Adrenocortical carcinoma: a practical guide for clinicians

Authors: Fassnacht, Martin ^{a, b, c, *}, Puglisi, Soraya ^d, Kimpel, Otilia ^a, Terzolo, Massimo ^d

Source: In The Lancet Diabetes & Endocrinology May 2025 13(5):438-452

Adjuvant mitotane versus surveillance in low-grade, localised adrenocortical carcinoma (ADIUVO): an international, multicentre, open-label, randomised, phase 3 trial and observational study

Authors: Terzolo, Massimo ^†, Fassnacht, Martin ^†, Perotti, Paola, Libé, Rossella, Kastelan, Darko, Lacroix, André, Arlt, Wiebke, Haak, Harm Reinout, Loli, Paola, Decoudier, Bénédicte, Lasolle, Helene, Quinkler, Marcus, Haissaguerre, Magalie, Chabre, Olivier, Caron, Philippe, Stigliano, Antonio, Giordano, Roberta, Zatelli, Maria Chiara, Bancos, Irina, Fragoso, Maria Candida Barisson Villares, Canu, Letizia, Luconi, Michaela, Puglisi, Soraya ^*, Basile, Vittoria, Reimondo, Giuseppe, Kroiss, Matthias, Megerle, Felix, Hahner, Stefanie, Kimpel, Otilia, Dusek, Tina, Nölting, Svenja, Bourdeau, Isabelle, Chortis, Vasileios, Ettaieb, Madeleine Hester, Cosentini, Deborah, Grisanti, Salvatore, Baudin, Eric, Berchialla, Paola, Bovis, Francesca, Sormani, Maria Pia, Bruzzi, Paolo, Beuschlein, Felix, Bertherat, Jerome, Berruti, Alfredo

Source: In The Lancet Diabetes & Endocrinology October 2023 11(10):720-730

Emerging role of IGF1R and IR expression and localisation in adrenocortical carcinomas.

Authors: Catalano, Rosa, Nozza, Emma, Altieri, Barbara, Esposito, Emanuela, Croci, Giorgio A., Barbieri, Anna Maria, Treppiedi, Donatella, Di Bari, Sonia, Kimpel, Otilia, Detomas, Mario, Tamburello, Mariangela, Schauer, Marc P., Herterich, Sabine, Angelousi, Anna, Luconi, Michaela, Canu, Letizia, Nesi, Gabriella, Hantel, Constanze, Sigala, Sandra, Landwehr, Laura-Sophie

Source: Cell Communication & Signaling; 3/4/2025, Vol. 23 Issue 1, p1-16, 16p

Subject Terms: SOMATOMEDIN A, MEDICAL sciences, TUMOR markers, CELL membranes, CELL growth

The Value of Local Therapies in Advanced Adrenocortical Carcinoma.

Authors: Kimpel, Otilia¹ (AUTHOR) altieri_b@ukw.de, Altieri, Barbara¹ (AUTHOR) dischinger_u@ukw.de, Laganà, Marta² (AUTHOR) martagana@gmail.com, Vogl, Thomas J.³ (AUTHOR) t.vogl@em.uni-frankfurt.de, Adwan, Hamzah³ (AUTHOR), Dusek, Tina⁴ (AUTHOR) tdusek@mef.hr, Basile, Vittoria⁵ (AUTHOR) basile_vittoria@libero.it, Pittaway, James⁶ (AUTHOR) j.pittaway@qmul.ac.uk, Dischinger, Ulrich¹ (AUTHOR) matthias.kroiss@med.uni-muenchen.de, Quinkler, Marcus⁷ (AUTHOR) marcusquinkler@t-online.de, Kroiss, Matthias^1,8 (AUTHOR) fassnacht_m@ukw.de, Puglisi, Soraya⁵ (AUTHOR) soraya.puglisi@unito.it, Cosentini, Deborah² (AUTHOR) deborah.cosentini@gmail.com, Kickuth, Ralph⁹ (AUTHOR) kickuth_r@ukw.de, Kastelan, Darko⁴ (AUTHOR) darko.kastelan@kbc-zagreb.hr, Fassnacht, Martin^1,10 (AUTHOR)

Source: Cancers. Feb2024, Vol. 16 Issue 4, p706. 19p.

