Retrospective observational studies in ultra-rare sarcomas: A consensus paper from the Connective Tissue Oncology Society (CTOS) community of experts on the minimum requirements for the evaluation of activity of systemic treatments

Authors: Stacchiotti, Silvia, Maria Frezza, Anna, Demetri, George D., Blay, Jean-Yves, Bajpai, Jyoti, Baldi, Giacomo G., Baldini, Elizabeth H., Benjamin, Robert S., Bonvalot, Sylvie, Bovée, Judith V.M.G., Callegaro, Dario, Casali, Paolo G., D'Angelo, Sandra P., Davis, Elizabeth J., Dei Tos, Angelo P., Demicco, Elizabeth G., Desai, Jayesh, Dileo, Palma, Eriksson, Mikael, Gelderblom, Hans, George, Suzanne, Gladdy, Rebecca A., Gounder, Mrinal M., Gupta, Abha A., Haas, Rick, Hayes, Andrea, Hohenberger, Peter, Jones, Kevin B., Jones, Robin L., Kasper, Bernd, Kawai, Akira, Kirsch, David G., Kleinerman, Eugenie S., Le Cesne, Axel, Maestro, Roberta, Martin Broto, Javier, Maki, Robert G., Miah, Aisha B., Palmerini, Emanuela, Patel, Shreaskumar R., Raut, Chandrajit P., Razak, Albiruni R.A., Reed, Damon R., Rutkowski, Piotr, Sanfilippo, Roberta G., Sbaraglia, Marta, Schaefer, Inga-Marie, Strauss, Dirk C., Strauss, Sandra J., Tap, William D., Thomas, David M., Trama, Annalisa, Trent, Jonathan C., van der Graaf, Winette T.A., van Houdt, Winan J., von Mehren, Margaret, Wilky, Breelyn A., Fletcher, Christopher D.M., Gronchi, Alessandro, Miceli, Rosalba, Wagner, Andrew J.

Source: In Cancer Treatment Reviews November 2022 110

Nucleus-mitochondria positive feedback loop formed by ERK5 S496 phosphorylation-mediated poly (ADP-ribose) polymerase activation provokes persistent pro-inflammatory senescent phenotype and accelerates coronary atherosclerosis after chemo-radiation

Authors: Kotla, Sivareddy, Zhang, Aijun, Imanishi, Masaki, Ko, Kyung Ae, Lin, Steven H., Gi, Young Jin, Moczygemba, Margie, Isgandarova, Sevinj, Schadler, Keri L., Chung, Caroline, Milgrom, Sarah A., Banchs, Jose, Yusuf, Syed Wamique, Amaya, Diana N., Guo, Huifang, Thomas, Tamlyn N., Shen, Ying H., Deswal, Anita, Herrmann, Joerg, Kleinerman, Eugenie S., Entman, Mark L., Cooke, John P., Schifitto, Giovanni, Maggirwar, Sanjay B., McBeath, Elena, Gupte, Anisha A., Krishnan, Sunil, Patel, Zarana S., Yoon, Yisang, Burks, Jared K., Fujiwara, Keigi, Brookes, Paul S., Le, Nhat-Tu, Hamilton, Dale J., Abe, Jun-ichi

Source: In Redox Biology November 2021 47

Assessment of drug transporters involved in the urinary secretion of [99mTc]dimercaptosuccinic acid

Authors: Kobayashi, Masato, Mizutani, Asuka, Okamoto, Takaki, Muranaka, Yuka, Nishi, Kodai, Nishii, Ryuichi, Shikano, Naoto, Nakanishi, Takeo, Tamai, Ikumi, Kleinerman, Eugenie S., Kawai, Keiichi

Source: In Nuclear Medicine and Biology March-April 2021 94-95:92-97

Exercise intervention decreases acute and late doxorubicin‐induced cardiotoxicity

Authors: Wang, Fei, Chandra, Joya, Kleinerman, Eugenie S.

