The VLDLR entry receptor is required for the pathogenesis of multiple encephalitic alphaviruses

Authors: Palakurty, Sathvik ^{1, 2, 8}, Raju, Saravanan ^{1, 8}, Sariol, Alan ^{2, 8}, Chong, Zhenlu ², Wagoner, Ngan ², Ma, Hongming ², Zimmerman, Ofer ², Adams, Lucas J. ¹, Carmona, Camille ^{2, 3}, Liu, Zhuoming ³, Fremont, Daved H. ^{1, 3, 4}, Whelan, Sean P.J. ³, Klimstra, William B. ⁵, Diamond, Michael S. ^{1, 2, 3, 6, 7, 9, ∗}

Source: In Cell Reports 22 October 2024 43(10)

Structural and functional basis of VLDLR usage by Eastern equine encephalitis virus

Authors: Adams, Lucas J., Raju, Saravanan, Ma, Hongming, Gilliland, Theron, Jr., Reed, Douglas S., Klimstra, William B., Fremont, Daved H., Diamond, Michael S.

Source: In Cell 18 January 2024 187(2):360-374

Cryo-EM structures of alphavirus conformational intermediates in low pH–triggered prefusion states

Authors: Chen, Chun-Liang, Klose, Thomas, Sun, Chengqun, Kim, Arthur S., Buda, Geeta, Rossmann, Michael G., Diamond, Michael S., Klimstra, William B., Kuhn, Richard J.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2022 Jul . 119(30), 1-10.

Access URL: https://www.jstor.org/stable/27172029

Vertebrate-class-specific binding modes of the alphavirus receptor MXRA8

Authors: Zimmerman, Ofer, Zimmerman, Maxwell I., Raju, Saravanan, Nelson, Christopher A., Errico, John M., Madden, Emily A., Holmes, Autumn C., Hassan, Ahmed O., VanBlargan, Laura A., Kim, Arthur S., Adams, Lucas J., Basore, Katherine, Whitener, Bradley M., Palakurty, Sathvik, Davis-Adams, Hannah G., Sun, Chengqun, Gilliland, Theron, Jr., Earnest, James T., Ma, Hongming, Ebel, Gregory D., Zmasek, Christian, Scheuermann, Richard H., Klimstra, William B., Fremont, Daved H., Diamond, Michael S.

Source: In Cell 26 October 2023 186(22):4818-4833

Transchromosomic bovine-derived anti-SARS-CoV-2 polyclonal human antibodies protects hACE2 transgenic hamsters against multiple variants

Authors: Gilliland, Theron, Dunn, Matthew, Liu, Yanan, Alcorn, Maria D.H., Terada, Yutaka, Vasilatos, Shauna, Lundy, Jeneveve, Li, Rong, Nambulli, Sham, Larson, Deanna, Duprex, Paul, Wu, Hua, Luke, Thomas, Bausch, Christoph, Egland, Kristi, Sullivan, Eddie, Wang, Zhongde, Klimstra, William B.

Source: In iScience 20 October 2023 26(10)

Cryo-EM structure of eastern equine encephalitis virus in complex with heparan sulfate analogues

Authors: Chen, Chun-Liang, Hasan, S. Saif, Klose, Thomas, Sun, Yingyuan, Buda, Geeta, Sun, Chengqun, Klimstra, William B., Rossmann, Michael G.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2020 Apr . 117(16), 8890-8899.

Access URL: https://www.jstor.org/stable/26929658

Therapeutic alphavirus cross-reactive E1 human antibodies inhibit viral egress

Authors: Williamson, Lauren E., Reeder, Kristen M., Bailey, Kevin, Tran, Minh H., Roy, Vicky, Fouch, Mallorie E., Kose, Nurgun, Trivette, Andrew, Nargi, Rachel S., Winkler, Emma S., Kim, Arthur S., Gainza, Christopher, Rodriguez, Jessica, Armstrong, Erica, Sutton, Rachel E., Reidy, Joseph, Carnahan, Robert H., McDonald, W. Hayes, Schoeder, Clara T., Klimstra, William B., Davidson, Edgar, Doranz, Benjamin J., Alter, Galit, Meiler, Jens, Schey, Kevin L., Julander, Justin G., Diamond, Michael S., Crowe, James E., Jr.

Source: In Cell 19 August 2021 184(17):4430-4446

Pan-protective anti-alphavirus human antibodies target a conserved E1 protein epitope

Authors: Kim, Arthur S., Kafai, Natasha M., Winkler, Emma S., Gilliland, Theron C., Jr., Cottle, Emily L., Earnest, James T., Jethva, Prashant N., Kaplonek, Paulina, Shah, Aadit P., Fong, Rachel H., Davidson, Edgar, Malonis, Ryan J., Quiroz, Jose A., Williamson, Lauren E., Vang, Lo, Mack, Matthias, Crowe, James E., Jr., Doranz, Benjamin J., Lai, Jonathan R., Alter, Galit, Gross, Michael L., Klimstra, William B., Fremont, Daved H., Diamond, Michael S.

Source: In Cell 19 August 2021 184(17):4414-4429

Human Antibodies Protect against Aerosolized Eastern Equine Encephalitis Virus Infection

Authors: Williamson, Lauren E., Gilliland, Theron, Jr., Yadav, Pramod K., Binshtein, Elad, Bombardi, Robin, Kose, Nurgun, Nargi, Rachel S., Sutton, Rachel E., Durie, Clarissa L., Armstrong, Erica, Carnahan, Robert H., Walker, Lauren M., Kim, Arthur S., Fox, Julie M., Diamond, Michael S., Ohi, Melanie D., Klimstra, William B., Crowe, James E., Jr.

