Ruxolitinib for the treatment of steroid-refractory acute GVHD (REACH1): a multicenter, open-label phase 2 trial

Authors: Jagasia, Madan ^{1, 1}, Perales, Miguel-Angel ^{2, 3}, Schroeder, Mark A. ⁴, Ali, Haris ⁵, Shah, Nirav N. ⁶, Chen, Yi-Bin ⁷, Fazal, Salman ⁸, Dawkins, Fitzroy W. ⁹, Arbushites, Michael C. ⁹, Tian, Chuan ⁹, Connelly-Smith, Laura ^{10, 11}, Howell, Michael D. ⁹, Khoury, H. Jean ¹²

Source: In Blood 14 May 2020 135(20):1739-1749

A phase 1 trial of itacitinib, a selective JAK1 inhibitor, in patients with acute graft-versus-host disease

Authors: Schroeder, Mark A., Khoury, H. Jean, Jagasia, Madan, Ali, Haris, Schiller, Gary J., Staser, Karl, Choi, Jaebok, Gehrs, Leah, Arbushites, Michael C., Yan, Ying, Langmuir, Peter, Srinivas, Nithya, Pratta, Michael, Perales, Miguel-Angel, Chen, Yi-Bin, Meyers, Gabrielle, DiPersio, John F.

Source: In Blood Advances 28 April 2020 4(8):1656-1669

Myeloablative vs reduced-intensity conditioning allogeneic hematopoietic cell transplantation for chronic myeloid leukemia

Authors: Chhabra, Saurabh, Ahn, Kwang Woo, Hu, Zhen-Huan, Jain, Sandeep, Assal, Amer, Cerny, Jan, Copelan, Edward A., Daly, Andrew, DeFilipp, Zachariah, Gadalla, Shahinaz M., Gale, Robert Peter, Ganguly, Siddhartha, Hamilton, Betty K., Hildebrandt, Gerhard Carl, Hsu, Jack W., Inamoto, Yoshihiro, Kanate, Abraham S., Khoury, H. Jean, Lazarus, Hillard M., Litzow, Mark R., Nathan, Sunita, Olsson, Richard F., Pawarode, Attaphol, Ringden, Olle, Rowe, Jacob M., Saad, Ayman, Savani, Bipin N., Schouten, Harry C., Seo, Sachiko, Shah, Nirav N., Solh, Melhem, Stuart, Robert K., Ustun, Celalettin, Woolfrey, Ann E., Yared, Jean A., Alyea, Edwin P., Kalaycio, Matt E., Popat, Uday, Sobecks, Ronald M., Saber, Wael

Source: In Blood Advances 13 November 2018 2(21):2922-2936

Ponatinib efficacy and safety in Philadelphia chromosome–positive leukemia: final 5-year results of the phase 2 PACE trial

Authors: Cortes, Jorge E., Kim, Dong-Wook, Pinilla-Ibarz, Javier, le Coutre, Philipp D., Paquette, Ronald, Chuah, Charles, Nicolini, Franck E., Apperley, Jane F., Khoury, H. Jean, Talpaz, Moshe, DeAngelo, Daniel J., Abruzzese, Elisabetta, Rea, Delphine, Baccarani, Michele, Müller, Martin C., Gambacorti-Passerini, Carlo, Lustgarten, Stephanie, Rivera, Victor M., Haluska, Frank G., Guilhot, François, Deininger, Michael W., Hochhaus, Andreas, Hughes, Timothy P., Shah, Neil P., Kantarjian, Hagop M.

Source: In Blood 26 July 2018 132(4):393-404

Peritransplantation Red Blood Cell Transfusion Is Associated with Increased Risk of Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation

Authors: Hosoba, Sakura, Waller, Edmund K., Shenvi, Neeta, Graiser, Michael, Easley, Kirk A., Al-Kadhimi, Zaid, Andoh, Akira, Antun, Ana G., Barclay, Sheliagh, Josephson, Cassandra D., Koff, Jean L., Khoury, H. Jean, Langston, Amelia A., Zimring, James C., Roback, John D., Giver, Cynthia R. ^*

Source: In Biology of Blood and Marrow Transplantation May 2018 24(5):973-982

Pretransplant Consolidation Is Not Beneficial for Adults with ALL Undergoing Myeloablative Allogeneic Transplantation

