Blocking the SIRPα-CD47 axis promotes macrophage phagocytosis of exosomes derived from visceral adipose tissue and improves inflammation and metabolism in mice.

Authors: Lin, Yun-kai^1,2 (AUTHOR), Pan, Yu-fei² (AUTHOR), Jiang, Tian-yi² (AUTHOR), Chen, Yi-bin² (AUTHOR), Shang, Tai-yu² (AUTHOR), Xu, Meng-you² (AUTHOR), Feng, Hui-bo² (AUTHOR), Ma, Yun-han¹ (AUTHOR), Tan, Ye-xiong^1,2 (AUTHOR), Wang, Hong-yang^1,2,3 (AUTHOR) hywangk@vip.sina.com, Dong, Li-wei^1,2 (AUTHOR) dlw@smmu.edu.cn

Source: Journal of Biomedical Science. 2/28/2025, Vol. 32 Issue 1, p1-25. 25p.

Subject Terms: *WHITE adipose tissue, *KNOCKOUT mice, *MEDICAL sciences, *ADIPOSE tissues, *METABOLIC disorders

Insights into the role of hnRNPK in spermatogenesis via the piRNA pathway.

Authors: Xu, Haixia^1,2 (AUTHOR), Guo, Jiahua¹ (AUTHOR), Huang, Yueru¹ (AUTHOR), Zhang, Mengjia¹ (AUTHOR), Wang, Yuxi¹ (AUTHOR), Xia, Lianren¹ (AUTHOR), Cheng, Xiaofang^1,2 (AUTHOR), Meng, Tiantian^1,2 (AUTHOR), Hao, Ruijie^1,2 (AUTHOR), Wei, Xuefeng^1,2 (AUTHOR), Li, Cencen^1,2 (AUTHOR) licencen@xynu.edu.cn, Zhang, Pengpeng^1,2 (AUTHOR) ppzhang@xynu.edu.cn, Xu, Yongjie^1,2 (AUTHOR) xyj@xynu.edu.cn

Source: Scientific Reports. 2/22/2025, Vol. 15 Issue 1, p1-14. 14p.

Subject Terms: *KNOCKOUT mice, *CYTOLOGY, *FLUORESCENCE in situ hybridization, *LIFE sciences, *SPERMATOGENESIS, *PROTEOMICS, *MALE sterility in plants

Mint3 as a Molecular Target Activated in the Early Stage of Hepatocarcinogenesis.

Authors: Nishitani, Masaki¹ (AUTHOR), Okada, Hikari^1,2 (AUTHOR), Nio, Kouki¹ (AUTHOR), Hayashi, Tomoyuki^1,2 (AUTHOR), Terashima, Takeshi¹ (AUTHOR), Iida, Noriho¹ (AUTHOR), Shimakami, Tetsuro¹ (AUTHOR), Takatori, Hajime¹ (AUTHOR), Honda, Masao¹ (AUTHOR), Kaneko, Shuichi¹ (AUTHOR), Sakamoto, Takeharu² (AUTHOR), Yamashita, Taro¹ (AUTHOR) taroy62m@staff.kanazawa-u.ac.jp

Source: International Journal of Molecular Sciences. Feb2025, Vol. 26 Issue 4, p1430. 15p.

Subject Terms: *KNOCKOUT mice, *DRUG target, *HEPATOCELLULAR carcinoma, *TUMOR growth, *GENETIC regulation

Impaired cognitive function and decreased monoamine neurotransmitters in the DNAJC12 gene knockout mouse model.

Authors: Wang, Shunan^1,2,3 (AUTHOR), Shen, Ming³ (AUTHOR), Pang, Bo^1,2,3 (AUTHOR), Zhou, Bo⁴ (AUTHOR), Yuan, Yuan^1,2,3 (AUTHOR), Lu, Mei⁵ (AUTHOR), Deng, Xiangling^1,2,3 (AUTHOR), Yang, Min^1,2,3 (AUTHOR), Liu, Shufang³ (AUTHOR), Wang, Qiong^1,2,3 (AUTHOR), Xue, Mei^1,2,3 (AUTHOR), Xia, Qisheng⁶ (AUTHOR) xiaqs2002@163.com, Zhang, Zhixin² (AUTHOR) zhangzhixin032@163.com

Source: Orphanet Journal of Rare Diseases. 2/8/2025, Vol. 20 Issue 1, p1-12. 12p.

