Natural products targeting ubiquitination to combat kidney fibrosis

Authors: Lianhua Li, Xinhui Huang, Yao Chen, Jibin Liu, Yuhang Qiao, Wenyu Fan, Peiqing Zhang, Xiaoming Yan, Ming Chen

Source: Future Journal of Pharmaceutical Sciences, Vol 11, Iss 1, Pp 1-11 (2025)

Subject Terms: Kidney fibrosis, Ubiquitination, Deubiquitination, Natural products, Signaling pathway, TGF-β1/Smads, Therapeutics. Pharmacology, RM1-950, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://doaj.org/toc/2314-7253

Access URL: https://doaj.org/article/4a26969785b547bba5504fd413a8d7eb

Effect of Slit3 on kidney fibrosis in diabetic kidney disease rats

Authors: Huang Ming-fang, Dong Yang, Shadek-jiang Harinul, Gan Xin-yu, Shi Wen-li, Lu Chen

Source: Linchuang shenzangbing zazhi, Vol 25, Iss 1, Pp 50-58 (2025)

Subject Terms: slit guidance ligand 3, diabetic kidney disease, kidney fibrosis, Internal medicine, RC31-1245

File Description: electronic resource

Relation: https://doaj.org/toc/1671-2390

Access URL: https://doaj.org/article/84a645eef25d47bb915d011edf086fb7

Gucy1α1 specifically marks kidney, heart, lung and liver fibroblasts

Authors: Valeria Rudman-Melnick, Davy Vanhoutte, Kaitlynn Stowers, Michelle Sargent, Mike Adam, Qing Ma, Anne Karina T. Perl, Alexander G. Miethke, Ashley Burg, Tiffany Shi, David A. Hildeman, E. Steve S. Woodle, J. Matthew Kofron, Prasad Devarajan

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)

Subject Terms: Kidney fibrosis, CKD, Multiorgan fibroblast marker, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/9640b9d662d8426cb449a1fbe232065c

Towards clinical translation of urinary vitronectin for non-invasive detection and monitoring of renal fibrosis in kidney transplant patients

Authors: Marta Clos-Sansalvador, Omar Taco, Paula Rodríguez-Martínez, Sergio G. Garcia, Miriam Font-Morón, Jordi Bover, Anna Vila-Santandreu, Marcella Franquesa, Javier Juega, Francesc E. Borràs

Source: Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-13 (2024)

Subject Terms: (3–10): Biomarker, Kidney fibrosis, kidney transplant, Nephrology, Extracellular matrix, Liquid biopsy, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/f4a3645aca86410bb37e7bbfebfec8b8

Detecting kidney fibrosis using H-scan

Authors: Baek, Jihye, Hysi, Eno, He, Xiaolin, Yuen, Darren A., Kolios, Michael C., Parker, Kevin J.

Source: 2022 IEEE International Ultrasonics Symposium (IUS) Ultrasonics Symposium (IUS), 2022 IEEE International. :1-3 Oct, 2022

Relation: 2022 IEEE International Ultrasonics Symposium (IUS)

Cross-talk of renal cells through WNT signal transduction in the development of fibrotic kidneys

Authors: Yuhong Chen, Chao Xue

Source: Frontiers in Cell and Developmental Biology, Vol 12 (2025)

Subject Terms: cross-talk, kidney fibrosis, wnt/β-catenin signaling, macrophage, fibroblast, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2024.1517181/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/34804d55d22040808fd2ebe4f966e3e9

Protective effects and possible mechanisms of mesenchymal stem cells and mesenchymal stem cell-derived extracellular vesicles against kidney fibrosis in animal models: a systematic review and meta-analysis

Authors: Yuanchen Lv, Zibo Hua, Xiaomei Lu

Source: Frontiers in Pharmacology, Vol 15 (2025)

Subject Terms: mesenchymal stem cell, extracellular vesicle, kidney fibrosis, mice, systemic review, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2024.1511525/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/1b0a451f26154ed4a9d16cbdbfe420ea

Histopathological correlations of CT-based radiomics imaging biomarkers in native kidney biopsy

Authors: Yoon Ho Choi, Ji-Eun Kim, Ro Woon Lee, Byoungje Kim, Hyeong Chan Shin, Misun Choe, Yaerim Kim, Woo Yeong Park, Kyubok Jin, Seungyeup Han, Jin Hyuk Paek, Kipyo Kim

Source: BMC Medical Imaging, Vol 24, Iss 1, Pp 1-11 (2024)

Subject Terms: Radiomics, Kidney fibrosis, Histopathology, Chronic kidney disease, Medical technology, R855-855.5

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2342

Access URL: https://doaj.org/article/fecf03bbeab34e3182bdb96e0e1fc79e

System and Method for Detecting Anti-Kidney Fibrosis Drugs Based on Big Data

Authors: Gong, Lei, Zhou, Zhenghong

Source: 2021 Third International Conference on Inventive Research in Computing Applications (ICIRCA) Inventive Research in Computing Applications (ICIRCA), 2021 Third International Conference on. :1662-1665 Sep, 2021