Subject Terms: *RESEARCH, *ADRENAL cortex, *RADIO frequency therapy, *RADIOEMBOLIZATION, *CATHETER ablation, *MICROWAVES, *RETROSPECTIVE studies, *TREATMENT effectiveness, *DESCRIPTIVE statistics, *RESEARCH funding, *ADRENAL tumors, *LONGITUDINAL method

Long-term effects of cerebellar anodal transcranial direct current stimulation (tDCS) on the acquisition and extinction of conditioned eyeblink responses.

Authors: Kimpel, Otilia^1,2, Hulst, Thomas^1,3, Batsikadze, Giorgi¹, Ernst, Thomas M.¹, Nitsche, Michael A.^4,5, Timmann, Dagmar¹, Gerwig, Marcus¹ marcus.gerwig@uni-due.de

Source: Scientific Reports. 12/31/2020, Vol. 10 Issue 1, p1-11. 11p.

Subject Terms: *MOTOR learning, *TRANSCRANIAL direct current stimulation, *CLINICAL trials, *PUBLIC health, *DATA analysis

Recovery of adrenal function after stopping mitotane in patients with adrenocortical carcinoma.

Authors: Altieri, Barbara¹, Kimpel, Otilia¹, Megerle, Felix¹, Detomas, Mario¹, Chifu, Irina¹, Fuss, Carmina Teresa¹, Quinkler, Marcus², Kroiss, Matthias^1,3, Fassnacht, Martin^1,4,5 Fassnacht_M@ukw.de

Source: European Journal of Endocrinology. Feb2024, Vol. 190 Issue 2, p139-150. 12p.

Subject Terms: *ADRENAL cortex, *CONFIDENCE intervals, *DETECTION limit

Current Evidence on Local Therapies in Advanced Adrenocortical Carcinoma.

Authors: Kimpel, Otilia¹ (AUTHOR) Kimpel_o@ukw.de, Dischinger, Ulrich¹ (AUTHOR), Altieri, Barbara¹ (AUTHOR), Fuss, Carmina Teresa¹ (AUTHOR), Polat, Bülent² (AUTHOR), Kickuth, Ralph³ (AUTHOR), Kroiss, Matthias^1,4 (AUTHOR), Fassnacht, Martin^1,5 (AUTHOR)

Source: Hormone & Metabolic Research. Jan2024, Vol. 56 Issue 1, p91-98. 8p.

Subject Terms: *CARCINOMA, *DATABASE searching, *PREVENTIVE medicine, *RADIO frequency, *ARTERIAL catheters

Early Detection of Recurrence and Progress Using Serum Steroid Profiling by LC–MS/MS in Patients with Adrenocortical Carcinoma.

Authors: Kimpel, Otilia, Altieri, Barbara, Dischinger, Ulrich, Fuss, Carmina Teresa, Kurlbaum, Max, Fassnacht, Martin

Source: Metabolites (2218-1989); Jan2024, Vol. 14 Issue 1, p20, 11p

Subject Terms: LIQUID chromatography-mass spectrometry, NATALIZUMAB, STEROIDS

High Filamin a Expression in Adrenocortical Carcinomas Is Associated with a Favourable Tumour Behaviour: A European Multicentric Study.

Authors: Catalano, Rosa, Altieri, Barbara, Angelousi, Anna, Arosio, Maura, Bravi, Francesca, Canu, Letizia, Croci, Giorgio A., Detomas, Mario, Esposito, Emanuela, Ferrante, Emanuele, Ferrero, Stefano, Fuss, Carmina T., Kaltsas, Gregory, Kimpel, Otilia, Landwehr, Laura-Sophie, Luconi, Michaela, Morelli, Valentina, Nesi, Gabriella, Nozza, Emma, Sbiera, Silviu

Source: International Journal of Molecular Sciences; Dec2023, Vol. 24 Issue 23, p16573, 13p

Subject Terms: SOMATOMEDIN A, BIOMARKERS, CARCINOMA

Outcome of immunotherapy in adrenocortical carcinoma: a retrospective cohort study.

