Membrane protease prostasin promotes insulin secretion by regulating the epidermal growth factor receptor pathway

Authors: Toshihisa Ishii, Yoshikazu Miyasato, Masashi Ichijo, Kohei Uchimura, Fumihiko Furuya

Source: Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/f2d73d4640934da0a3242527067bd42c

A serine protease inhibitor camostat mesilate prevents podocyte apoptosis and attenuates podocyte injury in metabolic syndrome model rats

Authors: Teruhiko Mizumoto, Yutaka Kakizoe, Terumasa Nakagawa, Yasunobu Iwata, Yoshikazu Miyasato, Kohei Uchimura, Masataka Adachi, Qinyuan Deng, Manabu Hayata, Jun Morinaga, Taku Miyoshi, Yuichiro Izumi, Takashige Kuwabara, Yoshiki Sakai, Kimio Tomita, Kenichiro Kitamura, Masashi Mukoyama

Source: Journal of Pharmacological Sciences, Vol 146, Iss 4, Pp 192-199 (2021)

Subject Terms: Camostat mesilate, Serine protease, Metabolic syndrome, Podocyte injury, Proteinuria, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1347861321000360; https://doaj.org/toc/1347-8613

Access URL: https://doaj.org/article/59eec7db31444310acc443e68816d53e

Development of the Diabetic Kidney Disease Mouse Model Culturing Embryos in α-Minimum Essential Medium In Vitro, and Feeding Barley Diet Attenuated the Pathology

Authors: Shiori Ishiyama, Mayu Kimura, Takao Nakagawa, Yuka Fujimoto, Kohei Uchimura, Satoshi Kishigami, Kazuki Mochizuki

Source: Frontiers in Endocrinology, Vol 12 (2021)

Subject Terms: diabetic kidney disease (DKD), MEM mice, DOHaD (developmental origins of health and disease), barley, glomerulosclerosis, transforming growth factor beta (TGF- β), Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2021.746838/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/9460dd808d4f465080629a3c1920e000

Human Pluripotent Stem Cell-Derived Kidney Organoids with Improved Collecting Duct Maturation and Injury Modeling

Authors: Kohei Uchimura, Haojia Wu, Yasuhiro Yoshimura, Benjamin D. Humphreys

Source: Cell Reports, Vol 33, Iss 11, Pp 108514- (2020)

Subject Terms: kidney organoid, stem cells, collecting duct, scRNA-seq, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124720315035; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/406b28cf938c4803a18011d9b604134e

A serine protease inhibitor attenuates aldosterone-induced kidney injuries via the suppression of plasmin activity

Authors: Yutaka Kakizoe, Yoshikazu Miyasato, Tomoaki Onoue, Terumasa Nakagawa, Manabu Hayata, Kohei Uchimura, Jun Morinaga, Teruhiko Mizumoto, Masataka Adachi, Taku Miyoshi, Yoshiki Sakai, Kimio Tomita, Masashi Mukoyama, Kenichiro Kitamura

Source: Journal of Pharmacological Sciences, Vol 132, Iss 2, Pp 145-153 (2016)

Subject Terms: Aldosterone, Kidney injury, Serine protease, Plasmin, Serine protease inhibitor, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S134786131630130X; https://doaj.org/toc/1347-8613

Access URL: https://doaj.org/article/4f9c720a207e42d89d856d7808a43e91

Combination therapy with renin-angiotensin-aldosterone system inhibitor telmisartan and serine protease inhibitor camostat mesilate provides further renoprotection in a rat chronic kidney disease model

Authors: Yuki Narita, Miki Ueda, Kohei Uchimura, Yutaka Kakizoe, Yoshikazu Miyasato, Teruhiko Mizumoto, Jun Morinaga, Manabu Hayata, Terumasa Nakagawa, Masataka Adachi, Taku Miyoshi, Yoshiki Sakai, Daisuke Kadowaki, Sumio Hirata, Masashi Mukoyama, Kenichiro Kitamura

Source: Journal of Pharmacological Sciences, Vol 130, Iss 2, Pp 110-116 (2016)

Subject Terms: Chronic kidney diseases, Serine protease inhibitor, Camostat mesilate, Telmisartan, Combination therapy, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1347861316000049; https://doaj.org/toc/1347-8613

Access URL: https://doaj.org/article/a0568c95b4384664a6769932401155f7

Intelectin1 ameliorates macrophage activation via inhibiting the nuclear factor kappa B pathway.

