A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma

Authors: Pozniak, Joanna, Pedri, Dennis, Landeloos, Ewout, Van Herck, Yannick, Antoranz, Asier, Vanwynsberghe, Lukas, Nowosad, Ada, Roda, Niccolò, Makhzami, Samira, Bervoets, Greet, Maciel, Lucas Ferreira, Pulido-Vicuña, Carlos Ariel, Pollaris, Lotte, Seurinck, Ruth, Zhao, Fang, Flem-Karlsen, Karine, Damsky, William, Chen, Limin, Karagianni, Despoina, Cinque, Sonia, Kint, Sam, Vandereyken, Katy, Rombaut, Benjamin, Voet, Thierry, Vernaillen, Frank, Annaert, Wim, Lambrechts, Diether, Boecxstaens, Veerle, Saeys, Yvan, van den Oord, Joost, Bosisio, Francesca, Karras, Panagiotis, Shain, A. Hunter, Bosenberg, Marcus, Leucci, Eleonora, Paschen, Annette, Rambow, Florian, Bechter, Oliver, Marine, Jean-Christophe

Source: In Cell 4 January 2024 187(1):166-183

Safety, tolerability and impact on viral reservoirs of the addition to antiretroviral therapy of ABX464, an investigational antiviral drug, in individuals living with HIV-1: a Phase IIa randomised controlled study

Authors: Rutsaert, Sofie, Steens, Jean-Marc, Gineste, Paul ^*, Cole, Basiel, Kint, Sam, Barrett, P. Noel, Tazi, Jamal, Scherrer, Didier, Ehrlich, Hartmut J., Vandekerckhove, Linos

Source: In Journal of Virus Eradication January 2019 5(1):10-22

Cancer stem cell hypothesis 2.0 in glioblastoma: Where are we now and where are we going?

Authors: Sloan, Anthony R, Silver, Daniel J, Kint, Sam, Gallo, Marco, Lathia, Justin D

Source: Neuro-Oncology; May2024, Vol. 26 Issue 5, p785-795, 11p

Underestimated effect of intragenic HIV-1 DNA methylation on viral transcription in infected individuals

Authors: Kint, Sam, Trypsteen, Wim, De Spiegelaere, Ward, Malatinkova, Eva, Kinloch-de Loes, Sabine, De Meyer, Tim, Van Criekinge, Wim, Vandekerckhove, Linos

Source: Clinical epigenetics. 12(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100164518287.0x000001&indx=1&recIds=ETOCvdc_100164518287.0x000001

Evaluation of bisulfite kits for DNA methylation profiling in terms of DNA fragmentation and DNA recovery using digital PCR.

Authors: Kint, Sam^1,2 Sam.Kint@UGent.be, De Spiegelaere, Ward³, De Kesel, Jonas⁴, Vandekerckhove, Linos², Van Criekinge, Wim¹

Source: PLoS ONE. 6/14/2018, Vol. 13 Issue 6, p1-17. 17p.

Subject Terms: *SULFITES, *DNA methylation, *GENETIC transcription, *POLYMERASE chain reaction, *GEL electrophoresis, *THERAPEUTICS

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CD4+ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy.

Authors: Franken, Amelie^1,2 (AUTHOR), Bila, Michel^1,3,4,5 (AUTHOR), Mechels, Aurelie^1,2 (AUTHOR), Kint, Sam^1,6,7 (AUTHOR), Van Dessel, Jeroen⁵ (AUTHOR), Pomella, Valentina⁸ (AUTHOR), Vanuytven, Sebastiaan^6,7 (AUTHOR), Philips, Gino^1,2 (AUTHOR), Bricard, Orian^1,2 (AUTHOR), Xiong, Jieyi^1,2 (AUTHOR), Boeckx, Bram^1,2 (AUTHOR), Hatse, Sigrid^3,4 (AUTHOR), Van Brussel, Thomas^1,2 (AUTHOR), Schepers, Rogier^1,2 (AUTHOR), Van Aerde, Cedric⁹ (AUTHOR), Geurs, Sarah^6,7,10 (AUTHOR), Vandecaveye, Vincent¹¹ (AUTHOR), Hauben, Esther¹¹ (AUTHOR), Vander Poorten, Vincent^11,12 (AUTHOR), Verbandt, Sara⁸ (AUTHOR)

Source: Immunity (10747613). Mar2024, Vol. 57 Issue 3, p541-541. 1p.

Subject Terms: *T cells, *CYTOTOXIC T lymphocyte-associated molecule-4, *IMMUNOGLOBULIN producing cells, *T cell receptors, *MONONUCLEAR leukocytes