Suicidal behavior in ADHD: the role of comorbidity, psychosocial adversity, personality and genetic factors

Authors: Georg C. Ziegler, Silke Groß, Andrea Boreatti, Monika Heine, Rhiannon V. McNeill, Thorsten M. Kranz, Marcel Romanos, Christian P. Jacob, Andreas Reif, Sarah Kittel-Schneider, Klaus-Peter Lesch

Source: Discover Mental Health, Vol 4, Iss 1, Pp 1-13 (2024)

Subject Terms: ADHD, Suicide attempt, Psychosocial adversity, Comorbidity, Serotonin, 5-HTTLPR, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://doaj.org/toc/2731-4383

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Lipopolysaccharide triggers exacerbated microglial activation, excessive cytokine release and behavioural disturbances in mice with truncated Fused-in-Sarcoma Protein (FUS)

Authors: Alexander Trofimov, Dmitrii Pavlov, Anand Goswami, Anna Gorlova, Kirill Chaprov, Aleksei Umriukhin, Allan Kalueff, Alexey Deykin, Klaus-Peter Lesch, Daniel Clive Anthony, Tatyana Strekalova

Source: Brain, Behavior, & Immunity - Health, Vol 33, Iss , Pp 100686- (2023)

Subject Terms: Frontotemporal lobar degeneration (FTLD), Amyotrophic lateral sclerosis (ALS), Fused in sarcoma (FUS) protein, Lipopolysaccharide (LPS), Interleukin-1β (IL-1β), Tumour necrosis factor (TNF), Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S266635462300100X; https://doaj.org/toc/2666-3546

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Generation of a ST3GAL3 null mutant induced pluripotent stem cell (iPSC) line (UKWMPi002-A-3) by CRISPR/Cas9 genome editing

Authors: David Diouf, Maria Rosaria Vitale, Johanna Eva Maria Zöller, Ana-Magdalena Pineau, Eva Klopocki, Catharina Hamann, Georg Christoph Ziegler, Tim Vanmierlo, Daniel Van den Hove, Klaus-Peter Lesch

Source: Stem Cell Research, Vol 67, Iss , Pp 103038- (2023)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1873506123000247; https://doaj.org/toc/1873-5061

Access URL: https://doaj.org/article/72c76187c1894cd5bb3fa03e6ef50593

Serotonergic modulation of normal and abnormal brain dynamics: The genetic influence of the TPH2 G-703T genotype and DNA methylation on wavelet variance in children and adolescents with and without ADHD

Authors: Atae Akhrif, Marcel Romanos, Katharina Peters, Ann-Kathrin Furtmann, Julian Caspers, Klaus-Peter Lesch, Eva M. Meisenzahl-Lechner, Susanne Neufang

Source: PLoS ONE, Vol 18, Iss 4 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138254/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/1d84a02dd5b848199602065f6f5eaa16

Increased locomotor activity via regulation of GABAergic signalling in foxp2 mutant zebrafish—implications for neurodevelopmental disorders

Authors: Teresa M. Lüffe, Andrea D’Orazio, Moritz Bauer, Zoi Gioga, Victoria Schoeffler, Klaus-Peter Lesch, Marcel Romanos, Carsten Drepper, Christina Lillesaar

Source: Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)

Subject Terms: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://doaj.org/toc/2158-3188

Access URL: https://doaj.org/article/f279289aa55748f5b74643e24600f9e6

Immunomodulatory effects of new phytotherapy on human macrophages and TLR4- and TLR7/8-mediated viral-like inflammation in mice

Authors: Olesia Schapovalova, Anna Gorlova, Johannes de Munter, Elisaveta Sheveleva, Mikhail Eropkin, Nikita Gorbunov, Michail Sicker, Aleksei Umriukhin, Sergiy Lyubchyk, Klaus-Peter Lesch, Tatyana Strekalova, Careen A. Schroeter

Source: Frontiers in Medicine, Vol 9 (2022)

Subject Terms: toll-like receptors, SARS-CoV-2, inflammation, pro-inflammatory cytokines, mice, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmed.2022.952977/full; https://doaj.org/toc/2296-858X

