Genome-wide transcriptome analysis and drug target discovery reveal key genes and pathways in thyroid cancer metastasis

Authors: Minjing Zou, Amal Qattan, Monther Al-Alwan, Hazem Ghebeh, Naif Binjumah, Latifa Al-Haj, Khalid S. A. Khabar, Abdulmohsen Altaweel, Falah Almohanna, Abdullah M. Assiri, Abdelilah Aboussekhra, Ali S. Alzahrani, Yufei Shi

Source: Frontiers in Endocrinology, Vol 16 (2025)

Subject Terms: CD274 (PD-L1), TBXAS1, MERTK, IL6, thyroid cancer metastasis, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2025.1514264/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/73526e1f349c4953a1d6936ef3506aa9

Global analysis of the abundance of AU-rich mRNAs in response to glucocorticoid treatment

Authors: Zeyad Muazzen, Walid Moghrabi, Tala Bakheet, Linah Mahmoud, Maher Al-Saif, Khalid S. A. Khabar, Edward G. Hitti

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/41f8c1bd4da6413b9fafd53175f244c2

Beyond the exome: utility of long-read whole genome sequencing in exome-negative autosomal recessive diseases

Authors: Lama AlAbdi, Hanan E. Shamseldin, Ebtissal Khouj, Rana Helaby, Bayan Aljamal, Mashael Alqahtani, Aisha Almulhim, Halima Hamid, Mais O. Hashem, Firdous Abdulwahab, Omar Abouyousef, Amal Jaafar, Tarfa Alshidi, Mohammed Al-Owain, Amal Alhashem, Saeed Al Tala, Arif O. Khan, Elham Mardawi, Hisham Alkuraya, Eissa Faqeih, Manal Afqi, Salwa Alkhalifi, Zuhair Rahbeeni, Samya T. Hagos, Wijdan Al-Ahmadi, Seba Nadeef, Sateesh Maddirevula, Khalid S. A. Khabar, Alexander Putra, Angel Angelov, Changsook Park, Ana M. Reyes-Ramos, Husen Umer, Ikram Ullah, Patrick Driguez, Yoshinori Fukasawa, Ming Sin Cheung, Imed Eddine Gallouzi, Fowzan S. Alkuraya

Source: Genome Medicine, Vol 15, Iss 1, Pp 1-16 (2023)

Subject Terms: Long-read sequencing, Autozygome, STX3, ABHD12, C1orf109, FLVCR1, Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1756-994X

Access URL: https://doaj.org/article/fd9de43c2bca4f7999135a735e07781d

Differential upregulation of AU-rich element-containing mRNAs in COVID-19

Authors: Tala Bakheet, Khalid S. A. Khabar, Edward G. Hitti

Source: Human Genomics, Vol 16, Iss 1, Pp 1-10 (2022)

Subject Terms: AU-rich elements, Post-transcriptional gene regulation, COVID-19, Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1479-7364

Access URL: https://doaj.org/article/dfabde5d889f4cc88972b3d535e917f9

β-catenin attenuation leads to up-regulation of activating NKG2D ligands and tumor regression in BrafV600E-driven thyroid cancer cells

Authors: Minjing Zou, Suhad Al-Yahya, Monther Al-Alwan, Huda A. BinEssa, Khalid S. A. Khabar, Falah Almohanna, Abdullah M. Assiri, Abdulmohsen Altaweel, Amal Qattan, Brian F. Meyer, Ali S. Alzahrani, Yufei Shi

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: β-catenin, CTNNB1, BRAFV600E, NKG2D ligands, NK cells, thyroid cancer, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1171816/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/04631e41d80f49b3a9a9b059ef74c4bf

Post-transcriptional screen of cancer amplified genes identifies ERBB2/Her2 signaling as AU-rich mRNA stability-promoting pathway

Authors: Jenan Al-Matouq, Latifa Al-Haj, Maher Al-Saif, Khalid S. A. Khabar

Source: Oncogenesis, Vol 10, Iss 9, Pp 1-11 (2021)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2157-9024

Access URL: https://doaj.org/article/f4dd9cf583a24f0ba2326f7fb64215cd

Kinome inhibition reveals a role for polo‐like kinase 1 in targeting post‐transcriptional control in cancer

Authors: Qamraa H. Al‐Qahtani, Walid N. Moghrabi, Suhad Al‐Yahya, Latifa Al‐Haj, Maher Al‐Saif, Linah Mahmoud, Falah Al‐Mohanna, Norah Al‐Souhibani, Ayodele Alaiya, Edward Hitti, Khalid S. A. Khabar

Source: Molecular Oncology, Vol 15, Iss 8, Pp 2120-2139 (2021)

Subject Terms: AU‐rich elements, kinase inhibitors, mRNA decay, post‐transcriptional control, targeted therapy, breast cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1574-7891; https://doaj.org/toc/1878-0261

Access URL: https://doaj.org/article/9b16b262c2074fbf8d05f478d8b4d7df

Identification of a novel genetic locus underlying tremor and dystonia

Authors: Dorota Monies, Hussam Abou Al-Shaar, Ewa A. Goljan, Banan Al-Younes, Muna Monther Abdullah Al-Breacan, Maher Mohammed Al-Saif, Salma M. Wakil, Brian F. Meyer, Khalid S. A. Khabar, Saeed Bohlega

Source: Human Genomics, Vol 11, Iss 1, Pp 1-10 (2017)

Subject Terms: Dystonia, Tremor, Familial, Syndromic, Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s40246-017-0123-5; https://doaj.org/toc/1479-7364

Access URL: https://doaj.org/article/5b7cbc4813c3447b8ee52ae99170fc61

A novel mechanism for variable phenotypic expressivity in Mendelian diseases uncovered by an AU-rich element (ARE)-creating mutation

Authors: Nisha Patel, Arif O. Khan, Maher Al-Saif, Walid N. Moghrabi, Balsam M. AlMaarik, Niema Ibrahim, Firdous Abdulwahab, Mais Hashem, Tarfa Alshidi, Eman Alobeid, Rana A. Alomar, Saad Al-Harbi, Mohamed Abouelhoda, Khalid S. A. Khabar, Fowzan S. Alkuraya

Source: Genome Biology, Vol 18, Iss 1, Pp 1-10 (2017)

Subject Terms: AU-rich elements, Variable expressivity, Tissue-specific, Cornea, 3′UTR, Biology (General), QH301-705.5, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13059-017-1274-3; https://doaj.org/toc/1474-760X

Access URL: https://doaj.org/article/1b2694375998473488e8741b9e6ca008

Post-Transcriptional Inflammatory Response to Intracellular Bacterial c-di-AMP

Authors: Linah Mahmoud, Alaa S. Abdulkarim, Shaima Kutbi, Walid Moghrabi, Sulaiman Altwijri, Khalid S. A. Khabar, Edward G. Hitti

Source: Frontiers in Immunology, Vol 10 (2020)

Subject Terms: c-di-AMP, p38 MAPK, tristetraprolin/zink finger protein 36, AU-rich element, post-transcriptional regulation, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2019.03050/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/5399ffcf3b0a4fd5ab22a050c0a099b7

Temporally regulated traffic of HuR and its associated ARE-containing mRNAs from the chromatoid body to polysomes during mouse spermatogenesis.

Authors: Mai Nguyen Chi, Frédéric Chalmel, Eric Agius, Nathalie Vanzo, Khalid S A Khabar, Bernard Jégou, Dominique Morello

Source: PLoS ONE, Vol 4, Iss 3, p e4900 (2009)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC2659425?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/ace8e943faaf438abefccc185f0fc182