Identification of broad-spectrum neutralizing antibodies against influenza A virus and evaluation of their prophylactic efficacy in mice

Authors: Son, Sumin, Ahn, Soo Bin, Kim, Geonyeong, Jang, Yejin, Ko, Chunkyu, Kim, Meehyein, Kim, Sang Jick

Source: In Antiviral Research May 2023 213

SARS‐CoV‐2 Productively Infects Human Hepatocytes and Induces Cell Death.

Authors: Ko, Chunkyu, Cheng, Cho‐Chin, Mistretta, Daniele, Ambike, Shubhankar, Sacherl, Julia, Velkov, Stoyan, Liao, Bo‐Hung, Bester, Romina, Gültan, Merve, Polezhaeva, Olga, Herrmann, Alexander, Jakwerth, Constanze A., Schmidt‐Weber, Carsten B., Bugert, Joachim J., Wölfel, Roman, Grass, Vincent, Essbauer, Sandra, Schnepf, Daniel, Keppler, Oliver T., Vondran, Florian W. R.

Source: Journal of Medical Virology; Jan2025, Vol. 97 Issue 1, p1-12, 12p

T-cell engager antibodies enable T cells to control HBV infection and to target HBsAg-positive hepatoma in mice

Authors: Quitt, Oliver, Luo, Shanshan, Meyer, Marten, Xie, Zhe, Golsaz-Shirazi, Forough, Loffredo-Verde, Eva, Festag, Julia, Bockmann, Jan Hendrik, Zhao, Lili, Stadler, Daniela, Chou, Wen-Min, Tedjokusumo, Raindy, Wettengel, Jochen Martin, Ko, Chunkyu, Noeßner, Elfriede, Bulbuc, Nadja, Shokri, Fazel, Lüttgau, Sandra, Heikenwälder, Mathias, Bohne, Felix, Moldenhauer, Gerhard, Momburg, Frank, Protzer, Ulrike

Source: In Journal of Hepatology November 2021 75(5):1058-1071

Intramolecular recombination enables the formation of hepatitis B virus (HBV) cccDNA in mice after HBV genome transfer using recombinant AAV vectors

Authors: Ko, Chunkyu, Su, Jinpeng, Festag, Julia, Bester, Romina, Kosinska, Anna D., Protzer, Ulrike

Source: In Antiviral Research October 2021 194

Miniaturized Modular Click Chemistry‐enabled Rapid Discovery of Unique SARS‐CoV‐2 Mpro Inhibitors With Robust Potency and Drug‐like Profile.

Authors: Yang, Mianling¹, Lee, Myoung Kyu², Gao, Shenghua¹, Song, Letian¹, Jang, Hye‐Yeon², Jo, Inseong², Yang, Chun‐Chiao³, Sylvester, Katharina⁴, Ko, Chunkyu², Wang, Shuo¹, Ye, Bing¹, Tang, Kai¹, Li, Junyi¹, Gu, Manyu¹, Müller, Christa E.⁴, christa.mueller@uni-bonn.de, Sträter, Norbert³, strater@bbz.uni-leipzig.de, Liu, Xinyong¹, xinyongl@sdu.edu.cn, Kim, Meehyein², mkim@krict.re.kr, Zhan, Peng¹, zhanpeng1982@sdu.edu.cn

Source: Advanced Science; 11/20/2024, Vol. 11 Issue 43, p1-19, 19p

Miniaturized Modular Click Chemistry‐enabled Rapid Discovery of Unique SARS‐CoV‐2 M^pro Inhibitors With Robust Potency and Drug‐like Profile.

Authors: Yang, Mianling, Lee, Myoung Kyu, Gao, Shenghua, Song, Letian, Jang, Hye‐Yeon, Jo, Inseong, Yang, Chun‐Chiao, Sylvester, Katharina, Ko, Chunkyu, Wang, Shuo, Ye, Bing, Tang, Kai, Li, Junyi, Gu, Manyu, Müller, Christa E., Sträter, Norbert, Liu, Xinyong, Kim, Meehyein, Zhan, Peng

Source: Advanced Science; 11/20/2024, Vol. 11 Issue 43, p1-19, 19p

Subject Terms: CHEMICAL libraries, CLICK chemistry, CYTOTOXINS, SARS-CoV-2 Omicron variant, ANTIVIRAL agents

Comparative Analysis of the Antiviral Effects Mediated by Type I and III Interferons in Hepatitis B Virus–Infected Hepatocytes

Authors: Bockmann, Jan-Hendrik, Stadler, Daniela, Xia, Yuchen, Ko, Chunkyu, Wettengel, Jochen M., zur Wiesch, Julian Schulze, Dandri, Maura, Protzer, Ulrike

Source: The Journal of Infectious Diseases, 2019 Aug . 220(4), 567-577.

