In vitro broad-spectrum antiviral activity of MIT-001, a mitochondria-targeted reactive oxygen species scavenger, against severe acute respiratory syndrome coronavirus 2 and multiple zoonotic viruses

Authors: Lim, Taehun, Rajoriya, Shivani, Kim, Bohyeon, Natasha, Augustine, Im, Hyeonjoo, Shim, Hyun Soo, Yoo, Junsang, Kim, Jong Woo, Lee, Eun-Woo, Shin, Hye Jin, Kim, Soon Ha, Kim, Won-Keun

Source: In Virus Research April 2024 342

CBP-Mediated Acetylation of Importin α Mediates Calcium-Dependent Nucleocytoplasmic Transport of Selective Proteins in Drosophila Neurons

Authors: Cho, Jae Ho, Jo, Min Gu, Kim, Eun Seon, Lee, Na Yoon, Kim, Soon Ha, Chung, Chang Geon ^*, Park, Jeong Hyang ^*, Lee, Sung Bae ^*

Source: In Molecules and Cells November 2022 45(11):855-867

Pharmacokinetics and Tolerability of LC28-0126, a Novel Necrosis Inhibitor, After Multiple Ascending Doses: A Phase I Randomized, Double-blind, Placebo-controlled Study in Healthy Male Subjects

Authors: Kim, Eunwoo, Hwang, Inyoung, Lee, SeungHwan, Oh, Jaeseong, Chung, Hyewon, Jin, Myungwon, Kim, Soon Ha, Yu, Kyung-Sang

Source: In Clinical Therapeutics October 2020 42(10):1946-1954

Sirtuin 3 is essential for host defense against Mycobacterium abscessus infection through regulation of mitochondrial homeostasis

Authors: Kim, Young Jae, Lee, Sang-Hee, Jeon, Sang Min, Silwal, Prashanta, Seo, Ju-Young, Hanh, Bui Thi Bich, Park, June-Woo, Whang, Jake, Lee, Min Joung, Heo, Jun Young, Kim, Soon Ha, Kim, Jin-Man, Song, Gyu Yong, Jang, Jichan, Jo, Eun-Kyeong

Source: Virulence. 11(1):1225-1239

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100137102701.0x000001&indx=1&recIds=ETOCvdc_100137102701.0x000001

Germ Line Deletion of the CD1 Locus Exacerbates Diabetes in the NOD Mouse

Authors: Shi, Fu-Dong, Flodström, Malin, Balasa, Balaji, Kim, Soon Ha, Van Gunst, Kurt, Strominger, Jack L., Wilson, S. Brian, Sarvetnick, Nora

Source: Proceedings of the National Academy of Sciences of the United States of America, 2001 Jun 01. 98(12), 6777-6782.

Access URL: https://www.jstor.org/stable/3055888

Therapeutic Potential of a Novel Necrosis Inhibitor, 7-Amino-Indole, in Myocardial Ischemia–Reperfusion Injury

Authors: Hwang, In-Chang, Kim, Ju-Young, Kim, Ji-Hyun, Lee, Joo-Eun, Seo, Ji-Yun, Lee, Jae-Won, Park, Jonghanne, Yang, Han-Mo, Kim, Soon-Ha, Cho, Hyun-Jai, Kim, Hyo-Soo

Source: Hypertension. 71(6):1143-1155

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100058521477.0x000001&indx=1&recIds=ETOCvdc_100058521477.0x000001

NecroX-7 reduces necrotic core formation in atherosclerotic plaques of Apoe knockout mice

Authors: Grootaert, Mandy O.J., Schrijvers, Dorien M., Van Spaendonk, Hanne, Breynaert, Annelies, Hermans, Nina, Van Hoof, Viviane O., Takahashi, Nozomi, Vandenabeele, Peter, Kim, Soon Ha, De Meyer, Guido R.Y., Martinet, Wim

Source: In Atherosclerosis September 2016 252:166-174

NecroX-5 exerts anti-inflammatory and anti-fibrotic effects via modulation of the TNFα/Dcn/TGFβ1/Smad2 pathway in hypoxia/reoxygenation-treated rat hearts

Authors: Thu, Vu Thi, Kim, Hyoung Kyu, Long, Le Thanh, Thuy, To Thanh, Huy, Nguyen Quang, Kim, Soon Ha, Kim, Nari, Ko, Kyung Soo, Rhee, Byoung Doo, Han, Jin

Source: Korean journal of physiology & pharmacology. 20(3):305-314

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN606143060&indx=1&recIds=ETOCRN606143060

Neuroprotective effect of NecroX-5 against retinal degeneration in rodents

Authors: Kim, Hyung Il, Paik, Sun-Sook, Kim, Gyu Hyun, Kim, Muyan, Kim, Soon Ha, Kim, In-Beom

Source: NeuroReport. 27(15):1128-1133

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100035743728.0x000001&indx=1&recIds=ETOCvdc_100035743728.0x000001

