CfDNA-Based NGS IG Analysis in Lymphoma

Authors: Pott, Christiane, Kotrova, Michaela, Darzentas, Nikos, Brüggemann, Monika, Khouja, Mouhamad

Source: Methods in molecular biology. 2453:101-118

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN629444268&indx=1&recIds=ETOCRN629444268

Next‐generation sequencing and high DNA input identify previously missed measurable residual disease in peripheral blood of B‐cell precursor acute lymphoblastic leukaemia.

Authors: Bendig, Sonja, Bufe, Sandra, Kotrova, Michaela, Fricke, Birgit, Proske, Constantin, Darzentas, Franziska, Darzentas, Nikos, Schilhabel, Anke, Kehden, Britta, Chitadze, Guranda, Baldus, Claudia D., Gökbuget, Nicola, Brüggemann, Monika

Source: British Journal of Haematology; Jan2025, Vol. 206 Issue 1, p353-356, 4p

Subject Terms: LYMPHOBLASTIC leukemia, DNA, BLOOD plasma, MEASURING instruments, EARLY diagnosis, GLOBAL burden of disease, NUCLEOTIDE sequencing

Prognostic value of low-level MRD in adult acute lymphoblastic leukemia detected by low- and high-throughput methods

Authors: Kotrová, Michaela ^*, Koopmann, Johannes ^*, Trautmann, Heiko, Alakel, Nael, Beck, Joachim, Nachtkamp, Kathrin, Steffen, Björn, Raffel, Simon, Viardot, Andreas, Wethmar, Klaus, Darzentas, Nikos, Baldus, Claudia D., Gökbuget, Nicola ^†, Brüggemann, Monika ^{†, *}

Source: In Blood Advances 24 May 2022 6(10):3006-3010

T-cell diversity and exclusion of blood-derived T-cells in the tumor microenvironment of classical Hodgkin Lymphoma

Authors: Seifert, Nicole, Reinke, Sarah, Grund, Johanna, Müller-Meinhard, Berit, Richter, Julia, Heilmann, Thorsten, Schlößer, Hans, Kotrova, Michaela, Brüggemann, Monika, Borchmann, Peter, Bröckelmann, Paul J., Altenbuchinger, Michael, Klapper, Wolfram

Source: Leukemia; March 2025, Vol. 39 Issue: 3 p684-693, 10p

Next-Generation Sequencing Technology to Identify Minimal Residual Disease in Lymphoid Malignancies

Authors: Kotrova, Michaela, Darzentas, Nikos, Pott, Christiane, Brüggemann, Monika

Source: Methods in molecular biology. 2185:95-112

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN625212313&indx=1&recIds=ETOCRN625212313

Tumor and microenvironment response but no cytotoxic T-cell activation in classic Hodgkin lymphoma treated with anti-PD1

Authors: Reinke, Sarah ^*, Bröckelmann, Paul J. ^*, Iaccarino, Ingram, Garcia-Marquez, Maria, Borchmann, Sven, Jochims, Franziska, Kotrova, Michaela, Pal, Karol, Brüggemann, Monika, Hartmann, Elena, Sasse, Stephanie, Kobe, Carsten, Mathas, Stephan, Soekler, Martin, Keller, Ulrich, Bormann, Matthias, Zimmermann, Andreas, Richter, Julia, Fuchs, Michael, von Tresckow, Bastian, Borchmann, Peter, Schlößer, Hans, von Bergwelt-Baildon, Michael, Rosenwald, Andreas, Engert, Andreas, Klapper, Wolfram ^*

Source: In Blood 17 December 2020 136(25):2851-2863

The gray area of RQ-PCR-based measurable residual disease: subdividing the “positive, below quantitative range” category

Authors: Kotrova, Michaela, Fronkova, Eva, Svaton, Michael, Drandi, Daniela, Schön, Felix, Hoogeveen, Patricia, Hancock, Jeremy, Skotnicova, Aneta, Schilhabel, Anke, Eckert, Cornelia, Clappier, Emmanuelle, Cazzaniga, Gianni, Schäfer, Beat W., van Dongen, Jacques J. M., Ritgen, Matthias, Pott, Christiane, van der Velden, Vincent H. J., Trka, Jan, Brüggemann, Monika

Source: Leukemia; July 2024, Vol. 38 Issue: 7 p1617-1620, 4p

Minimal residual disease in adult ALL: technical aspects and implications for correct clinical interpretation

Authors: Brüggemann, Monika ^*, Kotrova, Michaela

Source: In Blood Advances 28 November 2017 1(25):2456-2466

Standardized flow cytometry for highly sensitive MRD measurements in B-cell acute lymphoblastic leukemia

Authors: Theunissen, Prisca ^*, Mejstrikova, Ester ^*, Sedek, Lukasz, van der Sluijs-Gelling, Alita J., Gaipa, Giuseppe, Bartels, Marius, Sobral da Costa, Elaine, Kotrová, Michaela, Novakova, Michaela, Sonneveld, Edwin, Buracchi, Chiara, Bonaccorso, Paola, Oliveira, Elen, te Marvelde, Jeroen G., Szczepanski, Tomasz, Lhermitte, Ludovic, Hrusak, Ondrej, Lecrevisse, Quentin, Grigore, Georgiana Emilia, Froňková, Eva, Trka, Jan, Brüggemann, Monika, Orfao, Alberto, van Dongen, Jacques J.M., van der Velden, Vincent H.J.