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Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival

Authors: Aude Muzerelle, Mariano Soiza-Reilly, Cornelia Hainer, Pierre-Louis Ruet, Klaus-Peter Lesch, Michael Bader, Natalia Alenina, Sophie Scotto-Lomassese, Patricia Gaspar

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/4ec7ccf69be14af68c79ac01c94cc2f6

The genetic architecture of human brainstem structures and their involvement in common brain disorders

Authors: Torbjørn Elvsåshagen, Shahram Bahrami, Dennis van der Meer, Ingrid Agartz, Dag Alnæs, Deanna M. Barch, Ramona Baur-Streubel, Alessandro Bertolino, Mona K. Beyer, Giuseppe Blasi, Stefan Borgwardt, Birgitte Boye, Jan Buitelaar, Erlend Bøen, Elisabeth Gulowsen Celius, Simon Cervenka, Annette Conzelmann, David Coynel, Pasquale Di Carlo, Srdjan Djurovic, Sarah Eisenacher, Thomas Espeseth, Helena Fatouros-Bergman, Lena Flyckt, Barbara Franke, Oleksandr Frei, Barbara Gelao, Hanne Flinstad Harbo, Catharina A. Hartman, Asta Håberg, Dirk Heslenfeld, Pieter J. Hoekstra, Einar A. Høgestøl, Rune Jonassen, Erik G. Jönsson, Karolinska Schizophrenia Project (KaSP) consortium, Peter Kirsch, Iwona Kłoszewska, Trine Vik Lagerberg, Nils Inge Landrø, Stephanie Le Hellard, Klaus-Peter Lesch, Luigi A. Maglanoc, Ulrik F. Malt, Patrizia Mecocci, Ingrid Melle, Andreas Meyer-Lindenberg, Torgeir Moberget, Jan Egil Nordvik, Lars Nyberg, Kevin S. O’ Connell, Jaap Oosterlaan, Marco Papalino, Andreas Papassotiropoulos, Paul Pauli, Giulio Pergola, Karin Persson, Dominique de Quervain, Andreas Reif, Jaroslav Rokicki, Daan van Rooij, Alexey A. Shadrin, André Schmidt, Emanuel Schwarz, Geir Selbæk, Hilkka Soininen, Piotr Sowa, Vidar M. Steen, Magda Tsolaki, Bruno Vellas, Lei Wang, Eric Westman, Georg C. Ziegler, Mathias Zink, Ole A. Andreassen, Lars T. Westlye, Tobias Kaufmann

Source: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/bb60787933434b12ab5b236140b403a3

Generation of multiple human iPSC lines from peripheral blood mononuclear cells of two SLC2A3 deletion and two SLC2A3 duplication carriers

Authors: Georg C. Ziegler, Franziska Radtke, Maria Rosaria Vitale, André Preuße, Eva Klopocki, Stefan Herms, Klaus-Peter Lesch

Source: Stem Cell Research, Vol 56, Iss , Pp 102526- (2021)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1873506121003731; https://doaj.org/toc/1873-5061

Access URL: https://doaj.org/article/888d95b7c3b240aea3350c226e3d1221

ASD-like behaviors, a dysregulated inflammatory response and decreased expression of PLP1 characterize mice deficient for sialyltransferase ST3GAL5

Authors: Tatyana Strekalova, Evgeniy Svirin, Ekaterina Veniaminova, Ekaterina Kopeikina, Tatyana Veremeyko, Amanda W.Y. Yung, Andrey Proshin, Susanne Walitza, Daniel C. Anthony, Lee Wei Lim, Klaus-Peter Lesch, Eugene D. Ponomarev

Source: Brain, Behavior, & Immunity - Health, Vol 16, Iss , Pp 100306- (2021)

Subject Terms: Lactosylceramide alpha-2,3-sialyltransferase (ST3GAL5), Major brain gangliosides, Autism spectrum disorder (ASD), Aggression, Proteolipid protein 1 (Plp1), Neuroinflammation, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666354621001095; https://doaj.org/toc/2666-3546

