LncRNAs and asymmetric cell division: The epigenetic mechanisms

Authors: Hsiao-Fan Chen, Kou-Juey Wu

Source: Biomedical Journal, Vol 48, Iss 2, Pp 100774- (2025)

Subject Terms: Asymmetric cell division, lncRNA, Stem cell, Wnt, Notch, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2319417024000775; https://doaj.org/toc/2319-4170

Access URL: https://doaj.org/article/6189ed556ee34e9e9f649b078e40d916

RP11‐367G18.1 V2 enhances clear cell renal cell carcinoma progression via induction of epithelial–mesenchymal transition

Authors: I‐Hung Shao, Pei‐Hua Peng, Heng‐Hsiung Wu, Ji‐Lin Chen, Joseph Chieh‐Yu Lai, Jeng‐Shou Chang, Han‐Tsang Wu, Kou‐Juey Wu, See‐Tong Pang, Kai‐Wen Hsu

Source: Cancer Medicine, Vol 12, Iss 8, Pp 9788-9801 (2023)

Subject Terms: clear cell renal cell carcinoma, epithelial–mesenchymal transition, H4K16Ac, hypoxia, lncRNA RP11‐367G18.1, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2045-7634

Access URL: https://doaj.org/article/0a9475d585f249369bc43712fd3e745c

Organ defects of the Usp7K444R mutant mouse strain indicate the essential role of K63-polyubiquitinated Usp7 in organ formation

Authors: Han-Tsang Wu, Yueh-Te Lin, Shan Hwu Chew, Kou-Juey Wu

Source: Biomedical Journal, Vol 46, Iss 1, Pp 122-133 (2023)

Subject Terms: Usp7, K63-linked polyubiquitination, Knock-in mouse, Glycogen storage, Polycystic kidney, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2319417022000282; https://doaj.org/toc/2319-4170

Access URL: https://doaj.org/article/183e7ae836344763929c89de4ad880b4

METTL4-mediated nuclear N6-deoxyadenosine methylation promotes metastasis through activating multiple metastasis-inducing targets

Authors: Kai-Wen Hsu, Joseph Chieh-Yu Lai, Jeng-Shou Chang, Pei-Hua Peng, Ching-Hui Huang, Der-Yen Lee, Yu-Cheng Tsai, Chi-Jung Chung, Han Chang, Chao-Hsiang Chang, Ji-Lin Chen, See-Tong Pang, Ziyang Hao, Xiao-Long Cui, Chuan He, Kou-Juey Wu

Source: Genome Biology, Vol 23, Iss 1, Pp 1-37 (2022)

Subject Terms: METTL4, 6mA, Hypoxia, lncRNA, ZMIZ1, Metastasis, Biology (General), QH301-705.5, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1474-760X

Access URL: https://doaj.org/article/6c0fad365ca1454eb69e277ce3013571

The role of hypoxia-induced long noncoding RNAs (lncRNAs) in tumorigenesis and metastasis

Authors: Pei-Hua Peng, Kai-Wen Hsu, Joseph Chieh-Yu Lai, Kou-Juey Wu

Source: Biomedical Journal, Vol 44, Iss 5, Pp 521-533 (2021)

Subject Terms: lncRNAs, Hypoxia, Epithelial–mesenchymal transition, Metastasis, Epigenetics, LncRNA RP11-390F4.3, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2319417021000305; https://doaj.org/toc/2319-4170

Access URL: https://doaj.org/article/86ef44f5776c45a98ea67ef8c448ff89

USP7 facilitates SMAD3 autoregulation to repress cancer progression in p53-deficient lung cancer

Authors: Yu-Ting Huang, An-Chieh Cheng, Hui-Chi Tang, Guo-Cheng Huang, Ling Cai, Ta-Hsien Lin, Kou-Juey Wu, Ping-Hui Tseng, Greg G. Wang, Wei-Yi Chen

Source: Cell Death and Disease, Vol 12, Iss 10, Pp 1-11 (2021)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2041-4889