Authors: Bejanyan, Nelli ^*, Zhang, Mei-Jie, Wang, Hai-Lin, Lazaryan, Aleksandr, de Lima, Marcos, Marks, David I., Sandmaier, Brenda M., Bachanova, Veronika, Rowe, Jacob, Tallman, Martin, Kebriaei, Partow, Kharfan-Dabaja, Mohamed, Peter Gale, Robert, Lazarus, Hillard M., Ustun, Celalettin, Copelan, Edward, Ky Hamilton, Betty, Schiller, Gary, Hogan, William, Hashmi, Shahrukh, Seftel, Matthew, Kanakry, Christopher G., Olsson, Richard F., Martino, Rodrigo, Saber, Wael, Khoury, H. Jean, Weisdorf, Daniel J.

Source: In Biology of Blood and Marrow Transplantation May 2018 24(5):945-955

Intravenous Busulfan Compared with Total Body Irradiation Pretransplant Conditioning for Adults with Acute Lymphoblastic Leukemia

Authors: Hogan, William, Battiwalla, Minoo, Copelan, Edward, Hildebrandt, Gerhard, Ganguly, Sid, Majhail, Navneet, Woolfrey, Ann, Nivison-Smith, Ian, Hertzberg, Mark, Diaz, Miguel Angel, Jakubowski, Ann, Ustun, Celalettin, Yong, Agnes, Freytes, Cesar, DeFilipp, Zachariah, Inamoto, Yoshi, Cahn, Jean-Yves, Savani, Bipin, Yared, Jean, Bajel, Ashish, Bacher, Ulrike, Uy, Geoffrey, Rizzieri, David, Wieduwilt, Matthew, Schultz, Kirk, Grunwald, Michael, Kamble, Rammurti, Qayed, Muna, Brammer, Jonathan, Ballen, Karen, Khera, Nandita, Schouten, Harry, Bierings, Marc, Kanakry, Christopher, Wood, William Allen, Saad, Ayman, Savoie, Lynn, Hamilton, Betty Ky, Aljurf, Mahmoud, Vij, Ravi, Pawarode, Attaphol, Olsson, Richard, Wirk, B. Mona, Beitinjaneh, Amer, Seo, Sachiko, Cerny, Jan, Akpek, Gorgun, Norkin, Maxim, Nishihori, Taiga, Lazaryan, Aleksandr, Sabloff, Mitchell, Kebriaei, Partow ^*, Anasetti, Claudio, Zhang, Mei-Jie, Wang, Hai-Lin, Aldoss, Ibrahim, de Lima, Marcos, Khoury, H. Jean, Sandmaier, Brenda M., Horowitz, Mary M., Artz, Andrew, Bejanyan, Nelli, Ciurea, Stefan, Lazarus, Hillard M., Gale, Robert Peter, Litzow, Mark, Bredeson, Christopher, Seftel, Matthew D., Pulsipher, Michael A., Boelens, Jaap-Jan, Alvarnas, Joseph, Champlin, Richard, Forman, Stephen, Pullarkat, Vinod, Weisdorf, Daniel, Marks, David I.

Source: In Biology of Blood and Marrow Transplantation April 2018 24(4):726-733

Recent advances in the genomics and therapy of BCR/ABL1-positive and -negative chronic myeloproliferative neoplasms

Authors: Mughal, Tariq I., Gotlib, Jason, Mesa, Ruben, Koschmieder, Steffen, Khoury, H. Jean, Cortes, Jorge E., Barbui, Tiziano, Hehlmann, Rüdiger, Mauro, Michael, Saussele, Susanne, Radich, Jerald P., Van Etten, Richard A., Saglio, Giuseppe, Verstovek, Srdnan, Gale, Robert Peter, Abdel-Wahab, Omar

Source: In Leukemia Research April 2018 67:67-74

Effects of Bosutinib Treatment on Renal Function in Patients With Philadelphia Chromosome-Positive Leukemias

Authors: Cortes, Jorge E., Gambacorti-Passerini, Carlo, Kim, Dong-Wook, Kantarjian, Hagop M., Lipton, Jeff H., Lahoti, Amit, Talpaz, Moshe, Matczak, Ewa, Barry, Elly, Leip, Eric, Brümmendorf, Tim H., Khoury, H. Jean

