Clinical validation of a targeted methylation-based multi-cancer early detection test using an independent validation set

Authors: Klein, E.A., Richards, D., Cohn, A., Tummala, M., Lapham, R., Cosgrove, D., Chung, G., Clement, J., Gao, J., Hunkapiller, N., Jamshidi, A., Kurtzman, K.N., Seiden, M.V., Swanton, C., Liu, M.C.

Source: In Annals of Oncology September 2021 32(9):1167-1177

Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA

Authors: Liu, Minetta C., Oxnard, Geoffrey R., Klein, Eric A., Smith, David, Richards, Donald, Yeatman, Timothy J., Cohn, Allen L., Lapham, Rosanna, Clement, Jessica, Parker, Alexander S., Tummala, Mohan K., McIntyre, Kristi, Sekeres, Mikkael A., Bryce, Alan H., Siegel, Robert, Wang, Xuezhong, Cosgrove, David P., Abu-Rustum, Nadeem R., Trent, Jonathan, Thiel, David D., Becerra, Carlos, Agrawal, Manish, Garbo, Lawrence E., Giguere, Jeffrey K., Michels, Ross M., Harris, Ronald P., Richey, Stephen L., McCarthy, Timothy A., Waterhouse, David M., Couch, Fergus J., Wilks, Sharon T., Krie, Amy K., Balaraman, Rama, Restrepo, Alvaro, Meshad, Michael W., Rieger-Christ, Kimberly, Sullivan, Travis, Lee, Christine M., Greenwald, Daniel R., Oh, William, Tsao, Che-Kai, Fleshner, Neil, Kennecke, Hagen F., Khalil, Maged F., Spigel, David R., Manhas, Atisha P., Ulrich, Brian K., Kovoor, Philip A., Stokoe, Christopher, Courtright, Jay G., Yimer, Habte A., Larson, Timothy G., Swanton, Charles, Seiden, Michael V., Cummings, Steven R., Absalan, Farnaz, Alexander, Gregory, Allen, Brian, Amini, Hamed, Aravanis, Alexander M., Bagaria, Siddhartha, Bazargan, Leila, Beausang, John F., Berman, Jennifer, Betts, Craig, Blocker, Alexander, Bredno, Joerg, Calef, Robert, Cann, Gordon, Carter, Jeremy, Chang, Christopher, Chawla, Hemanshi, Chen, Xiaoji, Chien, Tom C., Civello, Daniel, Davydov, Konstantin, Demas, Vasiliki, Desai, Mohini, Dong, Zhao, Fayzullina, Saniya, Fields, Alexander P., Filippova, Darya, Freese, Peter, Fung, Eric T., Gnerre, Sante, Gross, Samuel, Halks-Miller, Meredith, Hall, Megan P., Hartman, Anne-Renee, Hou, Chenlu, Hubbell, Earl, Hunkapiller, Nathan, Jagadeesh, Karthik, Jamshidi, Arash, Jiang, Roger, Jung, Byoungsok, Kim, TaeHyung, Klausner, Richard D., Kurtzman, Kathryn N., Lee, Mark, Lin, Wendy, Lipson, Jafi, Liu, Hai, Liu, Qinwen, Lopatin, Margarita, Maddala, Tara, Maher, M. Cyrus, Melton, Collin, Mich, Andrea, Nautiyal, Shivani, Newman, Jonathan, Newman, Joshua, Nicula, Virgil, Nicolaou, Cosmos, Nikolic, Ongjen, Pan, Wenying, Patel, Shilpen, Prins, Sarah A., Rava, Richard, Ronaghi, Neda, Sakarya, Onur, Satya, Ravi Vijaya, Schellenberger, Jan, Scott, Eric, Sehnert, Amy J., Shaknovich, Rita, Shanmugam, Avinash, Shashidhar, K.C., Shen, Ling, Shenoy, Archana, Shojaee, Seyedmehdi, Singh, Pranav, Steffen, Kristan K., Tang, Susan, Toung, Jonathan M., Valouev, Anton, Venn, Oliver, Williams, Richard T., Wu, Tony, Xu, Hui H., Yakym, Christopher, Yang, Xiao, Yecies, Jessica, Yip, Alexander S., Youngren, Jack, Yue, Jeanne, Zhang, Jingyang, Zhang, Lily, Zhang, Lori (Quan), Zhang, Nan, Curtis, Christina, Berry, Donald A., Liu, M.C., Oxnard, G.R., Klein, E.A., Swanton, C., Seiden, M.V.