Access URL: https://doaj.org/article/8608672414da4f6d81d931281e3c4f30

Repeated methamphetamine treatment increases spine density in the nucleus accumbens of serotonin transporter knockout mice

Authors: Yoshiyuki Kasahara, Yasufumi Sakakibara, Takashi Hiratsuka, Yuki Moriya, Klaus‐Peter Lesch, F. Scott Hall, George R. Uhl, Ichiro Sora

Source: Neuropsychopharmacology Reports, Vol 39, Iss 2, Pp 130-133 (2019)

Subject Terms: Therapeutics. Pharmacology, RM1-950, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://doaj.org/toc/2574-173X

Access URL: https://doaj.org/article/b28b36dddd2b4b0e85c5cfd36a3d1adc

Haploinsufficiency of the Attention-Deficit/Hyperactivity Disorder Risk Gene St3gal3 in Mice Causes Alterations in Cognition and Expression of Genes Involved in Myelination and Sialylation

Authors: Olga Rivero, Judit Alhama-Riba, Hsing-Ping Ku, Matthias Fischer, Gabriela Ortega, Péter Álmos, David Diouf, Daniel van den Hove, Klaus-Peter Lesch

Source: Frontiers in Genetics, Vol 12 (2021)

Subject Terms: St3gal3, sialyltransferase, sialic acid, psychiatric disorders, attention-deficit/hyperactivity disorder (ADHD), prefrontal cortex, Genetics, QH426-470

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fgene.2021.688488/full; https://doaj.org/toc/1664-8021

Access URL: https://doaj.org/article/0fedc2b3beae433fbbb1448dcf12beca

REVERSE phenotyping—Can the phenotype following constitutive Tph2 gene inactivation in mice be transferred to children and adolescents with and without adhd?

Authors: Atae Akhrif, Arunima Roy, Katharina Peters, Klaus‐Peter Lesch, Marcel Romanos, Angelika Schmitt‐Böhrer, Susanne Neufang

Source: Brain and Behavior, Vol 11, Iss 5, Pp n/a-n/a (2021)

Subject Terms: aggression, anxiety, attention‐deficit/hyperactivity disorder (ADHD), impulsivity, TPH2 G‐703T (rs4570625) polymorphism, Tph2‐/‐ mouse, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://doaj.org/toc/2162-3279

Access URL: https://doaj.org/article/b7726cf528804cab8a2e50aa7b6ee12b

Increased Oxidative Stress in the Prefrontal Cortex as a Shared Feature of Depressive- and PTSD-Like Syndromes: Effects of a Standardized Herbal Antioxidant

Authors: Johannes de Munter, Dmitrii Pavlov, Anna Gorlova, Michael Sicker, Andrey Proshin, Allan V. Kalueff, Andrey Svistunov, Daniel Kiselev, Andrey Nedorubov, Sergey Morozov, Aleksei Umriukhin, Klaus-Peter Lesch, Tatyana Strekalova, Careen A. Schroeter

Source: Frontiers in Nutrition, Vol 8 (2021)

Subject Terms: antioxidant nutrients, oxidative stress, depression, post-traumatic stress disorder, pro-inflammatory cytokines, prefrontal cortex, Nutrition. Foods and food supply, TX341-641

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnut.2021.661455/full; https://doaj.org/toc/2296-861X

Access URL: https://doaj.org/article/8362402b203242789858344cf0881b75

Generation of induced pluripotent stem cell (iPSC) lines carrying a heterozygous (UKWMPi002-A-1) and null mutant knockout (UKWMPi002-A-2) of Cadherin 13 associated with neurodevelopmental disorders using CRISPR/Cas9

Authors: Maria Rosaria Vitale, Johanna Eva Maria Zöller, Charline Jansch, Anna Janz, Frank Edenhofer, Eva Klopocki, Daniel van den Hove, Tim Vanmierlo, Olga Rivero, Nael Nadif Kasri, Georg Christoph Ziegler, Klaus-Peter Lesch

Source: Stem Cell Research, Vol 51, Iss , Pp 102169- (2021)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1873506121000155; https://doaj.org/toc/1873-5061

Access URL: https://doaj.org/article/4d1632977f6c4282a254d1e088eb36e8

Serotonin transporter genotype modulates resting state and predator stress-induced amygdala perfusion in mice in a sex-dependent manner.