Relation: 2021 Third International Conference on Inventive Research in Computing Applications (ICIRCA)

Feature Paper in Physiology and Pathology

Contributors: Roumeliotis, Stefanos, Minervini, Giuseppe

Subject Terms: kidney fibrosis, chronic kidney disease, TGFβR-1, flavonoids, pharmacokinetics, molecular docking, molecular dynamics simulations, retrospective cohort study, kidney disease, end-stage kidney disease, vitamin D, tuberculosis, type 2 diabetes mellitus, genetic susceptibility, molecular chaperons, heat shock factor 1 (HSF1), single nucleotide polymorphism, gene expression, protein folding, unfolded protein response, body mass index, obesity, sex dimorphism, NF-κB signaling, signaling dynamics, cell-fate decision, encoding and decoding, cellular information, human diseases, prolyl hydroxylase domain-containing protein, PHD protein, Phd1 gene, osteoblast, chondrocyte, knockout mice, phenotype, hypoxia-inducible factor, endochondral bone formation, MRI, prefrontal areas, putamen, gray matter volume, specific phobia, cognition, rice intake, adults, Qatar Biobank study, Neoplasia, exercise, sensitivity, chemotherapy, measurement of results reported by the patient, biomechanics, osteoarthritis, cartilage, musculoskeletal simulation, probabilistic modelling, experimental autoimmune encephalomyelitis, colitis, growth factors, nematode adaptation, angiogenesis, knee joint, biomarkers, extracellular vesicles, sepsis, coagulation, disseminated intravascular coagulation, sepsis-induced coagulopathy, laboratory evaluation, guidelines, cell competition, cellular Potts model, invasion, travelling wave, neutrophil extracellular traps, peripheral blood, infection, digital white blood cell differential, genetic disease, prevalence, penetrance, accurate diagnosis, disease iceberg effect, cumulative lifetime risk, familial aggregation, ozone, ozone therapy, oxidative stress, antioxidants defense, inflammation, dupilumab, biologic, dermatitis, lichen amyloidosis, primary cutaneous amyloidosis, primary localized cutaneous amyloidosis, IgG4-related disease, IgG4-related skin disease, immunoglobulin G4-related disease, immunoglobulin G4-related skin disease, WNT16, chondrocytes, mice, chondrogenesis, cell culture, subarachnoid hemorrhage, bone-marrow mesenchymal stem cells, cognitive impairment, high-mobility group box 1, central centrifugal cicatricial alopecia, scarring alopecia, pediatric, scarring hair loss, skin of colour, public health, ambulatory blood pressure, antihypertensive therapy, peritoneal dialysis, sex differences, geranylgeraniol, GGOH, bisphosphonates, medication-related osteonecrosis of the jaw, MRONJ, mevalonate pathway, platelets, PEVs, hemostasis, wound healing, carcinogenesis, therapy, imidacloprid, apoptosis, telencephalon, zebrafish, serous endometrial intraepithelial carcinoma, SEIC, MUSC, adjuvant therapy, relapse, BK-polyomavirus, decoy cell, polyoma nephropathy, large T antigen, VP1, complications, congenital heart disease, ECMO, extracorporeal life support, mortality, risk factors, single ventricle, BOLD signal variability, pediatrics, biomarker, fMRI, neurodevelopment, grip strength, young children, active play, growth and development, platelet-rich plasma, rhein, knee osteoarthritis, Crohn’s disease, intestinal ultrasonography, contrast-enhanced ultrasound, MR enterography, depressive disorders, cognitive function, physical function, dementia, older people, copepods, lipidomics, climate change, oceanic food chain, sentinel species, patient blood management, red blood cell, transfusion, hemoglobin, retrospective study, social isolation, space radiation, blood–brain barrier, lateral ventricle, post-stroke depression, behavioral tests, social activity, motor function, antidepressants, murine models of depression, Theatre studies, Music

File Description: application/octet-stream

Access URL: https://directory.doabooks.org/handle/20.500.12854/152786
https://mdpi.com/books/pdfview/book/10019

The critical role of endoplasmic reticulum stress and the stimulator of interferon genes (STING) pathway in kidney fibrosis

Authors: Andrade-Silva, Magaiver ^{1, 2, 3, 6}, Dhillon, Poonam ^{1, 2, 6}, Sanchez-Navarro, Andrea ^{1, 2}, Mukhi, Dhanunjay ^{1, 2}, Hu, Hailong ^{1, 2}, Kolligundla, Lakshmi P. ^{1, 2}, Bergeson, Andrea ^{1, 2}, Abedini, Amin ^{1, 2}, Levinsohn, Jonathan ^{1, 2}, Dumoulin, Bernhard ^{1, 2}, Câmara, Niels O.S. ³, Miner, Jonathan J. ⁴, Susztak, Katalin ^{1, 2, 5, ∗}

