X-206 exhibits broad-spectrum anti-β-coronavirus activity, covering SARS-CoV-2 variants and drug-resistant isolates

Authors: Sasaki, Jiei ^a, Sato, Akihiko ^{b, c, d}, Sasaki, Michihito ^{b, d}, Okabe, Iori ^e, Kodama, Kota ^{f, g}, Otsuguro, Satoko ^g, Yasuda, Kosuke ^h, Kojima, Hirotatsu ^h, Orba, Yasuko ^{b, d}, Sawa, Hirofumi ^d, Maenaka, Katsumi ^{g, i, j}, Yanagi, Yusuke ^e, Hashiguchi, Takao ^{a, k, ⁎}

Source: In Antiviral Research December 2024 232

Inhibition of QDPR synergistically modulates intracellular tetrahydrobiopterin profiles in cooperation with methotrexate

Authors: Hara, Satoshi, Kono, Haruka, Suto, Naoki, Kojima, Hirotatsu, Kishimoto, Kaito, Yoshino, Hiroshi, Niiyama, Shuhei, Kakihana, Yasuyuki, Ichinose, Hiroshi

Source: In Biochemical and Biophysical Research Communications 12 July 2024 717

Chemical inhibition of phosphatidylcholine biogenesis reveals its role in mitochondrial division

Authors: Shiino, Hiroya, Tashiro, Shinya, Hashimoto, Michiko, Sakata, Yuki, Hosoya, Takamitsu, Endo, Toshiya, Kojima, Hirotatsu, Tamura, Yasushi

Source: In iScience 15 March 2024 27(3)

AKT2 inhibition accelerates the acquisition of phagocytic ability in induced pluripotent stem cell–derived neutrophils

Authors: Hino, Toshiya, Nakahara, Fumio ^*, Miyauchi, Masashi ^*, Ito, Yusuke, Masamoto, Yosuke, Morita, Ken, Kagoya, Yuki, Kojima, Hirotatsu, Kurokawa, Mineo

Source: In Experimental Hematology February 2024 130

Application of Intramolecular O‑to‑N Phosphoryl Transfer Reaction to Design Fluorogenic Probes to Detect Activities of Enzymes That Metabolize Short Peptides and Acylamino Acids.

Authors: Sawayama, Risako, Minoda, Mayano, Kojima, Hirotatsu, Okabe, Takayoshi, Isayama, Yukari, Kato, Kazuki, Nishimasu, Hiroshi, Urano, Yasuteru, Komatsu, Toru

Source: ACS Sensors; 2/28/2025, Vol. 10 Issue 2, p664-670, 7p

N-Oleoyldopamine promotes the differentiation of mouse trophoblast stem cells into parietal trophoblast giant cells

Authors: Nishitani, Kenta, Hayakawa, Koji, Minatomoto, Masayuki, Tanaka, Keisuke, Ogawa, Hidehiko, Kojima, Hirotatsu, Tanaka, Satoshi

Source: Biochemical and biophysical research communications. 636(P1):205-212

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100175203462.0x000001&indx=1&recIds=ETOCvdc_100175203462.0x000001

Development of p62-Keap1 protein–protein interaction inhibitors as doxorubicin-sensitizers against non-small cell lung cancer

Authors: Yasuda, Daisuke, Yoshida, Ippei, Imamura, Riyo, Katagishi, Daiki, Takahashi, Kyoko, Kojima, Hirotatsu, Okabe, Takayoshi, Ichimura, Yoshinobu, Komatsu, Masaaki, Mashino, Tadahiko, Ohe, Tomoyuki

Source: In Results in Chemistry January 2022 4

Establishment of live-cell-based coupled assay system for identification of compounds to modulate metabolic activities of cells

Authors: Yanagi, Kouichi, Komatsu, Toru, Ogihara, Shusuke, Okabe, Takayoshi, Kojima, Hirotatsu, Nagano, Tetsuo, Ueno, Tasuku, Hanaoka, Kenjiro, Urano, Yasuteru

Source: In Cell Reports 6 July 2021 36(1)

Identification of novel compounds that inhibit SnRK2 kinase activity by high-throughput screening

Authors: Matsuoka, Shoko, Sato, Karin, Maruki-Imamura, Riyo, Noutoshi, Yoshiteru, Okabe, Takayoshi, Kojima, Hirotatsu, Umezawa, Taishi

Source: Biochemical and biophysical research communications. 537:57-63

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100135793074.0x000001&indx=1&recIds=ETOCvdc_100135793074.0x000001

Non-steroidal inhibitors of Drosophila melanogaster steroidogenic glutathione S-transferase Noppera-bo

Authors: Koiwai, Kotaro, Morohashi, Kana, Inaba, Kazue, Ebihara, Kana, Kojima, Hirotatsu, Okabe, Takayoshi, Yoshino, Ryunosuke, Hirokawa, Takatsugu, Nampo, Taiki, Fujikawa, Yuuta

Source: Journal of pesticide science. 46(1/2):75-87

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN626824557&indx=1&recIds=ETOCRN626824557

An integrated approach to unravel a crucial structural property required for the function of the insect steroidogenic Halloween protein Noppera-bo