Access URL: https://doaj.org/article/544bcba015934e9c8d44f0ccba4f1df9

Genetic Disruption of KLF1 K74 SUMOylation in Hematopoietic System Promotes Healthy Longevity in Mice

Authors: Yu‐Chiau Shyu, Po‐Cheng Liao, Ting‐Shou Huang, Chun‐Ju Yang, Mu‐Jie Lu, Shih‐Ming Huang, Xin‐Yu Lin, Cai‐Cin Liou, Yu‐Hsiang Kao, Chi‐Huan Lu, Hui‐Ling Peng, Jim‐Ray Chen, Wen‐Jin Cherng, Ning‐I Yang, Yung‐Chang Chen, Heng‐Chih Pan, Si‐Tse Jiang, Chih‐Chin Hsu, Gigin Lin, Shin‐Sheng Yuan, Paul Wei‐Che Hsu, Kou‐Juey Wu, Tung‐Liang Lee, Che‐Kun James Shen

Source: Advanced Science, Vol 9, Iss 25, Pp n/a-n/a (2022)

Subject Terms: aging, antiaging, hematopoietic stem cells (HSCs), KLF1/EKLF, SUMOylation, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/c0e4230186634e33ba72b19d29ff9002

The role of miRNA biogenesis and DDX17 in tumorigenesis and cancer stemness

Authors: Kou-Juey Wu

Source: Biomedical Journal, Vol 43, Iss 2, Pp 107-114 (2020)

Subject Terms: miRNA biogenesis, DDX17, Cancer stemness, HAUSP, K63-linked polyubiquitination, m6A, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2319417020300275; https://doaj.org/toc/2319-4170

Access URL: https://doaj.org/article/b33fa903b9ae43b48f3f53e726b7b465

Epigenetic regulation of epithelial-mesenchymal transition: focusing on hypoxia and TGF-β signaling

Authors: Yueh-Te Lin, Kou-Juey Wu

Source: Journal of Biomedical Science, Vol 27, Iss 1, Pp 1-10 (2020)

Subject Terms: Epithelial-mesenchymal transition, Hypoxia, TGF-β, Epigenetic regulation, HIF-1α, HDAC3, Medicine

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12929-020-00632-3; https://doaj.org/toc/1423-0127

Access URL: https://doaj.org/article/b522fb684626463bba361b6460874683

Ubiquitination by HUWE1 in tumorigenesis and beyond

Authors: Shih-Han Kao, Han-Tsang Wu, Kou-Juey Wu

Source: Journal of Biomedical Science, Vol 25, Iss 1, Pp 1-15 (2018)

Subject Terms: Ubiquitination, HUWE1, Tumorigenesis, Cancer therapeutics, Medicine

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12929-018-0470-0; https://doaj.org/toc/1423-0127

Access URL: https://doaj.org/article/f5cfe6c248b54a77ad0dced2a84d6ab7

K63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progression

Authors: Han-Tsang Wu, Yi-Chih Kuo, Jung-Jyh Hung, Chi-Hung Huang, Wei-Yi Chen, Teh-Ying Chou, Yeh Chen, Yi-Ju Chen, Yu-Ju Chen, Wei-Chung Cheng, Shu-Chun Teng, Kou-Juey Wu

Source: Nature Communications, Vol 7, Iss 1, Pp 1-17 (2016)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/eeab853bf97f403e830ddd4b444d9412

Regulation of Membrane-Type 4 Matrix Metalloproteinase by SLUG Contributes to Hypoxia-Mediated Metastasis

Authors: Chi-Hung Huang, Wen-Hao Yang, Shyue-Yih Chang, Shyh-Kuan Tai, Cheng-Hwei Tzeng, Jung-Yie Kao, Kou-Juey Wu, Muh-Hwa Yang

Source: Neoplasia: An International Journal for Oncology Research, Vol 11, Iss 12, Pp 1371-1382 (2009)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1476558609801061; https://doaj.org/toc/1476-5586; https://doaj.org/toc/1522-8002

Access URL: https://doaj.org/article/4e463c27120649e88b8472ba9a85c1b5

Endothelial Transdifferentiation of Tumor Cells Triggered by the Twist1-Jagged1-KLF4 Axis: Relationship between Cancer Stemness and Angiogenesis

Authors: Hsiao-Fan Chen, Kou-Juey Wu

Source: Stem Cells International, Vol 2016 (2016)

Subject Terms: Internal medicine, RC31-1245

File Description: electronic resource

Relation: https://doaj.org/toc/1687-966X; https://doaj.org/toc/1687-9678

Access URL: https://doaj.org/article/92a9166c680f4910bc17cbdcf2f947f6

Interaction between NBS1 and the mTOR/Rictor/SIN1 complex through specific domains.