Access URL: https://www.jstor.org/stable/26758743

Hepatitis B virus genome recycling and de novo secondary infection events maintain stable cccDNA levels

Authors: Ko, Chunkyu, Chakraborty, Anindita, Chou, Wen-Min, Hasreiter, Julia, Wettengel, Jochen M., Stadler, Daniela, Bester, Romina, Asen, Theresa, Zhang, Ke, Wisskirchen, Karin, McKeating, Jane A., Ryu, Wang-Shick, Protzer, Ulrike

Source: In Journal of Hepatology December 2018 69(6):1231-1241

SARS-CoV-2 productively infects human hepatocytes and induces cell death

Authors: Cheng, Cho-Chin, Ko, Chunkyu, Ambike, Shubhankar, Sacherl, Julia, Velkov, Stoyan, Liao, Bo-Hung, Bester, Romina, Gültan, Merve, Jakwerth, Constanze, Schmidt-Weber, Carsten, Bugert, Joachim, Wölfel, Roman, Grass, Vincent, Essbauer, Sandra, Keppler, Oliver, Mogler, Carolin, Vondran, Florian, Pichlmair, Andreas, Protzer, Ulrike

Source: Journal of hepatology. 78(S1):S945-S946

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195501112.0x000001&indx=1&recIds=ETOCvdc_100195501112.0x000001

Novel viral and host targets to cure hepatitis B

Authors: Ko, Chunkyu, Michler, Thomas, Protzer, Ulrike

Source: In Current Opinion in Virology June 2017 24:38-45

No Remdesivir Resistance Observed in the Phase 3 Severe and Moderate COVID-19 SIMPLE Trials.

Authors: Hedskog, Charlotte, Spinner, Christoph D., Protzer, Ulrike, Hoffmann, Dieter, Ko, Chunkyu, Gottlieb, Robert L., Askar, Medhat, Roestenberg, Meta, de Vries, Jutte J. C., Carbo, Ellen C., Martin, Ross, Li, Jiani, Han, Dong, Rodriguez, Lauren, Parvangada, Aiyappa, Perry, Jason K., Ferrer, Ricard, Antón, Andrés, Andrés, Cristina, Casares, Vanessa

Source: Viruses (1999-4915); Apr2024, Vol. 16 Issue 4, p546, 14p

Subject Terms: REMDESIVIR, CLINICAL trials, OXYGEN saturation, COVID-19 treatment, VIRAL load

Interferon‐induced degradation of the persistent hepatitis B virus cccDNA form depends on ISG20

Authors: Stadler, Daniela, Kächele, Martin, Jones, Alisha N, Hess, Julia, Urban, Christian, Schneider, Jessica, Xia, Yuchen, Oswald, Andreas, Nebioglu, Firat, Bester, Romina, Lasitschka, Felix, Ringelhan, Marc, Ko, Chunkyu, Chou, Wen‐Min, Geerlof, Arie, Klundert, Maarten A, Wettengel, Jochen M, Schirmacher, Peter, Heikenwälder, Mathias, Schreiner, Sabrina, Bartenschlager, Ralf, Pichlmair, Andreas, Sattler, Michael, Unger, Kristian, Protzer, Ulrike

Source: EMBO reports. 22(6)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100123658303.0x000001&indx=1&recIds=ETOCvdc_100123658303.0x000001

Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques

Authors: Burwitz, Benjamin, Wettengel, Jochen, Mück-Häusl, Martin, Ringelhan, Marc, Ko, Chunkyu, Festag, Marvin, Hammond, Katherine, Northrup, Mina, Bimber, Benjamin, Jacob, Thomas, Reed, Jason, Norris, Reed, Park, Byung, Moller-Tank, Sven, Esser, Knud, Greene, Justin, Wu, Helen, Abdulhaqq, Shaheed, Webb, Gabriela, Sutton, William, Klug, Alex, Swanson, Tonya, Legasse, Alfred, Vu, Tania, Asokan, Aravind, Haigwood, Nancy, Protzer, Ulrike, Sacha, Jonah

Source: Nature communications. 8(1):1-10

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100099944718.0x000001&indx=1&recIds=ETOCvdc_100099944718.0x000001

Analyses of HBV cccDNA Quantification and Modification

Authors: Xia, Yuchen, Stadler, Daniela, Ko, Chunkyu, Protzer, Ulrike

Source: Methods in molecular biology. 1540:59-72

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN609433927&indx=1&recIds=ETOCRN609433927

Synchronised infection identifies early rate‐limiting steps in the hepatitis B virus life cycle.