Source: In Clinical Lymphoma Myeloma and Leukemia October 2017 17(10):684-695

Intravenous Busulfan Compared with Total Body Irradiation Pretransplant Conditioning for Adults with Acute Lymphoblastic Leukemia

Authors: Kebriaei, Partow, Anasetti, Claudio, Zhang, Mei-Jie, Wang, Hai-Lin, Aldoss, Ibrahim, de Lima, Marcos, Khoury, H. Jean, Sandmaier, Brenda M., Horowitz, Mary M., Artz, Andrew, Bejanyan, Nelli, Ciurea, Stefan, Lazarus, Hillard M., Gale, Robert Peter, Litzow, Mark, Bredeson, Christopher, Seftel, Matthew D., Pulsipher, Michael A., Boelens, Jaap-Jan, Alvarnas, Joseph, Champlin, Richard, Forman, Stephen, Pullarkat, Vinod, Weisdorf, Daniel, Marks, David I.

Source: Biology of blood and marrow transplantation. 24(4):726-733

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100057344832.0x000001&indx=1&recIds=ETOCvdc_100057344832.0x000001

Comparison of Outcomes of Allogeneic Transplantation for Chronic Myeloid Leukemia with Cyclophosphamide in Combination with Intravenous Busulfan, Oral Busulfan, or Total Body Irradiation

Authors: Copelan, Edward A., Avalos, Belinda R., Ahn, Kwang Woo, Zhu, Xiaochun, Gale, Robert Peter, Grunwald, Michael R., Hamadani, Mehdi, Hamilton, Betty K., Hale, Gregory A., Marks, David I., Waller, Edmund K., Savani, Bipin N., Costa, Luciano J., Ramanathan, Muthalagu, Cahn, Jean-Yves, Khoury, H. Jean, Weisdorf, Daniel J., Inamoto, Yoshihiro, Kamble, Rammurti T., Schouten, Harry C., Wirk, Baldeep, Litzow, Mark R., Aljurf, Mahmoud D., van Besien, Koen W., Ustun, Celalettin, Bolwell, Brian J., Bredeson, Christopher N., Fasan, Omotayo, Ghosh, Nilanjan, Horowitz, Mary M., Arora, Mukta, Szer, Jeffrey, Loren, Alison W., Alyea, Edwin P., Cortes, Jorge, Maziarz, Richard T., Kalaycio, Matt E., Saber, Wael

Source: In Biology of Blood and Marrow Transplantation March 2015 21(3):552-558

Bosutinib safety and management of toxicity in leukemia patients with resistance or intolerance to imatinib and other tyrosine kinase inhibitors

Authors: Kantarjian, Hagop M., Cortes, Jorge E., Kim, Dong-Wook, Khoury, H. Jean, Brümmendorf, Tim H., Porkka, Kimmo, Martinelli, Giovanni, Durrant, Simon, Leip, Eric, Kelly, Virginia, Turnbull, Kathleen, Besson, Nadine, Gambacorti-Passerini, Carlo

Source: In Blood 27 February 2014 123(9):1309-1318

Clinical significance of quantitative monitoring and mutational analysis of BCR-ABL1 transcript in Philadelphia chromosome positive B lymphoblastic leukemia

Authors: Zhang, Linsheng, Ramjit, Ruan T., Hill, Charles E., Arellano, Martha, Khoury, H. Jean, Mann, Karen P.

Source: Leukemia & lymphoma. 57(2):364-369

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100035351082.0x000001&indx=1&recIds=ETOCvdc_100035351082.0x000001

Subcutaneous Omacetaxine Mepesuccinate in Patients With Chronic-Phase Chronic Myeloid Leukemia Previously Treated With 2 or More Tyrosine Kinase Inhibitors Including Imatinib

Authors: Cortes, Jorge E., Nicolini, Franck E., Wetzler, Meir, Lipton, Jeffrey H., Akard, Luke, Craig, Adam, Nanda, Nisha, Benichou, Annie-Claude, Leonoudakis, Janis, Khoury, H. Jean, Hochhaus, Andreas, Baccarani, Michele, Kantarjian, Hagop M.