Source: In Cell 23 December 2020 183(7):1884-1900

Microneedle array delivered recombinant coronavirus vaccines: Immunogenicity and rapid translational development

Authors: Kim, Eun, Erdos, Geza, Huang, Shaohua, Kenniston, Thomas W., Balmert, Stephen C., Carey, Cara Donahue, Raj, V. Stalin, Epperly, Michael W., Klimstra, William B., Haagmans, Bart L., Korkmaz, Emrullah, Falo, Louis D., Jr., Gambotto, Andrea

Source: In eBioMedicine May 2020 55

Cryo-EM Structures of Eastern Equine Encephalitis Virus Reveal Mechanisms of Virus Disassembly and Antibody Neutralization

Authors: Hasan, S. Saif, Sun, Chengqun, Kim, Arthur S., Watanabe, Yasunori, Chen, Chun-Liang, Klose, Thomas, Buda, Geeta, Crispin, Max, Diamond, Michael S., Klimstra, William B., Rossmann, Michael G.

Source: In Cell Reports 11 December 2018 25(11):3136-3147

Vascular permeability in the brain is a late pathogenic event during Rift Valley fever virus encephalitis in rats

Authors: Walters, Aaron W., Kujawa, Michael R., Albe, Joseph R., Reed, Douglas S., Klimstra, William B., Hartman, Amy L.

Source: Virology. 526:173-179

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100117583413.0x000001&indx=1&recIds=ETOCvdc_100117583413.0x000001

Protective antibodies against Eastern equine encephalitis virus bind to epitopes in domains A and B of the E2 glycoprotein

Authors: Kim, Arthur, Austin, S., Gardner, Christina, Zuiani, Adam, Reed, Douglas, Trobaugh, Derek, Sun, Chengqun, Basore, Katherine, Williamson, Lauren, Crowe, James, Slifka, Mark, Fremont, Daved, Klimstra, William, Diamond, Michael

Source: Nature microbiology. 4(1):187-197

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100099947671.0x000001&indx=1&recIds=ETOCvdc_100099947671.0x000001

Human immunoglobulin from transchromosomic bovines hyperimmunized with SARS-CoV-2 spike antigen efficiently neutralizes viral variants

Authors: Liu, Zhuoming, Wu, Hua, Egland, Kristi A., Gilliland, Theron C., Dunn, Matthew D., Luke, Thomas C., Sullivan, Eddie J., Klimstra, William B., Bausch, Christoph L., Whelan, Sean P. J.

Source: Human vaccines & immunotherapeutics. 18(2)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100155260088.0x000001&indx=1&recIds=ETOCvdc_100155260088.0x000001

The expression level of C19MC miRNAs in early pregnancy and in response to viral infection

Authors: Dumont, Tina M.F., Mouillet, Jean-Francois, Bayer, Avaraham, Gardner, Christina L., Klimstra, William B., Wolf, Dana G., Yagel, Simcha, Balmir, Fabiola, Binstock, Anna, Sanfilippo, Joseph S., Coyne, Carolyn B., Larkin, Jacob C., Sadovsky, Yoel

Source: In Placenta May 2017 53:23-29

Alphaviruses suppress host immunity by preventing myeloid cell replication and antagonizing innate immune responses

Authors: Trobaugh, Derek W, Klimstra, William B

Source: In Current Opinion in Virology April 2017 23:30-34

No evidence for enhanced disease with human polyclonal SARS-CoV-2 antibody in the ferret model.

Authors: Reed, Douglas S., McElroy, Anita K., Barbeau, Dominique J., McMillen, Cynthia M., Tilston-Lunel, Natasha L., Nambulli, Shamkumar, Cottle, Emily, Gilliland, Theron C., Rannulu, Hasala, Lundy, Jeneveve, Olsen, Emily L., O'Malley, Katherine J., Xia, Mengying, Hartman, Amy L., Luke, Thomas C., Egland, Kristi, Bausch, Christoph, Wu, Hua, Sullivan, Eddie J., Klimstra, William B.

Source: PLoS ONE; 6/20/2024, Vol. 19 Issue 6, p1-20, 20p

Subject Terms: SARS-CoV-2, FERRET, VIRAL shedding, FEVER, YOUNG adults, WEIGHT loss, IMMUNOGLOBULINS, LUNGS, CORONAVIRUSES

Geographic Terms: CHINA

MicroRNA Regulation of RNA Virus Replication and Pathogenesis

Authors: Trobaugh, Derek W., Klimstra, William B.

Source: In Trends in Molecular Medicine January 2017 23(1):80-93

Mxra8 is a receptor for multiple arthritogenic alphaviruses

Authors: Zhang, Rong, Kim, Arthur, Fox, Julie, Nair, Sharmila, Basore, Katherine, Klimstra, William, Rimkunas, Rebecca, Fong, Rachel, Lin, Hueylie, Poddar, Subhajit, Crowe, James, Doranz, Benjamin, Fremont, Daved, Diamond, Michael

Source: Nature. 557(7706):570-574

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140046557.0x000001&indx=1&recIds=ETOCvdc_100140046557.0x000001

Protective antibodies against Eastern equine encephalitis virus bind to epitopes in domains A and B of the E2 glycoprotein

Authors: Kim, Arthur S., Austin, S. Kyle, Gardner, Christina L., Zuiani, Adam, Reed, Douglas S., Trobaugh, Derek W., Sun, Chengqun, Basore, Katherine, Williamson, Lauren E., Crowe, James E., Slifka, Mark K., Fremont, Daved H., Klimstra, William B., Diamond, Michael S.

Source: Nature microbiology. 4(1):187-197

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130018265.0x000001&indx=1&recIds=ETOCvdc_100130018265.0x000001