Molecular dynamics investigation of deep eutectic solvent structure and properties based on hydrogen bond acceptor variation

Authors: Lane, Jenna N., Klimkowski, Valentine J., Hopkins, Todd A. ^⁎

Source: In Journal of Molecular Liquids 1 April 2025 423

Proteopedia entry: Histone modifying enzymes

Authors: Klimkowski, Valentine J., Macbeth, Mark R.

Source: Biochemistry and molecular biology education. 51(5):586-587

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195118145.0x000001&indx=1&recIds=ETOCvdc_100195118145.0x000001

Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo

Authors: Durham, Timothy B., Toth, James L., Klimkowski, Valentine J., Cao, Julia X.C., Siesky, Angela M., Alexander-Chacko, Jesline, Wu, Ginger Y., Dixon, Jeffrey T., McGee, James E., Wang, Yong, Guo, Sherry Y., Cavitt, Rachel Nicole, Schindler, John, Thibodeaux, Stefan J., Calvert, Nathan A., Coghlan, Michael J., Sindelar, Dana K., Christe, Michael, Kiselyov, Vladislav V., Michael, M. Dodson, Sloop, Kyle W.

Source: In Journal of Biological Chemistry 14 August 2015 290(33):20044-20059

Preparation and biological evaluation of conformationally constrained BACE1 inhibitors

Authors: Winneroski, Leonard L., Schiffler, Matthew A., Erickson, Jon A., May, Patrick C., Monk, Scott A., Timm, David E., Audia, James E., Beck, James P., Boggs, Leonard N., Borders, Anthony R., Boyer, Robert D., Brier, Richard A., Hudziak, Kevin J., Klimkowski, Valentine J., Garcia Losada, Pablo, Mathes, Brian M., Stout, Stephanie L., Watson, Brian M., Mergott, Dustin J.

Source: In Bioorganic & Medicinal Chemistry 1 July 2015 23(13):3260-3268

Proteopedia entry: Structure of complex membrane proteins solved using cryo‐electron microscopy

Authors: Johnson, R. Jeremy, Bassler, Grace, Harris, Emma, Heumann, Ryan, Hillan, Abby, Middlebrook, Carson, Mulawa, Daniel, Neal, Emily, Pomeroy, Julia, Ratz, Lizzy, Ritter, Alyssa, Rowe, Holly, Scheel, Andrew, Skaggs, Shelby, Smith, Harrison, Sullivan, Sam, Summers, Madi, Todd, Maxwell, Villarreal, Marisa, Voyles, Jaelyn, Wells, Rieser, Wisser, Layla, Klimkowski, Valentine J.

Source: Biochemistry and molecular biology education. 49(5):813-814

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130099289.0x000001&indx=1&recIds=ETOCvdc_100130099289.0x000001

Metabolism of LY654322, a Growth Hormone Secretagogue, to an Unusual Diimidazopyridine Metabolite

Authors: Borel, Anthony G. ^*, Jones, Timothy M., Barbuch, Robert J., Jackson, David A., Kulanthaivel, Palaniappan, Mattiuz, Edward, Klimkowski, Valentine J., Wheeler, William J. ¹, Rener, Gregory A.

Source: In Drug Metabolism and Disposition May 2011 39(5):740-749

Inhibition of thrombin activatable fibrinolysis inhibitor by cysteine derivatives

Authors: Do, Yee H., Gifford-Moore, Donetta S., Beight, Douglas W., Rathnachalam, Radhakrishnan, Klimkowski, Valentine J., Warshawsky, Alan M., Lu, Deshun

Source: In Thrombosis Research 2005 116(3):265-271

Anticoagulant agents

Anticoagulant agents

Novel Lipoglycopeptides as Inhibitors of Bacterial Signal Peptidase I

Authors: Kulanthaivel, Palaniappan, Kreuzman, Adam J., Strege, Mark A., Belvo, Matthew D., Smitka, Tim A., Clemens, Matthew, Swartling, James R., Minton, Kristina L., Zheng, Feng, Angleton, Eddie L., Mullen, Deborah, Jungheim, Louis N., Klimkowski, Valentine J., Nicas, Thalia I., Thompson, Richard C., Peng, Sheng-Bin ^‡

Source: In Journal of Biological Chemistry 27 August 2004 279(35):36250-36258

The design of potent, selective, non-covalent, peptide thrombin inhibitors utilizing imidazole as a S1 binding element

Authors: Wiley, Michael R., Weir, Leonard C., Briggs, Steven L., Chirgadze, Nickolay Y., Clawson, David, Gifford-Moore, Donetta S., Schacht, Aaron L., Smith, Gerald F., Vasudevan, Vasu, Zornes, Larry L., Klimkowski, Valentine J.

