ciRS-7 and miR-7 regulate ischemia-induced neuronal death via glutamatergic signaling

Authors: Scoyni, Flavia ^{1, 16, ∗}, Sitnikova, Valeriia ^{1, 15}, Giudice, Luca ^{1, 15}, Korhonen, Paula ¹, Trevisan, Davide M. ², Hernandez de Sande, Ana ³, Gomez-Budia, Mireia ¹, Giniatullina, Raisa ¹, Ugidos, Irene F. ¹, Dhungana, Hiramani ⁴, Pistono, Cristiana ¹, Korvenlaita, Nea ¹, Välimäki, Nelli-Noora ¹, Kangas, Salla M. ⁵, Hiltunen, Anniina E. ⁶, Gribchenko, Emma ¹, Kaikkonen-Määttä, Minna U. ¹, Koistinaho, Jari ^{1, 4}, Ylä-Herttuala, Seppo ¹, Hinttala, Reetta ^{5, 6}, Venø, Morten T. ^{7, 8}, Su, Junyi ⁸, Stoffel, Markus ⁹, Schaefer, Anne ^{10, 11}, Rajewsky, Nikolaus ¹², Kjems, Jørgen ⁸, LaPierre, Mary P. ⁹, Piwecka, Monika ¹³, Jolkkonen, Jukka ¹, Giniatullin, Rashid ¹, Hansen, Thomas B. ^{8, 14}, Malm, Tarja ^{1, ∗∗}

Source: In Cell Reports 26 March 2024 43(3)

Metabolomic, Lipidomic and Proteomic Characterisation of Lipopolysaccharide-induced Inflammation Mouse Model

Authors: Puris, Elena, Kouřil, Štěpán, Najdekr, Lukáš, Auriola, Seppo, Loppi, Sanna, Korhonen, Paula, Gómez-Budia, Mireia, Fricker, Gert, Kanninen, Katja M., Malm, Tarja, Friedecký, David, Gynther, Mikko

Source: In Neuroscience 1 August 2022 496:165-178

Subacute inhalation of ultrafine particulate matter triggers inflammation without altering amyloid beta load in 5xFAD mice

Authors: Saveleva, Liudmila, Vartiainen, Petra, Górová, Veronika, Chew, Sweelin, Belaya, Irina, Konttinen, Henna, Zucchelli, Martina, Korhonen, Paula, Kaartinen, Emma, Kortelainen, Miika, Lamberg, Heikki, Sippula, Olli, Malm, Tarja, Jalava, Pasi I., Kanninen, Katja M. ^*

Source: In Neurotoxicology March 2022 89:55-66

Inactivation of mouse transmembrane prolyl 4-hydroxylase increases blood brain barrier permeability and ischemia-induced cerebral neuroinflammation

Authors: Byts, Nadiya, Sharma, Subodh, Malm, Tarja, Kaakinen, Mika, Korhonen, Paula, Jaakkonen, Laura, Keuters, Meike, Huuskonen, Mikko, Pietilä, Ilkka, Koistinaho, Jari, Koivunen, Peppi, Myllyharju, Johanna

Source: In Journal of Biological Chemistry March 2022 298(3)

Sex Differences in Poststroke Inflammation: a Focus on Microglia Across the Lifespan

Authors: Ugidos, Irene F., Pistono, Cristiana, Korhonen, Paula, Gómez-Budia, Mireia, Sitnikova, Valeriia, Klecki, Pamela, Stanová, Iveta, Jolkkonen, Jukka, Malm, Tarja

Source: Stroke. 53(5):1500-1509

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100189942145.0x000001&indx=1&recIds=ETOCvdc_100189942145.0x000001

Systemic Inflammation Induced Changes in Protein Expression of ABC Transporters and Ionotropic Glutamate Receptor Subunit 1 in the Cerebral Cortex of Familial Alzheimer`s Disease Mouse Model

Authors: Puris, Elena, Auriola, Seppo, Korhonen, Paula, Loppi, Sanna, Kanninen, Katja M., Malm, Tarja, Koistinaho, Jari, Gynther, Mikko

Source: In Journal of Pharmaceutical Sciences December 2021 110(12):3953-3962

Glial smog: Interplay between air pollution and astrocyte-microglia interactions

Authors: Gómez-Budia, Mireia, Konttinen, Henna, Saveleva, Liudmila, Korhonen, Paula, Jalava, Pasi I., Kanninen, Katja M., Malm, Tarja