Authors: Hidetoshi Kobayashi, Kohei Uchimura, Toshihisa Ishii, Kazuya Takahashi, Kentaro Mori, Kyoichiro Tsuchiya, Fumihiko Furuya

Source: Endocrine Journal; 2022, Vol. 69 Issue 5, p539-546, 8p

Hyperthyroidism exacerbates ischemic reperfusion injury in the kidney.

Authors: Yasuno Yamaguchi, Kohei Uchimura, Kazuya Takahashi, Toshihisa Ishii, Shunichiro Hanai, Fumihiko Furuya

Source: Endocrine Journal; 2022, Vol. 69 Issue 3, p263-272, 10p

Hypoxia-induced thyroid hormone receptor expression regulates cell-cycle progression in renal tubule epithelial cells.

Authors: Shunichiro Hanai, Kohei Uchimura, Kazuya Takahashi, Toshihisa Ishii, Takahiko Mitsui, Fumihiko Furuya

Source: Endocrine Journal; 2021, Vol. 68 Issue 11, p1309-1320, 12p

Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury.

Authors: Yuhei Kirita, Haojia Wu, Kohei Uchimura, Wilson, Parker C., Humphreys, Benjamin D.

Source: Proceedings of the National Academy of Sciences of the United States of America; 7/7/2020, Vol. 117 Issue 27, p15874-15883, 10p

Subject Terms: KIDNEY injuries, GENE regulatory networks, CHRONIC kidney failure, CELL communication, WOUNDS & injuries

The antifibrotic effect of a serine protease inhibitor in the kidney.

Authors: Jun Morinaga, Yutaka Kakizoe, Taku Miyoshi, Tomoaki Onoue, Miki Ueda, Teruhiko Mizumoto, Rika Yamazoe, Kohei Uchimura, Manabu Hayata, Naoki Shiraishi, Masataka Adachi, Yoshiki Sakai, Kimio Tomita, Kenichiro Kitamura

Source: American Journal of Physiology: Renal Physiology; Aug2013, Vol. 305 Issue 2, pF173-F181, 9p

Effect of a serine protease inhibitor on the progression of chronic renal failure.

Authors: Manabu Hayata, Yutaka Kakizoe, Kohei Uchimura, Jun Morinaga, Rika Yamazoe, Teruhiko Mizumoto, Tomoaki Onoue, Miki Ueda, Naoki Shiraishi, Masataka Adachi, Taku Miyoshi, Yoshiki Sakai, Kimio Tomita, Kenichiro Kitamura

Source: American Journal of Physiology: Renal Physiology; Oct2012 Part 2, Vol. 72 Issue 4, pF1126-F1135, 10p

In vivo contribution of serine proteases to the proteolytic activation of γENaC in aldosterone-infused rats.

Authors: Kohei Uchimura¹, Yutaka Kakizoe¹, Tomoaki Onoue¹, Manabu Hayata¹, Jun Morinaga¹, Rika Yamazoe¹, Miki Ueda¹, Teruhiko Mizumoto¹, Masataka Adachi¹, Taku Miyoshi¹, Naoki Shiraishi¹, Yoshiki Sakai², Kimio Tomita¹, Kenichiro Kitamura¹ ken@gpo.kumamoto-u.ac.jp

Source: American Journal of Physiology: Renal Physiology. Oct2012, Vol. 303 Issue 7, pF939-F943. 5p.