NecroX-5 protects mitochondrial oxidative phosphorylation capacity and preserves PGC1α expression levels during hypoxia/reoxygenation injury

Authors: Thu, Vu Thi, Kim, Hyoung Kyu, Long, Le Thanh, Nyamaa, Bayalagmaa, Song, In-Sung, Thuy, To Thanh, Huy, Nguyen Quang, Marquez, Jubert, Kim, Soon Ha, Kim, Nari

Source: Korean journal of physiology & pharmacology. 20(2):201-212

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN605276707&indx=1&recIds=ETOCRN605276707

The Free Radical Scavenger NecroX-7 Attenuates Acute Graft-versus-Host Disease via Reciprocal Regulation of Th1/Regulatory T·Cells and Inhibition of HMGB1 Release

Authors: Im, Keon-Il, Kim, Nayoun, Lim, Jung-Yeon, Nam, Young-Sun, Lee, Eun-Sol, Kim, Eun-Jung, Kim, Hyoung Jin, Kim, Soon Ha, Cho, Seok-Goo

Source: Journal of immunology. 194(11):5223-5232

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN600986828&indx=1&recIds=ETOCRN600986828

Mitigating Age-Related Ovarian Dysfunction with the Anti-Inflammatory Agent MIT-001.

Authors: Kang, Min-Hee, Kim, Yu Jin, Cho, Min Jeong, Jang, JuYi, Koo, Yun Dong, Kim, Soon Ha, Lee, Jae Ho

Source: International Journal of Molecular Sciences; Oct2023, Vol. 24 Issue 20, p15158, 12p

Subject Terms: ANTI-inflammatory agents, NUCLEOTIDE sequencing, OVARIES, IMMUNE complexes, OVUM

The lipoprotein-associated phospholipase A2 inhibitor Darapladib sensitises cancer cells to ferroptosis by remodelling lipid metabolism.

Authors: Oh, Mihee, Jang, Seo Young, Lee, Ji-Yoon, Kim, Jong Woo, Jung, Youngae, Kim, Jiwoo, Seo, Jinho, Han, Tae-Su, Jang, Eunji, Son, Hye Young, Kim, Dain, Kim, Min Wook, Park, Jin-Sung, Song, Kwon-Ho, Oh, Kyoung-Jin, Kim, Won Kon, Bae, Kwang-Hee, Huh, Yong-Min, Kim, Soon Ha, Kim, Doyoun

Source: Nature Communications; 9/15/2023, Vol. 14 Issue 1, p1-17, 17p

Subject Terms: PHOSPHOLIPASE A2, LIPID metabolism, CANCER cells, METABOLIC regulation, ARACHIDONIC acid, PHOSPHOLIPASES, CYTOPLASM

A novel small molecule, NecroX-7, inhibits osteoclast differentiation by suppressing NF-κB activity and c-Fos expression

Authors: Kim, Hyun-Ju, Yoon, Kyung-Ae, Lee, Mi-Kyung, Kim, Soon Ha, Lee, In-Kyu, Kim, Shin-Yoon

Source: In Life Sciences 2 November 2012 91(19-20):928-934

NecroX-7 prevents oxidative stress-induced cardiomyopathy by inhibition of NADPH oxidase activity in rats

Authors: Park, Joonghoon, Park, Eok, Ahn, Bong-Hyun, Kim, Hyoung Jin, Park, Ji-hoon, Koo, Sun Young, Kwak, Hyo-Shin, Park, Heui Sul, Kim, Dong Wook, Song, Myoungsub, Yim, Hyeon Joo, Seo, Dong Ook, Kim, Soon Ha

Source: In Toxicology and Applied Pharmacology 15 August 2012 263(1):1-6

The Effect of Necrosis Inhibitor on Dextran Sulfate Sodium Induced Chronic Colitis Model in Mice.

Authors: Kim, Dongwoo, Koo, Ja Seol, Kim, Soon Ha, Park, Yeong Seo, Choe, Jung Wan, Kim, Seung Young, Hyun, Jong Jin, Jung, Sung Woo, Jung, Young Kul, Yim, Hyung Joon

Source: Pharmaceutics; Jan2023, Vol. 15 Issue 1, p222, 12p

Subject Terms: INFLAMMATORY bowel diseases, DEXTRAN sulfate, SODIUM sulfate, REVERSE transcriptase polymerase chain reaction, NF-kappa B, COLITIS

Indole compounds as an inhibitor of cellular necrosis

Evaluation of the Safety and Efficacy for Oral Mucositis Prevention of MIT-001 in Auto HSCT

Authors: Cho, Seok-Goo, Jeon, Youngwoo, Min, Gi June, Kim, Tong-Yoon, Kim, Soon Ha

Source: In Blood 2 November 2023 142 Supplement 1:2227-2227

Glucokinase activators and pharmaceutical compositions containing the same as an active ingredient

INDOLE AND INDAZOLE DERIVATIVES HAVING A CELL-, TISSUE- AND ORGAN-PRESERVING EFFECT