Source: In Neurochemistry International June 2020 136

Reduced binding of apoE4 to complement factor H promotes amyloid‐β oligomerization and neuroinflammation

Authors: Chernyaeva, Larisa, Ratti, Giorgio, Teirilä, Laura, Fudo, Satoshi, Rankka, Uni, Pelkonen, Anssi, Korhonen, Paula, Leskinen, Katarzyna, Keskitalo, Salla, Salokas, Kari, Gkolfinopoulou, Christina, Crompton, Katrina E, Javanainen, Matti, Happonen, Lotta, Varjosalo, Markku, Malm, Tarja, Leinonen, Ville, Chroni, Angeliki, Saavalainen, Päivi, Meri, Seppo, Kajander, Tommi, Wollman, Adam JM, Nissilä, Eija, Haapasalo, Karita

Source: EMBO reports. 24(7)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187366679.0x000001&indx=1&recIds=ETOCvdc_100187366679.0x000001

Dynamic release of neuronal extracellular vesicles containing miR‐21a‐5p is induced by hypoxia

Authors: Korvenlaita, Nea, Gómez‐Budia, Mireia, Scoyni, Flavia, Pistono, Cristiana, Giudice, Luca, Eamen, Shaila, Loppi, Sanna, Sande, Ana Hernández, Huremagic, Benjamin, Bouvy‐Liivrand, Maria, Heinäniemi, Merja, Kaikkonen, Minna U., Cheng, Lesley, Hill, Andrew F., Kanninen, Katja M., Jenster, Guido W., Royen, Martin E., Ramiro, Laura, Montaner, Joan, Batkova, Tereza, Mikulik, Robert, Giugno, Rosalba, Jolkkonen, Jukka, Korhonen, Paula, Malm, Tarja

Source: Journal of extracellular vesicles. 12(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100172697740.0x000001&indx=1&recIds=ETOCvdc_100172697740.0x000001

PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia

Authors: Konttinen, Henna, Cabral-da-Silva, Mauricio e Castro, Ohtonen, Sohvi, Wojciechowski, Sara, Shakirzyanova, Anastasia, Caligola, Simone, Giugno, Rosalba, Ishchenko, Yevheniia, Hernández, Damián, Fazaludeen, Mohammad Feroze, Eamen, Shaila, Budia, Mireia Gómez, Fagerlund, Ilkka, Scoyni, Flavia, Korhonen, Paula, Huber, Nadine, Haapasalo, Annakaisa, Hewitt, Alex W., Vickers, James, Smith, Grady C., Oksanen, Minna, Graff, Caroline, Kanninen, Katja M., Lehtonen, Sarka, Propson, Nicholas, Schwartz, Michael P., Pébay, Alice, Koistinaho, Jari, Ooi, Lezanne, Malm, Tarja

Source: In Stem Cell Reports 8 October 2019 13(4):669-683

Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis

Authors: Korhonen, Paula, Pollari, Eveliina, Kanninen, Katja M., Savchenko, Ekaterina, Lehtonen, Šárka, Wojciechowski, Sara, Pomeshchik, Yuriy, Van Den Bosch, Ludo, Goldsteins, Gundars, Koistinaho, Jari, Malm, Tarja

Source: In IBRO Reports June 2019 6:74-86

3D human brain cell models: New frontiers in disease understanding and drug discovery for neurodegenerative diseases

Authors: Korhonen, Paula, Malm, Tarja, White, Anthony R.

Source: In Neurochemistry International November 2018 120:191-199

Peripheral inflammatory markers and clinical correlations in patients with frontotemporal lobar degeneration with and without the C9orf72 repeat expansion

Authors: Katisko, Kasper, Solje, Eino, Korhonen, Paula, Jääskeläinen, Olli, Loppi, Sanna, Hartikainen, Päivi, Koivisto, Anne M., Kontkanen, Aleksi, Korhonen, Ville E., Helisalmi, Seppo, Malm, Tarja, Herukka, Sanna-Kaisa, Remes, Anne M., Haapasalo, Annakaisa

Source: Journal of neurology. 267(1):76-86

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100141519190.0x000001&indx=1&recIds=ETOCvdc_100141519190.0x000001

Changes in nuclear and cytoplasmic microRNA distribution in response to hypoxic stress

Authors: Turunen, Tiia, Roberts, Thomas, Laitinen, Pia, Väänänen, Mari-Anna, Korhonen, Paula, Malm, Tarja, Ylä-Herttuala, Seppo, Turunen, Mikko