Authors: Remde, Hanna, Schmidt-Pennington, Laura, Reuter, Miriam, Landwehr, Laura-Sophie, Jensen, Marie, Lahner, Harald, Kimpel, Otilia, Altieri, Barbara, Laubner, Katharina, Schreiner, Jochen, Bojunga, Joerg, Kircher, Stefan, Kunze, Catarina Alisa, Pohrt, Anne, Teleanu, Maria-Veronica, Hübschmann, Daniel, Stenzinger, Albrecht, Glimm, Hanno, Fröhling, Stefan, Fassnacht, Martin

Source: European Journal of Endocrinology; Jun2023, Vol. 188 Issue 6, p485-493, 9p

Subject Terms: HEALTH outcome assessment, IMMUNOTHERAPY, CARCINOMA

Efficacy and safety of radiation therapy in advanced adrenocortical carcinoma.

Authors: Kimpel, Otilia¹ (AUTHOR), Schindler, Paul¹ (AUTHOR), Schmidt-Pennington, Laura² (AUTHOR), Altieri, Barbara¹ (AUTHOR), Megerle, Felix¹ (AUTHOR), Haak, Harm³ (AUTHOR), Pittaway, James⁴ (AUTHOR), Dischinger, Ulrich¹ (AUTHOR), Quinkler, Marcus^2,5 (AUTHOR), Mai, Knut² (AUTHOR), Kroiss, Matthias^1,6 (AUTHOR), Polat, Bülent⁷ (AUTHOR), Fassnacht, Martin^1,8 (AUTHOR) Fassnacht_m@ukw.de

Source: British Journal of Cancer. Feb2023, Vol. 128 Issue 4, p586-593. 8p.

Coincidence of primary adrenocortical carcinoma and melanoma: three CASE reports.

Authors: Ko, Ye Lynn, Kumar, Vaishnavi, Lippert, Juliane, Diaz-Cano, Salvador, Skordilis, Kassiani, Kimpel, Otilia, Kircher, Stefan, Asia, Miriam, Elhassan, Yasir S., Altieri, Barbara, Ronchi, Cristina L.

Source: BMC Endocrine Disorders; 1/6/2023, Vol. 23 Issue 1, p1-11, 11p

Subject Terms: ADENOCARCINOMA, ADRENAL glands, SEQUENCE analysis, MELANOMA, LI-Fraumeni syndrome, METASTASIS, DIFFERENTIAL diagnosis, GENES

Plasma Steroid Profiling in Patients With Adrenal Incidentaloma.

Authors: Berke, Kristina, Constantinescu, Georgiana, Masjkur, Jimmy, Kimpel, Otilia, Dischinger, Ulrich, Peitzsch, Mirko, Kwapiszewska, Aleksandra, Dobrowolski, Piotr, Nölting, Svenja, Reincke, Martin, Beuschlein, Felix, Bornstein, Stefan R., Prejbisz, Aleksander, Lenders, Jacques W. M., Fassnacht, Martin, Eisenhofer, Graeme

Source: Journal of Clinical Endocrinology & Metabolism; Mar2022, Vol. 107 Issue 3, pe1181-e1193, 12p

Subject Terms: PHEOCHROMOCYTOMA, HYDROXYPROGESTERONE

Adjuvant platinum-based chemotherapy in radically resected adrenocortical carcinoma: a cohort study.

Authors: Kimpel, Otilia¹ (AUTHOR), Bedrose, Sara^2,3 (AUTHOR), Megerle, Felix¹ (AUTHOR), Berruti, Alfredo⁴ (AUTHOR), Terzolo, Massimo⁵ (AUTHOR), Kroiss, Matthias^1,6,7 (AUTHOR), Mai, Knut⁸ (AUTHOR), Dekkers, Olaf M.^9,10 (AUTHOR), Habra, Mouhammed Amir² (AUTHOR), Fassnacht, Martin^1,6 (AUTHOR) Fassnacht_m@ukw.de

Source: British Journal of Cancer. Oct2021, Vol. 125 Issue 9, p1233-1238. 6p.

Management of Patients With Glucocorticoid-Related Diseases and COVID-19.

Authors: Chifu, Irina, Detomas, Mario, Dischinger, Ulrich, Kimpel, Otilia, Megerle, Felix, Hahner, Stefanie, Fassnacht, Martin, Altieri, Barbara

Source: Frontiers in Endocrinology; 9/14/2021, Vol. 12, p1-16, 16p

Subject Terms: ADRENAL tumors, COVID-19, CUSHING'S syndrome, SARS-CoV-2, ANGIOTENSIN converting enzyme, ADRENAL insufficiency