Subject Terms: *AMINO acid metabolism disorders, *KNOCKOUT mice, *GENE expression, *GENE knockout, *TRYPTOPHAN hydroxylase

Compensatory synaptotagmin-11 expression conceals parkinson's disease-like phenotypes in parkin knockout mice.

Authors: Dong, Nan^1,2,3 (AUTHOR), Xie, Zhenli¹ (AUTHOR), Wei, Anqi¹ (AUTHOR), Yang, Yuxin⁴ (AUTHOR), Deng, Yongning³ (AUTHOR), Cheng, Xu² (AUTHOR), Wang, Bianbian¹ (AUTHOR), Chen, Yang¹ (AUTHOR), Gu, Yuhao¹ (AUTHOR), Yao, Jingyu¹ (AUTHOR), Qin, Yuhao² (AUTHOR), Zheng, Chaowen¹ (AUTHOR), Zhang, Xi⁵ (AUTHOR), Zhang, Yuqing⁵ (AUTHOR), Kang, Xinjiang^2,4 (AUTHOR), Chen, Guoqing⁶ (AUTHOR) 18844191869@163.com, Qu, Qiumin³ (AUTHOR) quqiumin@126.com, Wang, Changhe^1,2,3 (AUTHOR) changhewang@xjtu.edu.cn, Xu, Huadong¹ (AUTHOR) hdxu2022@xjtu.edu.cn

Source: Cell Communication & Signaling. 2/3/2025, Vol. 23 Issue 1, p1-12. 12p.

Subject Terms: *PARKINSON'S disease, *KNOCKOUT mice, *SUBSTANTIA nigra, *PARKIN (Protein), *TRANSGENIC mice, *MEDICAL sciences

Progesterone Promotes Anti-Anxiety/Depressant-like Behavior and Trophic Actions of BDNF in the Hippocampus of Female Nuclear Progesterone Receptor, but Not 5α-Reductase, Knockout Mice.

Authors: Frye, Cheryl A.^1,2 (AUTHOR) cheryl.a.frye@gmail.com, Cleveland, Daina M.¹ (AUTHOR) anjalis13@berkeley.edu, Sadarangani, Anjali¹ (AUTHOR) torgersen.jennifer@gmail.com, Torgersen, Jennifer K.^1,2 (AUTHOR)

Source: International Journal of Molecular Sciences. Feb2025, Vol. 26 Issue 3, p1173. 21p.

Subject Terms: *BRAIN-derived neurotrophic factor, *KNOCKOUT mice, *PROGESTATIONAL hormones, *PREGNANOLONE, *PROGESTERONE, *AMYGDALOID body, *ESTRUS

Systematic ocular phenotyping of 8,707 knockout mouse lines identifies genes associated with abnormal corneal phenotypes.

Authors: Vo, Peter¹ (AUTHOR), Imai-Leonard, Denise M.² (AUTHOR), Yang, Benjamin³ (AUTHOR), Briere, Andrew⁴ (AUTHOR), Shao, Andy⁵ (AUTHOR), Casanova, M. Isabel⁶ (AUTHOR), Adams, David⁷ (AUTHOR), Amano, Takanori⁸ (AUTHOR), Amarie, Oana⁹ (AUTHOR), Berberovic, Zorana¹⁰ (AUTHOR), Bower, Lynette¹¹ (AUTHOR), Braun, Robert¹² (AUTHOR), Brown, Steve¹³ (AUTHOR), Burrill, Samantha¹² (AUTHOR), Cho, Soo Young¹⁴ (AUTHOR), Clementson-Mobbs, Sharon¹⁵ (AUTHOR), D'Souza, Abigail¹⁰ (AUTHOR), Dickinson, Mary¹⁶ (AUTHOR), Eskandarian, Mohammad¹⁰ (AUTHOR), Flenniken, Ann M.¹⁰ (AUTHOR)

Source: BMC Genomics. 1/20/2025, Vol. 26 Issue 1, p1-11. 11p.

Subject Terms: *CORNEAL dystrophies, *KNOCKOUT mice, *LIFE sciences, *HUMAN phenotype, *PROTEIN analysis

Inflammatory adhesion mediates myocardial segmental necroptosis induced by mixed lineage kinase domain-like protein in acute myocardial infarction.

