Mathematical modeling of the early modeled CA-125 longitudinal kinetics (KELIM-PARP) as a pragmatic indicator of rucaparib efficacy in patients with recurrent ovarian carcinoma in ARIEL2 & STUDY 10Research in context

Authors: Olivier Colomban, Elizabeth M. Swisher, Rebecca Kristeleit, Iain McNeish, Ronnie Shapira-Frommer, Sandra Goble, Kevin K. Lin, Lara Maloney, Gilles Freyer, Benoit You

Source: EBioMedicine, Vol 89, Iss , Pp 104477- (2023)

Subject Terms: Ovarian neoplasm, CA-125 antigen, Poly (ADP-ribose) polymerase inhibitors, Decision support techniques, Medicine, Medicine (General), R5-920

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Relation: http://www.sciencedirect.com/science/article/pii/S2352396423000427; https://doaj.org/toc/2352-3964

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Molecular and clinical determinants of response and resistance to rucaparib for recurrent ovarian cancer treatment in ARIEL2 (Parts 1 and 2)

Authors: Elizabeth M. Swisher, Tanya T. Kwan, Amit M. Oza, Anna V. Tinker, Isabelle Ray-Coquard, Ana Oaknin, Robert L. Coleman, Carol Aghajanian, Gottfried E. Konecny, David M. O’Malley, Alexandra Leary, Diane Provencher, Stephen Welch, Lee-may Chen, Andrea E. Wahner Hendrickson, Ling Ma, Prafull Ghatage, Rebecca S. Kristeleit, Oliver Dorigo, Ashan Musafer, Scott H. Kaufmann, Julia A. Elvin, Douglas I. Lin, Setsuko K. Chambers, Erin Dominy, Lan-Thanh Vo, Sandra Goble, Lara Maloney, Heidi Giordano, Thomas Harding, Alexander Dobrovic, Clare L. Scott, Kevin K. Lin, Iain A. McNeish

Source: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

Subject Terms: Science

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Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/4c0bb318d2464bacb5fcd01f6ceefda3

Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma

Authors: Olga Kondrashova, Monique Topp, Ksenija Nesic, Elizabeth Lieschke, Gwo-Yaw Ho, Maria I. Harrell, Giada V. Zapparoli, Alison Hadley, Robert Holian, Emma Boehm, Valerie Heong, Elaine Sanij, Richard B. Pearson, John J. Krais, Neil Johnson, Orla McNally, Sumitra Ananda, Kathryn Alsop, Karla J. Hutt, Scott H. Kaufmann, Kevin K. Lin, Thomas C. Harding, Nadia Traficante, Australian Ovarian Cancer Study (AOCS), Anna deFazio, Iain A. McNeish, David D. Bowtell, Elizabeth M. Swisher, Alexander Dobrovic, Matthew J. Wakefield, Clare L. Scott

Source: Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/daa72fc740814394b7993401524f3f72

A Quantitative Chemotherapy Genetic Interaction Map Reveals Factors Associated with PARP Inhibitor Resistance

Authors: Hsien-Ming Hu, Xin Zhao, Swati Kaushik, Lilliane Robillard, Antoine Barthelet, Kevin K. Lin, Khyati N. Shah, Andy D. Simmons, Mitch Raponi, Thomas C. Harding, Sourav Bandyopadhyay

Source: Cell Reports, Vol 23, Iss 3, Pp 918-929 (2018)

Subject Terms: Biology (General), QH301-705.5

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Relation: http://www.sciencedirect.com/science/article/pii/S2211124718304546; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/c909b47692df44cdb6150df68cfc7bc1

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Detection of latent brain states from spontaneous neural activity in the amygdala.

Authors: Alexa Aucoin, Kevin K Lin, Katalin M Gothard

Source: PLoS Computational Biology, Vol 21, Iss 2, p e1012247 (2025)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-734X; https://doaj.org/toc/1553-7358

Access URL: https://doaj.org/article/b64b4d0c0a5a48a7ae45052ce303fda8

A data-informed mean-field approach to mapping of cortical parameter landscapes.

Authors: Zhuo-Cheng Xiao, Kevin K Lin, Lai-Sang Young

Source: PLoS Computational Biology, Vol 17, Iss 12, p e1009718 (2021)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-734X; https://doaj.org/toc/1553-7358

Access URL: https://doaj.org/article/e61a7815bd3f4c7dac6fa9a89795c581

Encoding in Balanced Networks: Revisiting Spike Patterns and Chaos in Stimulus-Driven Systems.

Authors: Guillaume Lajoie, Kevin K Lin, Jean-Philippe Thivierge, Eric Shea-Brown

Source: PLoS Computational Biology, Vol 12, Iss 12, p e1005258 (2016)

Subject Terms: Biology (General), QH301-705.5

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Relation: http://europepmc.org/articles/PMC5156368?pdf=render; https://doaj.org/toc/1553-734X; https://doaj.org/toc/1553-7358

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Circadian clock genes contribute to the regulation of hair follicle cycling.

Authors: Kevin K Lin, Vivek Kumar, Mikhail Geyfman, Darya Chudova, Alexander T Ihler, Padhraic Smyth, Ralf Paus, Joseph S Takahashi, Bogi Andersen

Source: PLoS Genetics, Vol 5, Iss 7, p e1000573 (2009)

Subject Terms: Genetics, QH426-470

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Relation: http://europepmc.org/articles/PMC2705795?pdf=render; https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404

Access URL: https://doaj.org/article/a406f16a95c24a51a2b4ae7054ea2f88