Orthologs of Plasmodium ICM1 are dispensable for Ca2+ mobilization in Toxoplasma gondii

Authors: Gabriel Cabral, Bingjian Ren, Hugo Bisio, Dawson Otey, Dominique Soldati-Favre, Kevin M. Brown

Source: Microbiology Spectrum, Vol 12, Iss 10 (2024)

Subject Terms: Toxoplasma gondii, Toxoplasma, Plasmodium, calcium, calcium flux, calcium signaling, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2165-0497

Access URL: https://doaj.org/article/a18a1a40b1244acb88a81d0fb053a288

Apicomplexan phosphodiesterases in cyclic nucleotide turnover: conservation, function, and therapeutic potential

Authors: William J. Moss, Lorenzo Brusini, Ronja Kuehnel, Mathieu Brochet, Kevin M. Brown

Source: mBio, Vol 15, Iss 2 (2024)

Subject Terms: phosphodiesterase, PDE, cyclic nucleotide, cGMP, cAMP, parasite, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/db88c2eeeb0c472fb95d9276197b39d8

ezQTL: A Web Platform for Interactive Visualization and Colocalization of QTLs and GWAS Loci

Authors: Tongwu Zhang, Alyssa Klein, Jian Sang, Jiyeon Choi, Kevin M. Brown

Source: Genomics, Proteomics & Bioinformatics, Vol 20, Iss 3, Pp 541-548 (2022)

Subject Terms: Genome-wide association study, Expression quantitative trait locus, Colocalization, Linkage disequilibrium, Visualization, Biology (General), QH301-705.5, Computer applications to medicine. Medical informatics, R858-859.7

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1672022922000699; https://doaj.org/toc/1672-0229

Access URL: https://doaj.org/article/b0c1ee09d15840da814393da57908ba7

A large Canadian cohort provides insights into the genetic architecture of human hair colour

Authors: Frida Lona-Durazo, Marla Mendes, Rohit Thakur, Karen Funderburk, Tongwu Zhang, Michael A. Kovacs, Jiyeon Choi, Kevin M. Brown, Esteban J. Parra

Source: Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/7614308995024767a5781ceb0a2db94c

Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma

Authors: Jiyeon Choi, Tongwu Zhang, Andrew Vu, Julien Ablain, Matthew M. Makowski, Leandro M. Colli, Mai Xu, Rebecca C. Hennessey, Jinhu Yin, Harriet Rothschild, Cathrin Gräwe, Michael A. Kovacs, Karen M. Funderburk, Myriam Brossard, John Taylor, Bogdan Pasaniuc, Raj Chari, Stephen J. Chanock, Clive J. Hoggart, Florence Demenais, Jennifer H. Barrett, Matthew H. Law, Mark M. Iles, Kai Yu, Michiel Vermeulen, Leonard I. Zon, Kevin M. Brown

Source: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/670b26b5d219499083d912a34bb1bf00

The genomic and epigenomic evolutionary history of papillary renal cell carcinomas

Authors: Bin Zhu, Maria Luana Poeta, Manuela Costantini, Tongwu Zhang, Jianxin Shi, Steno Sentinelli, Wei Zhao, Vincenzo Pompeo, Maurizio Cardelli, Boian S. Alexandrov, Burcak Otlu, Xing Hua, Kristine Jones, Seth Brodie, Malgorzata Ewa Dabrowska, Jorge R. Toro, Meredith Yeager, Mingyi Wang, Belynda Hicks, Ludmil B. Alexandrov, Kevin M. Brown, David C. Wedge, Stephen Chanock, Vito Michele Fazio, Michele Gallucci, Maria Teresa Landi

Source: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/ffda5b58926c4a49be8ed66041ae4d4b

Investigating the genetic architecture of eye colour in a Canadian cohort

Authors: Frida Lona-Durazo, Rohit Thakur, Erola Pairo-Castineira, Karen Funderburk, Tongwu Zhang, Michael A. Kovacs, Jiyeon Choi, Ian J. Jackson, Kevin M. Brown, Esteban J. Parra

Source: iScience, Vol 25, Iss 6, Pp 104485- (2022)

Subject Terms: Genetics, Genomics, Human Genetics, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004222007568; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/9627efbe93934e65bd0ec8890dd5f6ce

Functional Analysis of the Expanded Phosphodiesterase Gene Family in Toxoplasma gondii Tachyzoites

Authors: William J. Moss, Caitlyn E. Patterson, Alexander K. Jochmans, Kevin M. Brown