Source: In Clinical Lymphoma, Myeloma and Leukemia October 2013 13(5):584-591

Reduced intensity conditioning is superior to nonmyeloablative conditioning for older chronic myelogenous leukemia patients undergoing hematopoietic cell transplant during the tyrosine kinase inhibitor era

Authors: Warlick, Erica, Ahn, Kwang Woo, Pedersen, Tanya L., Artz, Andrew, de Lima, Marcos, Pulsipher, Michael, Akpek, Gorgun, Aljurf, Mahmoud, Cahn, Jean-Yves, Cairo, Mitchell, Chen, Yi-Bin, Cooper, Brenda, Deol, Abhinav, Giralt, Sergio, Gupta, Vikas, Khoury, H. Jean, Kohrt, Holbrook, Lazarus, Hillard M., Lewis, Ian, Olsson, Richard, Pidala, Joseph, Savani, Bipin N., Seftel, Matthew, Socié, Gerard, Tallman, Martin, Ustun, Celaettin, Vij, Ravi, Vindeløv, Lars, Weisdorf, Daniel

Source: In Blood 26 April 2012 119(17):4083-4090

Bosutinib is active in chronic phase chronic myeloid leukemia after imatinib and dasatinib and/or nilotinib therapy failure

Authors: Khoury, H. Jean, Cortes, Jorge E., Kantarjian, Hagop M., Gambacorti-Passerini, Carlo, Baccarani, Michele, Kim, Dong-Wook, Zaritskey, Andrey, Countouriotis, Athena, Besson, Nadine, Leip, Eric, Kelly, Virginia, Brümmendorf, Tim H.

Source: In Blood 12 April 2012 119(15):3403-3412

Safety and efficacy of bosutinib (SKI-606) in chronic phase Philadelphia chromosome–positive chronic myeloid leukemia patients with resistance or intolerance to imatinib

Authors: Cortes, Jorge E. ^*, Kantarjian, Hagop M., Brümmendorf, Tim H., Kim, Dong-Wook, Turkina, Anna G., Shen, Zhi-Xiang, Pasquini, Ricardo, Khoury, H. Jean, Arkin, Steven, Volkert, Angela, Besson, Nadine, Abbas, Richat, Wang, Junyuan, Leip, Eric, Gambacorti-Passerini, Carlo

Source: In Blood 27 October 2011 118(17):4567-4576

Prognostic Significance of Leukopenia at the Time of Diagnosis in Acute Myeloid Leukemia

Authors: Arellano, Martha, Bernal-Mizrachi, Leon, Pan, Lin, Tighiouart, Mourad, Souza, Liliana, Guo, Xiangxue, McLemore, Morgan, Lima, Lisa, Sunay, Susan, Heffner, Leonard T., Chen, Zhengjia, Chen, Georgia Zhou, Langston, Amelia, Winton, Elliott, Khoury, H. Jean

Source: In Clinical Lymphoma Myeloma and Leukemia October 2011 11(5):427-432

Outcomes of Newly Diagnosed Chronic Phase Chronic Myeloid Leukemia Following an Elective Switch From Second-Generation Tyrosine Kinase Inhibitor to Imatinib

Authors: Kota, Vamsi K., Kong, Jee Hyun, Arellano, Martha, El Rassi, Fuad, Gaddh, Manila, Heffner, Leonard T., Winton, Elliott F., Jillella, Anand P., McLemore, Morgan L., Khoury, H. Jean

Source: Clinical lymphoma, myeloma & leukemia. 17(12):e71-e73

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100060903860.0x000001&indx=1&recIds=ETOCvdc_100060903860.0x000001

The outcome of full-intensity and reduced-intensity conditioning matched sibling or unrelated donor transplantation in adults with Philadelphia chromosome–negative acute lymphoblastic leukemia in first and second complete remission

Authors: Marks, David I., Wang, Tao, Pérez, Waleska S., Antin, Joseph H., Copelan, Edward, Gale, Robert Peter, George, Biju, Gupta, Vikas, Halter, Joerg, Khoury, H. Jean, Klumpp, Thomas R., Lazarus, Hillard M., Lewis, Victor A., McCarthy, Philip, Rizzieri, David A., Sabloff, Mitchell, Szer, Jeff, Tallman, Martin S., Weisdorf, Daniel J. ^*

Source: In Blood 22 July 2010 116(3):366-374