Source: In Blood 19 January 2017 129(3):347-357

Analysis of measurable residual disease by IG/TR gene rearrangements: quality assurance and updated EuroMRD guidelines

Authors: van der Velden, Vincent H. J., Dombrink, Isabel, Alten, Julia, Cazzaniga, Giovanni, Clappier, Emmanuelle, Drandi, Daniela, Eckert, Cornelia, Fronkova, Eva, Hancock, Jeremy, Kotrova, Michaela, Kraemer, Rebekka, Montonen, Mirkka, Pfeifer, Heike, Pott, Christiane, Raff, Thorsten, Trautmann, Heiko, Cavé, Hélène, Schäfer, Beat W., van Dongen, Jacques J. M., Trka, Jan, Brüggemann, Monika

Source: Leukemia; June 2024, Vol. 38 Issue: 6 p1315-1322, 8p

ETV6/RUNX1‐like acute lymphoblastic leukemia: A novel B‐cell precursor leukemia subtype associated with the CD27/CD44 immunophenotype

Authors: Zaliova, Marketa, Kotrova, Michaela, Bresolin, Silvia, Stuchly, Jan, Stary, Jan, Hrusak, Ondrej, te Kronnie, Geertruy, Trka, Jan, Zuna, Jan, Vaskova, Martina

Source: Genes, chromosomes & cancer. 56(8):608-616

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100077656818.0x000001&indx=1&recIds=ETOCvdc_100077656818.0x000001

Somatic TP53 mutations are preleukemic events in acute lymphoblastic leukemia

Authors: Chitadze, Guranda, Stengel, Anna, John-Klaua, Cathrin, Bruckmüller, Julien, Trautmann, Heiko, Kotrova, Michaela, Darzentas, Franziska, Kelm, Miriam, Pal, Karol, Darzentas, Nikos, Bastian, Lorenz, Kehden, Britta, Wessels, Wiebke, Ströh, Aeint-Steffen, Oberg, Hans-Heinrich, Altrock, Philipp M., Baer, Constance, Meggendorfer, Manja, Gökbuget, Nicola, Baldus, Claudia D., Haferlach, Claudia, Brüggemann, Monika

Source: In Blood 30 March 2023 141(13):1640-1644

NGS better discriminates true MRD positivity for the risk stratification of childhood ALL treated on an MRD-based protocol

Authors: Svaton, Michael ^∗, Skotnicova, Aneta ^∗, Reznickova, Leona, Rennerova, Andrea, Valova, Tatana, Kotrova, Michaela, van der Velden, Vincent H. J., Brüggemann, Monika, Darzentas, Nikos, Langerak, Anton W., Zuna, Jan, Stary, Jan, Trka, Jan, Fronkova, Eva

Source: In Blood 2 February 2023 141(5):529-533

Dominant T-cell Receptor Delta Rearrangements in B-cell Precursor Acute Lymphoblastic Leukemia: Leukemic Markers or Physiological γδ T Repertoire?

Authors: Kelm, Miriam, Darzentas, Franziska, Darzentas, Nikos, Kotrova, Michaela, Wessels, Wiebke, Bendig, Sonja, Baldus, Claudia D., Lettau, Marcus, Gökbuget, Nicola, Kabelitz, Dieter, Brüggemann, Monika, Chitadze, Guranda

Source: HemaSphere; Sep2023, Vol. 7 Issue 9, p1-4, 4p

Distinct bilineal leukemia immunophenotypes are not genetically determined

Authors: Kotrova, Michaela, Musilova, Alena, Stuchly, Jan, Fiser, Karel, Starkova, Julia, Mejstrikova, Ester, Stary, Jan, Zuna, Jan, Hrusak, Ondrej, Trka, Jan

Source: Blood. 128(18):2263-2265

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN608721999&indx=1&recIds=ETOCRN608721999

The predictive strength of next-generation sequencing MRD detection for relapse compared with current methods in childhood ALL

Authors: Kotrova, Michaela, Muzikova, Katerina, Mejstrikova, Ester, Novakova, Michaela, Bakardjieva-Mihaylova, Violeta, Fiser, Karel, Stuchly, Jan, Giraud, Mathieu, Salson, Mikaël, Pott, Christiane

Source: Blood. 126(8):1045-1047

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN602511052&indx=1&recIds=ETOCRN602511052

Reshaping MRD Detection Strategies: Next-Generation Sequencing and High DNA Input Identify Previously Missed Measurable Residual Disease in Peripheral Blood of B-Cell Precursor Acute Lmyphoblastic Leukemia

Authors: Bendig, Sonja, Bufe, Sandra, Fricke, Birgit, Proske, Constantin, Darzentas, Nikos, Kehden, Britta, Chitadze, Guranda, Baldus, Claudia D, Kotrova, Michaela, Goekbuget, Nicola, Brüggemann, Monika

Source: In Blood 2 November 2023 142 Supplement 1:4354-4354

Disease Kinetics Measured By Circulating Tumor DNA Correlates with Treatment Response after Tafasitamab in Combination with R-CHOP with or without Lenalidomide in First Line Treatment of DLBCL

Authors: Khouja, Mouhamad, Schilhabel, Anke, Kotrova, Michaela, Brüggemann, Monika, Kuffer, Christian, Blair, Derek, Darzentas, Nikos, Pott, Christiane

Source: In Blood 23 November 2021 138 Supplement 1:3498-3498

NGS-Based MRD Quantitation: An Alternative to qPCR Validated on a Large Consecutive Cohort of Children with ALL

Authors: Svaton, Michael, Skotnicova, Aneta, Reznickova, Leona, Rennerova, Andrea, Valova, Tatana, Kotrova, Michaela, van der Velden, Vincent H.J., Brüggemann, Monika, Darzentas, Nikos, Langerak, Anton W., Zuna, Jan, Stary, Jan, Trka, Jan, Fronkova, Eva

Source: In Blood 23 November 2021 138 Supplement 1:1314-1314

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