Source: In Annals of Oncology June 2020 31(6):745-759

Investigation of early cancerous changes in bladder tissue by autofluorescence

Authors: Arendt, J.T., Levin, H.S., Klein, E.A., Manoharan, R., Feld, M.S., Cothren, R.M.

Source: Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 'Magnificent Milestones and Emerging Opportunities in Medical Engineering' (Cat. No.97CH36136) Engineering in medicine and biology Engineering in Medicine and Biology Society, 1997. Proceedings of the 19th Annual International Conference of the IEEE. 5:2290-2293 vol.5 1997

Relation: Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 'Magnificent Milestones and Emerging Opportunities in Medical Engineering'

Deep androgen receptor suppression in prostate cancer exploits sexually dimorphic renal expression for systemic glucocorticoid exposure

Authors: Alyamani, M., Li, J., Patel, M., Taylor, S., Nakamura, F., Berk, M., Przybycin, C., Posadas, E.M., Madan, R.A., Gulley, J.L., Rini, B., Garcia, J.A., Klein, E.A., Sharifi, N.

Source: In Annals of Oncology March 2020 31(3):369-376

A randomized controlled Alzheimer's disease prevention trial's evolution into an exposure trial: The preadvise trial

Authors: Kryscio, R.J., Abner, E.L., Schmitt, F.A., Goodman, P.J., Mendiondo, M., Caban-Holt, A., Dennis, B.C., Mathews, M., Klein, E.A., Crowley, J.J.

Source: In The Journal of nutrition, health and aging January 2013 17(1):72-75

1184P Early real-world experience with positive multi-cancer early detection (MCED) test cases and negative initial diagnostic work-up

Authors: Westgate, C., Gordon, O., Margolis, M., Oh, Y., Broyles, D., Friedman, J., Jones, W., Ferrell, J., Venn, O., Jiang, R., Leake, S., Hubbell, E., Fung, E.T., Klein, E.A., Venstrom, J., Shaknovich, R.S., O'Donnell, E.

Source: In Annals of Oncology September 2024 35 Supplement 2:S766-S767

1183P Impact of multicancer early detection (MCED) test on participant-reported outcomes (PRO) and behavioral intentions by cancer risk

Authors: Dilaveri, C.A., McDonnell, C.H., III, Klein, E.A., Reid, R., Marinac, C.R., Nadauld, L., Chung, K.C., Lopatin, M., Fung, E.T., Schrag, D., Patrick, D.L.

Source: In Annals of Oncology September 2024 35 Supplement 2:S766-S766

Phase II Trial of Neoadjuvant Nab-Paclitaxel in High Risk Patients With Prostate Cancer Undergoing Radical Prostatectomy

Authors: Shepard, D.R., Dreicer, R. ^†, Garcia, J., Elson, P., Magi-Galluzzi, C., Raghavan, D., Stephenson, A.J., Klein, E.A.

Source: In The Journal of Urology 2009 181(4):1672-1677

Response to W.C. Taylor, and C. Fiala and E.P. Diamandis

Authors: Liu, M.C., Oxnard, G.R., Klein, E.A., Swanton, C., Seiden, M.

Source: In Annals of Oncology September 2020 31(9):1268-1270

903O A prospective study of a multi-cancer early detection blood test

Authors: Schrag, D., McDonnell, C.H., III, Nadauld, L., Dilaveri, C.A., Klein, E.A., Reid, R., Marinac, C.R., Chung, K.C., Lopatin, M., Fung, E.T., Beer, T.M.

Source: In Annals of Oncology September 2022 33 Supplement 7:S961-S961

908P Evaluation of anxiety, distress and satisfaction with a multi-cancer early detection test

Authors: Schrag, D., Beer, T.M., McDonnell, C.H., III, Nadauld, L., Dilaveri, C.A., Klein, E.A., Reid, R., Marinac, C.R., Chung, K.C., Lopatin, M., Fung, E.T., Patrick, D.L.

Source: In Annals of Oncology September 2022 33 Supplement 7:S963-S963

Performance of a Multi-Cancer Detection Test as a Tool for Diagnostic Resolution of Symptomatic Gynecological Cancers

Authors: Liu, M.C., Bryce, A.H., Seiden, M.V., Thiel, D., Richards, D., Becerra, C., Kurtzman, K.N., Chen, X., Wu, T., Zhang, Q., Gao, J., Zhang, N., Hubbell, E., Jamshidi, A., Fung, E.T., Klein, E.A.

