Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps

Authors: Coline Plé, Heng-Keat Tam, Anais Vieira Da Cruz, Nina Compagne, Juan-Carlos Jiménez-Castellanos, Reinke T. Müller, Elizabeth Pradel, Wuen Ee Foong, Giuliano Malloci, Alexia Ballée, Moritz A. Kirchner, Parisa Moshfegh, Adrien Herledan, Andrea Herrmann, Benoit Deprez, Nicolas Willand, Attilio Vittorio Vargiu, Klaas M. Pos, Marion Flipo, Ruben C. Hartkoorn

Source: Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/2d5e83c99b5c4265bf969d47fed84ba5

Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms

Authors: Alina Ornik-Cha, Julia Wilhelm, Jessica Kobylka, Hanno Sjuts, Attilio V. Vargiu, Giuliano Malloci, Julian Reitz, Anja Seybert, Achilleas S. Frangakis, Klaas M. Pos

Source: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/0fa39d64c8884cc2b68766a6f47a6795

Allosteric drug transport mechanism of multidrug transporter AcrB

Authors: Heng-Keat Tam, Wuen Ee Foong, Christine Oswald, Andrea Herrmann, Hui Zeng, Klaas M. Pos

Source: Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/6482f47ba7254e868df9dbcc9afdc705

Update on the Discovery of Efflux Pump Inhibitors against Critical Priority Gram-Negative Bacteria

Authors: Nina Compagne, Anais Vieira Da Cruz, Reinke T. Müller, Ruben C. Hartkoorn, Marion Flipo, Klaas M. Pos

Source: Antibiotics, Vol 12, Iss 1, p 180 (2023)

Subject Terms: efflux pump inhibitor, RND multidrug efflux pump, Gram-negative bacteria, antimicrobial resistance, antibiotic resistance breakers, AcrB, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2079-6382/12/1/180; https://doaj.org/toc/2079-6382

Access URL: https://doaj.org/article/c36548178e0f4e1bb0879082e17f1a6c

Binding of Tetracyclines to Acinetobacter baumannii TetR Involves Two Arginines as Specificity Determinants

Authors: Manuela Sumyk, Stephanie Himpich, Wuen Ee Foong, Andrea Herrmann, Klaas M. Pos, Heng-Keat Tam

Source: Frontiers in Microbiology, Vol 12 (2021)

Subject Terms: transcription repressor, antibiotic resistance, Acinetobacter baumannii, TetR family, tetracycline transporter, tetracycline, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmicb.2021.711158/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/7078066933ec4613b75534d886a22ae8

Characterization and Molecular Determinants for β-Lactam Specificity of the Multidrug Efflux Pump AcrD from Salmonella typhimurium

Authors: Jenifer Cuesta Bernal, Jasmin El-Delik, Stephan Göttig, Klaas M. Pos

Source: Antibiotics, Vol 10, Iss 12, p 1494 (2021)

Subject Terms: antibiotic resistance, efflux pump, RND, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2079-6382/10/12/1494; https://doaj.org/toc/2079-6382

Access URL: https://doaj.org/article/48773c4e68264ebea3ceeff8364d19a0

Dynamics of Intact MexAB-OprM Efflux Pump: Focusing on the MexA-OprM Interface

Authors: Cesar A. López, Timothy Travers, Klaas M. Pos, Helen I. Zgurskaya, S. Gnanakaran

Source: Scientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/cf62dd8e3374478284349c2fc6b3abe6

Transport of lipophilic carboxylates is mediated by transmembrane helix 2 in multidrug transporter AcrB

Authors: Christine Oswald, Heng-Keat Tam, Klaas M. Pos

Source: Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/fa3b0c6a09c14ed89a4c26f47061ebab

Tripartite assembly of RND multidrug efflux pumps

Authors: Laetitia Daury, François Orange, Jean-Christophe Taveau, Alice Verchère, Laura Monlezun, Céline Gounou, Ravi K. R. Marreddy, Martin Picard, Isabelle Broutin, Klaas M. Pos, Olivier Lambert

Source: Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/eba793de8123457e92c40e3142a2ad4f

Correction to ApprovedDrugs Containing Thiols as Inhibitors of Metallo-β-lactamases:Strategy To Combat Multidrug-Resistant Bacteria.

Authors: Franca-M. Klingler, ThomasA. Wichelhaus, Denia Frank, Jenifer Cuesta-Bernal, Jasmin El-Delik, H. Florian Müller, Hanno Sjuts, Stephan Göttig, Arno Koenigs, Klaas M. Pos, Denys Pogoryelov, Ewgenij Proschak

Source: Journal of Medicinal Chemistry; Aug2015, Vol. 58 Issue 15, p6320-6320, 1p

Cytochrome c Oxidase Biogenesis and Metallochaperone Interactions: Steps in the Assembly Pathway of a Bacterial Complex.

Authors: Sonja Schimo, Ilka Wittig, Klaas M Pos, Bernd Ludwig

Source: PLoS ONE, Vol 12, Iss 1, p e0170037 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5249081?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/5161ee565b9745efbb9474b7c39551df

Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB

Authors: Thomas Eicher, Markus A Seeger, Claudio Anselmi, Wenchang Zhou, Lorenz Brandstätter, François Verrey, Kay Diederichs, José D Faraldo-Gómez, Klaas M Pos

Source: eLife, Vol 3 (2014)

Subject Terms: antibiotic resistance, efflux pump, drug transport, H+ transport, mechanistic coupling, drug resistance, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/03145; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/5381a1a21a394137af37560d2520b895