Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern

Authors: Pfeffer, Inga, Brewitz, Lennart, Krojer, Tobias, Jensen, Sacha A., Kochan, Grazyna T., Kershaw, Nadia J., Hewitson, Kirsty S., McNeill, Luke A., Kramer, Holger, Münzel, Martin, Hopkinson, Richard J., Oppermann, Udo, Handford, Penny A., McDonough, Michael A., Schofield, Christopher J.

Source: Nature communications. 10(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130621666.0x000001&indx=1&recIds=ETOCvdc_100130621666.0x000001

Structural and Mechanistic Studies on γ-Butyrobetaine Hydroxylase

Authors: Leung, Ivanhoe K.H., Krojer, Tobias J., Kochan, Grazyna T., Henry, Luc, von Delft, Frank, Claridge, Timothy D.W., Oppermann, Udo, McDonough, Michael A., Schofield, Christopher J.

Source: In Chemistry & Biology 2010 17(12):1316-1324

Ejection of structural zinc leads to inhibition of γ-butyrobetaine hydroxylase

Authors: Rydzik, Anna M., Brem, Jürgen, Struwe, Weston B., Kochan, Grazyna T., Benesch, Justin L.P., Schofield, Christopher J.

Source: In Bioorganic & Medicinal Chemistry Letters 1 November 2014 24(21):4954-4957

Crystal structure of PHYHD1A, a 2OG oxygenase related to phytanoyl-CoA hydroxylase

Authors: Zhang, Zhihong, Kochan, Grazyna T., Ng, Stanley S., Kavanagh, Kathryn L., Oppermann, Udo, Schofield, Christopher J., McDonough, Michael A.

Source: In Biochemical and Biophysical Research Communications 20 May 2011 408(4):553-558

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

Comparison of the substrate selectivity and biochemical properties of human and bacterial γ-butyrobetaine hydroxylase.

Authors: Rydzik, Anna M., Leung, Ivanhoe K. H., Kochan, Grazyna T., Loik, Nikita D., Henry, Luc, McDonough, Michael A., Claridge, Timothy D. W., Schofield, Christopher J.

Source: Organic & Biomolecular Chemistry; 2014, Vol. 12 Issue 33, p6354-6358, 5p

Modulating carnitine levels by targeting its biosynthesis - selective inhibition of γ-butyrobetaine hydroxylase.

Authors: Rydzik, Anna M., Chowdhury, Rasheduzzaman, Kochan, Grazyna T., Williams, Sophie T., McDonough, Michael A., Kawamura, Akane, Schofield, Christopher J.

Source: Chemical Science; 2014, Vol. 5 Issue 5, p1765-1771, 7p

This result is not displayed to guests.
Login for full access.

Development and Application of a Fluoride-Detection-Based Fluorescence Assay for γ-Butyrobetaine Hydroxylase.

Authors: Rydzik, Anna M., Leung, Ivanhoe K. H., Kochan, Grazyna T., Thalhammer, Armin, Oppermann, Udo, Claridge, Timothy D. W., Schofield, Christopher J.

Source: ChemBioChem; Jul2012, Vol. 13 Issue 11, p1559-1563, 5p

This result is not displayed to guests.
Login for full access.

Oxygenase-Catalyzed Desymmetrization of N, N-Dialkyl-piperidine-4-carboxylic Acids.

Authors: Rydzik, Anna M.¹, Leung, Ivanhoe K. H.¹, Kochan, Grazyna T.^2,3, McDonough, Michael A.¹, Claridge, Timothy D. W.¹, Schofield, Christopher J.¹, christopher.schofield@chem.ox.ac.uk

Source: Angewandte Chemie; Oct2014, Vol. 126 Issue 41, p11105-11107, 3p

ChemInform Abstract: Fluoromethylated Derivatives of Carnitine biosynthesis Intermediates - Synthesis and Applications.

Authors: Rydzik, Anna M., Leung, Ivanhoe K. H., Thalhammer, Armin, Kochan, Grazyna T., Claridge, Timothy D. W., Schofield, Christopher J.

Source: ChemInform; May2014, Vol. 45 Issue 19, pno-no, 1p