Associations of sedentary time, physical activity, and fitness with muscle glucose uptake in adults with metabolic syndrome

Authors: Garthwaite, Taru, Sjöros, Tanja, Laine, Saara, Koivumäki, Mikko, Vähä‐Ypyä, Henri, Eskola, Olli, Rajander, Johan, Kallio, Petri, Saarenhovi, Maria, Löyttyniemi, Eliisa, Sievänen, Harri, Houttu, Noora, Laitinen, Kirsi, Kalliokoski, Kari, Vasankari, Tommi, Knuuti, Juhani, Heinonen, Ilkka

Source: Scandinavian journal of medicine & science in sports. 33(3):353-358

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100173690051.0x000001&indx=1&recIds=ETOCvdc_100173690051.0x000001

Blood biomarkers of neurodegeneration associate differently with amyloid deposition, medial temporal atrophy, and cerebrovascular changes in APOE ε4-enriched cognitively unimpaired elderly.

Authors: Koivumäki, Mikko¹ (AUTHOR) mikkkoi@utu.fi, Ekblad, Laura^1,2 (AUTHOR), Lantero-Rodriguez, Juan³ (AUTHOR), Ashton, Nicholas J.^3,4,5,6 (AUTHOR), Karikari, Thomas K.^3,7 (AUTHOR), Helin, Semi¹ (AUTHOR), Parkkola, Riitta⁸ (AUTHOR), Lötjönen, Jyrki⁹ (AUTHOR), Zetterberg, Henrik^{3,10,11,12,13,14} (AUTHOR), Blennow, Kaj^3,11 (AUTHOR), Rinne, Juha O.^1,15 (AUTHOR), Snellman, Anniina^1,3 (AUTHOR)

Source: Alzheimer's Research & Therapy. 5/18/2024, Vol. 16 Issue 1, p1-15. 15p.

Subject Terms: *GLIAL fibrillary acidic protein, *APOLIPOPROTEIN E, *TAU proteins, *ATROPHY, *AMYLOID

Head-to-head comparison of plasma p-tau181, p-tau231 and glial fibrillary acidic protein in clinically unimpaired elderly with three levels of APOE4-related risk for Alzheimer's disease

Authors: Snellman, Anniina, Ekblad, Laura L., Ashton, Nicholas J., Karikari, Thomas K., Lantero-Rodriguez, Juan, Pietilä, Elina, Koivumäki, Mikko, Helin, Semi, Karrasch, Mira, Zetterberg, Henrik, Blennow, Kaj, Rinne, Juha O.

Source: In Neurobiology of Disease July 2023 183

Standing is associated with insulin sensitivity in adults with metabolic syndrome

Authors: Garthwaite, Taru, Sjöros, Tanja, Koivumäki, Mikko, Laine, Saara, Vähä-Ypyä, Henri, Saarenhovi, Maria, Kallio, Petri, Löyttyniemi, Eliisa, Sievänen, Harri, Houttu, Noora, Laitinen, Kirsi, Kalliokoski, Kari, Vasankari, Tommi, Knuuti, Juhani, Heinonen, Ilkka

Source: In Journal of Science and Medicine in Sport December 2021 24(12):1255-1260

First-in-Humans Study of ^6^8Ga-DOTA-Siglec-9, a PET Ligand Targeting Vascular Adhesion Protein 1

Authors: Viitanen, Riikka, Moisio, Olli, Lankinen, Petteri, Li, Xiang-Guo, Koivumäki, Mikko, Suilamo, Sami, Tolvanen, Tuula, Taimen, Kirsi, Mali, Markku, Kohonen, Ia

Source: Journal of nuclear medicine. 62(4):577-583

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN626355261&indx=1&recIds=ETOCRN626355261

SV2A PET shows hippocampal synaptic loss in cognitively unimpaired APOE ε4/ε4 homozygotes.

Authors: Snellman, Anniina, Tuisku, Jouni, Koivumäki, Mikko, Wahlroos, Saara, Aarnio, Richard, Rajander, Johan, Karrasch, Mira, Ekblad, Laura L., Rinne, Juha O.

Source: Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2024, Vol. 20 Issue 12, p8802-8813, 12p

Improving Layman Readability of Clinical Narratives with Unsupervised Synonym Replacement
Medical Informatics Europe (Conference)

Authors: Moen, Hans, Peltonen, Laura-Maria, Koivumäki, Mikko, Suhonen, Henry, Salakoski, Tapio, Ginter, Filip, Salanterä, Sanna

Source: Studies in health technology and informatics. 247:725-729

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCCN604075827&indx=1&recIds=ETOCCN604075827

Daily standing time, dietary fiber, and intake of unsaturated fatty acids are beneficially associated with hepatic insulin sensitivity in adults with metabolic syndrome.

