Assay of Sphingosine 1-phosphate Transporter Spinster Homolog 2 (Spns2) Inhibitors

Authors: Yugesh Kharel, Tao Huang, Webster L. Santos, Kevin R. Lynch

Source: SLAS Discovery, Vol 28, Iss 6, Pp 284-287 (2023)

Subject Terms: S1P, Sphingosine-1-phosphate, Spns2, Spinster homology 2, Transporter inhibitor, Assay, Medicine (General), R5-920, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2472555223000503; https://doaj.org/toc/2472-5552

Access URL: https://doaj.org/article/f30aa10ed599499bad24cce5472fd6c0

A Novel Sphingosine Kinase Inhibitor Suppresses Chikungunya Virus Infection

Authors: Opeoluwa O. Oyewole, Kyle Dunnavant, Shaurav Bhattarai, Yugesh Kharel, Kevin R. Lynch, Webster L. Santos, St. Patrick Reid

Source: Viruses, Vol 14, Iss 6, p 1123 (2022)

Subject Terms: Sphingosine kinase 2, Chikungunya virus, SLL3071511 inhibitor, antiviral, drug discovery, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/14/6/1123; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/45f5f4a0389f4f04843cbfadb7963cd4

Lysophosphatidic acid counteracts glucagon-induced hepatocyte glucose production via STAT3

Authors: Evan P. Taddeo, Stefan R. Hargett, Sujoy Lahiri, Marin E. Nelson, Jason A. Liao, Chien Li, Jill K. Slack-Davis, Jose L. Tomsig, Kevin R. Lynch, Zhen Yan, Thurl E. Harris, Kyle L. Hoehn

Source: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/e280b7810e98472f94e89b5b849f2537

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Sphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate.

Authors: Yugesh Kharel, Amanda M. Gellett, Jose L. Tomsig, Perry C. Kennedy, Morgan L. Moyer, Kevin R. Lynch

Source: Biochemical Journal; Dec2011, Vol. 440 Issue 3, p345-353, 9p

Subject Terms: SPHINGOSINE, ENZYME inhibitors, PHOSPHATES, CELL migration, CELLULAR signal transduction, G protein-coupled receptor kinases, LABORATORY mice, EPIDERMAL growth factor

Lipid phosphate phosphohydrolase type 1 (LPP1) degrades extracellular lysophosphatidic acid in vivo.

Authors: Jose L. Tomsig, Ashley H. Snyder, Evgeny V. Berdyshev, Anastasia Skobeleva, Chifundo Mataya, Viswanathan Natarajan, David N. Brindley, Kevin R. Lynch

Source: Biochemical Journal; May2009, Vol. 419 Issue 3, p611-618, 8p

Subject Terms: PHOSPHATASES, LYSOPHOSPHOLIPIDS, LIPIDS, CELL proliferation, CELL growth, WOUND healing, BLOOD platelets

Asymmetric Synthesis of Conformationally Constrained Fingolimod Analogues—Discovery of an Orally Active Sphingosine 1-Phosphate Receptor Type-1 Agonist and Receptor Type-3 Antagonist.

Authors: Ran Zhu, Ashley H. Snyder, Yugesh Kharel, Lisa Schaffter, Qin Sun, Perry C. Kennedy, Kevin R. Lynch, Timothy L. Macdonald

Source: Journal of Medicinal Chemistry; Nov2007, Vol. 50 Issue 25, p6428-6435, 8p

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Saccharomyces cerevisiae as a platform for assessing sphingolipid lipid kinase inhibitors.

Authors: Yugesh Kharel, Sayeh Agah, Tao Huang, Anna J Mendelson, Oluwafunmilayo T Eletu, Peter Barkey-Bircann, James Gesualdi, Jeffrey S Smith, Webster L Santos, Kevin R Lynch

Source: PLoS ONE, Vol 13, Iss 4, p e0192179 (2018)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5908134?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/42b1f7bb56ed403fa5674802e9803675

Decreased peritoneal ovarian cancer growth in mice lacking expression of lipid phosphate phosphohydrolase 1.

Authors: John Nakayama, Timothy A Raines, Kevin R Lynch, Jill K Slack-Davis

Source: PLoS ONE, Vol 10, Iss 3, p e0120071 (2015)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4359083?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/d16f227d74f649d5a22c60bbacb1dd0b