Source: In Kidney International February 2025 107(2):302-316

SR9009 attenuates TGF-β1-induced renal fibrotic responses by inhibiting the NOX4/p38 signaling pathway in NRK-49F cells

Authors: Takaguri, Akira, Shinohe, Sari, Noro, Ryuta, Sakuraba, Mei, Satoh, Chihiro, Ohashi, Runa, Satoh, Kumi ^⁎

Source: In European Journal of Pharmacology 15 January 2025 987

Hypermethylation and suppression of microRNA219a-2 activates the ALDH1L2/GSH/PAI-1 pathway for fibronectin degradation in renal fibrosis

Authors: Wei, Qingqing ^{1, ∗}, Xiao, Xiao ^{1, 8}, Huo, Emily ^{1, 2}, Guo, Chunyuan ^{1, 9}, Zhou, Xiangjun ³, Hu, Xiaoru ^{4, 10}, Dong, Charles ⁵, Shi, Huidong ⁶, Dong, Zheng ^{1, 7, ∗∗}

Source: In Molecular Therapy 8 January 2025 33(1):249-262

Epigenetic therapeutics attenuate kidney injury and fibrosis by restoring the expression of epigenetically reprogrammed fibrogenic genes and signaling pathways

Authors: Acharya, Narayan ^{a, 1}, Kandel, Ramji ^{a, 1}, Roy, Priti ^a, Warraich, Irfan ^b, Singh, Kamaleshwar P ^{a, ⁎}

Source: In European Journal of Pharmaceutical Sciences 1 January 2025 204

Salinomycin attenuates kidney fibrosis and inflammation in mice with unilateral ureteral obstruction

Authors: Chen, Kuan-Hsing ^{a, b}, Hsu, Hsiang-Hao ^a, Yang, Huang-Yu ^a, Ko, Yi-Ching ^a, Hung, Cheng-Chieh ^{a, ⁎}

Source: In Biochemical and Biophysical Research Communications January 2025 742

Identification of common and specific fibrosis-related genes in three common chronic kidney diseases

Authors: Zhangning Fu, Xiaodong Geng, Chao Liu, Wanjun Shen, Zheyi Dong, Guannan Sun, Guangyan Cai, Xiangmei Chen, Quan Hong

Source: Renal Failure, Vol 46, Iss 1 (2024)

Subject Terms: Kidney fibrosis, chronic kidney disease, NanoString technology, Diseases of the genitourinary system. Urology, RC870-923

File Description: electronic resource

Relation: https://doaj.org/toc/0886-022X; https://doaj.org/toc/1525-6049

Access URL: https://doaj.org/article/b74ca09f5ab84dfe9396f48b6664a705

Nuclear translocation of SIRT4 mediates deacetylation of U2AF2 to modulate renal fibrosis through alternative splicing-mediated upregulation of CCN2

Authors: Guangyan Yang, Jiaqing Xiang, Xiaoxiao Yang, Xiaomai Liu, Yanchun Li, Lixing Li, Lin Kang, Zhen Liang, Shu Yang

Source: eLife, Vol 13 (2024)

Subject Terms: kidney fibrosis, pre-mRNA splicing, U2 snRNP, SIRT4, U2AF2, CCN2, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/98524; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/481cc4190c714201aaa47edeadcf4c29

A mathematical model of glomerular fibrosis in diabetic kidney disease to predict therapeutic efficacy

Authors: Haryana Y. Thomas, Ashlee N. Ford Versypt

Source: Frontiers in Pharmacology, Vol 15 (2024)

Subject Terms: kidney fibrosis, advanced glycation end products, mesangial cells (MCs), systems pharmacology, systems biology, metabolic memory effect, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2024.1481768/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/dcda3b9867c5435ca3ceeaf68f56d014

A bioprinted and scalable model of human tubulo-interstitial kidney fibrosis

Authors: Bouwens, Daphne ^{a, 1}, Kabgani, Nazanin ^{a, 1}, Bergerbit, Cédric ^{d, e, 2}, Kim, Hyojin ^{a, 2}, Ziegler, Susanne ^a, Ijaz, Sadaf ^a, Abdallah, Ali ^b, Haraszti, Tamás ^{c, d}, Maryam, Sidrah ^a, Omidinia-Anarkoli, Abdolrahman ^{d, e}, De Laporte, Laura ^{c, d, e}, Hayat, Sikander ^a, Jansen, Jitske ^a, Kramann, Rafael ^{a, f, ⁎}

Source: In Biomaterials May 2025 316

Desmodium caudatum (Thunb.) DC. extract attenuates hyperuricemia-induced renal fibrosis via modulating TGF-β1 pathway and uric acid transporters: Evidence from in vitro and in vivo studies

Authors: Lin, Hui-Hsuan ^{a, 1}, Liang, Yu-Hsuan ^{b, 1}, Chyau, Charng-Cherng ^c, Tseng, Chiao-Yun ^b, Zhang, Jun-Quan ^b, Chen, Jing-Hsien ^{b, d, ⁎}

Source: In Journal of Ethnopharmacology 9 April 2025 345