The PNUTS phosphatase complex controls transcription pause release

Authors: Kelley, Jessica R. ^{1, 4}, Dimitrova, Emilia ^{1, 4, ∗}, Maciuszek, Maciej ¹, Nguyen, Hieu T. ², Szczurek, Aleksander T. ¹, Hughes, Amy L. ¹, Blackledge, Neil P. ¹, Kettenbach, Arminja N. ^{2, 3}, Klose, Robert J. ^{1, 5, ∗∗}

Source: In Molecular Cell 19 December 2024 84(24):4843-4861

BAP1 constrains pervasive H2AK119ubl to control the transcriptional potential of the genome

Authors: Fursova, Nadezda A., Turberfield, Anne H., Blackledge, Neil P., Findlater, Emma L., Lastuvkova, Anna, Huseyin, Miles K., Dobrinić, Paula, Klose, Robert J.

Source: Genes & development. 35(9/10):749-770

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN626583427&indx=1&recIds=ETOCRN626583427

Understanding the interplay between CpG island-associated gene promoters and H3K4 methylation

Authors: Hughes, Amy L., Kelley, Jessica R., Klose, Robert J.

Source: In BBA - Gene Regulatory Mechanisms August 2020 1863(8)

Analysis of Genome Architecture during SCNT Reveals a Role of Cohesin in Impeding Minor ZGA

Authors: Zhang, Ke, Wu, Dan-Ya, Zheng, Hui, Wang, Yao, Sun, Qiao-Ran, Liu, Xin, Wang, Li-Yan, Xiong, Wen-Jing, Wang, Qiujun, Rhodes, James D.P., Xu, Kai, Li, Lijia, Lin, Zili, Yu, Guang, Xia, Weikun, Huang, Bo, Du, Zhenhai, Yao, Yao, Nasmyth, Kim A., Klose, Robert J., Miao, Yi-Liang, Xie, Wei

Source: In Molecular Cell 16 July 2020 79(2):234-250

Recycling of modified H2A-H2B provides short-term memory of chromatin states

Authors: Flury, Valentin, Reverón-Gómez, Nazaret, Alcaraz, Nicolas, Stewart-Morgan, Kathleen R., Wenger, Alice, Klose, Robert J., Groth, Anja

Source: Cell. 186(5):1050-1065.e19

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186492589.0x000001&indx=1&recIds=ETOCvdc_100186492589.0x000001

PRC1 Catalytic Activity Is Central to Polycomb System Function

Authors: Blackledge, Neil P., Fursova, Nadezda A., Kelley, Jessica R., Huseyin, Miles K., Feldmann, Angelika, Klose, Robert J.

Source: In Molecular Cell 20 February 2020 77(4):857-874

Cohesin Disrupts Polycomb-Dependent Chromosome Interactions in Embryonic Stem Cells

Authors: Rhodes, James D.P., Feldmann, Angelika, Hernández-Rodríguez, Benjamín, Díaz, Noelia, Brown, Jill M., Fursova, Nadezda A., Blackledge, Neil P., Prathapan, Praveen, Dobrinic, Paula, Huseyin, Miles K., Szczurek, Aleksander, Kruse, Kai, Nasmyth, Kim A., Buckle, Veronica J., Vaquerizas, Juan M., Klose, Robert J.

Source: In Cell Reports 21 January 2020 30(3):820-835

Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression

Authors: Fursova, Nadezda A., Blackledge, Neil P., Nakayama, Manabu, Ito, Shinsuke, Koseki, Yoko, Farcas, Anca M., King, Hamish W., Koseki, Haruhiko, Klose, Robert J.

Source: In Molecular Cell 6 June 2019 74(5):1020-1036

The Polycomb system sustains promoters in a deep OFF state by limiting pre-initiation complex formation to counteract transcription

Authors: Szczurek, Aleksander T., Dimitrova, Emilia, Kelley, Jessica R., Blackledge, Neil P., Klose, Robert J.

Source: Nature Cell Biology; October 2024, Vol. 26 Issue: 10 p1700-1711, 12p

Distinct contributions of DNA methylation and histone acetylation to the genomic occupancy of transcription factors

Authors: Cusack, Martin, King, Hamish W., Spingardi, Paolo, Kessler, Benedikt M., Klose, Robert J., Kriaucionis, Skirmantas

Source: Genome research. 30(10):1393-1406

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN624968072&indx=1&recIds=ETOCRN624968072

Getting under the skin of Polycomb-dependent gene regulation

Authors: Blackledge, Neil P., Klose, Robert J.