Authors: Laine, Saara, Sjöros, Tanja, Garthwaite, Taru, Honka, Miikka-Juhani, Löyttyniemi, Eliisa, Eskola, Olli, Saarenhovi, Maria, Kallio, Petri, Koivumäki, Mikko, Vähä-Ypyä, Henri, Sievänen, Harri, Vasankari, Tommi, Hirvonen, Jussi, Laitinen, Kirsi, Houttu, Noora, Kalliokoski, Kari, Saunavaara, Virva, Knuuti, Juhani, Heinonen, Ilkka H. A.

Source: Frontiers in Endocrinology; 2024, p1-14, 14p

Subject Terms: UNSATURATED fatty acids, DIETARY fiber, INSULIN sensitivity, METABOLIC syndrome, LDL cholesterol, INSULIN, POSITRON emission tomography, SEDENTARY behavior

Sedentary time associates detrimentally and physical activity beneficially with metabolic flexibility in adults with metabolic syndrome.

Authors: Garthwaite, Taru, Sjöros, Tanja, Laine, Saara, Koivumäki, Mikko, Vähä-Ypyä, Henri, Verho, Tiina, Norha, Jooa, Kallio, Petri, Saarenhovi, Maria, Löyttyniemi, Eliisa, Sievänen, Harri, Houttu, Noora, Laitinen, Kirsi, Kalliokoski, Kari K., Vasankari, Tommi, Knuuti, Juhani, Heinonen, Ilkka

Source: American Journal of Physiology: Endocrinology & Metabolism; Apr2024, Vol. 326 Issue 4, p503-514, 12p

Subject Terms: METABOLIC syndrome, PHYSICAL activity, EXERCISE intensity, CARDIOPULMONARY fitness, ADULTS, ENERGY metabolism, METABOLIC disorders, SEDENTARY behavior

Exercise training decreases pancreatic fat content and improves beta cell function regardless of baseline glucose tolerance: a randomised controlled trial

Authors: Heiskanen, Marja A., Motiani, Kumail K., Mari, Andrea, Saunavaara, Virva, Eskelinen, Jari-Joonas, Virtanen, Kirsi A., Koivumäki, Mikko, Löyttyniemi, Eliisa, Nuutila, Pirjo, Kalliokoski, Kari K., Hannukainen, Jarna C.

Source: Diabetologia. 61(8):1817-1828

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100125285995.0x000001&indx=1&recIds=ETOCvdc_100125285995.0x000001

Sprint interval training decreases left-ventricular glucose uptake compared to moderate-intensity continuous training in subjects with type 2 diabetes or prediabetes

Authors: Heiskanen, Marja, Sjöros, Tanja, Heinonen, Ilkka, Löyttyniemi, Eliisa, Koivumäki, Mikko, Motiani, Kumail, Eskelinen, Jari-Joonas, Virtanen, Kirsi, Knuuti, Juhani, Hannukainen, Jarna, Kalliokoski, Kari

Source: Scientific reports. 7(1):1-11

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100179703220.0x000001&indx=1&recIds=ETOCvdc_100179703220.0x000001

Insulin resistance and body mass index are associated with TSPO PET in cognitively unimpaired elderly.

Authors: Ekblad, Laura L, Tuisku, Jouni, Koivumäki, Mikko, Helin, Semi, Rinne, Juha O, Snellman, Anniina

Source: Journal of Cerebral Blood Flow & Metabolism; Sep2023, Vol. 43 Issue 9, p1588-1600, 13p

Unsupervised Phrase-Level Query Rewriting for Assisting Search in Clinical Free Text
World congress on medical and health informatics

Authors: Moen, Hans, Peltonen, Laura, Suhonen, Henry, Koivumäki, Mikko, Salakoski, Tapio, Salanterä, Sanna

Source: Studies in health technology and informatics. 264(2):1550-1551

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCCN607575779&indx=1&recIds=ETOCCN607575779

APOE ε4 gene dose effect on imaging and blood biomarkers of neuroinflammation and beta-amyloid in cognitively unimpaired elderly.

Authors: Snellman, Anniina, Ekblad, Laura L., Tuisku, Jouni, Koivumäki, Mikko, Ashton, Nicholas J., Lantero-Rodriguez, Juan, Karikari, Thomas K., Helin, Semi, Bucci, Marco, Löyttyniemi, Eliisa, Parkkola, Riitta, Karrasch, Mira, Schöll, Michael, Zetterberg, Henrik, Blennow, Kaj, Rinne, Juha O.