Authors: Wei, Lijiang¹ (AUTHOR), Wan, Naifu¹ (AUTHOR), Zhu, Wentong¹ (AUTHOR), Liu, Chenchen¹ (AUTHOR), Chen, Zeyu¹ (AUTHOR), Rong, Wuwei¹ (AUTHOR), Zhang, Lujun² (AUTHOR), Xie, Meifeng² (AUTHOR), Qin, Yueqi³ (AUTHOR), Sun, Ting⁴ (AUTHOR) beibeisun2008@163.com, Jing, Qing² (AUTHOR) qjing@sinh.ac.cn, Lyu, Ankang¹ (AUTHOR) lvankangrj@163.com

Source: Cell Communication & Signaling. 1/17/2025, Vol. 23 Issue 1, p1-19. 19p.

Subject Terms: *KNOCKOUT mice, *MYOCARDIAL injury, *LABORATORY mice, *CORONARY arteries, *PROTEIN kinases

Correction to: PHARC syndrome: an overview.

Authors: Harutyunyan, Lusine^1,2,3 (AUTHOR), Callaerts, Patrick¹ (AUTHOR), Vermeer, Sascha¹ (AUTHOR) sascha.vermeer@uzleuven.be

Source: Orphanet Journal of Rare Diseases. 1/8/2025, Vol. 20 Issue 1, p1-4. 4p.

Subject Terms: *PHOSPHATIDYLSERINES, *KNOCKOUT mice, *LIPIDS, *MICE, *SPECIES

The Role of Endogenous Beta-Endorphin and Enkephalins in the Crosstalk Between Ethanol and Morphine.

Authors: Tseng, Andy¹ (AUTHOR) tsenga@westernu.edu, Ahmad, Syed Muzzammil¹ (AUTHOR), Hamid, Abdul¹ (AUTHOR), Lutfy, Kabirullah¹ (AUTHOR) klutfy@westernu.edu

Source: Pharmaceuticals (14248247). Jan2025, Vol. 18 Issue 1, p107. 14p.

Subject Terms: *ENKEPHALINS, *KNOCKOUT mice, *OPIOID receptors, *MORPHINE, *MICE, *NARCOTICS, *OPIOID peptides, *NALTREXONE

Intratesticular creatine maintains spermatogenesis by defining tight junctions.

Authors: Kuribayashi, Sohei^1,2 (AUTHOR), Fukuhara, Shinichiro¹ (AUTHOR) fukuhara@uro.med.osaka-u.ac.jp, Kitakaze, Hiroaki^1,2 (AUTHOR), Tsujimura, Go¹ (AUTHOR), Imanaka, Takahiro¹ (AUTHOR), Ueda, Norichika¹ (AUTHOR), Takezawa, Kentaro¹ (AUTHOR), Ikawa, Masahito² (AUTHOR), Nonomura, Norio¹ (AUTHOR)

Source: Scientific Reports. 12/28/2024, Vol. 14 Issue 1, p1-10. 10p.

Subject Terms: *KNOCKOUT mice, *TIGHT junctions, *SPERM count, *SPERM motility, *REPRODUCTIVE health, *SPERMATOGENESIS

Spop deficiency impairs adipogenesis and promotes thermogenic capacity in mice.

Authors: Li, Qinghe¹ (AUTHOR) liqinghe@caas.cn, Liu, Yuhong¹ (AUTHOR), Wang, Yuanyuan² (AUTHOR), Zhang, Qi¹ (AUTHOR), Zhang, Na¹ (AUTHOR), Song, Danli¹ (AUTHOR), Wang, Fei³ (AUTHOR), Gao, Qianmei¹ (AUTHOR), Chen, Yuxin² (AUTHOR), Zhang, Gaomeng¹ (AUTHOR), Wen, Jie¹ (AUTHOR), Zhao, Guiping¹ (AUTHOR) zhaoguiping@caas.cn, Chen, Li^4,5 (AUTHOR) chenli@zaas.ac.cn, Gao, Yu² (AUTHOR) gaoyu@bbmc.edu.cn

Source: PLoS Genetics. 12/16/2024, Vol. 20 Issue 12, p1-15. 15p.

Subject Terms: *ANIMAL development, *KNOCKOUT mice, *UBIQUITIN ligases, *X chromosome, *BODY weight, *ADIPOGENESIS, *WEIGHT gain

The Promising Potential of Ezh1 Inhibition as a Therapeutic Strategy Against Dengue Infections.