Authors: Jann F Kolter, Markus F Hildenbrand, Sandy Popp, Stephan Nauroth, Julian Bankmann, Lisa Rother, Jonas Waider, Jürgen Deckert, Esther Asan, Peter M Jakob, Klaus-Peter Lesch, Angelika Schmitt-Böhrer

Source: PLoS ONE, Vol 16, Iss 2, p e0247311 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/46be1085dfe14b58aaf588564f7ba889

Impulsivity and Venturesomeness in an Adult ADHD Sample: Relation to Personality, Comorbidity, and Polygenic Risk

Authors: Oliver Grimm, Heike Weber, Sarah Kittel-Schneider, Thorsten M. Kranz, Christian P. Jacob, Klaus-Peter Lesch, Andreas Reif

Source: Frontiers in Psychiatry, Vol 11 (2020)

Subject Terms: impulsivity, ADHD, polygenic risk score, venturesomeness, substance abuse disorder, attention, Psychiatry, RC435-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fpsyt.2020.557160/full; https://doaj.org/toc/1664-0640

Access URL: https://doaj.org/article/a9ac251a781845c7b7f93da03d8e14d7

Generation of a human induced pluripotent stem cell (iPSC) line from a 51-year-old female with attention-deficit/hyperactivity disorder (ADHD) carrying a duplication of SLC2A3

Authors: Charline Jansch, Katharina Günther, Jonas Waider, Georg C. Ziegler, Andrea Forero, Sina Kollert, Evgeniy Svirin, Dirk Pühringer, Chee Keong Kwok, Reinhard Ullmann, Anna Maierhofer, Julia Flunkert, Thomas Haaf, Frank Edenhofer, Klaus-Peter Lesch

Source: Stem Cell Research, Vol 28, Iss , Pp 136-140 (2018)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1873506118300497; https://doaj.org/toc/1873-5061

Access URL: https://doaj.org/article/1c21998df05b4e85b4bdbcfa9a227207

Predation Stress Causes Excessive Aggression in Female Mice with Partial Genetic Inactivation of Tryptophan Hydroxylase-2: Evidence for Altered Myelination-Related Processes

Authors: Evgeniy Svirin, Ekaterina Veniaminova, João Pedro Costa-Nunes, Anna Gorlova, Aleksei Umriukhin, Allan V. Kalueff, Andrey Proshin, Daniel C. Anthony, Andrey Nedorubov, Anna Chung Kwan Tse, Susanne Walitza, Lee Wei Lim, Klaus-Peter Lesch, Tatyana Strekalova

Source: Cells, Vol 11, Iss 6, p 1036 (2022)

Subject Terms: tryptophan hydroxylase-2 (Tph2), female aggression, 5-HT receptors, glycogen synthase kinase-3 β (GSK-3β), myelination, predation stress, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/11/6/1036; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/1d928175d94c41c88d9ce9c1c27ddaf2

Sex-Specific ADHD-like Behaviour, Altered Metabolic Functions, and Altered EEG Activity in Sialyltransferase ST3GAL5-Deficient Mice

Authors: Tatyana Strekalova, Ekaterina Veniaminova, Evgeniy Svirin, Ekaterina Kopeikina, Tatyana Veremeyko, Amanda W. Y. Yung, Andrey Proshin, Shawn Zheng Kai Tan, Sharafuddin Khairuddin, Lee Wei Lim, Klaus-Peter Lesch, Susanne Walitza, Daniel C. Anthony, Eugene D. Ponomarev

Source: Biomolecules, Vol 11, Iss 12, p 1759 (2021)

Subject Terms: lactosylceramide alpha-2,3-sialyltransferase (ST3GAL5), attention-deficit/hyperactivity disorder (ADHD), insulin receptor (IR), sex differences, electroencephalogram (EEG), mice, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/11/12/1759; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/b5aba7368ea34b16b074c8815ed02464