Source: mSphere, Vol 7, Iss 1 (2022)

Subject Terms: Toxoplasma gondii, apicomplexan parasites, cyclic nucleotides, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2379-5042

Access URL: https://doaj.org/article/e355ec7d25ca45d58557ca48f796cf71

Analysis of DNA methylation patterns in the tumor immune microenvironment of metastatic melanoma

Authors: Shamik Mitra, Martin Lauss, Rita Cabrita, Jiyeon Choi, Tongwu Zhang, Karolin Isaksson, Håkan Olsson, Christian Ingvar, Ana Carneiro, Johan Staaf, Markus Ringnér, Kari Nielsen, Kevin M. Brown, Göran Jönsson

Source: Molecular Oncology, Vol 14, Iss 5, Pp 933-950 (2020)

Subject Terms: DNA methylation, immune cells, melanoma, pan‐cancer, tumor microenvironment, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1574-7891; https://doaj.org/toc/1878-0261

Access URL: https://doaj.org/article/ea1b27aaf4e44965bc4683fbca62bede

Meta-analysis of GWA studies provides new insights on the genetic architecture of skin pigmentation in recently admixed populations

Authors: Frida Lona-Durazo, Natalia Hernandez-Pacheco, Shaohua Fan, Tongwu Zhang, Jiyeon Choi, Michael A. Kovacs, Stacie K. Loftus, Phuong Le, Melissa Edwards, Cesar A. Fortes-Lima, Celeste Eng, Scott Huntsman, Donglei Hu, Enrique Javier Gómez-Cabezas, Lilia Caridad Marín-Padrón, Jonas Grauholm, Ole Mors, Esteban G. Burchard, Heather L. Norton, William J. Pavan, Kevin M. Brown, Sarah Tishkoff, Maria Pino-Yanes, Sandra Beleza, Beatriz Marcheco-Teruel, Esteban J. Parra

Source: BMC Genetics, Vol 20, Iss 1, Pp 1-16 (2019)

Subject Terms: Skin pigmentation, Genome-wide association study, Admixed populations, Meta-analysis, Complex trait, Gene expression, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12863-019-0765-5; https://doaj.org/toc/1471-2156

Access URL: https://doaj.org/article/5c5c17591ea24c80a800ded9416b746c

Large-scale cross-cancer fine-mapping of the 5p15.33 region reveals multiple independent signals

Authors: Hongjie Chen, Arunabha Majumdar, Lu Wang, Siddhartha Kar, Kevin M. Brown, Helian Feng, Constance Turman, Joe Dennis, Douglas Easton, Kyriaki Michailidou, Jacques Simard, Timothy Bishop, Iona C. Cheng, Jeroen R. Huyghe, Stephanie L. Schmit, Tracy A. O’Mara, Amanda B. Spurdle, Puya Gharahkhani, Johannes Schumacher, Janusz Jankowski, Ines Gockel, Melissa L. Bondy, Richard S. Houlston, Robert B. Jenkins, Beatrice Melin, Corina Lesseur, Andy R. Ness, Brenda Diergaarde, Andrew F. Olshan, Christopher I. Amos, David C. Christiani, Maria T. Landi, James D. McKay, Myriam Brossard, Mark M. Iles, Matthew H. Law, Stuart MacGregor, Jonathan Beesley, Michelle R. Jones, Jonathan Tyrer, Stacey J. Winham, Alison P. Klein, Gloria Petersen, Donghui Li, Brian M. Wolpin, Rosalind A. Eeles, Christopher A. Haiman, Zsofia Kote-Jarai, Fredrick R. Schumacher, Paul Brennan, Stephen J. Chanock, Valerie Gaborieau, Mark P. Purdue, Paul Pharoah, Rayjean J. Hung, Laufey T. Amundadottir, Peter Kraft, Bogdan Pasaniuc, Sara Lindström

Source: HGG Advances, Vol 2, Iss 3, Pp 100041- (2021)

Subject Terms: cancer, pleiotropy, fine-mapping, 5p15.33 region, TERT, CLPTM1L, Genetics, QH426-470

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666247721000221; https://doaj.org/toc/2666-2477

Access URL: https://doaj.org/article/9a140da595294f2c8d5b24dbeb44a4af

Genome-wide association study identifies multiple risk loci for renal cell carcinoma