Source: In Bioorganic & Medicinal Chemistry Letters 1999 9(18):2767-2772

Dibasic benzo[ b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 2: sidechain optimization and demonstration of in vivo efficacy

Authors: Zhang, Minsheng, Bailey, Dianna L., Bastian, Jolie A., Briggs, Stephen L., Chirgadze, Nickolay Y., Clawson, David K., Denney, Michael L., Gifford-Moore, Donetta S., Harper, Richard W., Johnson, Lea M., Klimkowski, Valentine J., Kohn, Todd J., Lin, Ho-Shen, McCowan, Jefferson R., Richett, Michael E., Sall, Daniel J., Smith, Amy J., Smith, Gerald F., Snyder, David W., Takeuchi, Kumiko, Utterback, Barbara G., Yan, Sau-Chi B.

Source: In Bioorganic & Medicinal Chemistry Letters 1999 9(5):775-780

Circularly polarized luminescence of Sm (III) and Eu (III) complexes with chiral ligand (R/S)‐BINAPO.

Authors: Cotter, Daniel¹, Dodder, Spencer¹, Klimkowski, Valentine J.¹, Hopkins, Todd A.¹, tahopkin@butler.edu

Source: Chirality; Apr2019, Vol. 31 Issue 4, p301-311, 11p

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Investigation of the terminal P4 domain in a series of d-phenylglycinamide-based factor Xa inhibitors

Authors: Franciskovich, Jeffry B., Masters, John J., Weber, Wayne W., Klimkowski, Valentine J., Chouinard, Michael, Sipes, Philip R., Johnson, Lea M., Snyder, David W., Chastain, Marcia K., Craft, Trelia J., Towner, Richard D., Gifford-Moore, Donetta S., Froelich, Larry L., Smallwood, Jeffrey K., Foster, Ronald S., Smith, Gerald F., Liebeschuetz, John W., Murray, Christopher W., Young, Stephen C.

Source: In Bioorganic & Medicinal Chemistry Letters 2007 17(24):6910-6913

d-Phenylglycinol-derived non-covalent factor Xa inhibitors: Effect of non-peptidic S4 linkage elements on affinity and anticoagulant activity

Authors: Klimkowski, Valentine J., Watson, Brian M., Wiley, Michael R., Liebeschuetz, John, Franciskovich, Jeffry B., Marimuthu, Jothirajah, Bastian, Jolie A., Sall, Daniel J., Smallwood, Jeffrey K., Chirgadze, Nikolay Y., Smith, Gerald F., Foster, Ronald S., Craft, Trelia, Sipes, Philip, Chastain, Marcia, Sheehan, Scott M.

Source: In Bioorganic & Medicinal Chemistry Letters 2007 17(21):5801-5805

Anthranilamide inhibitors of factor Xa

Authors: Mendel, David, Marquart, Angela L., Joseph, Sajan, Waid, Philip, Yee, Ying K., Tebbe, Anne Louise, Ratz, Andrew M., Herron, David K., Goodson, Theodore, Masters, John J., Franciskovich, Jeffry B., Tinsley, Jennifer M., Wiley, Michael R., Weir, Leonard C., Kyle, Jeffrey A., Klimkowski, Valentine J., Smith, Gerald F., Towner, Richard D., Froelich, Larry L., Buben, John, Craft, Trelia J.

Source: In Bioorganic & Medicinal Chemistry Letters 2007 17(17):4832-4836

Discovery of non-covalent dipeptidyl peptidase IV inhibitors which induce a conformational change in the active site

Authors: Sheehan, Scott M., Mest, Hans-Juergen, Watson, Brian M., Klimkowski, Valentine J., Timm, David E., Cauvin, Annick, Parsons, Stephen H., Shi, Qing, Canada, Emily J., Wiley, Michael R., Ruehter, Gerd, Evers, Britta, Petersen, Soenke, Blaszczak, Larry C., Pulley, Shon R., Margolis, Brandon J., Wishart, Graham N., Renson, Beatrice, Hankotius, Dirk, Mohr, Michael, Zechel, Johann-Christian, Michael Kalbfleisch, J., Dingess-Hammond, Elizabeth A., Boelke, Andre, Weichert, Andreas G.

Source: In Bioorganic & Medicinal Chemistry Letters 2007 17(6):1765-1768

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Identification of Potent andSelective Hydantoin Inhibitorsof Aggrecanase-1 and Aggrecanase-2 That Are Efficaciousin Both Chemical and Surgical Models of Osteoarthritis.

Authors: Durham, Timothy B., Klimkowski, Valentine J., Rito, Christopher J., Marimuthu, Jothirajah, Toth, James L., Liu, Chin, Durbin, Jim D., Stout, Stephanie L., Adams, Lisa, Swearingen, Craig, Lin, Chaohua, Chambers, Mark G., Thirunavukkarasu, Kannan, Wiley, Michael R.

Source: Journal of Medicinal Chemistry; Dec2014, Vol. 57 Issue 24, p10476-10485, 10p