Source: Cancer medicine. 10(21):7572-7584

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100132963597.0x000001&indx=1&recIds=ETOCvdc_100132963597.0x000001

Bempegaldesleukin (BEMPEG; NKTR‐214) efficacy as a single agent and in combination with checkpoint‐inhibitor therapy in mouse models of osteosarcoma

Authors: Hennessy, Marlene, Wahba, Andrew, Felix, Kumar, Cabrera, Mariella, Segura, Maria Gabriela, Kundra, Vikas, Ravoori, Murali K., Stewart, John, Kleinerman, Eugenie S., Jensen, Vanessa Behrana, Gopalakrishnan, Vidya, Pena, Rhoneil, Quach, Phi, Kim, Grace, Kivimäe, Saul, Madakamutil, Loui, Overwijk, Willem W., Zalevsky, Jonathan, Gordon, Nancy

Source: International journal of cancer. 148(8):1928-1937

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100115429349.0x000001&indx=1&recIds=ETOCvdc_100115429349.0x000001

CD103 + cDC1 Dendritic Cell Vaccine Therapy for Osteosarcoma Lung Metastases.

Authors: Yang, Yuanzheng, Zhou, Yifan, Wang, Jian, Zhou, You, Watowich, Stephanie S., Kleinerman, Eugenie S.

Source: Cancers; Oct2024, Vol. 16 Issue 19, p3251, 19p

Subject Terms: THERAPEUTIC use of antineoplastic agents, OSTEOSARCOMA, LYMPH nodes, BIOLOGICAL models, FLUOROIMMUNOASSAY, RESEARCH funding, T cells, T-test (Statistics), CANCER vaccines, TREATMENT effectiveness, IMMUNE system, MANN Whitney U Test, DESCRIPTIVE statistics, METASTASIS, MICE, CELL lines, SPLEEN, IMMUNOHISTOCHEMISTRY, LUNG tumors, ANIMAL experimentation, GENE expression profiling, ONE-way analysis of variance, STAINS & staining (Microscopy), DATA analysis software, DENDRITIC cells

[131I]MIBG exports via MRP transporters and inhibition of the MRP transporters improves accumulation of [131I]MIBG in neuroblastoma

Authors: Kobayashi, Masato, Mizutani, Asuka, Nishi, Kodai, Muranaka, Yuka, Nishii, Ryuichi, Shikano, Naoto, Nakanishi, Takeo, Tamai, Ikumi, Kleinerman, Eugenie S., Kawai, Keiichi

Source: In Nuclear Medicine and Biology November-December 2020 90-91:49-54

The Fas/FasL Signaling Pathway: Its Role in the Metastatic Process and as a Target for Treating Osteosarcoma Lung Metastases

Authors: Koshkina, Nadya, Yang, Yuanzheng, Kleinerman, Eugenie S.

Source: Advances in experimental medicine and biology. 1258:177-188

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN624599194&indx=1&recIds=ETOCRN624599194

Exosomes: Dynamic Mediators of Extracellular Communication in the Tumor Microenvironment

Authors: Wolf-Dennen, Kerri, Kleinerman, Eugenie S.

Source: Advances in experimental medicine and biology. 1258:189-198

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN624599207&indx=1&recIds=ETOCRN624599207

Anthracycline-Induced Cardiotoxicity: Causes, Mechanisms, and Prevention

Authors: Bhagat, Anchit, Kleinerman, Eugenie S.

Source: Advances in experimental medicine and biology. 1257:181-192

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN624445738&indx=1&recIds=ETOCRN624445738

BMTP-11 is active in preclinical models of human osteosarcoma and a candidate targeted drug for clinical translation

Authors: Lewis, Valerae O., Devarajan, Eswaran, Cardó-Vila, Marina, Thomas, Dafydd G., Kleinerman, Eugenie S., Marchiò, Serena, Sidman, Richard L., Pasqualini, Renata, Arap, Wadih

Source: Proceedings of the National Academy of Sciences of the United States of America, 2017 Jul . 114(30), 8065-8070.

Access URL: https://www.jstor.org/stable/26486155

Early skeletal muscle loss in adolescent and young adult cancer patients treated with anthracycline chemotherapy.

Authors: Wooten, Savannah V., Wang, Fei, Roth, Michael E., Liu, Guanshu, Livingston, J. Andrew, Amini, Behrang, Gilchrist, Susan C., Hildebrandt, Michelle, Kleinerman, Eugenie S.

Source: Cancer Medicine; Nov2023, Vol. 12 Issue 22, p20798-20809, 12p

Subject Terms: SKELETAL muscle, YOUNG adults, CANCER patients, THORACIC vertebrae, SOLEUS muscle

Exosomal communication by metastatic osteosarcoma cells modulates alveolar macrophages to an M2 tumor-promoting phenotype and inhibits tumoricidal functions

Authors: Wolf-Dennen, Kerri, Gordon, Nancy, Kleinerman, Eugenie S.