Source: Alzheimer's Research & Therapy; 4/4/2023, Vol. 15 Issue 1, p1-15, 15p

Subject Terms: GLIAL fibrillary acidic protein, APOLIPOPROTEIN E, TRANSLOCATOR proteins, POSITRON emission tomography, NEUROINFLAMMATION

Corrigendum to 'Standing is associated with insulin sensitivity in adults with metabolic syndrome. Journal of Science and Medicine in Sport 24 (2021) 1255–1260'

Authors: Garthwaite, Taru, Sjöros, Tanja, Koivumäki, Mikko, Laine, Saara, Vähä-Ypyä, Henri, Saarenhovi, Maria, Kallio, Petri, Löyttyniemi, Eliisa, Sievänen, Harri, Houttu, Noora, Laitinen, Kirsi, Kalliokoski, Kari, Vasankari, Tommi, Knuuti, Juhani, Heinonen, Ilkka

Source: Journal of science and medicine in sport. 25(6):541-541

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100163550870.0x000001&indx=1&recIds=ETOCvdc_100163550870.0x000001

Reducing Sedentary Time and Whole-Body Insulin Sensitivity in Metabolic Syndrome: A 6-Month Randomized Controlled Trial.

Authors: SJÖROS, TANJA, LAINE, SAARA, GARTHWAITE, TARU, VÄHÄ-YPYÄ, HENRI, LÖYTTYNIEMI, ELIISA, KOIVUMÄKI, MIKKO, HOUTTU, NOORA, LAITINEN, Kirsi, KALLIOKOSKI, Kari K., SIEVÄNEN, HARRI, VASANKARI, TOMMI, KNUUTI, JUHANI, HEINONEN, ILKKA H.A.

Source: Medicine & Science in Sports & Exercise; Mar2023, Vol. 55 Issue 3, p342-353, 12p

ASIC-E4: Interplay of Beta-Amyloid, Synaptic Density and Neuroinflammation in Cognitively Normal Volunteers With Three Levels of Genetic Risk for Late-Onset Alzheimer's Disease – Study Protocol and Baseline Characteristics.

Authors: Snellman, Anniina, Ekblad, Laura L., Koivumäki, Mikko, Lindgrén, Noora, Tuisku, Jouni, Perälä, Merja, Kallio, Lila, Lehtonen, Riina, Saunavaara, Virva, Saunavaara, Jani, Oikonen, Vesa, Aarnio, Richard, Löyttyniemi, Eliisa, Parkkola, Riitta, Karrasch, Mira, Zetterberg, Henrik, Blennow, Kaj, Rinne, Juha O.

Source: Frontiers in Neurology; 2/9/2022, Vol. 13, p1-14, 14p

Subject Terms: DISEASE risk factors, AMYLOID plaque, POSITRON emission tomography, CEREBROSPINAL fluid examination, MAGNETIC resonance imaging, NEUROINFLAMMATION

Company/Entity: GOTEBORGS universitet

First-in-Human Study of ⁶⁸Ga-DOTA-Siglec-9, PET Ligand Targeting Vascular Adhesion Protein 1.

Authors: Viitanen, Riikka, Moisio, Olli, Lankinen, Petteri, Xiang-Guo Li, Koivumäki, Mikko, Suilamo, Sami, Tolvanen, Tuula, Taimen, Kirsi, Mali, Markku, Kohonen, Ia, Koskivirta, Ilpo, Oikonen, Vesa, Virtanen, Helena, Santalahti, Kristiina, Autio, Anu, Saraste, Antti, Pirilä, Laura, Nuutila, Pirjo, Knuuti, Juhani, Jalkanen, Sirpa

Source: Journal of Nuclear Medicine; Nov2020, Vol. 61 Issue 11, p1-30, 38p

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Intramyocellular lipid accumulation after sprint interval and moderate‐intensity continuous training in healthy and diabetic subjects.

Authors: Sjöros, Tanja, Saunavaara, Virva, Löyttyniemi, Eliisa, Koivumäki, Mikko, Heinonen, Ilkka H. A., Eskelinen, Jari‐Joonas, Virtanen, Kirsi A., Hannukainen, Jarna C., Kalliokoski, Kari K.

Source: Physiological Reports; Feb2019, Vol. 7 Issue 3, pN.PAG-N.PAG, 1p

Subject Terms: PROTON magnetic resonance spectroscopy, HIGH-intensity interval training, TIBIALIS anterior, TYPE 2 diabetes