Authors: Ghislaine Scelo, Mark P. Purdue, Kevin M. Brown, Mattias Johansson, Zhaoming Wang, Jeanette E. Eckel-Passow, Yuanqing Ye, Jonathan N. Hofmann, Jiyeon Choi, Matthieu Foll, Valerie Gaborieau, Mitchell J. Machiela, Leandro M. Colli, Peng Li, Joshua N. Sampson, Behnoush Abedi-Ardekani, Celine Besse, Helene Blanche, Anne Boland, Laurie Burdette, Amelie Chabrier, Geoffroy Durand, Florence Le Calvez-Kelm, Egor Prokhortchouk, Nivonirina Robinot, Konstantin G. Skryabin, Magdalena B. Wozniak, Meredith Yeager, Gordana Basta-Jovanovic, Zoran Dzamic, Lenka Foretova, Ivana Holcatova, Vladimir Janout, Dana Mates, Anush Mukeriya, Stefan Rascu, David Zaridze, Vladimir Bencko, Cezary Cybulski, Eleonora Fabianova, Viorel Jinga, Jolanta Lissowska, Jan Lubinski, Marie Navratilova, Peter Rudnai, Neonila Szeszenia-Dabrowska, Simone Benhamou, Geraldine Cancel-Tassin, Olivier Cussenot, Laura Baglietto, Heiner Boeing, Kay-Tee Khaw, Elisabete Weiderpass, Borje Ljungberg, Raviprakash T. Sitaram, Fiona Bruinsma, Susan J. Jordan, Gianluca Severi, Ingrid Winship, Kristian Hveem, Lars J. Vatten, Tony Fletcher, Kvetoslava Koppova, Susanna C. Larsson, Alicja Wolk, Rosamonde E. Banks, Peter J. Selby, Douglas F. Easton, Paul Pharoah, Gabriella Andreotti, Laura E. Beane Freeman, Stella Koutros, Demetrius Albanes, Satu Männistö, Stephanie Weinstein, Peter E. Clark, Todd L. Edwards, Loren Lipworth, Susan M. Gapstur, Victoria L. Stevens, Hallie Carol, Matthew L. Freedman, Mark M. Pomerantz, Eunyoung Cho, Peter Kraft, Mark A. Preston, Kathryn M. Wilson, J. Michael Gaziano, Howard D. Sesso, Amanda Black, Neal D. Freedman, Wen-Yi Huang, John G. Anema, Richard J. Kahnoski, Brian R. Lane, Sabrina L. Noyes, David Petillo, Bin Tean Teh, Ulrike Peters, Emily White, Garnet L. Anderson, Lisa Johnson, Juhua Luo, Julie Buring, I-Min Lee, Wong-Ho Chow, Lee E. Moore, Christopher Wood, Timothy Eisen, Marc Henrion, James Larkin, Poulami Barman, Bradley C. Leibovich, Toni K. Choueiri, G. Mark Lathrop, Nathaniel Rothman, Jean-Francois Deleuze, James D. McKay, Alexander S. Parker, Xifeng Wu, Richard S. Houlston, Paul Brennan, Stephen J. Chanock

Source: Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/ad47bc9f89b649d087928811441ea01d

Genetic Heterogeneity of BRAF Fusion Kinases in Melanoma Affects Drug Responses

Authors: Thomas Botton, Eric Talevich, Vivek Kumar Mishra, Tongwu Zhang, A. Hunter Shain, Céline Berquet, Alexander Gagnon, Robert L. Judson, Robert Ballotti, Antoni Ribas, Meenhard Herlyn, Stéphane Rocchi, Kevin M. Brown, Nicholas K. Hayward, Iwei Yeh, Boris C. Bastian

Source: Cell Reports, Vol 29, Iss 3, Pp 573-588.e7 (2019)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124719311866; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/0cc277c61e1b4388ac070ad9ad16b2a2

Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148

Authors: Jun Fang, Jinping Jia, Matthew Makowski, Mai Xu, Zhaoming Wang, Tongwu Zhang, Jason W. Hoskins, Jiyeon Choi, Younghun Han, Mingfeng Zhang, Janelle Thomas, Michael Kovacs, Irene Collins, Marta Dzyadyk, Abbey Thompson, Maura O'Neill, Sudipto Das, Qi Lan, Roelof Koster, PanScan Consortium, TRICL Consortium, GenoMEL Consortium, Rachael S. Stolzenberg-Solomon, Peter Kraft, Brian M. Wolpin, Pascal W. T. C. Jansen, Sara Olson, Katherine A. McGlynn, Peter A. Kanetsky, Nilanjan Chatterjee, Jennifer H. Barrett, Alison M. Dunning, John C. Taylor, Julia A. Newton-Bishop, D. Timothy Bishop, Thorkell Andresson, Gloria M. Petersen, Christopher I. Amos, Mark M. Iles, Katherine L. Nathanson, Maria Teresa Landi, Michiel Vermeulen, Kevin M. Brown, Laufey T. Amundadottir