Authors: Jian-Qiu Wang, Jian-Hong Chen, Yen-Chung Chen, Mei-Yu Chen, Chia-Ying Hsieh, Shu-Chun Teng, Kou-Juey Wu

Source: PLoS ONE, Vol 8, Iss 6, p e65586 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3675082?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/ebea836a5483424687678327e2df0e1e

Hypoxia-regulated target genes implicated in tumor metastasis.

Authors: Ya-Ping Tsai¹ (AUTHOR), Kou-Juey Wu^1,2,3 (AUTHOR) kjwu2@ym.edu.tw

Source: Journal of Biomedical Science. 2012, Vol. 19 Issue 1, p102-108. 7p. 1 Chart.

C-MYC activates protein kinase A (PKA) by direct transcriptional activation of the PKA catalytic subunit beta (PKA-Cβ) gene.

Authors: Kou-Juey Wu, Mattioli, Michela, Morse III, Herbert C., Dalla-Favera, Riccardo

Source: Oncogene. 11/7/2002, Vol. 21 Issue 51, p7872. 11p. 5 Diagrams, 1 Graph.

Subject Terms: *ONCOGENES, *PROTEIN kinases, *PROTEIN synthesis, *MICE

Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition.

Authors: Muh-Hwa Yang^1,2,3,4,5, mhyang2@vghtpe.gov.tw, Dennis Shin-Shian Hsu^1,5, Hsei-Wei Wang^1,4,6, Hsiao-Jung Wang¹, Hsin-Yi Lan¹, Wen-Hao Yang¹, Chi-Hung Huang⁷, Shou-Yen Kao⁸, Cheng-Hwai Tzeng³, Shyh-Kuan Tai⁹, Shyue-Yih Chang^4,9, Oscar Kuang-Sheng Lee^1,10, Kou-Juey Wu^4,5, kjwu2@ym.edu.tw

Source: Nature Cell Biology; Oct2010, Vol. 12 Issue 10, p982-992, 11p, 2 Color Photographs, 10 Charts, 14 Graphs

Direct regulation of TWIST by HIF-1α promotes metastasis.

Authors: Muh-Hwa Yang^1,2,3,4, Min-Zu Wu¹, Shih-Hwa Chiou^2,5, Po-Min Chen^3,4, Shyue-Yih Chang^4,6, Chung-Ji Liu⁷, Shu-Chun Teng⁸, Kou-Juey Wu^1,2,4, kjwu2@ym.edu.tw

Source: Nature Cell Biology; Mar2008, Vol. 10 Issue 3, p295-305, 11p, 1 Black and White Photograph, 1 Diagram, 6 Graphs

DriverDBv2: a database for human cancer driver gene research.

Authors: I-Fang Chung, Chen-Yang Chen, Shih-Chieh Su, Chia-Yang Li, Kou-Juey Wu, Hsei-Wei Wang, Wei-Chung Cheng

Source: Nucleic Acids Research; 2016 Database issue, Vol. 44, pD975-D979, 5p

TET1 regulates hypoxia-induced epithelialmesenchymal transition by acting as a co-activator.

Authors: Ya-Ping Tsai, Hsiao-Fan Chen, Sung-Yuan Chen, Wei-Chung Cheng, Hsei-Wei Wang, Zih-Jie Shen, Chunxiao Song, Shu-Chun Teng, Chuan He, Kou-Juey Wu

Source: Genome Biology; 2014, Vol. 15 Issue 12, p513-525, 13p, 1 Diagram, 5 Graphs