In Vitro and In Vivo Comparison of Random versus Site-Specific Conjugation of Bifunctional Chelating Agents to the CD33-Binding Antibody for Use in Alpha- and Beta-Radioimmunotherapy

Authors: Kevin J. H. Allen, Connor Frank, Rubin Jiao, Mackenzie E. Malo, Michele Bello, Laura De Nardo, Laura Meléndez-Alafort, Ekaterina Dadachova

Source: ACS Omega, Vol 9, Iss 50, Pp 50000-50011 (2024)

Subject Terms: Chemistry, QD1-999

File Description: electronic resource

Relation: https://doaj.org/toc/2470-1343

Access URL: https://doaj.org/article/9c25636aec204013ab78119e84c94520

Comparative Molecular Characterization and Pharmacokinetics of IgG1-Fc and Engineered Fc Human Antibody Variants to Insulin-like Growth Factor 2 Receptor (IGF2R)

Authors: Chandra B. Prabaharan, Sabeena Giri, Kevin J. H. Allen, Katrina E. M. Bato, Therese R. Mercado, Mackenzie E. Malo, Jorge L. C. Carvalho, Ekaterina Dadachova, Maruti Uppalapati

Source: Molecules, Vol 28, Iss 15, p 5839 (2023)

Subject Terms: osteosarcoma (OS), insulin-like growth factor 2 receptor (IGF2R), monoclonal antibodies, neonatal Fc receptor (FcRn), radioimmunotherapy (RIT), Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/28/15/5839; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/48fe470b2a6848f39dc41d8d274e15e4

Image-Based Dosimetry in Dogs and Cross-Reactivity with Human Tissues of IGF2R-Targeting Human Antibody

Authors: Kevin J. H. Allen, Ohyun Kwon, Matthew R. Hutcheson, Joseph J. Grudzinski, Stuart M. Cain, Frederic A. Cruz, Remitha M. Vinayakamoorthy, Ying S. Sun, Lindsay Fairley, Chandra B. Prabaharan, Ryan Dickinson, Valerie MacDonald-Dickinson, Maruti Uppalapati, Bryan P. Bednarz, Ekaterina Dadachova

Source: Pharmaceuticals, Vol 16, Iss 7, p 979 (2023)

Subject Terms: IGF2R, osteosarcoma, image-based dosimetry RAPID, 89Zr, 177Lu, tissue cross-reactivity, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/16/7/979; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/c4e817e3f39f4e6b99757ca74f03bafa

225Ac‐labeled CD33‐targeting antibody reverses resistance to Bcl‐2 inhibitor venetoclax in acute myeloid leukemia models

Authors: Ravendra Garg, Kevin J. H. Allen, Wojciech Dawicki, Eileen M. Geoghegan, Dale L. Ludwig, Ekaterina Dadachova

Source: Cancer Medicine, Vol 10, Iss 3, Pp 1128-1140 (2021)

Subject Terms: 225Ac‐lintuzumab, acute myeloid leukemia, Bcl‐2, radioimmunotherapy, venetoclax, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2045-7634

Access URL: https://doaj.org/article/af252bdb1a414e8c8cac047a8543fb55

Evaluation of novel highly specific antibodies to cancer testis antigen Centrin‐1 for radioimmunoimaging and radioimmunotherapy of pancreatic cancer

Authors: Rubin Jiao, Kevin J. H. Allen, Mackenzie E. Malo, Muath Helal, Zewei Jiang, Karishma Smart, Susan V. Buhl, David Rickles, Ruth A. Bryan, Ekaterina Dadachova

Source: Cancer Medicine, Vol 8, Iss 11, Pp 5289-5300 (2019)

Subject Terms: 177Lutetium, 213Bismuth, centrin1, pancreatic adenocarcinoma, radioimmunotherapy, SPECT/CT imaging, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2045-7634

Access URL: https://doaj.org/article/9ed1c8cdf1a4417bbfe386cc7289b284

In Vitro and In Vivo Characterization of 89Zirconium-Labeled Lintuzumab Molecule

Authors: Kevin J. H. Allen, Rubin Jiao, Jason Li, Denis R. Beckford-Vera, Ekaterina Dadachova

Source: Molecules, Vol 27, Iss 19, p 6589 (2022)

Subject Terms: lintuzumab, 89Zirconium, positron emission tomography, acute myeloid leukemia, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/27/19/6589; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/64a555f53e1848abaf5da07be6768c4e

Radioimmunotherapy Targeting IGF2R on Canine-Patient-Derived Osteosarcoma Tumors in Mice and Radiation Dosimetry in Canine and Pediatric Models

Authors: Jaline Broqueza, Chandra B. Prabaharan, Kevin J. H. Allen, Rubin Jiao, Darrell R. Fisher, Ryan Dickinson, Valerie MacDonald-Dickinson, Maruti Uppalapati, Ekaterina Dadachova

Source: Pharmaceuticals, Vol 15, Iss 1, p 10 (2021)

Subject Terms: osteosarcoma, IGF2R, radioimmunotherapy, canine-patient-derived Gracie tumors, human dosimetry, canine dosimetry, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/15/1/10; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/1fee13fead964d35bc77671f57e68319

Radioimmunotherapy of Blastomycosis in a Mouse Model With a (1→3)-β-Glucans Targeting Antibody

Authors: Muath Helal, Kevin J. H. Allen, Bruce van Dijk, Joshua D. Nosanchuk, Elisabeth Snead, Ekaterina Dadachova

Source: Frontiers in Microbiology, Vol 11 (2020)

Subject Terms: radioimmunotherapy, Blastomyces dermatitidis, (1→3)-β-glucan, mouse model, 213Bismuth, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fmicb.2020.00147/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/33b37536d50d414f9e6a7e775fdc0456

Safety Evaluation of an Alpha-Emitter Bismuth-213 Labeled Antibody to (1→3)-β-Glucan in Healthy Dogs as a Prelude for a Trial in Companion Dogs with Invasive Fungal Infections

Authors: Muath Helal, Kevin J. H. Allen, Hilary Burgess, Rubin Jiao, Mackenzie E. Malo, Matthew Hutcheson, Ekaterina Dadachova, Elisabeth Snead

Source: Molecules, Vol 25, Iss 16, p 3604 (2020)

Subject Terms: radioimmunotherapy, bismuth-213, invasive fungal infections, 1-3-beta-glucan, dogs, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/25/16/3604; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/de6d4df6c8714d2596cee4c49a3fde5d

Comparative Radioimmunotherapy of Experimental Melanoma with Novel Humanized Antibody to Melanin Labeled with 213Bismuth and 177Lutetium

Authors: Kevin J. H. Allen, Rubin Jiao, Mackenzie E. Malo, Connor Frank, Darrell R. Fisher, David Rickles, Ekaterina Dadachova

Source: Pharmaceutics, Vol 11, Iss 7, p 348 (2019)

Subject Terms: radioimmunotherapy, humanized antibody, melanin, B16-F10 melanoma, 213Bismuth, 177Lutetium, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/11/7/348; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/fac8916038564d71940458814e0fa11a

Biodistribution of a Radiolabeled Antibody in Mice as an Approach to Evaluating Antibody Pharmacokinetics

Authors: Kevin J. H. Allen, Rubin Jiao, Mackenzie E. Malo, Connor Frank, Ekaterina Dadachova

Source: Pharmaceutics, Vol 10, Iss 4, p 262 (2018)

Subject Terms: pharmacokinetics, antibodies, radiolabeling, biodistribution, mouse models, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/10/4/262; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/2517bad1a2be45e1bd3e5fbe52e17b2a