Source: Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/6d29a2104a5544a480a010afb3a1a202

Secretory Microneme Proteins Induce T-Cell Recall Responses in Mice Chronically Infected with Toxoplasma gondii

Authors: Iti Saraav, Qiuling Wang, Kevin M. Brown, L. David Sibley

Source: mSphere, Vol 4, Iss 1 (2019)

Subject Terms: antigen-specific T cells, gamma interferon detection assays, memory T cells, microneme antigens, recall response, toxoplasmosis, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2379-5042

Access URL: https://doaj.org/article/f39f027f8e634a85b411915e3d234755

A Transcriptionally Inactive ATF2 Variant Drives Melanomagenesis

Authors: Giuseppina Claps, Yann Cheli, Tongwu Zhang, Marzia Scortegagna, Eric Lau, Hyungsoo Kim, Jianfei Qi, Jian-Liang Li, Brian James, Andreas Dzung, Mitchell P. Levesque, Reinhard Dummer, Nicholas K. Hayward, Marcus Bosenberg, Kevin M. Brown, Ze’ev A. Ronai

Source: Cell Reports, Vol 15, Iss 9, Pp 1884-1892 (2016)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124716305162; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/3850dc004e8748c790379ebd4ad2af6d

Downregulation of the Ubiquitin Ligase RNF125 Underlies Resistance of Melanoma Cells to BRAF Inhibitors via JAK1 Deregulation

Authors: Hyungsoo Kim, Dennie T. Frederick, Mitchell P. Levesque, Zachary A. Cooper, Yongmei Feng, Clemens Krepler, Laurence Brill, Yardena Samuels, Nicholas K. Hayward, Ally Perlina, Adriano Piris, Tongwu Zhang, Ruth Halaban, Meenhard M. Herlyn, Kevin M. Brown, Jennifer A. Wargo, Reinhard Dummer, Keith T. Flaherty, Ze’ev A. Ronai

Source: Cell Reports, Vol 11, Iss 9, Pp 1458-1473 (2015)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124715004660; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/adafe221293748a28456eeb05b0f1a0b

Plasma Membrane Association by N-Acylation Governs PKG Function in Toxoplasma gondii

Authors: Kevin M. Brown, Shaojun Long, L. David Sibley

Source: mBio, Vol 8, Iss 3 (2017)

Subject Terms: Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/74433ec6713a4bfa807368c1f4e4b78c

Correction: Publisher correction: Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148

Authors: Jun Fang, Jinping Jia, Matthew Makowski, Mai Xu, Zhaoming Wang, Tongwu Zhang, Jason W. Hoskins, Jiyeon Choi, Younghun Han, Mingfeng Zhang, Janelle Thomas, Michael Kovacs, Irene Collins, Marta Dzyadyk, Abbey Thompson, Maura O'Neill, Sudipto Das, Qi Lan, Roelof Koster, Rachael S. Stolzenberg-Solomon, Peter Kraft, Brian M. Wolpin, Pascal W. T. C. Jansen, Sara Olson, Katherine A. McGlynn, Peter A. Kanetsky, Nilanjan Chatterjee, Jennifer H. Barrett, Alison M. Dunning, John C. Taylor, Julia A. Newton-Bishop, D Timothy Bishop, Thorkell Andresson, Gloria M. Petersen, Christopher I. Amos, Mark M. Iles, Katherine L. Nathanson, Maria Teresa Landi, Michiel Vermeulen, Kevin M. Brown, Laufey T. Amundadottir

Source: Nature Communications, Vol 9, Iss 1, Pp 1-2 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/147c64a9878c4dcc95df20ed5c41cdd3

Efficient Gene Disruption in Diverse Strains of Toxoplasma gondii Using CRISPR/CAS9

Authors: Bang Shen, Kevin M. Brown, Tobie D. Lee, L. David Sibley

Source: mBio, Vol 5, Iss 3 (2014)

Subject Terms: Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/3703bfd008c74408aa12a7cbc922e88c