Source: In The Journal of Minimally Invasive Gynecology November 2021 28(11) Supplement:S45-S46

637P Biochemical response (PSA0) and testosterone (T) recovery in Metacure, a multi-arm multi-modality (MM) therapy (tx) for very high risk localized (HRL) and low volume metastatic (LVM) prostatic adenocarcinoma

Authors: Teo, M.Y., McBride, S., Gopalan, A., Benoliel, H., Eastham, J.A., Goh, A., Szmulewitz, R., Morgans, A.K., Bubley, G., Gupta, S., Klein, E.A., Nguyen, P., Kibel, A.S., Wagner, A., Kaplan, I.D., Eggener, S.E., Liauw, S.L., Taplin, M.E., Scher, H.

Source: In Annals of Oncology September 2021 32 Supplement 5:S667-S668

1123O Evaluation of cell-free DNA approaches for multi-cancer early detection

Authors: Liu, M.C., Jamshidi, A., Klein, E.A., Venn, O., Hubbell, E., Beausang, J.F., Zhang, N., Kurtzman, K.N., Hou, C., Richards, D.A., Yeatman, T.J., Cohn, A.L., Thiel, D.D., Tummala, M.K., McIntyre, K., Sekeres, M.A., Bryce, A.H., Seiden, M.V., Swanton, C.

Source: In Annals of Oncology September 2021 32 Supplement 5:S921-S921

Electronic packaging techniques for surveyor lunar spacecraft

Authors: Hawley, A.E., Klein, E.A., Lenhart, D.D., Shrum, L.R.

Source: Proceedings of the IEEE Proc. IEEE Proceedings of the IEEE. 51(3):537-537 Mar, 1963

LBA77 - Simultaneous multi-cancer detection and tissue of origin (TOO) localization using targeted bisulfite sequencing of plasma cell-free DNA (cfDNA)

Authors: Oxnard, G.R. ¹, Klein, E.A. ², Seiden, M.V. ³, Hubbell, E. ⁴, Venn, O. ⁴, Jamshidi, A. ⁴, Zhang, N. ⁴, Beausang, J.F. ⁴, Gross, S. ⁴, Kurtzman, K.N. ⁵, Fung, E.T. ⁵, Allen, B. ⁶, Fields, A.P. ⁴, Liu, H. ⁶, Sekeres, M.A. ⁷, Richards, D.A. ⁸, Yu, P.P. ⁹, Aravanis, A.M. ⁴, Hartman, A.-R. ⁵, Liu, M.C. ¹⁰

Source: In Annals of Oncology October 2019 30 Supplement 5:v912-v912

Laparoscopic radical cystectomy and continent orthotopic ileal neobladder performed completely intracorporeally: the initial experience. : J Urol 2002;168:13–18.

Authors: Gill, I.S, Kaouk, J.H, Meraney, A.M, Desai, M.M, Ulchaker, J.C, Klein, E.A, Savage, S.J, Sung, G.T

Source: In Urologic Oncology: Seminars and Original Investigations 2003 21(2):164-165

Comparison of the efficacy of local therapies for localized prostate cancer in the prostate-specific antigen era: a large single-institution experience with radical prostatectomy and external-beam radiotherapy

Authors: Kupelian, P.A, Elshaikh, M, Reddy, C.A, Zippe, C, Klein, E.A, Ritter, Mark A

Source: In Urologic Oncology: Seminars and Original Investigations 2003 21(4):308-309

Declining Rates of Extracapsular Extension After Radical Prostatectomy .

Authors: Jhaveri, F.M., Klein, E.A., Kupelian, P.A., Zippe, C., Levin, H.S.

Source: Prostate Journal. Apr2000, Vol. 2 Issue 2, p103. 2/3p.

Subject Terms: *PERIODICALS, *PROSTATECTOMY, *PROSTATE cancer

Dosimetric Analysis of the Brachial Plexus among Patients Treated by Post-mastectomy Radiation Therapy for Breast Cancer

Authors: Klein, E.A.¹, Stanic, S.¹, Cui, J.¹, Mathai, M.¹, Do, L.V.¹, Purdy, J.A.¹, Chen, A.M.¹

Source: International Journal of Radiation Oncology, Biology, Physics. Nov2009 Supplement, Vol. 75 Issue 3, pS207-S207. 1p.