Authors: Chakraborty, Anindita^1,2 (AUTHOR), Ko, Chunkyu¹ (AUTHOR), Henning, Christin¹ (AUTHOR), Lucko, Aaron¹ (AUTHOR), Harris, James M.³ (AUTHOR), Chen, Fuwang¹ (AUTHOR), Zhuang, Xiaodong³ (AUTHOR), Wettengel, Jochen M.¹ (AUTHOR), Roessler, Stephanie⁴ (AUTHOR), Protzer, Ulrike^1,2,5 (AUTHOR), McKeating, Jane A.³ (AUTHOR) jane.mckeating@ndm.ox.ac.uk

Source: Cellular Microbiology. Dec2020, Vol. 22 Issue 12, p1-13. 13p.

Subject Terms: *HEPATITIS B virus, *PARTICLE dynamics, *DNA viruses, *CELL culture, *CIRCULAR RNA

Blocking sense‐strand activity improves potency, safety and specificity of anti‐hepatitis B virus short hairpin RNA

Authors: Michler, Thomas, Große, Stefanie, Mockenhaupt, Stefan, Röder, Natalie, Stückler, Ferdinand, Knapp, Bettina, Ko, Chunkyu, Heikenwalder, Mathias, Protzer, Ulrike, Grimm, Dirk

Source: EMBO molecular medicine. 8(9):1082-1098

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186098857.0x000001&indx=1&recIds=ETOCvdc_100186098857.0x000001

A New Regulatory Mechanism of NF-κB Activation by I-κBβ in Cancer Cells

Authors: Kim, Jung Mo, Voll, Reinhard E., Ko, Chunkyu, Kim, Dae-Seok, Park, Kang-Seo, Kim, Soo-Youl

Source: In Journal of Molecular Biology 26 December 2008 384(4):756-765

Quantification of the hepatitis B virus cccDNA: evidence-based guidelines for monitoring the key obstacle of HBV cure

Authors: Allweiss, Lena, Testoni, Barbara, Yu, Mei, Lucifora, Julie, Ko, Chunkyu, Qu, Bingqian, Lu¨tgehetmann, Marc, Guo, Haitao, Urban, Stephan, Fletcher, Simon P, Protzer, Ulrike, Levrero, Massimo, Zoulim, Fabien, Dandri, Maura

Source: Gut; 2023, Vol. 72 Issue: 5 p972-983, 12p

THU-256 - SARS-CoV-2 productively infects human hepatocytes and induces cell death

Authors: Cheng, Cho-Chin, Ko, Chunkyu, Ambike, Shubhankar, Sacherl, Julia, Velkov, Stoyan, Liao, Bo-Hung, Bester, Romina, Gültan, Merve, Jakwerth, Constanze, Schmidt-Weber, Carsten, Bugert, Joachim, Wölfel, Roman, Grass, Vincent, Essbauer, Sandra, Keppler, Oliver, Mogler, Carolin, Vondran, Florian, Pichlmair, Andreas, Protzer, Ulrike

Source: In Journal of Hepatology June 2023 78 Supplement 1:S945-S946

Targeting genomic SARS-CoV-2 RNA with siRNAs allows efficient inhibition of viral replication and spread.

Authors: Ambike, Shubhankar, Cheng, Cho-Chin, Feuerherd, Martin, Velkov, Stoyan, Baldassi, Domizia, Afridi, Suliman Qadir, Porras-Gonzalez, Diana, Wei, Xin, Hagen, Philipp, Kneidinger, Nikolaus, Stoleriu, Mircea Gabriel, Grass, Vincent, Burgstaller, Gerald, Pichlmair, Andreas, Merkel, Olivia M, Ko, Chunkyu, Michler, Thomas

Source: Nucleic Acids Research; 1/11/2022, Vol. 50 Issue 1, p333-349, 17p