Source: Genes & development. 35(5/6):301-303

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN625744499&indx=1&recIds=ETOCRN625744499

The SET1 Complex Selects Actively Transcribed Target Genes via Multivalent Interaction with CpG Island Chromatin

Authors: Brown, David A., Di Cerbo, Vincenzo, Feldmann, Angelika, Ahn, Jaewoo, Ito, Shinsuke, Blackledge, Neil P., Nakayama, Manabu, McClellan, Michael, Dimitrova, Emilia, Turberfield, Anne H., Long, Hannah K., King, Hamish W., Kriaucionis, Skirmantas, Schermelleh, Lothar, Kutateladze, Tatiana G., Koseki, Haruhiko, Klose, Robert J.

Source: In Cell Reports 5 September 2017 20(10):2313-2327

ATACing DNA Methylation during Differentiation

Authors: Kriaucionis, Skirmantas, Klose, Robert J.

Source: Molecular cell. 77(6):1159-1161

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100100481754.0x000001&indx=1&recIds=ETOCvdc_100100481754.0x000001

Biochemical Identification of Nonmethylated DNA by BioCAP-Seq

Authors: Long, Hannah K., Rose, Nathan R., Blackledge, Neil P., Klose, Robert J.

Source: Methods in molecular biology. 1766:15-30

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN615568889&indx=1&recIds=ETOCRN615568889

Polycomb repressive complex 1 shapes the nucleosome landscape but not accessibility at target genes

Authors: King, Hamish W., Fursova, Nadezda A., Blackledge, Neil P., Klose, Robert J.

Source: Genome research. 28(10):1494-1507

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN617618033&indx=1&recIds=ETOCRN617618033

Extensive DNA methylome rearrangement during early lamprey embryogenesis.

Authors: Angeloni, Allegra, Fissette, Skye, Kaya, Deniz, Hammond, Jillian M., Gamaarachchi, Hasindu, Deveson, Ira W., Klose, Robert J., Li, Weiming, Zhang, Xiaotian, Bogdanovic, Ozren

Source: Nature Communications; 3/4/2024, Vol. 15 Issue 1, p1-14, 14p

Subject Terms: GENE rearrangement, LAMPREYS, SEA lamprey, DNA methylation, EMBRYOLOGY, EPIGENOMICS, SPERMATOZOA

MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia

Authors: Kerry, Jon, Godfrey, Laura, Repapi, Emmanouela, Tapia, Marta, Blackledge, Neil P., Ma, Helen, Ballabio, Erica, O'Byrne, Sorcha, Ponthan, Frida, Heidenreich, Olaf, Roy, Anindita, Roberts, Irene, Konopleva, Marina, Klose, Robert J., Geng, Huimin, Milne, Thomas A.

Source: Cell reports. 18(2):482-495

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100059137879.0x000001&indx=1&recIds=ETOCvdc_100059137879.0x000001

Understanding the relationship between DNA methylation and histone lysine methylation

Authors: Rose, Nathan R., Klose, Robert J.

Source: In BBA - Gene Regulatory Mechanisms December 2014 1839(12):1362-1372

Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation

Authors: Blackledge, Neil P., Farcas, Anca M., Kondo, Takashi, King, Hamish W., McGouran, Joanna F., Hanssen, Lars L.P., Ito, Shinsuke, Cooper, Sarah, Kondo, Kaori, Koseki, Yoko, Ishikura, Tomoyuki, Long, Hannah K., Sheahan, Thomas W., Brockdorff, Neil, Kessler, Benedikt M., Koseki, Haruhiko, Klose, Robert J.

Source: In Cell 5 June 2014 157(6):1445-1459

Identifying proteins bound to native mitotic ESC chromosomes reveals chromatin repressors are important for compaction

Authors: Djeghloul, Dounia, Patel, Bhavik, Kramer, Holger, Dimond, Andrew, Whilding, Chad, Brown, Karen, Kohler, Anne-Céline, Feytout, Amelie, Veland, Nicolas, Elliott, James, Bharat, Tanmay A. M., Tarafder, Abul K., Löwe, Jan, Ng, Bee L., Guo, Ya, Guy, Jacky, Huseyin, Miles K., Klose, Robert J., Merkenschlager, Matthias, Fisher, Amanda G.

Source: Nature communications. 11(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100174546693.0x000001&indx=1&recIds=ETOCvdc_100174546693.0x000001