Authors: Koiwai, Kotaro, Inaba, Kazue, Morohashi, Kana, Enya, Sora, Arai, Reina, Kojima, Hirotatsu, Okabe, Takayoshi, Fujikawa, Yuuta, Inoue, Hideshi, Yoshino, Ryunosuke, Hirokawa, Takatsugu, Kato, Koichiro, Fukuzawa, Kaori, Shimada-Niwa, Yuko, Nakamura, Akira, Yumoto, Fumiaki, Senda, Toshiya, Niwa, Ryusuke

Source: In Journal of Biological Chemistry 15 May 2020 295(20):7154-7167

Inhibitors of the protein–protein interaction between phosphorylated p62 and Keap1 attenuate chemoresistance in a human hepatocellular carcinoma cell line

Authors: Yasuda, Daisuke, Ohe, Tomoyuki, Takahashi, Kyoko, Imamura, Riyo, Kojima, Hirotatsu, Okabe, Takayoshi, Ichimura, Yoshinobu, Komatsu, Masaaki, Yamamoto, Masayuki, Nagano, Tetsuo, Mashino, Tadahiko

Source: Free radical research. 54(11-12):859-871

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100121229550.0x000001&indx=1&recIds=ETOCvdc_100121229550.0x000001

Metabolic-Pathway-Oriented Screening Targeting S-Adenosyl-L-methionine Reveals the Epigenetic Remodeling Activities of Naturally Occurring Catechols

Authors: Ogihara, Shusuke, Komatsu, Toru, Itoh, Yukihiro, Miyake, Yuka, Suzuki, Takayoshi, Yanagi, Kouichi, Kimura, Yusuke, Ueno, Tasuku, Hanaoka, Kenjiro, Kojima, Hirotatsu

Source: Journal of the American Chemical Society. 142(1):21-26

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN622791923&indx=1&recIds=ETOCRN622791923

Inexpensive High-Throughput Screening of Kinase Inhibitors Using One-Step Enzyme-Coupled Fluorescence Assay for ADP Detection

Authors: Imamura, Riyo Maruki, Kumagai, Kazuo, Nakano, Hirofumi, Okabe, Takayoshi, Nagano, Tetsuo, Kojima, Hirotatsu ^*

Source: In SLAS Discovery March 2019 24(3):284-294

Novel indole and benzothiophene ring derivatives showing differential modulatory activity against human epithelial sodium channel subunits, ENaC β and γ

Authors: Kasahara, Yoichi, Sakurai, Takanobu, Matsuda, Ryusei, Narukawa, Masataka, Yasuoka, Akihito, Mori, Naoki, Watanabe, Hidenori, Okabe, Takayoshi, Kojima, Hirotatsu, Abe, Keiko, Misaka, Takumi, Asakura, Tomiko

Source: Bioscience, biotechnology, and biochemistry. 83(2):243-250

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100075111309.0x000001&indx=1&recIds=ETOCvdc_100075111309.0x000001

Identification of novel selective P2Y6 receptor antagonists by high-throughput screening assay

Authors: Ito, Masaaki, Egashira, Shin-ichiro, Yoshida, Kazuki, Mineno, Tomoko, Kumagai, Kazuo, Kojima, Hirotatsu, Okabe, Takayoshi, Nagano, Tetsuo, Ui, Michio, Matsuoka, Isao

Source: In Life Sciences 1 July 2017 180:137-142

Discovery of Novel Binders to Sterol Regulatory Element-Binding Protein‑1 by High-Throughput Screening.

Authors: Maruyama, Takashi, Takahashi, Yu, Hiro, Kahori, Murase, Kohji, Kojima, Hirotatsu, Okabe, Takayoshi, Yamauchi, Yoshio, Sato, Ryuichiro

Source: ACS Medicinal Chemistry Letters; 5/9/2024, Vol. 15 Issue 5, p667-676, 10p

A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model

Authors: Tsuburaya, Naomi, Homma, Kengo, Higuchi, Tsunehiko, Balia, Andrii, Yamakoshi, Hiroyuki, Shibata, Norio, Nakamura, Seiichi, Nakagawa, Hidehiko, Ikeda, Shin-ichi, Umezawa, Naoki, Kato, Nobuki, Yokoshima, Satoshi, Shibuya, Masatoshi, Shimonishi, Manabu, Kojima, Hirotatsu, Okabe, Takayoshi, Nagano, Tetsuo, Naguro, Isao, Imamura, Keiko, Inoue, Haruhisa, Fujisawa, Takao, Ichijo, Hidenori

Source: Nature communications. 9(1):1-12

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100170088124.0x000001&indx=1&recIds=ETOCvdc_100170088124.0x000001

A novel diacylglycerol kinase α-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune response

Authors: Liu, Ke ^*, Kunii, Naoko ^*, Sakuma, Megumi ^†, Yamaki, Atsumi ^*, Mizuno, Satoru ^*, Sato, Mayu ^*, Sakai, Hiromichi ^*, Kado, Sayaka ^§, Kumagai, Kazuo ^**, Kojima, Hirotatsu ^**, Okabe, Takayoshi ^**, Nagano, Tetsuo ^**, Shirai, Yasuhito ^†, Sakane, Fumio ^*

Source: In Journal of Lipid Research March 2016 57(3):368-379

Reduction of Amyloid‑β Production without Inhibiting Secretase Activity by MS-275.

Authors: Mitsuishi, Yachiyo, Nakano, Masaki, Kojima, Hirotatsu, Okabe, Takayoshi, Nishimura, Masaki

Source: ACS Chemical Neuroscience; 3/20/2024, Vol. 15 Issue 6, p1234-1241, 8p