Source: Scientific reports. 9(1):1-12

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185511500.0x000001&indx=1&recIds=ETOCvdc_100185511500.0x000001

The Copper bis(thiosemicarbazone) Complex CuII(atsm) Is Protective Against Cerebral Ischemia Through Modulation of the Inflammatory Milieu

Authors: Huuskonen, Mikko T., Tuo, Qing-zhang, Loppi, Sanna, Dhungana, Hiramani, Korhonen, Paula, McInnes, Lachlan E., Donnelly, Paul S., Grubman, Alexandra, Wojciechowski, Sara, Lejavova, Katarina, Pomeshchik, Yuriy, Periviita, Laura, Kosonen, Lotta, Giordano, Martina, Walker, Frederick R., Liu, Rong, Bush, Ashley I., Koistinaho, Jari, Malm, Tarja, White, Anthony R., Lei, Peng, Kanninen, Katja M.

Source: In Neurotherapeutics April 2017 14(2):519-532

Particulate matter from car exhaust alters function of human iPSC-derived microglia.

Authors: Jäntti, Henna, Jonk, Steffi, Gómez Budia, Mireia, Ohtonen, Sohvi, Fagerlund, Ilkka, Fazaludeen, Mohammad Feroze, Aakko-Saksa, Päivi, Pebay, Alice, Lehtonen, Šárka, Koistinaho, Jari, Kanninen, Katja M., Jalava, Pasi I., Malm, Tarja, Korhonen, Paula

Source: Particle & Fibre Toxicology; 2/15/2024, Vol. 21 Issue 1, p1-21, 21p

Subject Terms: PARTICULATE matter, INDUCED pluripotent stem cells, DISEASE risk factors, AIR pollutants, MICROGLIA, OLFACTORY receptors

Alzheimer's disease‐induced phagocytic microglia express a specific profile of coding and non‐coding RNAs.

Authors: Scoyni, Flavia, Giudice, Luca, Väänänen, Mari‐Anna, Downes, Nicholas, Korhonen, Paula, Choo, Xin Yi, Välimäki, Nelli‐Noora, Mäkinen, Petri, Korvenlaita, Nea, Rozemuller, Annemieke J, de Vries, Helga E, Polo, Jose, Turunen, Tiia A, Ylä‐Herttuala, Seppo, Hansen, Thomas B, Grubman, Alexandra, Kaikkonen, Minna U, Malm, Tarja

Source: Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Feb2024, Vol. 20 Issue 2, p954-974, 21p

Immunomodulation by interleukin-33 is protective in stroke through modulation of inflammation

Authors: Korhonen, Paula, Kanninen, Katja M., Lehtonen, Šárka, Lemarchant, Sighild, Puttonen, Katja A., Oksanen, Minna, Dhungana, Hiramani, Loppi, Sanna, Pollari, Eveliina, Wojciechowski, Sara, Kidin, Iurii, García-Berrocoso, Teresa, Giralt, Dolors, Montaner, Joan, Koistinaho, Jari, Malm, Tarja

Source: In Brain Behavior and Immunity October 2015 49:322-336

Peripheral inflammation preceeding ischemia impairs neuronal survival through mechanisms involving miR‐127 in aged animals

Authors: Loppi, Sanna, Korhonen, Paula, Bouvy‐Liivrand, Maria, Caligola, Simone, Turunen, Tiia A., Turunen, Mikko P., Hernandez de Sande, Ana, Kołosowska, Natalia, Scoyni, Flavia, Rosell, Anna, García‐Berrocoso, Teresa, Lemarchant, Sighild, Dhungana, Hiramani, Montaner, Joan, Koistinaho, Jari, Kanninen, Katja M., Kaikkonen, Minna U., Giugno, Rosalba, Heinäniemi, Merja, Malm, Tarja

Source: Aging cell. 20(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100114565516.0x000001&indx=1&recIds=ETOCvdc_100114565516.0x000001

Interleukin-33 treatment reduces secondary injury and improves functional recovery after contusion spinal cord injury

Authors: Pomeshchik, Yuriy, Kidin, Iurii, Korhonen, Paula, Savchenko, Ekaterina, Jaronen, Merja, Lehtonen, Sarka, Wojciechowski, Sara, Kanninen, Katja, Koistinaho, Jari, Malm, Tarja

Source: In Brain Behavior and Immunity February 2015 44:68-81