Source: Oncoimmunology. 9(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100132046413.0x000001&indx=1&recIds=ETOCvdc_100132046413.0x000001

Delta-like ligand 4–Notch signaling regulates bone marrow–derived pericyte/vascular smooth muscle cell formation

Authors: Stewart, Keri Schadler, Zhou, Zhichao, Zweidler-McKay, Patrick, Kleinerman, Eugenie S.

Source: In Blood 13 January 2011 117(2):719-726

Vascular modulation through exercise improves chemotherapy efficacy in Ewing sarcoma

Authors: Morrell, Miriam B. G., Alvarez‐Florez, Claudia, Zhang, Aiqian, Kleinerman, Eugenie S., Savage, Hannah, Marmonti, Enrica, Park, Minjeong, Shaw, Angela, Schadler, Keri L.

Source: Pediatric blood & cancer. 66(9)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100085909982.0x000001&indx=1&recIds=ETOCvdc_100085909982.0x000001

The Histone Deacetylase Inhibitor, MS-275 (Entinostat), Downregulates c-FLIP, Sensitizes Osteosarcoma Cells to FasL, and Induces the Regression of Osteosarcoma Lung Metastases

Authors: Rao-Bindal, Krithi, Koshkina, Nadezhda V., Stewart, John, Kleinerman, Eugenie S.

Source: Current cancer drug targets. 13(4):411-422

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100083474610.0x000001&indx=1&recIds=ETOCvdc_100083474610.0x000001

Aerosol Gemcitabine after Amputation Inhibits Osteosarcoma Lung Metastases but Not Wound Healing.

Authors: Kleinerman, Eugenie S.¹, Yu, Ling², Dao, Jasmine³, Hayes-Jordan, Andrea A.⁴, Lindsey, Brock⁵, Kawedia, Jitesh D.⁶, Stewart, John⁷, Gordon, Nancy¹

Source: Sarcoma. 1/21/2018, p1-12. 12p. 1 Color Photograph, 6 Graphs.

Subject Terms: *THERAPEUTIC use of antimetabolites, *AEROSOLS, *AMPUTATION, *ANIMAL experimentation, *BIOMARKERS, *CANCER relapse, *CELL adhesion molecules, *CELL lines, *CYTOKINES, *GROWTH factors, *IMMUNOHISTOCHEMISTRY, *INTERLEUKINS, *LUNG tumors, *MACROPHAGES, *MAST cells, *METASTASIS, *MICE, *OSTEOSARCOMA, *WOUND healing, *VASCULAR endothelial growth factors

Meet the Editorial Board Member

Authors: Kleinerman, Eugenie S.

Source: Cardiovascular & hematological disorders drug targets. 21(2):87-87

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100138400304.0x000001&indx=1&recIds=ETOCvdc_100138400304.0x000001

Pramlintide: A Novel Therapeutic Approach for Osteosarcoma through Metabolic Reprogramming.

Authors: Yang, Yuanzheng, Peng, Zhanglong, Flores, Elsa R., Kleinerman, Eugenie S.

Source: Cancers; Sep2022, Vol. 14 Issue 17, p4310, 17p

Subject Terms: PROTEIN metabolism, FLOW cytometry, STATISTICAL significance, IN vivo studies, OSTEOSARCOMA, ANIMAL experimentation, WESTERN immunoblotting, ONE-way analysis of variance, HYPOGLYCEMIC agents, METABOLIC reprogramming, APOPTOSIS, TREATMENT effectiveness, T-test (Statistics), CELL proliferation, TUMOR markers, MICE, PANCREATIC hormones, GLYCOLYSIS, CELL death

Doxorubicin-induced cardiotoxicity is mediated by neutrophils through release of neutrophil elastase.

Authors: Bhagat, Anchit, Shrestha, Pradeep, Jeyabal, Prince, Zhanglong Peng, Watowich, Stephanie S., Kleinerman, Eugenie S.

Source: Frontiers in Oncology; 8/10/2022, Vol. 12, p1-14, 14p

Subject Terms: LEUKOCYTE elastase, CARDIOTOXICITY, NEUTROPHILS, KNOCKOUT mice, IMMUNE response