Arimoclomol upregulates expression of genes belonging to the coordinated lysosomal expression and regulation (CLEAR) network

Authors: Shammas, Hadeel ^a, Petersen, Nikolaj H.T. ^b, Klein, Pontus ^c, Koustrup, Anja ^d, Pedersen, Marianne T. ^e, Bie, Anne S. ^f, Mickle, Travis ^a, Fog, Cathrine K. ^g, Jensen, Thomas Kirkegaard ^h, Guenther, Sven ^a

Source: In Molecular Genetics and Metabolism February 2025 144(2)

Antisense Therapy for a Common Corneal Dystrophy Ameliorates TCF4 Repeat Expansion-Mediated Toxicity

Authors: Zarouchlioti, Christina, Sanchez-Pintado, Beatriz, Hafford Tear, Nathaniel J., Klein, Pontus, Liskova, Petra, Dulla, Kalyan, Semo, Ma’ayan, Vugler, Anthony A., Muthusamy, Kirithika, Dudakova, Lubica, Levis, Hannah J., Skalicka, Pavlina, Hysi, Pirro, Cheetham, Michael E., Tuft, Stephen J., Adamson, Peter, Hardcastle, Alison J., Davidson, Alice E.

Source: In The American Journal of Human Genetics 5 April 2018 102(4):528-539

Functions of GDNF/Ret signaling in models of autosomal recessive Parkinson’s disease

Authors: Klein, Pontus

Contributors: Klein, Rüdiger

Availability: http://data.europeana.eu/aggregation/europeana/2048441/item_KLD7UFFN6NZXAQ4J5ZK7JXOSVSLTCQBV

Arimoclomol increases the transcription of lysosomal genes, including NPC1 and NPC2, to facilitate lysosomal function

Authors: Petersen, Nikolaj H.T., Klein, Pontus, Valacca, Cristina, Bie, Anne, Magnoni, Raffaella, Pedersen, Marianne T., Lampp, Andrea C., Fog, Cathrine K., Kirkegaard, Thomas T.

Source: Molecular genetics and metabolism. 135(2):S96-S96

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100154952304.0x000001&indx=1&recIds=ETOCvdc_100154952304.0x000001

Pro-Survival Role for Parkinson's Associated Gene DJ-1 Revealed in Trophically Impaired Dopaminergic Neurons.

Authors: Aron, Liviu¹, Klein, Pontus¹, Pham, Thu-Trang², Kramer, Edgar R.³, Wurst, Wolfgang², Klein, Rüdiger¹ rklein@neuro.mpg.de

Source: PLoS Biology. May2010, Vol. 8 Issue 5, p1-16. 16p. 8 Graphs.

Subject Terms: *SUBSTANTIA nigra, *NEURONS, *PARKINSON'S disease, *OXIDATIVE stress, *NEURODEGENERATION, *ANIMAL genetics, *DROSOPHILA

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Mutant huntingtin interacts with β-tubulin and disrupts vesicular transport and insulin secretion.

Authors: Smith, Ruben, Bacos, Karl, Fedele, Valentina, Soulet, Denis, Walz, Helena A., Obermüller, Stefanie, Lindqvist, Anders, Björkqvist, Maria, Klein, Pontus, Önnerfjord, Patrik, Brundin, Patrik, Mulder, Hindrik, Li, Jia-Yi

Source: Human Molecular Genetics; Oct2009, Vol. 18 Issue 20, p3942-3954, 13p, 2 Diagrams, 6 Graphs

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