kovari, Ladislau C.

Source: In Journal of Structural Biology November 2013 184(2):245-250

Structure‐Based Design and Evaluation of Peptidomimetic Inhibitors Against the Human Norovirus Protease

Authors: Muzzarelli, Kendall Marie, Brunzelle, Joseph, Kovari, Iulia, Yang, Zhe, Kovari, Ladislau

Source: FASEB journal. 34(S1):1-1

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100141610479.0x000001&indx=1&recIds=ETOCvdc_100141610479.0x000001

Fyn Binds to and Phosphorylates the Kidney Slit Diaphragm Component Nephrin

Authors: Verma, Rakesh ^‡, Wharram, Bryan ^‡, Kovari, Iulia ^‡, Kunkel, Robin ^§, Nihalani, Deepak ^‡, Wary, Kishore K. ^¶, Wiggins, Roger C. ^‡, Killen, Paul ^§, Holzman, Lawrence B. ^{‡, ∥, **}

Source: In Journal of Biological Chemistry 6 June 2003 278(23):20716-20723

Nephrin and Neph1 Co-localize at the Podocyte Foot Process Intercellular Junction and Form cis Hetero-oligomers

Authors: Barletta, Gina-Marie ^{§, ‡}, Kovari, Iulia A. ^{§, ¶}, Verma, Rakesh K. ^¶, Kerjaschki, Dontscho ^∥, Holzman, Lawrence B. ^{¶, **, ‡‡}

Source: In Journal of Biological Chemistry 23 May 2003 278(21):19266-19271

Participation of RAP1 protein in expression of the Saccharomyces cerevisiae arginase (CAR1) gene.

Authors: Kovari, Ladislau Z., Kovari, Iulia, Cooper, Terrance G.

Source: Journal of Bacteriology; February 1993, Vol. 175 Issue 4, p941-951, 11p

Nephrin localizes to the slit pore of the glomerular epithelial cell

Authors: Holzman, Lawrence B., ST John, Patricia L., Kovari, Iulia A., Verma, Rakesh, Holthofer, Harry, Abrahamson, Dale R. ^*

Source: In Kidney International October 1999 56(4):1481-1491

Design, synthesis and evaluation of a potent substrate analog inhibitor identified by scanning Ala/Phe mutagenesis, mimicking substrate co-evolution, against multidrug-resistant HIV-1 protease

Authors: Yedidi, Ravikiran S., Muhuhi, Joseck M., Liu, Zhigang, Bencze, Krisztina Z., Koupparis, Kyriacos, O’Connor, Carrie E., Kovari, Iulia A., Spaller, Mark R., Kovari, Ladislau C.

Source: In Biochemical and Biophysical Research Communications 6 September 2013 438(4):703-708

Crystallographic study of multi-drug resistant HIV-1 protease lopinavir complex: Mechanism of drug recognition and resistance

Authors: Liu, Zhigang, Yedidi, Ravikiran S., Wang, Yong, Dewdney, Tamaria G., Reiter, Samuel J., Brunzelle, Joseph S., Kovari, Iulia A., Kovari, Ladislau C.

Source: In Biochemical and Biophysical Research Communications 26 July 2013 437(2):199-204

Insights into the mechanism of drug resistance: X-ray structure analysis of multi-drug resistant HIV-1 protease ritonavir complex

Authors: Liu, Zhigang, Yedidi, Ravikiran S., Wang, Yong, Dewdney, Tamaria G., Reiter, Samuel J., Brunzelle, Joseph S., Kovari, Iulia A., Kovari, Ladislau C.

Source: In Biochemical and Biophysical Research Communications 8 February 2013 431(2):232-238

Conserved hydrogen bonds and water molecules in MDR HIV-1 protease substrate complexes

Authors: Liu, Zhigang, Wang, Yong, Yedidi, Ravikiran S., Dewdney, Tamaria G., Reiter, Samuel J., Brunzelle, Joseph S., Kovari, Iulia A., Kovari, Ladislau C.

Source: In Biochemical and Biophysical Research Communications 18 January 2013 430(3):1022-1027

Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds

Authors: Yedidi, Ravikiran S., Liu, Zhigang, Wang, Yong, Brunzelle, Joseph S., Kovari, Iulia A., Woster, Patrick M., Kovari, Ladislau C., Gupta, Deepak

Source: In Biochemical and Biophysical Research Communications 11 May 2012 421(3):413-417

The higher barrier of darunavir and tipranavir resistance for HIV-1 protease

Authors: Wang, Yong, Liu, Zhigang, Brunzelle, Joseph S., Kovari, Iulia A., Dewdney, Tamaria G., Reiter, Samuel J., Kovari, Ladislau C.

Source: In Biochemical and Biophysical Research Communications 9 September 2011 412(4):737-742