Authors: Liu, Danping^1,2,3,4 (AUTHOR), Tan, Ningxin^1,2,3,4 (AUTHOR), Chi, Peidong^5,6 (AUTHOR), Huang, Junqi^1,2,3,4 (AUTHOR) huangjq@mail.sysu.edu.cn, Melgaço, Juliana (AUTHOR) juliana.melgaco@gmail.com

Source: Journal of Immunology Research. 11/20/2024, Vol. 2024, p1-23. 23p.

Subject Terms: *GENE expression, *KNOCKOUT mice, *GENE knockout, *DENGUE viruses, *BONE marrow

Tlx Promotes Stroke-Induced Neurogenesis and Neuronal Repair in Young and Aged Mice.

Authors: Khan, Dilaware¹ (AUTHOR), Bock, Dagmar² (AUTHOR), Liu, Hai-Kun³ (AUTHOR) l.haikun@dkfz.de, Muhammad, Sajjad^1,4 (AUTHOR) sajjad.muhammad@med.uni-duesseldorf.de

Source: International Journal of Molecular Sciences. Nov2024, Vol. 25 Issue 22, p12440. 12p.

Subject Terms: *NEURAL stem cells, *KNOCKOUT mice, *STROKE, *GENE expression, *PROGENITOR cells, *DEVELOPMENTAL neurobiology

Tissue‐specific functions of MSCs are linked to homeostatic muscle maintenance and alter with aging.

Authors: Kurosawa, Tamaki¹ (AUTHOR), Ikemoto‐Uezumi, Madoka² (AUTHOR), Yoshimoto, Yuki³ (AUTHOR), Minato, Keitaro⁴ (AUTHOR), Kaji, Noriyuki⁵ (AUTHOR), Chaen, Takashi¹ (AUTHOR), Hase, Eiji⁶ (AUTHOR), Minamikawa, Takeo⁶ (AUTHOR), Yasui, Takeshi⁷ (AUTHOR), Horiguchi, Kazuhide⁸ (AUTHOR), Iino, Satoshi⁹ (AUTHOR), Hori, Masatoshi¹ (AUTHOR) horimasa@g.ecc.u‐tokyo.ac.jp, Uezumi, Akiyoshi² (AUTHOR) uezumi@bioreg.kyushu‐u.ac.jp

Source: Aging Cell. Nov2024, Vol. 23 Issue 11, p1-17. 17p.

Subject Terms: *STROMAL cells, *KNOCKOUT mice, *MUSCLE mass, *PHENOTYPES, *HETEROGENEITY

Elucidation of DPP‐4 involvement in systemic distribution and renal reabsorption of linagliptin by PBPK modeling with a cluster Gauss–Newton method.

Authors: Nakamura, Ryo^1,2 (AUTHOR), Yoshikado, Takashi¹ (AUTHOR) takashi.yoshikado@yok.hamayaku.ac.jp, Aoki, Yasunori³ (AUTHOR), Sugiyama, Yuichi^3,4 (AUTHOR), Chiba, Koji¹ (AUTHOR)

Source: CTS: Clinical & Translational Science. Oct2024, Vol. 17 Issue 10, p1-14. 14p.

Subject Terms: *ORAL drug administration, *KNOCKOUT mice, *INTRAVENOUS therapy, *AUTORADIOGRAPHY, *LINAGLIPTIN, *PEPTIDASE

Knock-Out of IKKepsilon Ameliorates Atherosclerosis and Fatty Liver Disease by Alterations of Lipid Metabolism in the PCSK9 Model in Mice.

Authors: Weiss, Ulrike¹ (AUTHOR) weiss-ulrike@gmx.de, Mungo, Eleonora¹ (AUTHOR) mungo@med.uni-frankfurt.de, Haß, Michelle¹ (AUTHOR) hass@med.uni-frankfurt.de, Benning, Denis¹ (AUTHOR) benning@med.uni-frankfurt.de, Gurke, Robert^1,2 (AUTHOR) gurke@med.uni-frankfurt.de, Hahnefeld, Lisa^1,2 (AUTHOR) hahnefeld@med.uni-frankfurt.de, Dorochow, Erika¹ (AUTHOR) geisslinger@em.uni-frankfurt.de, Schlaudraff, Jessica³ (AUTHOR) schlaudraff@med.uni-frankfurt.de, Schmid, Tobias⁴ (AUTHOR) t.schmid@biochem.uni-frankfurt.de, Kuntschar, Silvia⁴ (AUTHOR) silvia.kuntschar@gmail.com, Meyer, Sofie⁴ (AUTHOR) s.meyer@biochem.uni-frankfurt.de, Medert, Rebekka⁵ (AUTHOR) rebekka.medert@pharma.uni-heidelberg.de, Freichel, Marc⁵ (AUTHOR) marc.freichel@pharma.uni-heidelberg.de, Geisslinger, Gerd^1,2 (AUTHOR), Niederberger, Ellen^1,2 (AUTHOR) e.niederberger@em.uni-frankfurt.de

Source: International Journal of Molecular Sciences. Oct2024, Vol. 25 Issue 19, p10721. 20p.

Subject Terms: *FATTY liver, *KNOCKOUT mice, *MONOUNSATURATED fatty acids, *ATHEROSCLEROTIC plaque, *LIPID metabolism

Correction: Hao et al. Enhanced Chemoprevention of Prostate Cancer by Combining Arctigenin with Green Tea and Quercetin in Prostate-Specific Phosphatase and Tensin Homolog Knockout Mice. Biomolecules 2024, 14 , 105.

Authors: Hao, Qiongyu^1,2 (AUTHOR) qiongyuhao@cdrewu.edu, Henning, Susanne M.³ (AUTHOR) shenning@mednet.ucla.edu, Magyar, Clara E.⁴ (AUTHOR) cmagyar@mednet.ucla.edu, Said, Jonathan⁴ (AUTHOR) jsaid@mednet.ucla.edu, Zhong, Jin^5,6 (AUTHOR) jin.zhong@va.gov, Rettig, Matthew B.⁷ (AUTHOR) mrettig@mednet.ucla.edu, Vadgama, Jaydutt V.^1,2 (AUTHOR) jayvadgama@cdrewu.edu, Wang, Piwen^1,3 (AUTHOR) piwenwang@cdrewu.edu

Source: Biomolecules (2218-273X). Feb2025, Vol. 15 Issue 2, p160. 3p.

Subject Terms: *PTEN protein, *KNOCKOUT mice, *DRINKING water, *BODY weight, *CANCER chemoprevention

Keratinocyte derived extracellular vesicles mediated crosstalk between epidermis and dermis in UVB-induced skin inflammation.

Authors: Li, Yubin^1,2 (AUTHOR), Baniel, Avital^1,2 (AUTHOR), Diaz, DeAnna^1,2 (AUTHOR), Ogawa-Momohara, Mariko^1,2 (AUTHOR), Ricco, Cristina^1,2 (AUTHOR), Eldaboush, Ahmed^1,2 (AUTHOR), Bashir, Muhammad^1,2 (AUTHOR), Sharma, Meena^1,2 (AUTHOR), Liu, Ming-Lin^1,2 (AUTHOR), Werth, Victoria P.^1,2 (AUTHOR) Victoria.Werth@pennmedicine.upenn.edu

Source: Cell Communication & Signaling. 9/30/2024, Vol. 22 Issue 1, p1-13. 13p.

Subject Terms: *KNOCKOUT mice, *EXTRACELLULAR vesicles, *SKIN inflammation, *KERATINOCYTES, *DERMIS, *IRRADIATION, KERATINOCYTE differentiation

Threonine Phosphorylation and the Yin and Yang of STAT1: Phosphorylation-Dependent Spectrum of STAT1 Functionality in Inflammatory Contexts.

Authors: Elbrashy, Maha M.^1,2 (AUTHOR) mahahosny36@ifrec.osaka-u.ac.jp, Metwally, Hozaifa¹ (AUTHOR) hozaifa1@ifrec.osaka-u.ac.jp, Sakakibara, Shuhei^1,3 (AUTHOR), Kishimoto, Tadamitsu¹ (AUTHOR) hozaifa1@ifrec.osaka-u.ac.jp

Source: Cells (2073-4409). Sep2024, Vol. 13 Issue 18, p1531. 14p.

Subject Terms: *KNOCKOUT mice, *AUTOIMMUNE diseases, *PHOSPHORYLATION, *MEDICAL model, *INTERFERONS, *TYPE I interferons, *THREONINE